Quantitative comparison and metabolite profiling of saponins in different parts of the root of panax notoginseng

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 36, 2014, Pages 9024-9034

  Wang, Jing Rong ^a,b   Yau, Lee Fong ^a   Gao, Wei Na ^a   Liu, Yong ^b   Yick, Pui Wing ^b   Liu, Liang ^a,b   Jiang, Zhi Hong ^a,b  

^a MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Macao)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

ginsenosides, LC MS; metabolomics; notoginseng; root

Indexed keywords

BIOMOLECULES; MULTIVARIANT ANALYSIS; PHARMACODYNAMICS;

GINSENOSIDES; METABOLITE PROFILES; METABOLITE PROFILING; METABOLOMICS; MULTI VARIATE ANALYSIS; NOTOGINSENG; QUANTITATIVE COMPARISON; ROOT;

METABOLITES;

PANAX NOTOGINSENG;

GINSENOSIDE; GINSENOSIDE RB 2; SAPONIN;

CHEMISTRY; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLOMICS; PANAX NOTOGINSENG; PLANT ROOT; REPRODUCIBILITY; RHIZOME;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; METABOLOMICS; PANAX NOTOGINSENG; PLANT ROOTS; REPRODUCIBILITY OF RESULTS; RHIZOME; SAPONINS;

EID: 84922311323     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf502214x     Document Type: Article

References (46)

