Chemical sympathectomy attenuates inflammation, glycocalyx shedding and coagulation disorders in rats with acute traumatic coagulopathy

Blood Coagulation and Fibrinolysis

Volumn 26, Issue 2, 2015, Pages 152-160

  Xu, Lin ^a   Yu, Wen Kui ^a   Lin, Zhi Liang ^a   Tan, Shan Jun ^a   Bai, Xiao Wu ^a   Ding, Kai ^a   Li, Ning ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

catecholamine; chemical sympathectomy; coagulopathy; heart rate variability; hemorrhage; trauma

Indexed keywords

CATECHOLAMINE; FIBRINOGEN; OXIDOPAMINE; PLASMIN; SYNDECAN 1; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TRAUMATIC COAGULOPATHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NEUROPATHY; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; CHEMICAL SYMPATHECTOMY; CONTROLLED STUDY; FIBRINOLYSIS; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SHOCK; THROMBOCYTE ACTIVATION; ANIMAL; BLOOD; GLYCOCALYX; METABOLISM; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; GLYCOCALYX; INFLAMMATION; MALE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SYMPATHECTOMY, CHEMICAL;

EID: 84922400429     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0000000000000211     Document Type: Article

References (33)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38:185-193.
2. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway. Ann Surg 2007; 245:812-818.
3. Floccard B, Rugeri L, Faure A, Saint DM, Boyle EM, Peguet O, et al. Early coagulopathy in trauma patients: an on-scene and hospital admission study. Injury 2012; 43:26-32.
4. Chapman MP, Moore EE, Ramos CR, Ghasabyan A, Harr JN, Chin TL, et al. Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy. J Trauma Acute Care Surg 2013; 75:961-967.
5. Kashuk JL, Moore EE, Sawyer M, Wohlauer M, Pezold M, Barnett C, et al. Primary fibrinolysis is integral in the pathogenesis of the acute coagulopathy of trauma. Ann Surg 2010; 252:434-442; discussion 443-444.
6. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008; 248:447-458.
7. Cohen MJ, Kutcher M, Redick B, Nelson M, Call M, Knudson MM, et al. Clinical and mechanistic drivers of acute traumatic coagulopathy. J Trauma Acute Care Surg 2013; 75:S40-47.
8. Frith D, Goslings JC, Gaarder C, Maegele M, Cohen MJ, Allard S, et al. Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations. J Thromb Haemost 2010; 8:1919-1925.
9. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. High circulating adrenaline levels at admission predict increased mortality after trauma. J Trauma Acute Care Surg 2012; 72:428-436.
10. Johansson PI, Stensballe J, Rasmussen LS, Ostrowski SR. A high admission syndecan-1 level, a marker of endothelial glycocalyx degradation, is associated with inflammation, protein C depletion, fibrinolysis, and increased mortality in trauma patients. Ann Surg 2011; 254:194-200.
11. Pierce A, Pittet JF. Inflammatory response to trauma: implications for coagulation and resuscitation. Curr Opin Anaesthesiol 2014; 27:246-252.
12. Preckel D, von Kanel R. Regulation of hemostasis by the sympathetic nervous system: any contribution to coronary artery disease. Heartdrug 2004; 4:123-130.
13. Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 2005; 131:417-430.
14. Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg 2012; 73:60-66.
15. Molina PE. Neurobiology of the stress response: contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury. Shock (Augusta, Ga ) 2005; 24:3-10.
16. Dias da Silva VJ, Paton JF. Introduction: the interplay between the autonomic and immune systems. Exp Physiol 2012; 97:1143-1145.
17. Morris JA Jr, Norris PR, Ozdas A, Waitman LR, Harrell FE Jr, Williams AE, et al. Reduced heart rate variability: an indicator of cardiac uncoupling and diminished physiologic reserve in 1, 425 trauma patients. J Trauma 2006; 60:1165-1173; discussion 1173-1174.
18. Patel MB, McKenna JW, Alvarez JM, Sugiura A, Jenkins JM, Guillamondegui OD, et al. Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial. Trials 2012; 13:177.
19. Chaswal M, Das S, Prasad J, Katyal A, Fahim M. Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress. Can JPhysiol Pharmacol 2011; 89:865-874.
20. Chesebro BB, Rahn P, Carles M, Esmon CT, Xu J, Brohi K, et al. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock (Augusta, Ga) 2009; 32:659-665.
21. Picklo MJ. Methods of sympathetic degeneration and alteration. J Auton Nerv Syst 1997; 62:111-125.
22. Darlington DN, Craig T, Gonzales MD, Schwacha MG, Cap AP, Dubick MA. Acute coagulopathy of trauma in the rat. Shock 2013; 39:440-446.
23. Yamakawa K, Matsumoto N, Imamura Y, Muroya T, Yamada T, Nakagawa J, et al. Electrical vagus nerve stimulation attenuates systemic inflammation and improves survival in a rat heatstroke model. PLoS One 2013; 8:e56728.
24. Heffernan DS, Inaba K, Arbabi S, Cotton BA. Sympathetic hyperactivity after traumatic brain injury and the role of beta-blocker therapy. J Trauma 2010; 69:1602-1609.
25. Cooke WH, Salinas J, Convertino VA, Ludwig DA, Hinds D, Duke JH, et al. Heart rate variability and its association with mortality in prehospital trauma patients. J Trauma 2006; 60:363-370; discussion 370.
26. Norris PR, Morris JA Jr, Ozdas A, Grogan EL, Williams AE. Heart rate variability predicts trauma patient outcome as early as 12 h: implications for military and civilian triage. J Surg Res 2005; 129:122-128.
27. Kawada T, Akiyama T, Shimizu S, Kamiya A, Uemura K, Turner MJ, et al. Sympathetic afferent stimulation inhibits central vagal activation induced by intravenous medetomidine in rats. Acta Physiol (Oxford, England) 2013; 209:55-61.
28. Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, Huston J, et al. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 2005; 201:1113-1123.
29. Hermann GE, Rogers RC. TNF alpha: a trigger of autonomic dysfunction. Neuroscientist 2008; 14:53-67.
30. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 2013; 11:307-314.
31. Jiang X, Wang Y, Hand AR, Gillies C, Cone RE, Kirk J, et al. Storage and release of tissue plasminogen activator by sympathetic axons in resistance vessel walls. Microvasc Res 2002; 64:438-447.
32. Wang Y, Jiang X, Hand AR, Gilles C, Kirk J, Cone RE, et al. Additional evidence that the sympathetic nervous system regulates the vessel wall release of tissue plasminogen activator. Blood Coagul Fibrinolysis 2002; 13:471-481.
33. Chappell D, Hofmann-Kiefer K, Jacob M, Rehm M, Briegel J, Welsch U, et al. TNF-alpha induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin. Basic Res Cardiol 2009; 104:78-89.