Direct visualization of Smad1/5/8-mediated transcriptional activity identifies podocytes and collecting ducts as major targets of BMP signalling in healthy and diseased kidneys

Journal of Pathology

Volumn 224, Issue 1, 2011, Pages 121-132

  Leeuwis, Jan Willem ^a   Nguyen, Tri Q ^a   Chuva De Sousa Lopes, Susana M ^b   Van Der Giezen, Dionne M ^a   Van Der Ven, Kevin ^a   Rouw, Peter J H ^a   Offerhaus, G Johan A ^a   Mummery, Christine L ^b   Goldschmeding, Roel ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

bone morphogenetic protein; BRE; GFP; kidney; podocytes; SMAD

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 1A; BONE MORPHOGENETIC PROTEIN RESPONSIVE ELEMENT; GREEN FLUORESCENT PROTEIN; OSTEOGENIC PROTEIN 1; PROTEIN; PROTEIN ALK2; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLOMERULUS; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOGLYCOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL PROCEDURES; KIDNEY COLLECTING TUBULE; KIDNEY DISEASE; KIDNEY MEDULLA; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UPREGULATION; URETER OBSTRUCTION;

ACUTE KIDNEY INJURY; ANIMALS; BONE MORPHOGENETIC PROTEINS; KIDNEY DISEASES; KIDNEY TUBULES, COLLECTING; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PODOCYTES; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; TRANSCRIPTIONAL ACTIVATION; URETERAL OBSTRUCTION;

EID: 79953777423     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2844     Document Type: Article

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