메뉴 건너뛰기




Volumn 72, Issue 1, 2015, Pages 86-96

Chemobrain: A critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy

Author keywords

Cancer chemotherapy; Chemobrain; Cognition dysfunction; Cytokines and epigenetics

Indexed keywords

ANTIINFECTIVE AGENT; BETAINE; CREBINOSTAT; CYCLOPHOSPHAMIDE; CYTOKINE; DOXORUBICIN; EPIRUBICIN; FLUOROURACIL; HISTONE DEACETYLASE INHIBITOR; METHOTREXATE; PACLITAXEL; S ADENOSYLMETHIONINE; SIRTUIN; TAXANE DERIVATIVE; THALIDOMIDE; TOPOTECAN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 84922279139     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2014.12.006     Document Type: Review
Times cited : (157)

References (133)
  • 2
    • 0029853452 scopus 로고    scopus 로고
    • What do cancer patients mean when they complain of concentration and memory problems?
    • Cull A., et al. What do cancer patients mean when they complain of concentration and memory problems?. Br J Cancer 1996, 74(10):1674-1679.
    • (1996) Br J Cancer , vol.74 , Issue.10 , pp. 1674-1679
    • Cull, A.1
  • 3
    • 84869115823 scopus 로고    scopus 로고
    • Cancer- and cancer treatment-associated cognitive change: an update on the state of the science
    • Ahles T.A., Root J.C., Ryan E.L. Cancer- and cancer treatment-associated cognitive change: an update on the state of the science. J Clin Oncol 2012, 30(30):3675-3686.
    • (2012) J Clin Oncol , vol.30 , Issue.30 , pp. 3675-3686
    • Ahles, T.A.1    Root, J.C.2    Ryan, E.L.3
  • 4
    • 44849099262 scopus 로고    scopus 로고
    • Cognitive function in breast cancer patients prior to adjuvant treatment
    • Ahles T.A., et al. Cognitive function in breast cancer patients prior to adjuvant treatment. Breast Cancer Res Treat 2008, 110(1):143-152.
    • (2008) Breast Cancer Res Treat , vol.110 , Issue.1 , pp. 143-152
    • Ahles, T.A.1
  • 5
    • 3242771406 scopus 로고    scopus 로고
    • 'Chemobrain' in breast carcinoma?: A prologue
    • Wefel J.S., et al. 'Chemobrain' in breast carcinoma?: A prologue. Cancer 2004, 101(3):466-475.
    • (2004) Cancer , vol.101 , Issue.3 , pp. 466-475
    • Wefel, J.S.1
  • 6
    • 2442649323 scopus 로고    scopus 로고
    • The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial
    • Wefel J.S., et al. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer 2004, 100(11):2292-2299.
    • (2004) Cancer , vol.100 , Issue.11 , pp. 2292-2299
    • Wefel, J.S.1
  • 7
    • 77954898295 scopus 로고    scopus 로고
    • Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer
    • Wefel J.S., et al. Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer 2010, 116(14):3348-3356.
    • (2010) Cancer , vol.116 , Issue.14 , pp. 3348-3356
    • Wefel, J.S.1
  • 8
    • 0020686106 scopus 로고
    • Chemotherapy and cognitive defects in cancer patients
    • Silberfarb P.M. Chemotherapy and cognitive defects in cancer patients. Annu Rev Med 1983, 34:35-46.
    • (1983) Annu Rev Med , vol.34 , pp. 35-46
    • Silberfarb, P.M.1
  • 9
    • 79960131410 scopus 로고    scopus 로고
    • Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer
    • de Ruiter M.B., et al. Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Hum Brain Mapp 2011, 32(8):1206-1219.
    • (2011) Hum Brain Mapp , vol.32 , Issue.8 , pp. 1206-1219
    • de Ruiter, M.B.1
  • 10
    • 20544449196 scopus 로고    scopus 로고
    • Cancer as a risk factor for long-term cognitive deficits and dementia
    • Heflin L.H., et al. Cancer as a risk factor for long-term cognitive deficits and dementia. J Natl Cancer Inst 2005, 97(11):854-856.
    • (2005) J Natl Cancer Inst , vol.97 , Issue.11 , pp. 854-856
    • Heflin, L.H.1
  • 11
    • 41549111000 scopus 로고    scopus 로고
    • Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop
    • Vardy J., et al. Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. Ann Oncol 2008, 19(4):623-629.
