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Volumn 26, Issue 6, 2012, Pages 841-848

Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid

Author keywords

Lipoic acid; Antioxidant; Oxidative stress; PCB; ROS

Indexed keywords

CATALASE; CHLORINE; DIHYDROLIPOATE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; POLYCHLORINATED BIPHENYL DERIVATIVE; POLYCHLORINATED BIPHENYL QUINONE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

EID: 84863851924     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.04.028     Document Type: Article
Times cited : (37)

References (70)
  • 1
    • 0033230607 scopus 로고    scopus 로고
    • Role of redox potential and reactive oxygen species in stress signaling
    • Adler V., Yin Z., Tew K.D., Ronai Z. Role of redox potential and reactive oxygen species in stress signaling. Oncogene 1999, 18:6104-6111.
    • (1999) Oncogene , vol.18 , pp. 6104-6111
    • Adler, V.1    Yin, Z.2    Tew, K.D.3    Ronai, Z.4
  • 2
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 3
    • 70350125897 scopus 로고    scopus 로고
    • Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells
    • Al-Anati L., Hogberg J., Stenius U. Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells. Chem. Biol. Interact. 2009, 182:191-198.
    • (2009) Chem. Biol. Interact. , vol.182 , pp. 191-198
    • Al-Anati, L.1    Hogberg, J.2    Stenius, U.3
  • 4
    • 0022272493 scopus 로고
    • Determination of glutathione and glutathione disulfide in biological samples
    • Anderson M.E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 1985, 113:548-555.
    • (1985) Methods Enzymol. , vol.113 , pp. 548-555
    • Anderson, M.E.1
  • 7
    • 0023130150 scopus 로고
    • Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions
    • Beyer W.F., Fridovich I. Assaying for superoxide dismutase activity: some large consequences of minor changes in conditions. Anal. Biochem. 1987, 161:559-566.
    • (1987) Anal. Biochem. , vol.161 , pp. 559-566
    • Beyer, W.F.1    Fridovich, I.2
  • 8
    • 34248525050 scopus 로고    scopus 로고
    • Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative
    • Brown S.E., Ross M.F., Sanjuan-Pla A., Manas A.R., Smith R.A., Murphy M.P. Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative. Free Radical Biol. Med. 2007, 42:1766-1780.
    • (2007) Free Radical Biol. Med. , vol.42 , pp. 1766-1780
    • Brown, S.E.1    Ross, M.F.2    Sanjuan-Pla, A.3    Manas, A.R.4    Smith, R.A.5    Murphy, M.P.6
  • 9
    • 33645938310 scopus 로고    scopus 로고
    • Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health
    • Carpenter D.O. Polychlorinated biphenyls (PCBs): routes of exposure and effects on human health. Rev. Environ. Health 2006, 21:1-23.
    • (2006) Rev. Environ. Health , vol.21 , pp. 1-23
    • Carpenter, D.O.1
  • 10
    • 70349253911 scopus 로고    scopus 로고
    • Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells
    • Dreiem A., Rykken S., Lehmler H.J., Robertson L.W., Fonnum F. Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells. Toxicol. Appl. Pharmacol. 2009, 240:306-313.
    • (2009) Toxicol. Appl. Pharmacol. , vol.240 , pp. 306-313
    • Dreiem, A.1    Rykken, S.2    Lehmler, H.J.3    Robertson, L.W.4    Fonnum, F.5
  • 11
    • 58749086004 scopus 로고    scopus 로고
    • Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats
    • Elumalai P., Krishnamoorthy G., Selvakumar K., Arunkumar R., Venkataraman P., Arunakaran J. Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats. Reprod. Toxicol. 2009, 27:41-45.
    • (2009) Reprod. Toxicol. , vol.27 , pp. 41-45
    • Elumalai, P.1    Krishnamoorthy, G.2    Selvakumar, K.3    Arunkumar, R.4    Venkataraman, P.5    Arunakaran, J.6
  • 12
    • 79951575880 scopus 로고    scopus 로고
    • [Alpha]-lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-[beta]
    • Foo N.-P., Lin S.-H., Lee Y.-H., Wu M.-J., Wang Y.-J. [Alpha]-lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-[beta]. Toxicology 2011, 282:39-46.
