Assessing the role of orthoh-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein

Toxicology and Applied Pharmacology

Volumn 162, Issue 1, 2000, Pages 10-21

  Chauhan, Kamlesh R ^a,b   Kodavanti, Prasada Rao S ^b   McKinney, James D ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Competitive transthyretin binding; Molecular modeling; Neurotoxicity; Polychlorinated biphenyls; Prealbumin binding; Structure activity relationship; Thyroid hormones

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; POLYCHLORINATED BIPHENYL DERIVATIVE; PREALBUMIN; THYROID HORMONE; AROCLOR; BROMINE; CALCIUM; CHLORINE; DOPAMINE; IODINE; POLYCHLORINATED BIPHENYL; PROTEIN KINASE C; THYROXINE; THYROXINE BINDING PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CHEMICAL STRUCTURE; MOLECULAR MODEL; PROTEIN BINDING; SECOND MESSENGER; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DOSE RESPONSE; METABOLISM;

AROCLORS; BINDING, COMPETITIVE; BROMINE; CALCIUM; CHLORINE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; IODINE; POLYCHLORINATED BIPHENYLS; PREALBUMIN; PROTEIN KINASE C; STRUCTURE-ACTIVITY RELATIONSHIP; THYROXINE; THYROXINE-BINDING PROTEINS;

EID: 0033621580     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8826     Document Type: Article

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