    • (2008) Ann Oncol , vol.19 , Issue.4 , pp. 623-629
    • Vardy, J.1
  • 12
    • 77951297300 scopus 로고    scopus 로고
    • Cognitive function after adjuvant treatment for early breast cancer: a population-based longitudinal study
    • Debess J., et al. Cognitive function after adjuvant treatment for early breast cancer: a population-based longitudinal study. Breast Cancer Res Treat 2010, 121(1):91-100.
    • (2010) Breast Cancer Res Treat , vol.121 , Issue.1 , pp. 91-100
    • Debess, J.1
  • 13
    • 28044469510 scopus 로고    scopus 로고
    • Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma
    • Donovan K.A., et al. Cognitive functioning after adjuvant chemotherapy and/or radiotherapy for early-stage breast carcinoma. Cancer 2005, 104(11):2499-2507.
    • (2005) Cancer , vol.104 , Issue.11 , pp. 2499-2507
    • Donovan, K.A.1
  • 14
    • 84864333909 scopus 로고    scopus 로고
    • The impact of chemotherapy-induced cognitive impairment on the psychosocial adjustment of patients with nonmetastatic colorectal cancer
    • Galica J., et al. The impact of chemotherapy-induced cognitive impairment on the psychosocial adjustment of patients with nonmetastatic colorectal cancer. Clin J Oncol Nurs 2012, 16(2):163-169.
    • (2012) Clin J Oncol Nurs , vol.16 , Issue.2 , pp. 163-169
    • Galica, J.1
  • 15
    • 78649958408 scopus 로고    scopus 로고
    • Two different sides of 'chemobrain': determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study
    • Hermelink K., et al. Two different sides of 'chemobrain': determinants and nondeterminants of self-perceived cognitive dysfunction in a prospective, randomized, multicenter study. Psychooncology 2010, 19(12):1321-1328.
    • (2010) Psychooncology , vol.19 , Issue.12 , pp. 1321-1328
    • Hermelink, K.1
  • 16
    • 81055144374 scopus 로고    scopus 로고
    • Long-term cognitive impairment in older adult twins discordant for gynecologic cancer treatment
    • Kurita K., et al. Long-term cognitive impairment in older adult twins discordant for gynecologic cancer treatment. J Gerontol A Biol Sci Med Sci 2011, 66(12):1343-1349.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , Issue.12 , pp. 1343-1349
    • Kurita, K.1
  • 17
    • 77955775948 scopus 로고    scopus 로고
    • The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study
    • Tager F.A., et al. The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study. Breast Cancer Res Treat 2010, 123(1):25-34.
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.1 , pp. 25-34
    • Tager, F.A.1
  • 18
    • 33645792884 scopus 로고    scopus 로고
    • Chemotherapy-induced cognitive impairment in women with breast cancer: a critique of the literature
    • Jansen C.E., et al. Chemotherapy-induced cognitive impairment in women with breast cancer: a critique of the literature. Oncol Nurs Forum 2005, 32(2):329-342.
    • (2005) Oncol Nurs Forum , vol.32 , Issue.2 , pp. 329-342
    • Jansen, C.E.1
  • 19
    • 0037080459 scopus 로고    scopus 로고
    • Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    • Ahles T.A., et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol 2002, 20(2):485-493.
    • (2002) J Clin Oncol , vol.20 , Issue.2 , pp. 485-493
    • Ahles, T.A.1
  • 20
    • 0032481412 scopus 로고    scopus 로고
    • Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy
    • van Dam F.S., et al. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. J Natl Cancer Inst 1998, 90(3):210-218.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.3 , pp. 210-218
    • van Dam, F.S.1
  • 21
    • 33847688460 scopus 로고    scopus 로고
    • The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy
    • Mehnert A., et al. The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy. Patient Educ Couns 2007, 66(1):108-118.
    • (2007) Patient Educ Couns , vol.66 , Issue.1 , pp. 108-118
    • Mehnert, A.1
  • 22
    • 0345735492 scopus 로고    scopus 로고
    • Cognitive dysfunction and subjective complaints of cancer patients. a cross-sectional study in a cancer rehabilitation centre
    • Poppelreuter M., et al. Cognitive dysfunction and subjective complaints of cancer patients. a cross-sectional study in a cancer rehabilitation centre. Eur J Cancer 2004, 40(1):43-49.
    • (2004) Eur J Cancer , vol.40 , Issue.1 , pp. 43-49
    • Poppelreuter, M.1
  • 23
    • 33750365529 scopus 로고    scopus 로고
    • Cognitive function, fatigue, and menopausal symptoms in breast cancer patients receiving adjuvant chemotherapy: evaluation with patient interview after formal assessment
    • Downie F.P., et al. Cognitive function, fatigue, and menopausal symptoms in breast cancer patients receiving adjuvant chemotherapy: evaluation with patient interview after formal assessment. Psychooncology 2006, 15(10):921-930.
