Sympathetic afferent stimulation inhibits central vagal activation induced by intravenous medetomidine in rats

Acta Physiologica

Volumn 209, Issue 1, 2013, Pages 55-61

  Kawada, T ^a   Akiyama, T ^a   Shimizu, S ^a   Kamiya, A ^a   Uemura, K ^a   Turner, M J ^a   Shirai, M ^a   Sugimachi, M ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

Author keywords

Acetylcholine; Cardiac microdialysis; Medetomidine; Rats; Vagal nerve stimulation; Visceral afferent

Indexed keywords

ACETYLCHOLINE; MEDETOMIDINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT;

ACETYLCHOLINE RELEASE; ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE; MICRODIALYSIS; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; STELLATE GANGLION; SYMPATHETIC AFFERENT STIMULATION; VAGUS NERVE; VAGUS NERVE STIMULATION; ANIMAL; BLOOD PRESSURE; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; PROCEDURES; WISTAR KYOTO RAT;

ACETYLCHOLINE; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BLOOD PRESSURE; MEDETOMIDINE; RATS, INBRED WKY; VAGUS NERVE; VAGUS NERVE STIMULATION;

EID: 84881557858     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12123     Document Type: Article

References (26)

1. Agarwal, S.K. & Calaresu, F.R. 1992. Electrical stimulation of nucleus tractus solitarius excites vagal preganglionic cardiomotor neurons of the nucleus ambiguus in rats. Brain Res 574, 320-324.
2. Akiyama, T., Yamazaki, T. & Ninomiya, I. 1994. In vivo detection of endogenous acetylcholine release in cat ventricles. Am J Physiol 266, H854-H860.
3. Bhuiyan, M.E., Waki, H., Gouraud, S.S., Takagishi, M., Cui, H., Yamazaki, T., Kohsaka, A. & Maeda, M. 2009. Complex cardiovascular actions of alpha-adrenergic receptors expressed in the nucleus tractus solitarii of rats. Exp Physiol 94, 773-784.
4. Cerati, D. & Schwartz, P.J. 1991. Single cardiac vagal fiber activity, acute myocardial ischemia, and risk for sudden death. Circ Res 69, 1389-1401.
5. De Ferrari, G.M., Crijns, H.J., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., Raspopovic, S., Klein, H., Swedberg, K., Schwartz, P.J. & CardioFit Multicenter Trial Investigators. 2011. Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. Eur Heart J 32, 847-855.
6. Gao, L., Schultz, H.D., Patel, K.P., Zucker, I.H. & Wang, W. 2005. Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension 45, 1173-1181.
7. Glantz, S.A. 2002. Primer of Biostatistics, 5th edn, McGraw-Hill, New York.
8. Gnecchi Ruscone, T., Lombardi, F., Malfatto, G. & Malliani, A. 1987. Attenuation of baroreceptive mechanisms by cardiovascular sympathetic afferent fibers. Am J Physiol 253, H787-H791.
9. Kawada, T., Akiyama, T., Shimizu, S., Kamiya, A., Uemura, K., Li, M., Shirai, M. & Sugimachi, M. 2009. Detection of endogenous acetylcholine release during brief ischemia in the rabbit ventricle: a possible trigger for ischemic preconditioning. Life Sci 85, 597-601.
10. + channels inhibit vagal acetylcholine release at the rabbit sinoatrial node. Auton Neurosci 156, 149-151.
11. 2-adrenergic stimulation is impaired in spontaneously hypertensive rats. Acta Physiol (Oxf) 206, 72-79.
12. Li, M., Zheng, C., Sato, T., Kawada, T., Sugimachi, M. & Sunagawa, K. 2004. Vagal nerve stimulation markedly improves long-term survival after chronic heart failure in rats. Circulation 109, 120-124.
13. Malliani, A. 1990. Cardiocardiac excitatory reflexes during myocardial ischemia. Basic Res Cardiol 85(Suppl 1), 243-252.
14. Malliani, A. & Montano, N. 2002. Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions. Hypertension 39, 63-68.
15. Minsi, A.J. & Thames, M.D. 1991. Activation of cardiac sympathetic afferents during coronary occlusion. Evidence for reflex activation of sympathetic nervous system during transmural myocardial ischemia in the dog. Circulation 84, 357-367.
16. Pan, H. & Chen, S. 2002. Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats. J Neurophysiol 87, 660-668.
17. Persson, P.B. & Henriksson, J. 2011. Good publication practise in physiology. Acta Physiol 203, 403-407.
18. 2-receptor agonist, diminishes GABAergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1347, 65-70.
19. Pirec, V., Laurito, C.E., Lu, Y. & Yeomans, D.C. 2001. The combined effects of N-type calcium channel blockers and morphine on Aδ versus C fiber mediated nociception. Anesth Analg 92, 239-243.
20. Schwartz, P.J. 2011. Vagal stimulation for heart diseases: from animals to men. - An example of translational cardiology. Circ J 75, 20-27.
21. Schwartz, P.J., Pagani, M., Lombardi, F., Malliani, A. & Brown, A.M. 1973. A cardiocardiac sympathovagal reflex in the cat. Circ Res 32, 215-220.
22. Shimizu, S., Akiyama, T., Kawada, T., Shishido, T., Yamazaki, T., Kamiya, A., Mizuno, M., Sano, S. & Sugimachi, M. 2009. In vivo direct monitoring of vagal acetylcholine release to the sinoatrial node. Auton Neurosci 148, 44-49.
23. 2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control. Circ J 76, 152-159.
24. Snedecor, G.W. & Cochran, W.G. 1989. Statistical Methods, 8th edn, pp. 290-291. Iowa State University Press, Iowa.
25. Wang, W.Z., Gao, L., Pan, Y.X., Zucker, I.H. & Wang, W. 2006. Differential effects of cardiac sympathetic afferent stimulation on neurones in the nucleus tractus solitarius. Neurosci Lett 400, 146-150.
26. Wetzel, G.T., Goldstein, D. & Brown, J.H. 1985. Acetylcholine release from rat atria can be regulated through an alpha 1-adrenergic receptor. Circ Res 56, 763-766.