Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial

Trials

Volumn 13, Issue , 2012, Pages

  Patel, Mayur B ^a,b   McKenna, John W ^b   Alvarez, JoAnn M ^c   Sugiura, Ayaka ^b   Jenkins, Judith M ^b   Guillamondegui, Oscar D ^b   Pandharipande, Pratik P ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adrenergic blockade; Agitation; Alpha2 agonist; Autonomic dysfunction; Beta blocker; Clonidine; Propranolol; Sympathetic hyperactivity; Sympathetic storm; Traumatic brain injury

Indexed keywords

ANALGESIC AGENT; ANTIHYPERTENSIVE AGENT; CATECHOLAMINE; CLONIDINE; NEUROLEPTIC AGENT; NORADRENALIN; PLACEBO; PROPRANOLOL; SEDATIVE AGENT;

ADRENERGIC RECEPTOR BLOCKING; ARTICLE; BEHAVIOR; CATECHOLAMINE URINE LEVEL; COMA; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; EXECUTIVE FUNCTION; GLASGOW OUTCOME SCALE; HEART ARRHYTHMIA; HEART RATE VARIABILITY; HOSPITAL DISCHARGE; HUMAN; INFECTION; LENGTH OF STAY; MEMORY; MORTALITY; NEUROPSYCHOLOGY; NEURORADIOLOGY; NORADRENALIN BLOOD LEVEL; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SYMPATHETIC FUNCTION; TRAUMATIC BRAIN INJURY;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC FIBERS; BIOLOGICAL MARKERS; BRAIN INJURIES; CATECHOLAMINES; CLONIDINE; COGNITION; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; GLASGOW COMA SCALE; HEMODYNAMICS; HUMANS; NEUROLOGIC EXAMINATION; NEUROPSYCHOLOGICAL TESTS; PROPRANOLOL; QUALITY OF LIFE; RESEARCH DESIGN; SYMPATHETIC NERVOUS SYSTEM; TENNESSEE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84870707526     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-13-177     Document Type: Article

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