Platelet P2Y12 receptors are involved in the haemostatic effect of notoginsenoside Ft1, a saponin isolated from Panax notoginseng

British Journal of Pharmacology

Volumn 171, Issue 1, 2014, Pages 214-223

  Gao, B ^a,b   Huang, L ^a,b   Liu, H ^a   Wu, H ^a   Zhang, E ^a,b   Yang, L ^a   Wu, X ^a   Wang, Z ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

haemostasis; notoginsenoside Ft1; P2Y12 receptor; Panax notoginseng; saponin

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; CALCIUM; CLOPIDOGREL; CYCLIC AMP; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RG 3; GINSENOSIDE RH 2; NOTOGINSENOSIDE FT1; PANAX NOTOGINSENG EXTRACT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTHROMBIN; PROTOPANAXADIOL; PURINERGIC P2Y12 RECEPTOR; SAPONIN; THROMBIN; THROMBOPLASTIN; TICAGRELOR; UNCLASSIFIED DRUG; ANTITHROMBOCYTIC AGENT; P2Y12 PROTEIN, RAT; PLANT EXTRACT; PURINERGIC P2 RECEPTOR; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ASSAY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HEMOSTASIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NONHUMAN; PANAX NOTOGINSENG; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RAT; SIGNAL TRANSDUCTION; THROMBIN TIME; THROMBOCYTE AGGREGATION; ANIMAL; BINDING SITE; DOSE RESPONSE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; MEDICINAL PLANT; METABOLISM; PHOSPHORYLATION; PHYTOTHERAPY; PROTEIN BINDING; THROMBOCYTE; TIME; WISTAR RAT;

HAEMOSTASIS; NOTOGINSENOSIDE FT1; P2Y12 RECEPTOR; PANAX NOTOGINSENG; SAPONIN;

ANIMALS; BINDING SITES; BLOOD PLATELETS; CALCIUM; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HEMOSTASIS; HUMANS; MOLECULAR DOCKING SIMULATION; PANAX NOTOGINSENG; PARTIAL THROMBOPLASTIN TIME; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; PROTHROMBIN TIME; PROTO-ONCOGENE PROTEINS C-AKT; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; SAPONINS; SIGNAL TRANSDUCTION; THROMBIN TIME; TIME FACTORS; TRANSFECTION;

EID: 84890286488     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12435     Document Type: Article

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