    • (2006) Psychooncology , vol.15 , Issue.10 , pp. 921-930
    • Downie, F.P.1
  • 24
    • 14844343586 scopus 로고    scopus 로고
    • The effects of adjuvant chemotherapy on cognition in women with breast cancer-preliminary results of an observational longitudinal study
    • Shilling V., et al. The effects of adjuvant chemotherapy on cognition in women with breast cancer-preliminary results of an observational longitudinal study. Breast 2005, 14(2):142-150.
    • (2005) Breast , vol.14 , Issue.2 , pp. 142-150
    • Shilling, V.1
  • 25
    • 77951098847 scopus 로고    scopus 로고
    • Neuropsychological functioning and quality of life during the first year after completing chemotherapy for breast cancer
    • Reid-Arndt S.A., Hsieh C., Perry M.C. Neuropsychological functioning and quality of life during the first year after completing chemotherapy for breast cancer. Psychooncology 2010, 19(5):535-544.
    • (2010) Psychooncology , vol.19 , Issue.5 , pp. 535-544
    • Reid-Arndt, S.A.1    Hsieh, C.2    Perry, M.C.3
  • 26
    • 20144387340 scopus 로고    scopus 로고
    • Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study
    • Fliessbach K., et al. Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study. Neurology 2005, 64(7):1184-1188.
    • (2005) Neurology , vol.64 , Issue.7 , pp. 1184-1188
    • Fliessbach, K.1
  • 27
    • 67749131036 scopus 로고    scopus 로고
    • Cognitive deficits as long-term side-effects of adjuvant therapy in breast cancer patients: 'subjective' complaints and 'objective' neuropsychological test results
    • Weis J., Poppelreuter M., Bartsch H.H. Cognitive deficits as long-term side-effects of adjuvant therapy in breast cancer patients: 'subjective' complaints and 'objective' neuropsychological test results. Psychooncology 2009, 18(7):775-782.
    • (2009) Psychooncology , vol.18 , Issue.7 , pp. 775-782
    • Weis, J.1    Poppelreuter, M.2    Bartsch, H.H.3
  • 28
    • 67649730025 scopus 로고    scopus 로고
    • Effects of specific neuropsychological training programs for breast cancer patients after adjuvant chemotherapy
    • Poppelreuter M., Weis J., Bartsch H.H. Effects of specific neuropsychological training programs for breast cancer patients after adjuvant chemotherapy. J Psychosoc Oncol 2009, 27(2):274-296.
    • (2009) J Psychosoc Oncol , vol.27 , Issue.2 , pp. 274-296
    • Poppelreuter, M.1    Weis, J.2    Bartsch, H.H.3
  • 29
    • 84865440840 scopus 로고    scopus 로고
    • Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review
    • Hutchinson A.D., et al. Objective and subjective cognitive impairment following chemotherapy for cancer: a systematic review. Cancer Treat Rev 2012, 38(7):926-934.
    • (2012) Cancer Treat Rev , vol.38 , Issue.7 , pp. 926-934
    • Hutchinson, A.D.1
  • 30
    • 84864800690 scopus 로고    scopus 로고
    • Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors
    • Bruno J., Hosseini S.M., Kesler S. Altered resting state functional brain network topology in chemotherapy-treated breast cancer survivors. Neurobiol Dis 2012, 48(3):329-338.
    • (2012) Neurobiol Dis , vol.48 , Issue.3 , pp. 329-338
    • Bruno, J.1    Hosseini, S.M.2    Kesler, S.3
  • 31
    • 79951471900 scopus 로고    scopus 로고
    • Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients
    • Deprez S., et al. Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients. Hum Brain Mapp 2011, 32(3):480-493.
    • (2011) Hum Brain Mapp , vol.32 , Issue.3 , pp. 480-493
    • Deprez, S.1
  • 32
    • 79959558529 scopus 로고    scopus 로고
    • International cognition and cancer task force recommendations to harmonise studies of cognitive function in patients with cancer
    • Wefel J.S., et al. International cognition and cancer task force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol 2011, 12(7):703-708.
    • (2011) Lancet Oncol , vol.12 , Issue.7 , pp. 703-708
    • Wefel, J.S.1
  • 33
    • 84877584664 scopus 로고    scopus 로고
    • A comparison of cognitive function, sleep and activity levels in disease-free breast cancer patients with or without cancer-related fatigue syndrome
    • Minton O., Stone P.C. A comparison of cognitive function, sleep and activity levels in disease-free breast cancer patients with or without cancer-related fatigue syndrome. BMJ Support Palliat Care 2013, 2(3):231-238.