    • (2011) Toxicology , vol.282 , pp. 39-46
    • Foo, N.-P.1    Lin, S.-H.2    Lee, Y.-H.3    Wu, M.-J.4    Wang, Y.-J.5
  • 14
    • 2542509859 scopus 로고    scopus 로고
    • Effects on UDP glucuronosyl transferase, glutathione transferase, DT-diaphorase and glutathione reductase activities in rainbow trout liver after long-term exposure to PCB
    • Förlin L., Blom S., Celander M., Sturve J. Effects on UDP glucuronosyl transferase, glutathione transferase, DT-diaphorase and glutathione reductase activities in rainbow trout liver after long-term exposure to PCB. Mar. Environ. Res. 1996, 42:213-216.
    • (1996) Mar. Environ. Res. , vol.42 , pp. 213-216
    • Förlin, L.1    Blom, S.2    Celander, M.3    Sturve, J.4
  • 15
    • 0025973262 scopus 로고
    • Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients
    • Girotti M.J., Khan N., McLellan B.A. Early measurement of systemic lipid peroxidation products in the plasma of major blunt trauma patients. J. Trauma 1991, 31:32-35.
    • (1991) J. Trauma , vol.31 , pp. 32-35
    • Girotti, M.J.1    Khan, N.2    McLellan, B.A.3
  • 16
    • 0033709975 scopus 로고    scopus 로고
    • The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro)
    • Gultekin F., Ozturk M., Akdogan M. The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro). Arch. Toxicol. 2000, 74:533-538.
    • (2000) Arch. Toxicol. , vol.74 , pp. 533-538
    • Gultekin, F.1    Ozturk, M.2    Akdogan, M.3
  • 17
    • 0016275313 scopus 로고
    • Glutathione S-transferases. The first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 1974, 249:7130-7139.
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 18
    • 0014276153 scopus 로고
    • Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation
    • Heath R.L., Packer L. Photoperoxidation in isolated chloroplasts. I. Kinetics and stoichiometry of fatty acid peroxidation. Arch. Biochem. Biophys. 1968, 125:189-198.
    • (1968) Arch. Biochem. Biophys. , vol.125 , pp. 189-198
    • Heath, R.L.1    Packer, L.2
  • 20
    • 77950935963 scopus 로고    scopus 로고
    • Inadvertent polychlorinated biphenyls in commercial paint pigments
    • Hu D., Hornbuckle K.C. Inadvertent polychlorinated biphenyls in commercial paint pigments. Environ. Sci. Technol. 2010, 44:2822-2827.
    • (2010) Environ. Sci. Technol. , vol.44 , pp. 2822-2827
    • Hu, D.1    Hornbuckle, K.C.2
  • 23
    • 0026778866 scopus 로고
    • Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals
    • Kagan V.E., Shvedova A., Serbinova E., Khan S., Swanson C., Powell R., Packer L. Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem. Pharmacol. 1992, 44:1637-1649.
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1637-1649
    • Kagan, V.E.1    Shvedova, A.2    Serbinova, E.3    Khan, S.4    Swanson, C.5    Powell, R.6    Packer, L.7
  • 24
    • 17044363507 scopus 로고    scopus 로고
    • Changes in antioxidant defense systems by 2,2',5,5'-tetrachlorobiphenyl exposure in neuronal SK-N-MC cells
    • Lee J.Y., Kim J.W., Lim H.S., Joo W.H., Cho Y.K., Moon J.Y. Changes in antioxidant defense systems by 2,2',5,5'-tetrachlorobiphenyl exposure in neuronal SK-N-MC cells. Toxicol. Lett. 2005, 157:139-149.
    • (2005) Toxicol. Lett. , vol.157 , pp. 139-149
    • Lee, J.Y.1    Kim, J.W.2    Lim, H.S.3    Joo, W.H.4    Cho, Y.K.5    Moon, J.Y.6
  • 26
    • 0038817870 scopus 로고    scopus 로고
    • PCB-induced oxidative stress in the unicellular marine dinoflagellate Lingulodinium polyedrum
    • Leitao M.A., Cardozo K.H., Pinto E., Colepicolo P. PCB-induced oxidative stress in the unicellular marine dinoflagellate Lingulodinium polyedrum. Arch. Environ. Contam. Toxicol. 2003, 45:59-65.
