The PI3K/Akt and ERK pathways elevate thyroid hormone receptor β1 and TRH receptor to decrease thyroid hormones after exposure to PCB153 and p,p'-DDE

Chemosphere

Volumn 118, Issue 1, 2015, Pages 229-238

  Liu, Changjiang ^a,b   Li, Lianbing ^b   Ha, Mei ^c   Qi, Suqin ^a   Duan, Peng ^a   Yang, Kedi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Chongqing Key Laboratory of Birth Defects and Reproductive Health   (China)

^c Chongqing There Gorges College   (China)

Author keywords

ERK; P,p' DDE; PCB153; PI3K Akt; Thyroid hormone receptor 1; Thyrotropin releasing hormone receptor

Indexed keywords

CELL CULTURE; CHEMICAL ACTIVATION; ENDOCRINOLOGY; ORGANIC POLLUTANTS; POLYCHLORINATED BIPHENYLS;

P ,P' DDES; PCB153; PI3K/AKT; THYROID HORMONE RECEPTOR; THYROTROPIN RELEASING HORMONE RECEPTORS;

HORMONES;

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; 2,2',4,4',5,5' HEXACHLOROBIPHENYL; LIOTHYRONINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTIRELIN; PROTIRELIN RECEPTOR; THYROID HORMONE; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA 1; THYROID HORMONE RECEPTOR BETA; THYROID HORMONE RECEPTOR BETA 1; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG; WORTMANNIN; 2,4,5,2',4',5'-HEXACHLOROBIPHENYL; POLYCHLORINATED BIPHENYL;

CELL ORGANELLE; DDT; HOMEOSTASIS; HORMONE; INHIBITION; PCB; SIGNALING;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYPOTHALAMUS; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; RAT; SIGNAL TRANSDUCTION; WEIGHT GAIN; ANIMAL; BLOOD; CELL LINE; CULTURE TECHNIQUE; DRUG EFFECTS; EPITHELIUM CELL; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; THYROID GLAND;

ANIMALIA; RATTUS;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; DICHLORODIPHENYL DICHLOROETHYLENE; EPITHELIAL CELLS; HUMANS; HYPOTHALAMUS; MALE; MAP KINASE SIGNALING SYSTEM; PHOSPHATIDYLINOSITOL 3-KINASES; POLYCHLORINATED BIPHENYLS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, THYROTROPIN-RELEASING HORMONE; THYROID GLAND; THYROID HORMONE RECEPTORS BETA; THYROID HORMONES;

EID: 84922330912     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.09.023     Document Type: Article

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