    • (2013) BMJ Support Palliat Care , vol.2 , Issue.3 , pp. 231-238
    • Minton, O.1    Stone, P.C.2
  • 34
    • 33847195328 scopus 로고    scopus 로고
    • Candidate mechanisms for chemotherapy-induced cognitive changes
    • Ahles T.A., Saykin A.J. Candidate mechanisms for chemotherapy-induced cognitive changes. Nat Rev Cancer 2007, 7(3):192-201.
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 192-201
    • Ahles, T.A.1    Saykin, A.J.2
  • 35
    • 84864053222 scopus 로고    scopus 로고
    • Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study
    • McDonald B.C., et al. Alterations in brain activation during working memory processing associated with breast cancer and treatment: a prospective functional magnetic resonance imaging study. J Clin Oncol 2012, 30(20):2500-2508.
    • (2012) J Clin Oncol , vol.30 , Issue.20 , pp. 2500-2508
    • McDonald, B.C.1
  • 36
    • 33846312508 scopus 로고    scopus 로고
    • Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy
    • Inagaki M., et al. Smaller regional volumes of brain gray and white matter demonstrated in breast cancer survivors exposed to adjuvant chemotherapy. Cancer 2007, 109(1):146-156.
    • (2007) Cancer , vol.109 , Issue.1 , pp. 146-156
    • Inagaki, M.1
  • 37
    • 84855987898 scopus 로고    scopus 로고
    • Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning
    • Deprez S., et al. Longitudinal assessment of chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning. J Clin Oncol 2012, 30(3):274-281.
    • (2012) J Clin Oncol , vol.30 , Issue.3 , pp. 274-281
    • Deprez, S.1
  • 38
    • 84868200211 scopus 로고    scopus 로고
    • Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging
    • de Ruiter M.B., et al. Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Hum Brain Mapp 2012, 33(12):2971-2983.
    • (2012) Hum Brain Mapp , vol.33 , Issue.12 , pp. 2971-2983
    • de Ruiter, M.B.1
  • 39
    • 84876665206 scopus 로고    scopus 로고
    • Power failure: why small sample size undermines the reliability of neuroscience
    • Button K.S., et al. Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci 2013, 14(5):365-376.
    • (2013) Nat Rev Neurosci , vol.14 , Issue.5 , pp. 365-376
    • Button, K.S.1
  • 40
    • 41049084676 scopus 로고    scopus 로고
    • Automated neuropsychiatric measurements of information processing in fibromyalgia
    • Walitt B., et al. Automated neuropsychiatric measurements of information processing in fibromyalgia. Rheumatol Int 2008, 28(6):561-566.
    • (2008) Rheumatol Int , vol.28 , Issue.6 , pp. 561-566
    • Walitt, B.1
  • 41
    • 67651238727 scopus 로고    scopus 로고
    • Review of cognitive dysfunction in fibromyalgia: a convergence on working memory and attentional control impairments
    • Glass J.M. Review of cognitive dysfunction in fibromyalgia: a convergence on working memory and attentional control impairments. Rheum Dis Clin North Am 2009, 35(2):299-311.
    • (2009) Rheum Dis Clin North Am , vol.35 , Issue.2 , pp. 299-311
    • Glass, J.M.1
  • 42
    • 84883796702 scopus 로고    scopus 로고
    • Caught in the thickness of brain fog: exploring the cognitive symptoms of chronic fatigue syndrome
    • Ocon A.J. Caught in the thickness of brain fog: exploring the cognitive symptoms of chronic fatigue syndrome. Front Physiol 2013, 4:63.
    • (2013) Front Physiol , vol.4 , pp. 63
    • Ocon, A.J.1
  • 43
    • 77951735184 scopus 로고    scopus 로고
    • The American college of rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity
    • Wolfe F., et al. The American college of rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010, 62(5):600-610.
    • (2010) Arthritis Care Res (Hoboken) , vol.62 , Issue.5 , pp. 600-610
    • Wolfe, F.1
  • 44
    • 0023874790 scopus 로고
    • Chronic fatigue syndrome: a working case definition
    • Holmes G.P., et al. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988, 108(3):387-389.
    • (1988) Ann Intern Med , vol.108 , Issue.3 , pp. 387-389
    • Holmes, G.P.1
  • 46
    • 67650879535 scopus 로고    scopus 로고
    • Understanding fibromyalgia: lessons from the broader pain research community
    • Williams D.A., Clauw D.J. Understanding fibromyalgia: lessons from the broader pain research community. J Pain 2009, 10(8):777-791.