    • (2003) Arch. Environ. Contam. Toxicol. , vol.45 , pp. 59-65
    • Leitao, M.A.1    Cardozo, K.H.2    Pinto, E.3    Colepicolo, P.4
  • 29
    • 78751608731 scopus 로고    scopus 로고
    • Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls
    • Majkova Z., Layne J., Sunkara M., Morris A.J., Toborek M., Hennig B. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 2011, 251:41-49.
    • (2011) Toxicol. Appl. Pharmacol. , vol.251 , pp. 41-49
    • Majkova, Z.1    Layne, J.2    Sunkara, M.3    Morris, A.J.4    Toborek, M.5    Hennig, B.6
  • 30
    • 18144452679 scopus 로고    scopus 로고
    • Oxy radicals, lipid peroxidation and DNA damage
    • Marnett L.J. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 2002, 181-182:219-222.
    • (2002) Toxicology , pp. 219-222
    • Marnett, L.J.1
  • 31
    • 0030051958 scopus 로고    scopus 로고
    • Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl
    • McLean M.R., Bauer U., Amaro A.R., Robertson L.W. Identification of catechol and hydroquinone metabolites of 4-monochlorobiphenyl. Chem. Res. Toxicol. 1996, 9:158-164.
    • (1996) Chem. Res. Toxicol. , vol.9 , pp. 158-164
    • McLean, M.R.1    Bauer, U.2    Amaro, A.R.3    Robertson, L.W.4
  • 32
    • 0036070514 scopus 로고    scopus 로고
    • Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid
    • Moini H., Packer L., Saris N.E. Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid. Toxicol. Appl. Pharmacol. 2002, 182:84-90.
    • (2002) Toxicol. Appl. Pharmacol. , vol.182 , pp. 84-90
    • Moini, H.1    Packer, L.2    Saris, N.E.3
  • 33
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 34
    • 27744575183 scopus 로고    scopus 로고
    • Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)-induced oxidative damage in Leydig cells
    • Murugesan P., Muthusamy T., Balasubramanian K., Arunakaran J. Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)-induced oxidative damage in Leydig cells. Free Radical Res. 2005, 39:1259-1272.
    • (2005) Free Radical Res. , vol.39 , pp. 1259-1272
    • Murugesan, P.1    Muthusamy, T.2    Balasubramanian, K.3    Arunakaran, J.4
  • 35
    • 33947314329 scopus 로고    scopus 로고
    • Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells
    • Murugesan P., Muthusamy T., Balasubramanian K., Arunakaran J. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology 2007, 232:170-182.
    • (2007) Toxicology , vol.232 , pp. 170-182
    • Murugesan, P.1    Muthusamy, T.2    Balasubramanian, K.3    Arunakaran, J.4
  • 37
    • 0028822032 scopus 로고
    • 3,3',4,4'-Tetrachlorobiphenyl effects on antioxidant enzymes and glutathione status in different tissues of rainbow trout
    • Otto D.M., Moon T.W. 3,3',4,4'-Tetrachlorobiphenyl effects on antioxidant enzymes and glutathione status in different tissues of rainbow trout. Pharmacol. Toxicol. 1995, 77:281-287.
    • (1995) Pharmacol. Toxicol. , vol.77 , pp. 281-287
    • Otto, D.M.1    Moon, T.W.2
  • 38
    • 0030002618 scopus 로고    scopus 로고
    • Mixed-function oxidase enzyme activity and oxidative stress in lake trout (Salvelinus namaycush) exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB-126)
    • Palace V.P., Klaverkamp J.F., Lockhart W.L., Metner D.A., Muir D.C.G., Brown S.B. Mixed-function oxidase enzyme activity and oxidative stress in lake trout (Salvelinus namaycush) exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB-126). Environ. Toxicol. Chem. 1996, 15:955-960.
    • (1996) Environ. Toxicol. Chem. , vol.15 , pp. 955-960
    • Palace, V.P.1    Klaverkamp, J.F.2    Lockhart, W.L.3    Metner, D.A.4    Muir, D.C.G.5    Brown, S.B.6
  • 39
    • 0029619096 scopus 로고
    • Oxidative stress in fish exposed to model xenobiotics. Oxidatively modified forms of Cu, Zn-superoxide dismutase as potential biomarkers
    • Pedrajas J.R., Peinado J., Lopez-Barea J. Oxidative stress in fish exposed to model xenobiotics. Oxidatively modified forms of Cu, Zn-superoxide dismutase as potential biomarkers. Chem. Biol. Interact. 1995, 98:267-282.
