Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis

Journal of Pediatric Surgery

Volumn 41, Issue 4, 2006, Pages 742-747

  Feng, Jiexiong ^b   El Assal, Osama N ^b   Besner, Gail E ^a  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Apoptosis; Caspase 3; HB EGF; Necrotizing enterocolitis; TUNEL

Indexed keywords

CASPASE 3; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; FEMALE; HYPOTHERMIA; HYPOXIA; IMMUNOHISTOCHEMISTRY; INCIDENCE; NECROTIZING ENTEROCOLITIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ENTEROCOLITIS, NECROTIZING; EPIDERMAL GROWTH FACTOR; HEPARIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33645280594     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2005.12.020     Document Type: Article

References (23)

1. M.C. Henry, and R.L. Moss Current issues in the management of necrotizing enterocolitis Semin Perinatol 28 2004 221 233
2. J. Feng, O.N. El-Assal, and G.E. Besner Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis Semin Pediatr Surg 14 2005 167 174
3. H. Ford, S. Watkins, and K. Reblock The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis J Pediatr Surg 32 1997 275 282
4. E.P. Nadler, E. Dickinson, and A. Knisely Expression of inducible nitric oxide synthase and interleukin-12 in experimental necrotizing enterocolitis J Surg Res 92 2000 71 77
5. T. Jilling, J. Lu, and M. Jackson Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis Pediatr Res 55 2004 622 629
6. G.E. Besner, S. Higashiyama, and M. Klagsbrun Isolation and characterization of a macrophage-derived heparin-binding growth factor Cell Regul 1 1990 811 819
7. Feng J, El-Assal ON, Besner GE. Heparin-binding EGF-like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats. J Pediatr Surg [in press].
8. M.P. Michalsky, A. Kuhn, and V. Mehta Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro J Pediatr Surg 36 2001 1130 1135
9. B. Barlow, T.V. Santulli, and W.C. Heird An experimental study of acute neonatal enterocolitis-the important of breast milk J Pediatr Surg 9 1974 587 595
10. M.S. Caplan, E. Hedlund, and L. Adler Role of asphyxia and feeding in a neonatal rat model of necrotizing enterocolitis Pediatr Pathol 14 1994 1017 1028
11. J.A. Clark, R.H. Lane, and N.K. Maclennan Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis Am J Physiol Gastrointest Liver Physiol 288 2005 G755 G762
12. I. Ciftci, A. Dilsiz, and T.M. Aktan Effects of nitric oxide synthase inhibition on intestinal damage in rats with experimental necrotizing enterocolitis Eur J Pediatr Surg 14 2004 398 403
13. D.A. Potoka, J.S. Upperman, and E.P. Nadler NF-kappaB inhibition enhances peroxynitrite-induced enterocyte apoptosis J Surg Res 106 2002 7 14
14. J.S. Upperman, E.P. Nadle, and R.A. Hoffman Peroxynitrite induces enterocyte apoptosis in vitro by modulating mitochondrial membrane potential and PARS cleavage Surg Forum 1999 81 82
15. M.L. Lara-Marquez, V. Mehta, and M.P. Michalsky Heparin-binding EGF-like growth factor down regulates proinflammatory cytokine-induced nitric oxide and inducible nitric oxide synthase production in intestinal epithelial cells Nitric Oxide 6 2002 142 152
16. V.B. Mehta, and G.E. Besner Inhibition of NF-kappa B activation and its target genes by heparin-binding epidermal growth factor-like growth factor J Immunol 171 2003 6014 6022
17. G. Xia, M. Lara-Marquez, and M.H. Luquette Heparin-binding EGF-like growth factor decreases inducible nitric oxide synthase and nitric oxide production after intestinal ischemia/reperfusion injury Antioxid Redox Signal 3 2001 919 930
18. H. Takenobu, A. Yamazaki, and M. Hirata The stress- and inflammatory cytokine-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor is mediated by p38 MAPK, distinct from the 12-O-tetradecanoylphorbol-13-acetate- and lysophosphatidic acid-induced signaling cascades J Biol Chem 278 2003 17255 17262
19. S. Sakuda, S. Tamura, and A. Yamada NF-kappaB activation in non-parenchymal liver cells after partial hepatectomy in rats: possible involvement in expression of heparin-binding epidermal growth factor-like growth factor J Hepatol 36 2002 527 533
20. H.T. Nguyen, S.H. Bride, and A.B. Badawy Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis Am J Pathol 156 2000 889 898
21. J.M. Bryson, P.E. Coy, and K. Gottlob Increased hexokinase activity, of either ectopic or endogenous origin, protects renal epithelial cells against acute oxidant-induced cell death J Biol Chem 277 2002 11392 11400
22. M. Horikawa, S. Higashiyama, and S. Nomura Upregulation of endogenous heparin-binding EGF-like growth factor and its role as a survival factor in skeletal myotubes FEBS Lett 459 1999 100 104
23. M.A. Kuhn, G. Xia, and V.B. Mehta Heparin-binding EGF-like growth factor (HB-EGF) decreases oxygen free radical production in vitro and in vivo Antioxid Redox Signal 4 2002 639 646