메뉴 건너뛰기




Volumn 62, Issue 12, 2014, Pages 2558-2573

Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells

Author keywords

gastric juice; ginsenoside; LC MS; notoginseng; transformation

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CELLS; DEHYDRATION; HYDRATION; METABOLISM; METABOLITES; DISEASES;

EID: 84896963345     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf405482s     Document Type: Article
Times cited : (56)

References (66)
  • 1
    • 33747072624 scopus 로고    scopus 로고
    • Pharmacological activity of sanchi ginseng (Panax notoginseng)
    • Ng, T. B. Pharmacological activity of sanchi ginseng (Panax notoginseng) J. Pharm. Pharmacol. 2006, 58 (8) 1007-1019
    • (2006) J. Pharm. Pharmacol. , vol.58 , Issue.8 , pp. 1007-1019
    • Ng, T.B.1
  • 2
    • 0032708331 scopus 로고    scopus 로고
    • Anti-carcinogenic activity of the roots of Panax notoginseng. II
    • Konoshima, T.; Takasaki, M.; Tokuda, H. Anti-carcinogenic activity of the roots of Panax notoginseng. II Biol. Pharm. Bull. 1999, 22 (10) 1150-1152
    • (1999) Biol. Pharm. Bull. , vol.22 , Issue.10 , pp. 1150-1152
    • Konoshima, T.1    Takasaki, M.2    Tokuda, H.3
  • 3
    • 57349164037 scopus 로고    scopus 로고
    • Potential role of ginseng in the treatment of colorectal cancer
    • Wang, C. Z.; Yuan, C. S. Potential role of ginseng in the treatment of colorectal cancer Am. J. Chin. Med. 2008, 36 (6) 1019-1028
    • (2008) Am. J. Chin. Med. , vol.36 , Issue.6 , pp. 1019-1028
    • Wang, C.Z.1    Yuan, C.S.2
  • 4
    • 77951895210 scopus 로고    scopus 로고
    • A cohort study on the predictive value of factors influencing cardio-cerebro vascular death among people over 40 years of age
    • Yang, J. M.; Lu, F. H.; Jin, S. K.; Sun, S. W.; Zhao, Y. X.; Wang, S. J.; Zhou, X. H. A cohort study on the predictive value of factors influencing cardio-cerebro vascular death among people over 40 years of age Zhonghua Liuxingbingxue Zazhi 2007, 28 (2) 119-122
    • (2007) Zhonghua Liuxingbingxue Zazhi , vol.28 , Issue.2 , pp. 119-122
    • Yang, J.M.1    Lu, F.H.2    Jin, S.K.3    Sun, S.W.4    Zhao, Y.X.5    Wang, S.J.6    Zhou, X.H.7
  • 5
    • 77952138043 scopus 로고    scopus 로고
    • Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng
    • Ruan, J. Q.; Leong, W. I.; Yan, R.; Wang, Y. T. Characterization of metabolism and in vitro permeability study of notoginsenoside R1 from Radix notoginseng J. Agric. Food Chem. 2010, 58 (9) 5770-5776
    • (2010) J. Agric. Food Chem. , vol.58 , Issue.9 , pp. 5770-5776
    • Ruan, J.Q.1    Leong, W.I.2    Yan, R.3    Wang, Y.T.4
  • 6
    • 84859076529 scopus 로고    scopus 로고
    • Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen
    • He, N. W.; Zhao, Y.; Guo, L.; Shang, J.; Yang, X. B. Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen J. Med. Food 2012, 15 (4) 350-359
    • (2012) J. Med. Food , vol.15 , Issue.4 , pp. 350-359
    • He, N.W.1    Zhao, Y.2    Guo, L.3    Shang, J.4    Yang, X.B.5
  • 7
    • 0030753079 scopus 로고    scopus 로고
    • Bioactive saponins and glycosides. IX. Notoginseng (2): Structures of five new dammarane-type triterpene oligoglycosides, notoginsenosides-E, -G, -H, -I, and -J, and a novel acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, from the dried root of Panax notoginseng (Burk.) F. H. Chen
    • Yoshikawa, M.; Murakami, T.; Ueno, T.; Hirokawa, N.; Yashiro, K.; Murakami, N.; Yamahara, J.; Matsuda, H.; Saijoh, R.; Tanaka, O. Bioactive saponins and glycosides. IX. Notoginseng (2): structures of five new dammarane-type triterpene oligoglycosides, notoginsenosides-E, -G, -H, -I, and -J, and a novel acetylenic fatty acid glycoside, notoginsenic acid β-sophoroside, from the dried root of Panax notoginseng (Burk.) F. H. Chen Chem. Pharm. Bull. 1997, 45, 1056-1062
