Electrical Vagus Nerve Stimulation Attenuates Systemic Inflammation and Improves Survival in a Rat Heatstroke Model

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Yamakawa, Kazuma ^a   Matsumoto, Naoya ^a   Imamura, Yukio ^b   Muroya, Takashi ^a   Yamada, Tomoki ^a   Nakagawa, Junichiro ^a   Shimazaki, Junya ^a   Ogura, Hiroshi ^a   Kuwagata, Yasuyuki ^a   Shimazu, Takeshi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERLEUKIN 6; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ELECTROSTIMULATION; ENDOTHELIUM CELL; HEAT STRESS; HEAT STROKE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG ALVEOLUS CELL; MORTALITY; NEUROMODULATION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; RAT; SPLEEN CELL; SURVIVAL; SURVIVAL RATE; SURVIVAL TIME; VAGUS NERVE STIMULATION;

ANIMALS; ANTIGENS, CD11B; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION THERAPY; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HEAT STROKE; HEAT-SHOCK RESPONSE; INFLAMMATION; LUNG; MALE; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; SPLEEN; SURVIVAL ANALYSIS; VAGUS NERVE;

EID: 84873721486     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0056728     Document Type: Article

References (35)

1. Kondo M, Honda Y, Ono M, (2011) Growing concern about heatstroke this summer in Japan after Fukushima nuclear disaster. Environ Health Prev Med 16: 279-280.
2. Bouchama A, Knochel JP, (2002) Heat stroke. N Engl J Med 346: 1978-1988.
3. Leon LR, Helwig BG, (2010) Heat stroke: role of the systemic inflammatory response. J Appl Physiol 109: 1980-1988.
4. Bouchama A, (1995) Heatstroke: a new look at an ancient disease. Intensive Care Med 21: 623-625.
5. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, et al. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405: 458-462.
6. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, et al. (2003) Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421: 384-388.
7. Guarini S, Altavilla D, Cainazzo MM, Giuliani D, Bigiani A, et al. (2003) Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. Circulation 107: 1189-1194.
8. Cai B, Chen F, Ji Y, Kiss L, de Jonge WJ, et al. (2009) Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation. J Cell Mol Med 13: 3774-3785.
9. Bernik TR, Friedman SG, Ochani M, DiRaimo R, Susarla S, et al. (2002) Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg 36: 1231-1236.
10. Altavilla D, Guarini S, Bitto A, Mioni C, Giuliani D, et al. (2006) Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock. Shock 25: 500-506.
11. Bernik TR, Friedman SG, Ochani M, DiRaimo R, Ulloa L, et al. (2002) Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 195: 781-788.
12. Wang H, Liao H, Ochani M, Justiniani M, Lin X, et al. (2004) Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 10: 1216-1221.
13. van Westerloo DJ, Giebelen IA, Florquin S, Daalhuisen J, Bruno MJ, et al. (2005) The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 191: 2138-2148.
14. Chang CK, Chang CP, Chiu WT, Lin MT, (2006) Prevention and repair of circulatory shock and cerebral ischemia/injury by various agents in experimental heatstroke. Curr Med Chem 13: 3145-3154.
15. Sharma HS, (2005) Heat-related deaths are largely due to brain damage. Indian J Med Res 121: 621-623.
16. Hsiao SH, Chang CP, Chiu TH, Lin MT, (2007) Resuscitation from experimental heatstroke by brain cooling therapy. Resuscitation 73: 437-445.
17. Shen KH, Lin CH, Chang HK, Chen WC, Chen SH, (2008) Premarin can act via estrogen receptors to rescue mice from heatstroke-induced lethality. Shock 30: 668-674.
18. Hagiwara S, Iwasaka H, Matsumoto S, Hasegawa A, Yasuda N, et al. (2010) In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models. Shock 33: 282-288.
19. Hagiwara S, Iwasaka H, Shingu C, Matsumoto S, Uchida T, et al. (2010) High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Inflamm Res 59: 511-518.
20. Hagiwara S, Iwasaka H, Shingu C, Matsumoto S, Uchida T, et al. (2011) Danaparoid sodium attenuates the effects of heat stress. J Surg Res 171: 762-768.
21. Nybo L, (2007) Exercise and heat stress: cerebral challenges and consequences. Prog Brain Res 162: 29-43.
22. Bouchama A, Kunzelmann C, Dehbi M, Kwaasi A, Eldali A, et al. (2008) Recombinant activated protein C attenuates endothelial injury and inhibits procoagulant microparticles release in baboon heatstroke. Arterioscler Thromb Vasc Biol 28: 1318-1325.
23. Chen CC, Chen ZC, Lin MT, Hsu CC, (2009) Activated protein C improves heatstroke outcomes through restoration of normal hypothalamic and thermoregulatory function. Am J Med Sci 338: 382-387.
24. Bouchama A, Parhar RS, el-Yazigi A, Sheth K, al-Sedairy S, (1991) Endotoxemia and release of tumor necrosis factor and interleukin 1 alpha in acute heatstroke. J Appl Physiol 70: 2640-2644.
25. Tracey KJ, (2002) The inflammatory reflex. Nature 420: 853-859.
26. Niederbichler AD, Papst S, Claassen L, Jokuszies A, Steinstraesser L, et al. (2009) Burn-induced organ dysfunction: vagus nerve stimulation attenuates organ and serum cytokine levels. Burns 35: 783-789.
27. Song XM, Li JG, Wang YL, Liang H, Huang Y, et al. (2010) Effect of vagus nerve stimulation on thermal injury in rats. Burns 36: 75-81.
28. Bansal V, Costantini T, Ryu SY, Peterson C, Loomis W, et al. (2010) Stimulating the central nervous system to prevent intestinal dysfunction after traumatic brain injury. J Trauma 68: 1059-1064.
29. Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, et al. (2008) Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: a study in baboon model. Arterioscler Thromb Vasc Biol 28: 1130-1136.
30. Huang H, Lavoie-Lamoureux A, Lavoie JP, (2009) Cholinergic stimulation attenuates the IL-4 induced expression of E-selectin and vascular endothelial growth factor by equine pulmonary artery endothelial cells. Vet Immunol Immunopathol 132: 116-121.
31. Saeed RW, Varma S, Peng-Nemeroff T, Sherry B, Balakhaneh D, et al. (2005) Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 201: 1113-1123.
32. Wessler I, Kirkpatrick CJ, (2008) Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 154: 1558-1571.
33. Pohanka M, Snopkova S, Havlickova K, Bostik P, Sinkorova Z, et al. (2011) Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway. Curr Med Chem 18: 539-551.
34. Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, et al. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 203: 1623-1628.
35. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, et al. (2009) Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science 325: 612-616.