Clinical and mechanistic drivers of acute traumatic coagulopathy

Journal of Trauma and Acute Care Surgery

Volumn 75, Issue 1 SUPPL1, 2013, Pages

  Cohen, Mitchell Jay ^a   Kutcher, Matt ^a   Redick, Britt ^a   Nelson, Mary ^a   Call, Mariah ^a   Knudson, Margaret ^a   Schreiber, Martin A ^b   Bulger, Eileen M ^c   Muskat, Peter ^d   Alarcon, Louis H ^e   Myers, John G ^f   Rahbar, Mohammad H ^g,h   Brasel, Karen J ^k   Phelan, Herb A ^j   Del Junco, Deborah J ⁱ   Fox, Erin E ^g   Wade, Charles E ⁱ   Holcomb, John B ⁱ   Cotton, Bryan A ⁱ   Matijevic, Nena ⁱ  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CINCINNATI   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f Mays Cancer Center at UT Health San Antonio   (United States)

^g Center for Clinical and Translational Sciences   (United States)

^h UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ UNIVERSITY OF TEXAS   (United States)

^j UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^k MEDICAL COLLEGE OF WISCONSIN   (United States)

more..

Author keywords

Bleeding; Coagulation; Injury; PROMMTT; Trauma

Indexed keywords

BLOOD CLOTTING FACTOR;

ACUTE TRAUMATIC COAGULOPATHY; ADULT; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; CONFERENCE PAPER; CRYSTALLOID; FEMALE; GLASGOW COMA SCALE; HEART RATE; HUMAN; INJURY; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RESUSCITATION; SYSTOLIC BLOOD PRESSURE;

ADULT; BLOOD COAGULATION DISORDERS; BLOOD TRANSFUSION; FEMALE; FLUID THERAPY; HEMORRHAGE; HOSPITAL MORTALITY; HUMANS; INJURY SEVERITY SCORE; INTERVENTION STUDIES; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; RESUSCITATION; STATISTICS, NONPARAMETRIC; SURVIVAL RATE; TRAUMA CENTERS; TREATMENT OUTCOME; UNITED STATES; WOUNDS AND INJURIES;

EID: 84880405233     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31828fa43d     Document Type: Conference Paper

References (30)

1. Injury Chart Book. Geneva, Switzerland:World Health Orginization 2002.
2. Hess JR, Holcomb JB, Hoyt DB. Damage control resuscitation: the need for specific blood products to treat the coagulopathy of trauma. Transfusion. 2006;46:685-686.
3. Holcomb JB, McMullin NR, Pearse L, Caruso J,Wade CE, Oetjen-Gerdes L, Champion HR, Lawnick M, FarrW, Rodriguez S, et al. Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004. Ann Surg. 2007;245:986-991.
4. Cohen MJ. Towards hemostatic resuscitation: the changing understanding of acute traumatic biology, massive bleeding, and damage-control resuscitation. Surg Clin North Am. 2012;92:877-891.
5. Howard BM, Daley AT, Cohen MJ. Prohemostatic interventions in trauma: resuscitation-associated coagulopathy, acute traumatic coagulopathy, hemostatic resuscitation, and other hemostatic interventions. Semin ThrombHemost. 2012;38:250Y258.
6. CohenMJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF.Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255:379-385.
7. Cohen MJ, West M. Acute traumatic coagulopathy: from endogenous acute coagulopathy to systemic acquired coagulopathy and back. J Trauma. 2011;70(suppl 5):S47-S49.
8. Davenport R, Manson J, De'Ath H, Platton S, Coates A, Allard S, Hart D, Pearse R, Pasi KJ, MacCallum P, et al. Functional definition and characterization of acute traumatic coagulopathy. Crit Care Med. 2011;39: 2652-2658.
9. Kim SJ, Lee SW, Han GS, Moon SW, Choi SH, Hong YS. Acute traumatic coagulopathy decreased actual survival rate when compared with predicted survival rate in severe trauma. Emerg Med J. 2011.
10. Maegele M, Paffrath T, Bouillon B. Acute traumatic coagulopathy in severe injury: incidence, risk stratification, and treatment options. Dtsch Arztebl Int. 2011;108:827-835.
11. Scalea TM. Hemostatic resuscitation for acute traumatic coagulopathy. Scand J Trauma Resusc Emerg Med. 2011;19:2.
12. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127Y1130.
13. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39-44.
14. Rahbar MH, Fox EE, del Junco DJ, Cotton BA, Podbielski JM, Matijevic N, Cohen MJ, Schreiber MA, Zhang J, Mirhaji P, et al. Coordination and management of multicenter clinical studies in trauma: experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study. Resuscitation. 2012;83:459-464.
15. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149(pt 1): 818-824.
16. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211-1217; discussion 1217.
17. Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63:1254-1261; discussion 61-62.
18. Chesebro BB, Rahn P, Carles M, Esmon CT, Xu J, Brohi K, Frith D, Pittet JF, Cohen MJ. Increase in activated protein C mediates acute traumatic coagulopathy in mice. Shock. 2009;32:659-665.
19. Rizoli SB, Scarpelini S, Callum J, Nascimento B, Mann KG, Pinto R, Jansen J, Tien HC. Clotting factor deficiency in early trauma-associated coagulopathy. J Trauma. 2011;71(suppl 1):S427-S434.
20. Pati S, Khakoo AY, Zhao J, Jimenez F, Gerber MH, Harting M, Redell JB, Grill R, Matsuo Y, Guha S, et al. Human mesenchymal stem cells inhibit vascular permeability by modulating vascular endothelial cadherin/beta-catenin signaling. Stem Cells Dev. 2011;20:89-101.
21. Holcomb JB, Jenkins D, Rhee P, Johannigman J, Mahoney P, Mehta S, Mehta S, Cox ED, Gehrke MJ, Beilman GJ, Schreiber M, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma. J Trauma. 2007;62:307-310.
22. Borgman MA, Spinella PC, Holcomb JB, Blackbourne LH, Wade CE, Lefering R, Bouillon B, Maegele M. The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang. 2011;101:44-54.
23. Borgman MA, Spinella PC, Perkins JG, GrathwohlKW, Repine T, Beekley AC, Sebesta J, Jenkins D, Wade CE, Holcomb JB. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63:805-813.
24. Holcomb JB,Wade CE,Michalek JE, ChisholmGB, Zarzabal LA, Schreiber MA, Gonzalez EAL, Pomper GJ, Perkins JG, Spinella PC, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248:447-458.
25. Brown L, Call MS, MS K, Cohen MJ. A High FFP:PRBC transfusion ratio decreases mortality in all massively transfused trauma patients regardless of admission INR. J Trauma. 2011.
26. Esmon CT. The protein C pathway. Chest. 2003;124(suppl 3):26S-32S.
27. Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost. 2006;32(suppl 1):49-60.
28. Sorensen B, Tang M, Larsen OH, Laursen PN, Fenger-Eriksen C, Rea CJ. The role of fibrinogen: a new paradigm in the treatment of coagulopathic bleeding. Thromb Res. 2011;128(suppl 1):S13-S16.
29. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, et al. The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma. 2008;64(suppl 2):S79-S85; discussion S85.
30. Martini WZ, Holcomb JB. Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs. Ann Surg. 2007; 246:831-835.