    • (1997) Chem. Pharm. Bull. , vol.45 , pp. 1056-1062
    • Yoshikawa, M.1    Murakami, T.2    Ueno, T.3    Hirokawa, N.4    Yashiro, K.5    Murakami, N.6    Yamahara, J.7    Matsuda, H.8    Saijoh, R.9    Tanaka, O.10
  • 8
    • 38849199620 scopus 로고    scopus 로고
    • Two new dammarane-type bisdesmosides from the fruit pedicels of Panax notoginseng
    • Wang, X.-Y.; Wang, D.; Ma, X.-X.; Zhang, Y.-J.; Yang, C.-R. Two new dammarane-type bisdesmosides from the fruit pedicels of Panax notoginseng Helv. Chim. Acta 2008, 91, 60-66
    • (2008) Helv. Chim. Acta , vol.91 , pp. 60-66
    • Wang, X.-Y.1    Wang, D.2    Ma, X.-X.3    Zhang, Y.-J.4    Yang, C.-R.5
  • 9
    • 50349101675 scopus 로고    scopus 로고
    • Ginsenosides: Chemistry, biosynthesis, analysis, and potential health effects
    • Christensen, L. P. Ginsenosides: chemistry, biosynthesis, analysis, and potential health effects Adv. Food Nutr. Res. 2009, 55, 1-99
    • (2009) Adv. Food Nutr. Res. , vol.55 , pp. 1-99
    • Christensen, L.P.1
  • 10
    • 34248348678 scopus 로고    scopus 로고
    • Chemical characteristics of three medicinal plants of the Panax genus determined by HPLC-ELSD
    • Wan, J. B.; Li, S. P.; Chen, J. M.; Wang, Y. T. Chemical characteristics of three medicinal plants of the Panax genus determined by HPLC-ELSD J. Sep. Sci. 2007, 30 (6) 825-832
    • (2007) J. Sep. Sci. , vol.30 , Issue.6 , pp. 825-832
    • Wan, J.B.1    Li, S.P.2    Chen, J.M.3    Wang, Y.T.4
  • 11
    • 77951195189 scopus 로고    scopus 로고
    • Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng
    • Wang, J. R.; Leung, C. Y.; Ho, H. M.; Chai, S.; Yau, L. F.; Zhao, Z. Z.; Jiang, Z. H. Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng Chem. Biodiversity 2010, 7 (4) 975-983
    • (2010) Chem. Biodiversity , vol.7 , Issue.4 , pp. 975-983
    • Wang, J.R.1    Leung, C.Y.2    Ho, H.M.3    Chai, S.4    Yau, L.F.5    Zhao, Z.Z.6    Jiang, Z.H.7
  • 12
    • 0025981610 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats
    • Karikura, M.; Miyase, T.; Tanizawa, H.; Taniyama, T.; Takino, Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats Chem. Pharm. Bull. (Tokyo) 1991, 39 (2) 400-404
    • (1991) Chem. Pharm. Bull. (Tokyo) , vol.39 , Issue.2 , pp. 400-404
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Taniyama, T.4    Takino, Y.5
  • 13
    • 0025946582 scopus 로고
    • Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats
    • Karikura, M.; Miyase, T.; Tanizawa, H.; Taniyama, T.; Takino, Y. Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats Chem. Pharm. Bull. (Tokyo) 1991, 39 (9) 2357-2361
    • (1991) Chem. Pharm. Bull. (Tokyo) , vol.39 , Issue.9 , pp. 2357-2361
    • Karikura, M.1    Miyase, T.2    Tanizawa, H.3    Taniyama, T.4    Takino, Y.5
  • 14
    • 0021020463 scopus 로고
    • Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. IV. Decomposition of ginsenoside-Rg1 and -Rb1 in the digestive tract of rats
    • Odani, T.; Tanizawa, H.; Takino, Y. Studies on the absorption, distribution, excretion and metabolism of ginseng saponins. IV. Decomposition of ginsenoside-Rg1 and -Rb1 in the digestive tract of rats Chem. Pharm. Bull. (Tokyo) 1983, 31 (10) 3691-3697
    • (1983) Chem. Pharm. Bull. (Tokyo) , vol.31 , Issue.10 , pp. 3691-3697
    • Odani, T.1    Tanizawa, H.2    Takino, Y.3
  • 15
    • 0033626653 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1
