Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7

Biochemical Journal

Volumn 466, Issue , 2015, Pages 55-68

  Church, Rachel H ^a   Krishnakumar, Arjun ^a   Urbanek, Annika ^b   Geschwindner, Stefan ^c   Meneely, Julie ^a   Bianchi, Alessandro ^b   Basta, Barbro ^c   Monaghan, Sean ^a   Elliot, Christopher ^a   Mstedt, Maria Str O ^c   Ferguson, Neil ^b   Martin, Finian ^b   Brazil, Derek P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Bone morphogenetic protein (bmp); Fibrosis; Gremlin; Kidney epithelial cell; Smad; Surface plasmon resonance (spr)

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; GREMLIN1 PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG; BMP2 PROTEIN, HUMAN; BMP4 PROTEIN, HUMAN; GREM1 PROTEIN, HUMAN; PROTEIN BINDING; SIGNAL PEPTIDE; SMAD1 PROTEIN, HUMAN; SMAD5 PROTEIN, HUMAN; SMAD8 PROTEIN, HUMAN;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EMBRYO; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; MOLECULAR WEIGHT; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; SURFACE PLASMON RESONANCE; CELL LINE; CYTOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; CELL LINE; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY TUBULES, PROXIMAL; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SURFACE PLASMON RESONANCE;

EID: 84922287314     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140771     Document Type: Article

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