1. Gao, B.; Huang, L.; Liu, H.; Wu, H.; Zhang, E.; Yang, L.; Wu, X.; Wang, Z. Platelet P2Y(1)(2) receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng Br. J. Pharmacol. 2014, 171, 214-223
2. Que, W.; Liao, L.; Li, Y. Traditional Chinese medicinal composition with analgesic and hemostatic effects. CN1961912A, 2007.
3. Li, B.; Wang, Y.; Zuo, W.; Hong, W.; Meng, T.; Xiao, N. A water-soluble hemostatic gauze prepared from Panax notoginseng having function of activating blood and promoting healing, and its preparation. CN103623458A, 2014.
4. Han, J. B.; Hua, Y. Q.; Chen, L. Y.; Liu, L. M. Advances in smoothened-targeting therapies for pancreatic cancer: implication for drug discovery from herbal medicines J. Chin. Integr. Med. 2012, 10, 256-263
5. He, N. W.; Zhao, Y.; Guo, L.; Shang, J.; Yang, X. B. Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen J. Med. Food 2012, 15, 350-359
6. Ng, T. B. Pharmacological activity of sanchi ginseng (Panax notoginseng) J. Pharm. Pharmacol. 2006, 58, 1007-1019
7. Yoshikawa, M.; Murakami, T.; Ueno, T.; Yashiro, K.; Hirokawa, N.; Murakami, N.; Yamahara, J.; Matsuda, H.; Saijoh, R.; Tanaka, O. Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen Chem. Pharm. Bull. (Tokyo) 1997, 45, 1039-1045
8. Yoshikawa, M.; Morikawa, T.; Kashima, Y.; Ninomiya, K.; Matsuda, H. Structures of new dammarane-type triterpene saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal ginseng saponins J. Nat. Prod. 2003, 66, 922-927
9. Chan, R. Y.; Chen, W. F.; Dong, A.; Guo, D.; Wong, M. S. Estrogen-like activity of ginsenoside Rg1 derived from Panax notoginseng J. Clin. Endocrinol. Metab. 2002, 87, 3691-3695
10. Konoshima, T.; Takasaki, M.; Tokuda, H. Anti-carcinogenic activity of the roots of Panax notoginseng. II Biol. Pharm. Bull. 1999, 22, 1150-1152
11. Wang, C. Z.; Yuan, C. S. Potential role of ginseng in the treatment of colorectal cancer Am. J. Chin. Med. 2008, 36, 1019-1028
12. Yang, J. M.; Lu, F. H.; Jin, S. K.; Sun, S. W.; Zhao, Y. X.; Wang, S. J.; Zhou, X. H. [A cohort study on the predictive value of factors influencing cardio-cerebro vascular death among people over 40 years of age] Zhonghua Liu Xing Bing Xue Za Zhi 2007, 28, 119-122
13. Mao, Q.; Li, Y.; Li, S.-L.; Yang, J.; Zhang, P.-H.; Wang, Q. Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng Chin. J. Nat. Med. 2014, 12, 30-37
14. Dong, H.; Bai, L. P.; Wong, V. K.; Zhou, H.; Wang, J. R.; Liu, Y.; Jiang, Z. H.; Liu, L. The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives Molecules 2011, 16, 10619-10630
15. Ruan, J. Q.; Leong, W. I.; Yan, R.; Wang, Y. T. Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix Notoginseng J. Agric. Food Chem. 2010, 58, 5770-5776
16. Cui, H.; Zhang, C.; Lin, H.; Lu, W.; Cheng, H.; Wang, J. [Determination of effective components in different positions of Panax notoginseng by HPLC] Zhongyaocai 2009, 32, 1810-1813
17. Liu, J. H.; Lee, C. S.; Leung, K. M.; Yan, Z. K.; Shen, B. H.; Zhao, Z. Z.; Jiang, Z. H. Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method J. Agric. Food Chem. 2007, 55, 8830-8835
18. Kim, D. H. Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng J. Ginseng Res. 2012, 36, 1-15
19. Wan, J.-B.; Zhang, Q.-W.; Hong, S.-J.; Li, P.; Li, S.-P.; Wang, Y.-T. Chemical investigation of saponins in different parts of Panax notoginseng by pressurized liquid extraction and liquid chromatography-electrospray ionization-tandem mass spectrometry Molecules 2012, 17, 5836-5853
20. Yamada, Y.; Yuasa, Y.; Udaka, Y.; Takeuchi, K. Quality estimation by the head number of Tienchi ginseng Igaku to Seibutsugaku 1998, 137, 145-150
21. Zhang, C.; Bao, J.; Li, X.; Zheng, Y. HPLC determination of the amount of ginsenosides in different parts of Panax ginseng C. A. Mey. and P. quinquefolius L. and P. notoginseng (burk) F. H. Chen Yaowu Fenxi Zazhi 2005, 25, 1190-1194
22. Wang, D.; Zhu, H.; Chen, K.; Xu, M.; Zhang, Y.; Yang, C. Saponin accumulation in the seedling root of Panax notoginseng Chin. Med. 2011, 6 (5 http://www.cmjournal.org/content/6/1/5
23. Wang, D.; Li, H.; Chen, K.; Zhang, Y.; Yang, C. HPLC comparative analysis of ginsenoside saponins in different underground parts of Panax notoginseng Yunnan Zhiwu Yanjiu 2005, 27, 685-690, 694
24. Jia, X.-H.; Wang, C.-Q.; Liu, J.-H.; Li, X.-W.; Wang, X.; Shang, M.-Y.; Cai, S.-Q.; Zhu, S.; Komatsu, K. Comparative studies of saponins in 1-3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples J. Nat. Med. 2013, 67, 339-349