    • Wang, Y.; Wang, B. X.; Liu, T. H.; Minami, M.; Nagata, T.; Ikejima, T. Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1 Acta Pharmacol. Sin. 2000, 21, 792-796
    • (2000) Acta Pharmacol. Sin. , vol.21 , pp. 792-796
    • Wang, Y.1    Wang, B.X.2    Liu, T.H.3    Minami, M.4    Nagata, T.5    Ikejima, T.6
  • 16
    • 6944253961 scopus 로고    scopus 로고
    • Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants
    • Bae, E.-A.; Han, M. J.; Kim, E.-J.; Kim, D.-H. Transformation of ginseng saponins to ginsenoside Rh2 by acids and human intestinal bacteria and biological activities of their transformants Arch. Pharm. Res. 2004, 27, 61-67
    • (2004) Arch. Pharm. Res. , vol.27 , pp. 61-67
    • Bae, E.-A.1    Han, M.J.2    Kim, E.-J.3    Kim, D.-H.4
  • 17
    • 0036594246 scopus 로고    scopus 로고
    • Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity
    • Bae, E.-A.; Choo, M.-K.; Park, E.-K.; Park, S.-Y.; Shin, H.-Y.; Kim, D.-H. Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity Biol. Pharm. Bull. 2002, 25, 743-747
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 743-747
    • Bae, E.-A.1    Choo, M.-K.2    Park, E.-K.3    Park, S.-Y.4    Shin, H.-Y.5    Kim, D.-H.6
  • 18
    • 26444489991 scopus 로고    scopus 로고
    • Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect
    • Bae, E.-A.; Shin, J.-E.; Kim, D.-H. Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect Biol. Pharm. Bull. 2005, 28, 1903-1908
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 1903-1908
    • Bae, E.-A.1    Shin, J.-E.2    Kim, D.-H.3
  • 19
    • 0034113843 scopus 로고    scopus 로고
    • Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters
    • Hasegawa, H.; Lee, K. S.; Nagaoka, T.; Tezuka, Y.; Uchiyama, M.; Kadota, S.; Saiki, I. Pharmacokinetics of ginsenoside deglycosylated by intestinal bacteria and its transformation to biologically active fatty acid esters Biol. Pharm. Bull. 2000, 23, 298-304
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 298-304
    • Hasegawa, H.1    Lee, K.S.2    Nagaoka, T.3    Tezuka, Y.4    Uchiyama, M.5    Kadota, S.6    Saiki, I.7
  • 20
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao, T.; Kida, H.; Kanaoka, M.; Hattori, M.; Kobashi, K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng J. Pharm. Pharmacol. 1998, 50, 1155
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 1155
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 21
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins
    • Hasegawa, H.; Sung, J. H.; Benno, Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins Planta Med. 1997, 63, 436-440
    • (1997) Planta Med. , vol.63 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 22
    • 0028145120 scopus 로고
    • Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats
    • Takino, Y. Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats Yakugaku Zasshi 1994, 114, 550-564
    • (1994) Yakugaku Zasshi , vol.114 , pp. 550-564
    • Takino, Y.1
  • 23
    • 3142621044 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng. Basic and clinical trials: Metabolic activation of ginsenoside: Deglycosylation by intestinal bacteria and esterification with fatty acid
    • Hasegawa, H. Proof of the mysterious efficacy of ginseng. Basic and clinical trials: Metabolic activation of ginsenoside: Deglycosylation by intestinal bacteria and esterification with fatty acid J. Pharmacol. Sci. (Tokyo) 2004, 95, 153-157
    • (2004) J. Pharmacol. Sci. (Tokyo) , vol.95 , pp. 153-157
    • Hasegawa, H.1
  • 24
    • 70349451559 scopus 로고    scopus 로고
    • Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method