    • (1995) Chem. Biol. Interact. , vol.98 , pp. 267-282
    • Pedrajas, J.R.1    Peinado, J.2    Lopez-Barea, J.3
  • 41
    • 0024452934 scopus 로고
    • Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture
    • Rodman L.E., Shedlofsky S.I., Swim A.T., Robertson L.W. Effects of polychlorinated biphenyls on cytochrome P450 induction in the chick embryo hepatocyte culture. Arch. Biochem. Biophys. 1989, 275:252-262.
    • (1989) Arch. Biochem. Biophys. , vol.275 , pp. 252-262
    • Rodman, L.E.1    Shedlofsky, S.I.2    Swim, A.T.3    Robertson, L.W.4
  • 42
    • 0028138136 scopus 로고
    • Effect of polychlorinated biphenyls on the activity of antioxidant enzymes and lipid peroxidation in muscles and liver of two species of black sea fish
    • Rudneva T., Zherko N.V. Effect of polychlorinated biphenyls on the activity of antioxidant enzymes and lipid peroxidation in muscles and liver of two species of black sea fish. Biokhimiia 1994, 59:34-44.
    • (1994) Biokhimiia , vol.59 , pp. 34-44
    • Rudneva, T.1    Zherko, N.V.2
  • 43
    • 0027238889 scopus 로고
    • Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems
    • Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ. Health Perspect. 1993, 100:259-268.
    • (1993) Environ. Health Perspect. , vol.100 , pp. 259-268
    • Safe, S.1
  • 44
    • 0028235721 scopus 로고
    • Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment
    • Safe S.H. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit. Rev. Toxicol. 1994, 24:87-149.
    • (1994) Crit. Rev. Toxicol. , vol.24 , pp. 87-149
    • Safe, S.H.1
  • 45
    • 0343729906 scopus 로고    scopus 로고
    • 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production
    • Schlezinger J.J., Keller J., Verbrugge L.A., Stegeman J.J. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2000, 125:273-286.
    • (2000) Comp. Biochem. Physiol. C: Toxicol. Pharmacol. , vol.125 , pp. 273-286
    • Schlezinger, J.J.1    Keller, J.2    Verbrugge, L.A.3    Stegeman, J.J.4
  • 46
    • 79952771299 scopus 로고    scopus 로고
    • β-benzene hexachloride induces apoptosis of rat sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL
    • Shi Y., Song Y., Wang Y., Wang Y., Liang X., Hu Y., Yu H., Guan X., Cheng J., Yang K. β-benzene hexachloride induces apoptosis of rat sertoli cells through generation of reactive oxygen species and activation of JNKs and FasL. Environ. Toxicol. 2011, 26:124-135.
    • (2011) Environ. Toxicol. , vol.26 , pp. 124-135
    • Shi, Y.1    Song, Y.2    Wang, Y.3    Wang, Y.4    Liang, X.5    Hu, Y.6    Yu, H.7    Guan, X.8    Cheng, J.9    Yang, K.10
  • 47
    • 2342544918 scopus 로고    scopus 로고
    • Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress
    • Smith A.R., Shenvi S.V., Widlansky M., Suh J.H., Hagen T.M. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Curr. Med. Chem. 2004, 11:1135-1146.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 1135-1146
    • Smith, A.R.1    Shenvi, S.V.2    Widlansky, M.3    Suh, J.H.4    Hagen, T.M.5
  • 48
    • 55249085382 scopus 로고    scopus 로고
    • Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones
    • Song Y., Buettner G.R., Parkin S., Wagner B.A., Robertson L.W., Lehmler H.J. Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones. J. Org. Chem. 2008, 73:8296-8304.