    • (2009) J Pain , vol.10 , Issue.8 , pp. 777-791
    • Williams, D.A.1    Clauw, D.J.2
  • 47
    • 79956216585 scopus 로고    scopus 로고
    • An update on cancer- and chemotherapy-related cognitive dysfunction: current status
    • Janelsins M.C., et al. An update on cancer- and chemotherapy-related cognitive dysfunction: current status. Semin Oncol 2011, 38(3):431-438.
    • (2011) Semin Oncol , vol.38 , Issue.3 , pp. 431-438
    • Janelsins, M.C.1
  • 48
    • 84861673585 scopus 로고    scopus 로고
    • Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy
    • Wang X.M., et al. Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine 2012, 59(1):3-9.
    • (2012) Cytokine , vol.59 , Issue.1 , pp. 3-9
    • Wang, X.M.1
  • 49
    • 0038182619 scopus 로고    scopus 로고
    • Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms
    • Cleeland C.S., et al. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer 2003, 97(11):2919-2925.
    • (2003) Cancer , vol.97 , Issue.11 , pp. 2919-2925
    • Cleeland, C.S.1
  • 50
    • 47749150261 scopus 로고    scopus 로고
    • Cancer and inflammation: a complex relationship
    • Mantovani A., Pierotti M.A. Cancer and inflammation: a complex relationship. Cancer Lett 2008, 267(2):180-181.
    • (2008) Cancer Lett , vol.267 , Issue.2 , pp. 180-181
    • Mantovani, A.1    Pierotti, M.A.2
  • 51
    • 84922300276 scopus 로고    scopus 로고
    • Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesis
    • Lyon D., et al. Potential epigenetic mechanism(s) associated with the persistence of psychoneurological symptoms in women receiving chemotherapy for breast cancer: a hypothesis. Biol Res Nurs 2013.
    • (2013) Biol Res Nurs
    • Lyon, D.1
  • 52
    • 0034118647 scopus 로고    scopus 로고
    • Psychiatric side effects of interferon therapy: prevalence, proposed mechanisms, and future directions
    • Trask P.C., et al. Psychiatric side effects of interferon therapy: prevalence, proposed mechanisms, and future directions. J Clin Oncol 2000, 18(11):2316-2326.
    • (2000) J Clin Oncol , vol.18 , Issue.11 , pp. 2316-2326
    • Trask, P.C.1
  • 53
    • 14944351958 scopus 로고    scopus 로고
    • Stress-induced immune dysfunction: implications for health
    • Glaser R., Kiecolt-Glaser J.K. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005, 5(3):243-251.
    • (2005) Nat Rev Immunol , vol.5 , Issue.3 , pp. 243-251
    • Glaser, R.1    Kiecolt-Glaser, J.K.2
  • 54
    • 84872172092 scopus 로고    scopus 로고
    • Synergistic and antagonistic actions of acute or chronic social stressors and an endotoxin challenge vary over time following the challenge
    • Gibb J., Al-Yawer F., Anisman H. Synergistic and antagonistic actions of acute or chronic social stressors and an endotoxin challenge vary over time following the challenge. Brain Behav Immun 2013, 28:149-158.
    • (2013) Brain Behav Immun , vol.28 , pp. 149-158
    • Gibb, J.1    Al-Yawer, F.2    Anisman, H.3
  • 55
    • 0034999297 scopus 로고    scopus 로고
    • Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients
    • Capuron L., Ravaud A., Dantzer R. Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients. Psychosom Med 2001, 63(3):376-386.
    • (2001) Psychosom Med , vol.63 , Issue.3 , pp. 376-386
    • Capuron, L.1    Ravaud, A.2    Dantzer, R.3
  • 56
    • 0036649794 scopus 로고    scopus 로고
    • Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes
    • Tsavaris N., et al. Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes. Br J Cancer 2002, 87(1):21-27.
    • (2002) Br J Cancer , vol.87 , Issue.1 , pp. 21-27
    • Tsavaris, N.1
  • 57
    • 0347301733 scopus 로고    scopus 로고
    • Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy
    • Pusztai L., et al. Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy. Cytokine 2004, 25(3):94-102.
    • (2004) Cytokine , vol.25 , Issue.3 , pp. 94-102
    • Pusztai, L.1
  • 58
    • 6744262234 scopus 로고    scopus 로고
    • Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel
    • Penson R.T., et al. Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Int J Gynecol Cancer 2000, 10(1):33-41.