    • Joo, K. M.; Lee, J. H.; Jeon, H. Y.; Park, C. W.; Hong, D. K.; Jeong, H. J.; Lee, S. J.; Lee, S. Y.; Lim, K. M. Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method J. Pharm. Biomed. Anal. 2010, 51 (1) 278-283
    • (2010) J. Pharm. Biomed. Anal. , vol.51 , Issue.1 , pp. 278-283
    • Joo, K.M.1    Lee, J.H.2    Jeon, H.Y.3    Park, C.W.4    Hong, D.K.5    Jeong, H.J.6    Lee, S.J.7    Lee, S.Y.8    Lim, K.M.9
  • 25
    • 21344433027 scopus 로고    scopus 로고
    • Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs
    • Xie, H. T.; Wang, G. J.; Lv, H.; Sun, R. W.; Jiang, X. L.; Li, H.; Wang, W.; Huang, C. R.; Xu, M. J. Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs Eur. J. Drug Metab. Pharmacokinet. 2005, 30 (1-2) 63-67
    • (2005) Eur. J. Drug Metab. Pharmacokinet. , vol.30 , Issue.12 , pp. 63-67
    • Xie, H.T.1    Wang, G.J.2    Lv, H.3    Sun, R.W.4    Jiang, X.L.5    Li, H.6    Wang, W.7    Huang, C.R.8    Xu, M.J.9
  • 26
    • 20044364935 scopus 로고    scopus 로고
    • High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
    • Xie, H. T.; Wang, G. J.; Sun, J. G.; Tucker, I.; Zhao, X. C.; Xie, Y. Y.; Li, H.; Jiang, X. L.; Wang, R.; Xu, M. J.; Wang, W. High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies J Chromatogr., B: Anal. Technol. Biomed. Life Sci. 2005, 818 (2) 167-173
    • (2005) J Chromatogr., B: Anal. Technol. Biomed. Life Sci. , vol.818 , Issue.2 , pp. 167-173
    • Xie, H.T.1    Wang, G.J.2    Sun, J.G.3    Tucker, I.4    Zhao, X.C.5    Xie, Y.Y.6    Li, H.7    Jiang, X.L.8    Wang, R.9    Xu, M.J.10    Wang, W.11
  • 28
    • 0031303557 scopus 로고    scopus 로고
    • In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration
    • Wakabayashi, C.; Hasegawa, H.; Murata, J.; Saiki, I. In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration Oncol. Res. 1997, 9 (8) 411-417
    • (1997) Oncol. Res. , vol.9 , Issue.8 , pp. 411-417
    • Wakabayashi, C.1    Hasegawa, H.2    Murata, J.3    Saiki, I.4
  • 29
    • 3142596226 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng. Basic and clinical trials: Clinical effects of medical ginseng, korean red ginseng: Specifically, its anti-stress action for prevention of disease
    • Kaneko, H.; Nakanishi, K. Proof of the mysterious efficacy of ginseng. Basic and clinical trials: clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease J. Pharmacol. Sci. 2004, 95 (2) 158-162
    • (2004) J. Pharmacol. Sci. , vol.95 , Issue.2 , pp. 158-162
    • Kaneko, H.1    Nakanishi, K.2
  • 31
    • 84855174764 scopus 로고    scopus 로고
    • Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway
    • Hu, C.; Song, G.; Zhang, B.; Liu, Z.; Chen, R.; Zhang, H.; Hu, T. Intestinal metabolite compound K of panaxoside inhibits the growth of gastric carcinoma by augmenting apoptosis via Bid-mediated mitochondrial pathway J. Cell. Mol. Med. 2012, 16 (1) 96-106
    • (2012) J. Cell. Mol. Med. , vol.16 , Issue.1 , pp. 96-106
    • Hu, C.1    Song, G.2    Zhang, B.3    Liu, Z.4    Chen, R.5    Zhang, H.6    Hu, T.7
  • 32
    • 84863960161 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora
    • Yang, Z.; Wang, J. R.; Niu, T.; Gao, S.; Yin, T.; You, M.; Jiang, Z. H.; Hu, M. Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora Drug Metab. Dispos. 2012, 40 (8) 1538-1544
    • (2012) Drug Metab. Dispos. , vol.40 , Issue.8 , pp. 1538-1544
    • Yang, Z.1    Wang, J.R.2    Niu, T.3    Gao, S.4    Yin, T.5    You, M.6    Jiang, Z.H.7    Hu, M.8
  • 34
    • 84879097012 scopus 로고    scopus 로고
    • Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi)