25. Wang, J. R.; Yamasaki, Y.; Tanaka, T.; Kouno, I.; Jiang, Z. H. Dammarane-type triterpene saponins from the flowers of Panax notoginseng Molecules 2009, 14, 2087-2094
26. Yoshikawa, M.; Morikawa, T.; Yashiro, K.; Murakami, T.; Matsuda, H. Bioactive saponins and glycosides. XIX. Notoginseng (3): immunological adjuvant activity of notoginsenosides and related saponins: structures of notoginsenosides-L, -M, and -N from the roots of Panax notoginseng (Burk.) F. H. Chen Chem. Pharm. Bull. (Tokyo) 2001, 49, 1452-1456
27. Zhou, J.; Wu, M. Z.; Taniyasu, S.; Besso, H.; Tanaka, O.; Saruwatari, Y.; Fuwa, T. Dammarane-saponins of Sanchi ginseng, roots of Panax notoginseng (Burk.) F.H. Chen (Araliaceae): structures of new saponins, notoginsenosides-R1 and -R2, and identification of ginsenosides-Rg2 and -Rh1 Chem. Pharm. Bull. 1981, 29, 2844-2850
28. Komakine, N.; Okasaka, M.; Takaishi, Y.; Kawazoe, K.; Murakami, K.; Yamada, Y. New dammarane-type saponin from roots of Panax notoginseng J. Nat. Med. 2006, 60, 135-137
29. Qiu, L.; Jiao, Y.; Huang, G.-K.; Xie, J.-Z.; Miao, J.-H.; Yao, X.-S. New dammarane-type saponins from the roots of Panax notoginseng Helv. Chim. Acta 2014, 97, 102-111
30. Fu, H.-Z.; Zhong, R.-J.; Zhang, D.-M.; Wang, D. A new protopanaxadiol-type ginsenoside from the roots of Panax notoginseng J. Asian Nat. Prod. Res. 2013, 15, 1139-1143
31. Pei, Y.; Du, Q.; Liao, P. Y.; Chen, Z. P.; Wang, D.; Yang, C. R.; Kitazato, K.; Wang, Y. F.; Zhang, Y. J. Notoginsenoside ST-4 inhibits virus penetration of herpes simplex virus in vitro J. Asian Nat. Prod. Res. 2011, 13, 498-504
32. Liao, P. Y.; Wang, D.; Zhang, Y. J.; Yang, C. R. Dammarane-type glycosides from steamed notoginseng J. Agric. Food Chem. 2008, 56, 1751-1756
33. Xie, Y. Y.; Luo, D.; Cheng, Y. J.; Ma, J. F.; Wang, Y. M.; Liang, Q. L.; Luo, G. A. Steaming-induced chemical transformations and holistic quality assessment of red ginseng derived from Panax ginseng by means of HPLC-ESI-MS/MS(n)-based multicomponent quantification fingerprint J. Agric. Food Chem. 2012, 60, 8213-8224
34. Qin, F.; Yu, S.; Gao, Y.; Zheng, Y. Simultaneous determination of ginsenoside Rg1 and ginsenoside Re in total saponins of fibrous roots of Panax notoginseng by HPLC-MS/MS Zhongguo Yaofang 2010, 21, 2922-2924
35. Jiang, Y.; Wang, Q.; Ma, S.; Dang, X. Quantitative determination of saponins in the root of Panax pseudo-ginseng var. notoginseng by HPLC-ELSD and UV spectrophotometry Zhongcaoyao 2000, 31, 737-739
36. Wang, X.; Ni, J.; Guo, Y. Quantitative determination of ginsenoside Rg1 and Rb1 in Radix Notoginseng Beijing Zhongyiyao Daxue Xuebao 2000, 23, 38-40
37. Lang, W.; Lou, Z.; But, P. P. High-performance liquid chromatographic analysis of ginsenosides in Panax ginseng, P. quinquefolium, and P. notoginseng J. Chin. Pharm. Sci. 1993, 2, 133-143
38. Wan, X.-q.; Xia, B.-h.; Lou, Z.-h.; Peng, Y.-s.; Gong, Y.-c.; Wu, Y.-y. Determination of saponins in different processed products of Panax notoginseng Zhonghua Zhongyiyao Zazhi 2011, 26, 841-843
39. Dan, M.; Xie, G.; Gao, X.; Long, X.; Su, M.; Zhao, A.; Zhao, T.; Zhou, M.; Qiu, Y.; Jia, W. A rapid ultra-performance liquid chromatography-electrospray ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng Phytochem Anal. 2009, 20, 68-76
40. Toh, D. F.; New, L. S.; Koh, H. L.; Chan, E. C. Ultra-high performance liquid chromatography/time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginseng J. Pharm. Biomed. Anal. 2010, 52, 43-50
41. Hu, P.; Luo, G. A.; Wang, Q.; Zhao, Z. Z.; Wang, W.; Jiang, Z. H. The retention behavior of ginsenosides in HPLC and its application to quality assessment of Radix Ginseng Arch. Pharm. Res. 2009, 32, 667-676
42. Wang, J. R.; Leung, C. Y.; Ho, H. M.; Chai, S.; Yau, L. F.; Zhao, Z. Z.; Jiang, Z. H. Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng Chem. Biodivers. 2010, 7, 975-983
43. Dong, T. T. X.; Cui, X. M.; Song, Z. H.; Zhao, K. J.; Ji, Z. N.; Lo, C. K.; Tsim, K. W. K. Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents J. Agric. Food Chem. 2003, 51, 4617-4623
44. Clarke, J. D.; Alexander, D. C.; Ward, D. P.; Ryals, J. A.; Mitchell, M. W.; Wulff, J. E.; Guo, L. Assessment of genetically modified soybean in relation to natural variation in the soybean seed metabolome. Sci. Rep. 2013, 3, 3082.
45. Wang, J. R.; Yau, L. F.; Zhang, R.; Xia, Y.; Ma, J.; Ho, H. M.; Hu, P.; Hu, M.; Liu, L.; Jiang, Z. H. Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells J. Agric. Food Chem. 2014, 62, 2558-2573
46. Domon, B.; Costello, C. E. A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates Glycoconjugate J. 1988, 5, 397-409