    • (2000) Int J Gynecol Cancer , vol.10 , Issue.1 , pp. 33-41
    • Penson, R.T.1
  • 59
    • 84863477803 scopus 로고    scopus 로고
    • Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research
    • Janelsins M.C., et al. Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research. Support Care Cancer 2012, 20(4):831-839.
    • (2012) Support Care Cancer , vol.20 , Issue.4 , pp. 831-839
    • Janelsins, M.C.1
  • 60
    • 61349124871 scopus 로고    scopus 로고
    • Serum cytokine in response to chemo-radiotherapy for Hodgkin's disease
    • Villani F., et al. Serum cytokine in response to chemo-radiotherapy for Hodgkin's disease. Tumori 2008, 94(6):803-808.
    • (2008) Tumori , vol.94 , Issue.6 , pp. 803-808
    • Villani, F.1
  • 61
    • 84875367121 scopus 로고    scopus 로고
    • Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors
    • Kesler S., et al. Reduced hippocampal volume and verbal memory performance associated with interleukin-6 and tumor necrosis factor-alpha levels in chemotherapy-treated breast cancer survivors. Brain Behav Immun 2013, 30(Suppl):S109-S116.
    • (2013) Brain Behav Immun , vol.30 , Issue.SUPPL , pp. S109-S116
    • Kesler, S.1
  • 62
    • 84901330385 scopus 로고    scopus 로고
    • The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer
    • Pomykala K.L., et al. The association between pro-inflammatory cytokines, regional cerebral metabolism, and cognitive complaints following adjuvant chemotherapy for breast cancer. Brain Imaging Behav 2013, 7(4):511-523.
    • (2013) Brain Imaging Behav , vol.7 , Issue.4 , pp. 511-523
    • Pomykala, K.L.1
  • 63
    • 84884578556 scopus 로고    scopus 로고
    • Cytokine genetic variations and fatigue among patients with breast cancer
    • Bower J.E., et al. Cytokine genetic variations and fatigue among patients with breast cancer. J Clin Oncol 2013, 31(13):1656-1661.
    • (2013) J Clin Oncol , vol.31 , Issue.13 , pp. 1656-1661
    • Bower, J.E.1
  • 64
    • 33746882124 scopus 로고    scopus 로고
    • Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity
    • Tangpong J., et al. Adriamycin-induced, TNF-alpha-mediated central nervous system toxicity. Neurobiol Dis 2006, 23(1):127-139.
    • (2006) Neurobiol Dis , vol.23 , Issue.1 , pp. 127-139
    • Tangpong, J.1
  • 65
    • 21344472917 scopus 로고    scopus 로고
    • Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome
    • Meyers C.A., Albitar M., Estey E. Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer 2005, 104(4):788-793.
    • (2005) Cancer , vol.104 , Issue.4 , pp. 788-793
    • Meyers, C.A.1    Albitar, M.2    Estey, E.3
  • 66
    • 0034062158 scopus 로고    scopus 로고
    • Cytokines and the brain: implications for clinical psychiatry
    • Kronfol Z., Remick D.G. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 2000, 157(5):683-694.
    • (2000) Am J Psychiatry , vol.157 , Issue.5 , pp. 683-694
    • Kronfol, Z.1    Remick, D.G.2
  • 67
    • 0036901234 scopus 로고    scopus 로고
    • Cytokines and cognition-the case for a head-to-toe inflammatory paradigm
    • Wilson C.J., Finch C.E., Cohen H.J. Cytokines and cognition-the case for a head-to-toe inflammatory paradigm. J Am Geriatr Soc 2002, 50(12):2041-2056.
    • (2002) J Am Geriatr Soc , vol.50 , Issue.12 , pp. 2041-2056
    • Wilson, C.J.1    Finch, C.E.2    Cohen, H.J.3
  • 68
    • 0037320229 scopus 로고    scopus 로고
    • A new look for brain, behavior, and immunity
    • Kelley K.W. A new look for brain, behavior, and immunity. Brain Behav Immun 2003, 17(1):1-2.
    • (2003) Brain Behav Immun , vol.17 , Issue.1 , pp. 1-2
    • Kelley, K.W.1
  • 69
    • 70449529633 scopus 로고    scopus 로고
    • The blood-brain barrier and immune function and dysfunction
    • Banks W.A., Erickson M.A. The blood-brain barrier and immune function and dysfunction. Neurobiol Dis 2010, 37(1):26-32.