    • Hu, Z.; Yang, J.; Cheng, C.; Huang, Y.; Du, F.; Wang, F.; Niu, W.; Xu, F.; Jiang, R.; Gao, X.; Li, C. Combinatorial metabolism notably affects human systemic exposure to ginsenosides from orally administered extract of Panax notoginseng roots (Sanqi) Drug Metab. Dispos. 2013, 41 (7) 1457-1469
    • (2013) Drug Metab. Dispos. , vol.41 , Issue.7 , pp. 1457-1469
    • Hu, Z.1    Yang, J.2    Cheng, C.3    Huang, Y.4    Du, F.5    Wang, F.6    Niu, W.7    Xu, F.8    Jiang, R.9    Gao, X.10    Li, C.11
  • 35
    • 33646036727 scopus 로고    scopus 로고
    • High-performance liquid chromatography coupled with tandem mass spectrometry applied for metabolic study of ginsenoside Rb1 on rat
    • Qian, T.; Jiang, Z. H.; Cai, Z. High-performance liquid chromatography coupled with tandem mass spectrometry applied for metabolic study of ginsenoside Rb1 on rat Anal. Biochem. 2006, 352 (1) 87-96
    • (2006) Anal. Biochem. , vol.352 , Issue.1 , pp. 87-96
    • Qian, T.1    Jiang, Z.H.2    Cai, Z.3
  • 37
    • 84863960161 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora
    • Yang, Z.; Wang, J. R.; Niu, T.; Gao, S.; Yin, T.; You, M.; Jiang, Z. H.; Hu, M. Inhibition of P-glycoprotein leads to improved oral bioavailability of compound K, an anticancer metabolite of red ginseng extract produced by gut microflora Drug Metabolism and Dispos. 2012, 40 (8) 1538-1544
    • (2012) Drug Metabolism and Dispos. , vol.40 , Issue.8 , pp. 1538-1544
    • Yang, Z.1    Wang, J.R.2    Niu, T.3    Gao, S.4    Yin, T.5    You, M.6    Jiang, Z.H.7    Hu, M.8
  • 38
    • 79955683471 scopus 로고    scopus 로고
    • Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism
    • Zhou, H.; Hou, S. Z.; Luo, P.; Zeng, B.; Wang, J. R.; Wong, Y. F.; Jiang, Z. H.; Liu, L. Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism J. Ethnopharmacol. 2011, 135 (2) 287-298
    • (2011) J. Ethnopharmacol. , vol.135 , Issue.2 , pp. 287-298
    • Zhou, H.1    Hou, S.Z.2    Luo, P.3    Zeng, B.4    Wang, J.R.5    Wong, Y.F.6    Jiang, Z.H.7    Liu, L.8
  • 39
    • 3042663332 scopus 로고    scopus 로고
    • Hydrolytic Reaction of Plant Extracts to Generate Molecular Diversity: New Dammarane Glycosides from the Mild Acid Hydrolysate of Root Saponins of Panax notoginseng
    • Teng, R.-W.; Li, H.-Z.; Wang, D.-Z.; Yang, C.-R. Hydrolytic Reaction of Plant Extracts to Generate Molecular Diversity: New Dammarane Glycosides from the Mild Acid Hydrolysate of Root Saponins of Panax notoginseng Helv. Chim. Acta 2004, 87 (5) 1270-1278
    • (2004) Helv. Chim. Acta , vol.87 , Issue.5 , pp. 1270-1278
    • Teng, R.-W.1    Li, H.-Z.2    Wang, D.-Z.3    Yang, C.-R.4
  • 40
    • 0032936175 scopus 로고    scopus 로고
    • Dammarane-type triterpene glycosides from the leaves of Rhoiptelea chiliantha
    • Jiang, Z.-H.; Fukuoka, R.; Aoki, F.; Tanaka, T.; Kouno, I. Dammarane-type triterpene glycosides from the leaves of Rhoiptelea chiliantha Chem. Pharm. Bull. 1999, 47, 257-262
    • (1999) Chem. Pharm. Bull. , vol.47 , pp. 257-262
    • Jiang, Z.-H.1    Fukuoka, R.2    Aoki, F.3    Tanaka, T.4    Kouno, I.5
  • 41
    • 0029860777 scopus 로고    scopus 로고
    • An Efficient Asymmetric Epoxidation Method for trans -Olefins Mediated by a Fructose-Derived Ketone
    • Tu, Y.; Wang, Z.-X.; Shi, Y. An Efficient Asymmetric Epoxidation Method for trans -Olefins Mediated by a Fructose-Derived Ketone J. Am. Chem. Soc. 1996, 118, 9806-9807
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 9806-9807
    • Tu, Y.1    Wang, Z.-X.2    Shi, Y.3
  • 42
    • 3042663332 scopus 로고    scopus 로고
    • Hydrolytic reaction of plant extracts to generate molecular diversity: New dammarane glycosides from the mild acid hydrolysate of root saponins of Panax notoginseng