    • (2008) J. Org. Chem. , vol.73 , pp. 8296-8304
    • Song, Y.1    Buettner, G.R.2    Parkin, S.3    Wagner, B.A.4    Robertson, L.W.5    Lehmler, H.J.6
  • 49
    • 49049111308 scopus 로고    scopus 로고
    • Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies
    • Song Y., Wagner B.A., Lehmler H.J., Buettner G.R. Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies. Chem. Res. Toxicol. 2008, 21:1359-1367.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 1359-1367
    • Song, Y.1    Wagner, B.A.2    Lehmler, H.J.3    Buettner, G.R.4
  • 50
    • 67649836351 scopus 로고    scopus 로고
    • Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones
    • Song Y., Wagner B.A., Witmer J.R., Lehmler H.J., Buettner G.R. Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones. Proc. Natl. Acad. Sci. USA 2009, 106:9725-9730.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9725-9730
    • Song, Y.1    Wagner, B.A.2    Witmer, J.R.3    Lehmler, H.J.4    Buettner, G.R.5
  • 51
    • 64449088421 scopus 로고    scopus 로고
    • Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species
    • Spencer W.A., Lehmler H.J., Robertson L.W., Gupta R.C. Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species. Free Radical Biol. Med. 2009, 46:1346-1352.
    • (2009) Free Radical Biol. Med. , vol.46 , pp. 1346-1352
    • Spencer, W.A.1    Lehmler, H.J.2    Robertson, L.W.3    Gupta, R.C.4
  • 52
    • 34547774070 scopus 로고    scopus 로고
    • Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: protective role of alpha-tocopherol
    • Sridevi N., Venkataraman P., Senthilkumar K., Krishnamoorthy G., Arunakaran J. Oxidative stress modulates membrane bound ATPases in brain regions of PCB (Aroclor 1254) exposed rats: protective role of alpha-tocopherol. Biomed. Pharmacother. 2007, 61:435-440.
    • (2007) Biomed. Pharmacother. , vol.61 , pp. 435-440
    • Sridevi, N.1    Venkataraman, P.2    Senthilkumar, K.3    Krishnamoorthy, G.4    Arunakaran, J.5
  • 53
    • 0035098162 scopus 로고    scopus 로고
    • Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites
    • Srinivasan A., Lehmler H.J., Robertson L.W., Ludewig G. Production of DNA strand breaks in vitro and reactive oxygen species in vitro and in HL-60 cells by PCB metabolites. Toxicol. Sci. 2001, 60:92-102.
    • (2001) Toxicol. Sci. , vol.60 , pp. 92-102
    • Srinivasan, A.1    Lehmler, H.J.2    Robertson, L.W.3    Ludewig, G.4
  • 54
    • 0036223696 scopus 로고    scopus 로고
    • Sulfhydryl binding and topoisomerase inhibition by PCB metabolites
    • Srinivasan A., Robertson L.W., Ludewig G. Sulfhydryl binding and topoisomerase inhibition by PCB metabolites. Chem. Res. Toxicol. 2002, 15:497-505.
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 497-505
    • Srinivasan, A.1    Robertson, L.W.2    Ludewig, G.3
  • 55
    • 0037087577 scopus 로고    scopus 로고
    • Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls
    • Tharappel J.C., Lee E.Y., Robertson L.W., Spear B.T., Glauert H.P. Regulation of cell proliferation, apoptosis, and transcription factor activities during the promotion of liver carcinogenesis by polychlorinated biphenyls. Toxicol. Appl. Pharmacol. 2002, 179:172-184.
    • (2002) Toxicol. Appl. Pharmacol. , vol.179 , pp. 172-184
    • Tharappel, J.C.1    Lee, E.Y.2    Robertson, L.W.3    Spear, B.T.4    Glauert, H.P.5
  • 56
    • 78149489254 scopus 로고    scopus 로고
    • Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root
    • Tsukagoshi H., Busch W., Benfey P.N. Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root. Cell 2010, 143:606-616.
    • (2010) Cell , vol.143 , pp. 606-616
    • Tsukagoshi, H.1    Busch, W.2    Benfey, P.N.3
  • 57
    • 0035427597 scopus 로고    scopus 로고
    • Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress
    • Twaroski T.P., O'Brien M.L., Robertson L.W. Effects of selected polychlorinated biphenyl (PCB) congeners on hepatic glutathione, glutathione-related enzymes, and selenium status: implications for oxidative stress. Biochem. Pharmacol. 2001, 62:273-281.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 273-281
    • Twaroski, T.P.1    O'Brien, M.L.2    Robertson, L.W.3
  • 58
    • 33646791891 scopus 로고    scopus 로고
    • Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants
    • Valavanidis A., Vlahogianni T., Dassenakis M., Scoullos M. Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotoxicol. Environ. Saf. 2006, 64:178-189.