    • (2010) Neurobiol Dis , vol.37 , Issue.1 , pp. 26-32
    • Banks, W.A.1    Erickson, M.A.2
  • 70
    • 0037237881 scopus 로고    scopus 로고
    • Interactions of cytokines with the blood-brain barrier: implications for feeding
    • Pan W., Kastin A.J. Interactions of cytokines with the blood-brain barrier: implications for feeding. Curr Pharm Des 2003, 9(10):827-831.
    • (2003) Curr Pharm Des , vol.9 , Issue.10 , pp. 827-831
    • Pan, W.1    Kastin, A.J.2
  • 71
    • 84878923139 scopus 로고    scopus 로고
    • Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
    • Felger J.C., Lotrich F.E. Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 2013, 246C:199-229.
    • (2013) Neuroscience , vol.246 C , pp. 199-229
    • Felger, J.C.1    Lotrich, F.E.2
  • 72
    • 0141497911 scopus 로고    scopus 로고
    • Depression in cancer: new developments regarding diagnosis and treatment
    • Raison C.L., Miller A.H. Depression in cancer: new developments regarding diagnosis and treatment. Biol Psychiatry 2003, 54(3):283-294.
    • (2003) Biol Psychiatry , vol.54 , Issue.3 , pp. 283-294
    • Raison, C.L.1    Miller, A.H.2
  • 73
    • 0036071176 scopus 로고    scopus 로고
    • Fatigue and proinflammatory cytokine activity in breast cancer survivors
    • Bower J.E., et al. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom Med 2002, 64(4):604-611.
    • (2002) Psychosom Med , vol.64 , Issue.4 , pp. 604-611
    • Bower, J.E.1
  • 74
    • 0027314686 scopus 로고
    • Treatment-related fatigue and serum interleukin-1 levels in patients during external beam irradiation for prostate cancer
    • Greenberg D.B., et al. Treatment-related fatigue and serum interleukin-1 levels in patients during external beam irradiation for prostate cancer. J Pain Symptom Manage 1993, 8(4):196-200.
    • (1993) J Pain Symptom Manage , vol.8 , Issue.4 , pp. 196-200
    • Greenberg, D.B.1
  • 75
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: inflammation and the pathogenesis of depression
    • Raison C.L., Capuron L., Miller A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006, 27(1):24-31.
    • (2006) Trends Immunol , vol.27 , Issue.1 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 76
    • 34347394526 scopus 로고    scopus 로고
    • Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues
    • Chen Y., et al. Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues. Mol Interv 2007, 7(3):147-156.
    • (2007) Mol Interv , vol.7 , Issue.3 , pp. 147-156
    • Chen, Y.1
  • 77
    • 33846203801 scopus 로고    scopus 로고
    • Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain
    • Tangpong J., et al. Adriamycin-mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain. J Neurochem 2007, 100(1):191-201.
    • (2007) J Neurochem , vol.100 , Issue.1 , pp. 191-201
    • Tangpong, J.1
  • 78
    • 79955574686 scopus 로고    scopus 로고
    • 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-alpha release: implications for the reactive oxygen species-mediated mechanisms of chemobrain
    • Aluise C.D., et al. 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-alpha release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free Radic Biol Med 2011, 50(11):1630-1638.
    • (2011) Free Radic Biol Med , vol.50 , Issue.11 , pp. 1630-1638
    • Aluise, C.D.1
  • 79
    • 3242883361 scopus 로고    scopus 로고
    • DNA single-strand breaks and neurodegeneration
    • Caldecott K.W. DNA single-strand breaks and neurodegeneration. DNA Repair (Amst) 2004, 3(8-9):875-882.
    • (2004) DNA Repair (Amst) , vol.3 , Issue.8-9 , pp. 875-882
    • Caldecott, K.W.1
  • 80
    • 3242881313 scopus 로고    scopus 로고
    • The DNA double-strand break response in the nervous system
    • Abner C.W., McKinnon P.J. The DNA double-strand break response in the nervous system. DNA Repair (Amst) 2004, 3(8-9):1141-1147.
    • (2004) DNA Repair (Amst) , vol.3 , Issue.8-9 , pp. 1141-1147
    • Abner, C.W.1    McKinnon, P.J.2
  • 81
    • 4344682124 scopus 로고    scopus 로고
    • DNA damage and repair in type 2 diabetes mellitus
    • Blasiak J., et al. DNA damage and repair in type 2 diabetes mellitus. Mutat Res 2004, 554(1-2):297-304.
    • (2004) Mutat Res , vol.554 , Issue.1-2 , pp. 297-304
    • Blasiak, J.1
  • 82
    • 33745473218 scopus 로고    scopus 로고
    • DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy
    • Nadin S.B., et al. DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy. Cancer Lett 2006, 239(1):84-97.