    • Teng, R.-W.; Li, H.-Z.; Wang, D.-Z.; Yang, C.-R. Hydrolytic reaction of plant extracts to generate molecular diversity: new dammarane glycosides from the mild acid hydrolysate of root saponins of Panax notoginseng Helv. Chim. Acta 2004, 87, 1270-1278
    • (2004) Helv. Chim. Acta , vol.87 , pp. 1270-1278
    • Teng, R.-W.1    Li, H.-Z.2    Wang, D.-Z.3    Yang, C.-R.4
  • 43
    • 0035346353 scopus 로고    scopus 로고
    • Enzymatic synthesis of two ginsenoside Re-beta-xylosides
    • Ko, S. R.; Suzuki, Y.; Kim, Y. H.; Choi, K. J. Enzymatic synthesis of two ginsenoside Re-beta-xylosides Biosci. Biotechnol. Biochem. 2001, 65 (5) 1223-1226
    • (2001) Biosci. Biotechnol. Biochem. , vol.65 , Issue.5 , pp. 1223-1226
    • Ko, S.R.1    Suzuki, Y.2    Kim, Y.H.3    Choi, K.J.4
  • 44
    • 0242286040 scopus 로고    scopus 로고
    • Enzymatic preparation of ginsenosides Rg2, Rh1, and F1
    • Ko, S. R.; Choi, K. J.; Suzuki, K.; Suzuki, Y. Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 Chem. Pharm. Bull. (Tokyo) 2003, 51 (4) 404-408
    • (2003) Chem. Pharm. Bull. (Tokyo) , vol.51 , Issue.4 , pp. 404-408
    • Ko, S.R.1    Choi, K.J.2    Suzuki, K.3    Suzuki, Y.4
  • 46
    • 0028321482 scopus 로고
    • Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. III
    • Duc, N. M.; Kasai, R.; Ohtani, K.; Ito, A.; Nham, N. T.; Yamasaki, K.; Tanaka, O. Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III Chem. Pharm. Bull. (Tokyo) 1994, 42 (3) 634-640
    • (1994) Chem. Pharm. Bull. (Tokyo) , vol.42 , Issue.3 , pp. 634-640
    • Duc, N.M.1    Kasai, R.2    Ohtani, K.3    Ito, A.4    Nham, N.T.5    Yamasaki, K.6    Tanaka, O.7
  • 47
    • 67649845984 scopus 로고    scopus 로고
    • Dammarane-type triterpene saponins from the flowers of Panax notoginseng
    • Wang, J. R.; Yamasaki, Y.; Tanaka, T.; Kouno, I.; Jiang, Z. H. Dammarane-type triterpene saponins from the flowers of Panax notoginseng Molecules 2009, 14 (6) 2087-2094
    • (2009) Molecules , vol.14 , Issue.6 , pp. 2087-2094
    • Wang, J.R.1    Yamasaki, Y.2    Tanaka, T.3    Kouno, I.4    Jiang, Z.H.5
  • 48
    • 0030822914 scopus 로고    scopus 로고
    • Bioactive saponins and glycosides. VIII. Notoginseng (1): New dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen
    • Yoshikawa, M.; Murakami, T.; Ueno, T.; Yashiro, K.; Hirokawa, N.; Murakami, N.; Yamahara, J.; Matsuda, H.; Saijoh, R.; Tanaka, O. Bioactive saponins and glycosides. VIII. Notoginseng (1): new dammarane-type triterpene oligoglycosides, notoginsenosides-A, -B, -C, and -D, from the dried root of Panax notoginseng (Burk.) F.H. Chen Chem. Pharm. Bull. (Tokyo) 1997, 45 (6) 1039-1045
    • (1997) Chem. Pharm. Bull. (Tokyo) , vol.45 , Issue.6 , pp. 1039-1045
    • Yoshikawa, M.1    Murakami, T.2    Ueno, T.3    Yashiro, K.4    Hirokawa, N.5    Murakami, N.6    Yamahara, J.7    Matsuda, H.8    Saijoh, R.9    Tanaka, O.10
  • 49
    • 18744403057 scopus 로고    scopus 로고
    • Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells
    • Cheng, C. C.; Yang, S. M.; Huang, C. Y.; Chen, J. C.; Chang, W. M.; Hsu, S. L. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells Cancer Chemother. Pharmacol. 2005, 55 (6) 531-540
    • (2005) Cancer Chemother. Pharmacol. , vol.55 , Issue.6 , pp. 531-540
    • Cheng, C.C.1    Yang, S.M.2    Huang, C.Y.3    Chen, J.C.4    Chang, W.M.5    Hsu, S.L.6
  • 50
    • 4043137428 scopus 로고    scopus 로고
    • Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells
    • Popovich, D. G.; Kitts, D. D. Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells J. Biochem. Mol. Toxicol. 2004, 18 (3) 143-149