    • (2006) Ecotoxicol. Environ. Saf. , vol.64 , pp. 178-189
    • Valavanidis, A.1    Vlahogianni, T.2    Dassenakis, M.3    Scoullos, M.4
  • 61
    • 68349091503 scopus 로고    scopus 로고
    • Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin
    • Venkataraman P., Krishnamoorthy G., Selvakumar K., Arunakaran J. Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic Clin. Pharmacol. Toxicol. 2009, 105:92-97.
    • (2009) Basic Clin. Pharmacol. Toxicol. , vol.105 , pp. 92-97
    • Venkataraman, P.1    Krishnamoorthy, G.2    Selvakumar, K.3    Arunakaran, J.4
  • 63
    • 84863820890 scopus 로고    scopus 로고
    • Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells
    • Wei W., Li X.F., Li X.N., Chen X.M., Liu A.L., Lu W.Q. Oxidative stress and cell-cycle change induced by coexposed PCB126 and benzo(a) pyrene to human hepatoma (HepG2) cells. Environ. Toxicol. 2010.
    • (2010) Environ. Toxicol.
    • Wei, W.1    Li, X.F.2    Li, X.N.3    Chen, X.M.4    Liu, A.L.5    Lu, W.Q.6
  • 64
    • 67649390732 scopus 로고    scopus 로고
    • PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities
    • Wei W., Zhang C., Liu A.L., Xie S.H., Chen X.M., Lu W.Q. PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities. Toxicol. Lett. 2009, 189:91-95.
    • (2009) Toxicol. Lett. , vol.189 , pp. 91-95
    • Wei, W.1    Zhang, C.2    Liu, A.L.3    Xie, S.H.4    Chen, X.M.5    Lu, W.Q.6
  • 65
    • 36348938884 scopus 로고    scopus 로고
    • Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
    • Xia C., Meng Q., Liu L.Z., Rojanasakul Y., Wang X.R., Jiang B.H. Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res. 2007, 67:10823-10830.
    • (2007) Cancer Res. , vol.67 , pp. 10823-10830
    • Xia, C.1    Meng, Q.2    Liu, L.Z.3    Rojanasakul, Y.4    Wang, X.R.5    Jiang, B.H.6
  • 66
    • 78650518772 scopus 로고    scopus 로고
    • Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation
    • Xue C., Liu W., Wu J., Yang X., Xu H. Chemoprotective effect of N-acetylcysteine (NAC) on cellular oxidative damages and apoptosis induced by nano titanium dioxide under UVA irradiation. Toxicol. In Vitro 2011, 25:110-116.
    • (2011) Toxicol. In Vitro , vol.25 , pp. 110-116
    • Xue, C.1    Liu, W.2    Wu, J.3    Yang, X.4    Xu, H.5
  • 67
    • 62949192111 scopus 로고    scopus 로고
    • Time-dependent oxidative stress responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins
    • Zhang X., Xie P., Li D., Tang R., Lei H., Zhao Y. Time-dependent oxidative stress responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins. Bull. Environ. Contam. Toxicol. 2009, 82:574-578.
    • (2009) Bull. Environ. Contam. Toxicol. , vol.82 , pp. 574-578
    • Zhang, X.1    Xie, P.2    Li, D.3    Tang, R.4    Lei, H.5    Zhao, Y.6
  • 68
    • 27944509646 scopus 로고    scopus 로고
    • Protective effect of quercetin on Aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells
    • Zhang Y.M. Protective effect of quercetin on Aroclor 1254-induced oxidative damage in cultured chicken spermatogonial cells. Toxicol. Sci. 2005, 88:545-550.
    • (2005) Toxicol. Sci. , vol.88 , pp. 545-550
    • Zhang, Y.M.1
  • 69
    • 84863820891 scopus 로고    scopus 로고
    • Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid
    • Zhao F., Liu Z.Q. Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid. J. Biochem. Mol. Toxicol. 2010.
    • (2010) J. Biochem. Mol. Toxicol.
    • Zhao, F.1    Liu, Z.Q.2


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