Increase in activated protein C mediates acute traumatic coagulopathy in mice

Shock

Volumn 32, Issue 6, 2009, Pages 659-665

  Chesebro, Brian B ^a   Rahn, Pamela ^a   Carles, Michel ^a   Esmon, Charles T ^b,c   Xu, Jun ^c   Brohi, Karim ^d   Frith, Daniel ^d   Pittet, Jean François ^a   Cohen, Mitchell J ^a  

^a SAN FRANCISCO GENERAL HOSPITAL   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Coagulation; Hemorrhage; Hypoperfusion; Shock; Survival; Trauma

Indexed keywords

ACTIVATED PROTEIN C; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; CONTROLLED STUDY; EXPERIMENTAL MODEL; HEMATOLOGICAL PARAMETERS; HEMODYNAMIC PARAMETERS; HEMORRHAGIC SHOCK; HISTOPATHOLOGY; INJURY; LAPAROTOMY; LUNG; MEAN ARTERIAL PRESSURE; MORTALITY; MOUSE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; SURVIVAL TIME; THROMBOSIS;

ACUTE DISEASE; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; MALE; MICE; MICE, INBRED C57BL; PERFUSION; PROTEIN C; PULMONARY CIRCULATION; SHOCK, HEMORRHAGIC; TIME FACTORS; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 73849096747     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181a5a632     Document Type: Article

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