    • (2004) J. Biochem. Mol. Toxicol. , vol.18 , Issue.3 , pp. 143-149
    • Popovich, D.G.1    Kitts, D.D.2
  • 51
    • 2442452643 scopus 로고    scopus 로고
    • Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2
    • Popovich, D. G.; Kitts, D. D. Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2 Can. J. Physiol. Pharmacol. 2004, 82 (3) 183-190
    • (2004) Can. J. Physiol. Pharmacol. , vol.82 , Issue.3 , pp. 183-190
    • Popovich, D.G.1    Kitts, D.D.2
  • 52
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins
    • Hasegawa, H.; Sung, J. H.; Benno, Y. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins Planta Med. 1997, 63 (5) 436-440
    • (1997) Planta Med. , vol.63 , Issue.5 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 53
    • 0031736410 scopus 로고    scopus 로고
    • Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng
    • Akao, T.; Kida, H.; Kanaoka, M.; Hattori, M.; Kobashi, K. Intestinal bacterial hydrolysis is required for the appearance of compound K in rat plasma after oral administration of ginsenoside Rb1 from Panax ginseng J. Pharm. Pharmacol. 1998, 50 (10) 1155-1160
    • (1998) J. Pharm. Pharmacol. , vol.50 , Issue.10 , pp. 1155-1160
    • Akao, T.1    Kida, H.2    Kanaoka, M.3    Hattori, M.4    Kobashi, K.5
  • 54
    • 68049127779 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs
    • Gu, Y.; Wang, G. J.; Sun, J. G.; Jia, Y. W.; Wang, W.; Xu, M. J.; Lv, T.; Zheng, Y. T.; Sai, Y. Pharmacokinetic characterization of ginsenoside Rh2, an anticancer nutrient from ginseng, in rats and dogs Food Chem. Toxicol. 2009, 47 (9) 2257-2268
    • (2009) Food Chem. Toxicol. , vol.47 , Issue.9 , pp. 2257-2268
    • Gu, Y.1    Wang, G.J.2    Sun, J.G.3    Jia, Y.W.4    Wang, W.5    Xu, M.J.6    Lv, T.7    Zheng, Y.T.8    Sai, Y.9
  • 55
    • 21344433027 scopus 로고    scopus 로고
    • Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs
    • Xie, H. T.; Wang, G. J.; Lv, H.; Sun, R. W.; Jiang, X. L.; Li, H.; Wang, W.; Huang, C. R.; Xu, M. J. Development of a HPLC-MS assay for ginsenoside Rh2, a new anti-tumor substance from natural product and its pharacokinetic study in dogs Eur. J. Drug Metab. Pharmacokinet. 2005, 30 (1-2) 63-67
    • (2005) Eur. J. Drug Metab. Pharmacokinet. , vol.30 , Issue.12 , pp. 63-67
    • Xie, H.T.1    Wang, G.J.2    Lv, H.3    Sun, R.W.4    Jiang, X.L.5    Li, H.6    Wang, W.7    Huang, C.R.8    Xu, M.J.9
  • 56
    • 84862827090 scopus 로고    scopus 로고
    • Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study
    • Zhao, J.; Su, C.; Yang, C.; Liu, M.; Tang, L.; Su, W.; Liu, Z. Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: application in a pharmacokinetic study J. Pharm. Biomed. Anal. 2012, 64-65, 94-97
    • (2012) J. Pharm. Biomed. Anal. , vol.6465 , pp. 94-97
    • Zhao, J.1    Su, C.2    Yang, C.3    Liu, M.4    Tang, L.5    Su, W.6    Liu, Z.7
  • 58
    • 80053155942 scopus 로고    scopus 로고
    • Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms
    • Yang, Z.; Gao, S.; Wang, J.; Yin, T.; Teng, Y.; Wu, B.; You, M.; Jiang, Z.; Hu, M. Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms Drug Metab. Dispos. 2011, 39 (10) 1866-1872
    • (2011) Drug Metab. Dispos. , vol.39 , Issue.10 , pp. 1866-1872
    • Yang, Z.1    Gao, S.2    Wang, J.3    Yin, T.4    Teng, Y.5    Wu, B.6    You, M.7    Jiang, Z.8    Hu, M.9
  • 59
    • 77955607007 scopus 로고    scopus 로고
    • Intestinal absorption mechanisms of ginsenoside Rh2: Stereoselectivity and involvement of ABC transporters
