Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis

Journal of Immunology

Volumn 191, Issue 9, 2013, Pages 4540-4550

  Rankin, Andrew L ^a   Seth, Nilufer ^a   Keegan, Sean ^a   Andreyeva, Tatyana ^a   Cook, Tim A ^a   Edmonds, Jason ^a   Mathialagan, Nagappan ^a   Benson, Micah J ^a   Syed, Jameel ^a   Zhan, Yutian ^a   Benoit, Stephen E ^a   Miyashiro, Joy S ^a   Wood, Nancy ^a   Mohan, Shashi ^a   Peeva, Elena ^a   Ramaiah, Shashi K ^a   Messing, Dean ^a   Homer, Bruce L ^a   Dunussi Joannopoulos, Kyri ^a   Nickerson Nutter, Cheryl L ^a   Schnute, Mark E ^a   Douhan III, John ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 (1 CYANOPIPERIDIN 3 YL) 3 (4 [2,4 DIFLUOROPHENOXY]PHENYL) 1H PYRAZOLE 4 CARBOXAMIDE; BRUTON TYROSINE KINASE; BRUTON TYROSINE KINASE INHIBITOR; FC RECEPTOR; PF 06250112; UNCLASSIFIED DRUG; 5-AMINO-1-(1-CYANOPIPERIDIN-3-YL)-3-(4-(2,4-DIFLUOROPHENOXY)PHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE; AGAMMAGLOBULINAEMIA TYROSINE KINASE; PIPERIDINE DERIVATIVE; PROTEIN TYROSINE KINASE; PYRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; GERMINAL CENTER; IN VITRO STUDY; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PATHOGENESIS; PLASMA CELL; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEINURIA; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION; ANIMAL; ANTAGONISTS AND INHIBITORS; B LYMPHOCYTE; CELL PROLIFERATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GLOMERULONEPHRITIS; IMMUNOLOGY; KIDNEY; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; METABOLISM; NEW ZEALAND BLACK MOUSE; T LYMPHOCYTE;

ANIMALS; B-LYMPHOCYTES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; GERMINAL CENTER; GLOMERULONEPHRITIS; KIDNEY; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NZB; PIPERIDINES; PLASMA CELLS; PROTEIN-TYROSINE KINASES; PYRAZOLES; RECEPTORS, FC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84886074553     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301553     Document Type: Article

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