    • Gu, Y.; Wang, G. J.; Wu, X. L.; Zheng, Y. T.; Zhang, J. W.; Ai, H.; Sun, J. G.; Jia, Y. W. Intestinal absorption mechanisms of ginsenoside Rh2: stereoselectivity and involvement of ABC transporters Xenobiotica 2010, 40 (9) 602-612
    • (2010) Xenobiotica , vol.40 , Issue.9 , pp. 602-612
    • Gu, Y.1    Wang, G.J.2    Wu, X.L.3    Zheng, Y.T.4    Zhang, J.W.5    Ai, H.6    Sun, J.G.7    Jia, Y.W.8
  • 60
    • 84860014033 scopus 로고    scopus 로고
    • Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics
    • Zhang, J.; Zhou, F.; Niu, F.; Lu, M.; Wu, X.; Sun, J.; Wang, G. Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics PloS One 2012, 7 (4) e35768
    • (2012) PloS One , vol.7 , Issue.4 , pp. 35768
    • Zhang, J.1    Zhou, F.2    Niu, F.3    Lu, M.4    Wu, X.5    Sun, J.6    Wang, G.7
  • 61
    • 77957236253 scopus 로고    scopus 로고
    • Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: Metabolite profile, reaction phenotyping, and structure-metabolism relationship
    • Hao, H.; Lai, L.; Zheng, C.; Wang, Q.; Yu, G.; Zhou, X.; Wu, L.; Gong, P.; Wang, G. Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship Drug Metab. Dispos. 2010, 38 (10) 1731-1739
    • (2010) Drug Metab. Dispos. , vol.38 , Issue.10 , pp. 1731-1739
    • Hao, H.1    Lai, L.2    Zheng, C.3    Wang, Q.4    Yu, G.5    Zhou, X.6    Wu, L.7    Gong, P.8    Wang, G.9
  • 62
    • 33644553478 scopus 로고    scopus 로고
    • Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes
    • Liu, Y.; Ma, H.; Zhang, J. W.; Deng, M. C.; Yang, L. Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes Planta Med. 2006, 72 (2) 126-131
    • (2006) Planta Med. , vol.72 , Issue.2 , pp. 126-131
    • Liu, Y.1    Ma, H.2    Zhang, J.W.3    Deng, M.C.4    Yang, L.5
  • 63
    • 0036206368 scopus 로고    scopus 로고
    • In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1
    • Chang, T. K.; Chen, J.; Benetton, S. A. In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1 Drug Metab. Dispos. 2002, 30 (4) 378-384
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.4 , pp. 378-384
    • Chang, T.K.1    Chen, J.2    Benetton, S.A.3
  • 64
    • 84865039191 scopus 로고    scopus 로고
    • Ginsenosides as Anticancer Agents: In Vitro and in Vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action
    • Nag, S. A.; Qin, J. J.; Wang, W.; Wang, M. H.; Wang, H.; Zhang, R. Ginsenosides as Anticancer Agents: In Vitro and in Vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action Front. Pharmacol. 2012, 3, 25
    • (2012) Front. Pharmacol. , vol.3 , pp. 25
    • Nag, S.A.1    Qin, J.J.2    Wang, W.3    Wang, M.H.4    Wang, H.5    Zhang, R.6
  • 65
    • 78049250867 scopus 로고    scopus 로고
    • Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling
    • Wong, V. K.; Cheung, S. S.; Li, T.; Jiang, Z. H.; Wang, J. R.; Dong, H.; Yi, X. Q.; Zhou, H.; Liu, L. Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-kappaB signaling J. Cell. Biochem. 2010, 111 (4) 899-910
    • (2010) J. Cell. Biochem. , vol.111 , Issue.4 , pp. 899-910
    • Wong, V.K.1    Cheung, S.S.2    Li, T.3    Jiang, Z.H.4    Wang, J.R.5    Dong, H.6    Yi, X.Q.7    Zhou, H.8    Liu, L.9
  • 66
    • 0028321482 scopus 로고
    • Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II
    • Nguyen, M. D.; Kasai, R.; Ohtani, K.; Ito, A.; Nguyen, T. N.; Yamasaki, K.; Tanaka, O. Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II Chem. Pharm. Bull. (Tokyo) 1994, 42 (1) 115-122
    • (1994) Chem. Pharm. Bull. (Tokyo) , vol.42 , Issue.1 , pp. 115-122
    • Nguyen, M.D.1    Kasai, R.2    Ohtani, K.3    Ito, A.4    Nguyen, T.N.5    Yamasaki, K.6    Tanaka, O.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.