    • (2006) Cancer Lett , vol.239 , Issue.1 , pp. 84-97
    • Nadin, S.B.1
  • 83
    • 77956633238 scopus 로고    scopus 로고
    • Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction
    • Aluise C.D., et al. Chemo brain (chemo fog) as a potential side effect of doxorubicin administration: role of cytokine-induced, oxidative/nitrosative stress in cognitive dysfunction. Adv Exp Med Biol 2010, 678:147-156.
    • (2010) Adv Exp Med Biol , vol.678 , pp. 147-156
    • Aluise, C.D.1
  • 84
    • 34247145010 scopus 로고    scopus 로고
    • Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?
    • Stenvinkel P., et al. Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?. J Intern Med 2007, 261(5):488-499.
    • (2007) J Intern Med , vol.261 , Issue.5 , pp. 488-499
    • Stenvinkel, P.1
  • 85
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    • Jaenisch R., Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003, 33(Suppl):245-254.
    • (2003) Nat Genet , vol.33 , Issue.SUPPL , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 86
    • 84856181467 scopus 로고    scopus 로고
    • Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics
    • Heim C., Binder E.B. Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Exp Neurol 2012, 233(1):102-111.
    • (2012) Exp Neurol , vol.233 , Issue.1 , pp. 102-111
    • Heim, C.1    Binder, E.B.2
  • 87
    • 79251487813 scopus 로고    scopus 로고
    • The epigenetic landscape of addiction
    • Maze I., Nestler E.J. The epigenetic landscape of addiction. Ann N Y Acad Sci 2011, 1216:99-113.
    • (2011) Ann N Y Acad Sci , vol.1216 , pp. 99-113
    • Maze, I.1    Nestler, E.J.2
  • 88
    • 80052710759 scopus 로고    scopus 로고
    • Epigenetic mechanisms in stress and adaptation
    • Mifsud K.R., et al. Epigenetic mechanisms in stress and adaptation. Brain Behav Immun 2011, 25(7):1305-1315.
    • (2011) Brain Behav Immun , vol.25 , Issue.7 , pp. 1305-1315
    • Mifsud, K.R.1
  • 89
    • 84877927154 scopus 로고    scopus 로고
    • Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease
    • Adwan L., Zawia N.H. Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease. Pharmacol Ther 2013, 139(1):41-50.
    • (2013) Pharmacol Ther , vol.139 , Issue.1 , pp. 41-50
    • Adwan, L.1    Zawia, N.H.2
  • 90
    • 33744920106 scopus 로고    scopus 로고
    • Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
    • Levenson J.M., et al. Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J Biol Chem 2006, 281(23):15763-15773.
    • (2006) J Biol Chem , vol.281 , Issue.23 , pp. 15763-15773
    • Levenson, J.M.1
  • 91
    • 41649096261 scopus 로고    scopus 로고
    • DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
    • Miller C.A., Campbell S.L., Sweatt J.D. DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity. Neurobiol Learn Mem 2008, 89(4):599-603.
    • (2008) Neurobiol Learn Mem , vol.89 , Issue.4 , pp. 599-603
    • Miller, C.A.1    Campbell, S.L.2    Sweatt, J.D.3
  • 92
    • 84857094316 scopus 로고    scopus 로고
    • Advancing neuroscience through epigenetics: molecular mechanisms of learning and memory
    • Molfese D.L. Advancing neuroscience through epigenetics: molecular mechanisms of learning and memory. Dev Neuropsychol 2011, 36(7):810-827.
    • (2011) Dev Neuropsychol , vol.36 , Issue.7 , pp. 810-827
    • Molfese, D.L.1
  • 93
    • 79955134157 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory and synaptic function
    • Sultan F.A., Day J.J. Epigenetic mechanisms in memory and synaptic function. Epigenomics 2011, 3(2):157-181.
    • (2011) Epigenomics , vol.3 , Issue.2 , pp. 157-181
    • Sultan, F.A.1    Day, J.J.2
  • 94
    • 84866712181 scopus 로고    scopus 로고
    • Epigenetic regulation in drug addiction
    • Bilinski P., et al. Epigenetic regulation in drug addiction. Ann Agric Environ Med 2012, 19(3):491-496.
    • (2012) Ann Agric Environ Med , vol.19 , Issue.3 , pp. 491-496
    • Bilinski, P.1
  • 95
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008, 358(11):1148-1159.
    • (2008) N Engl J Med , vol.358 , Issue.11 , pp. 1148-1159
    • Esteller, M.1
  • 96
    • 84855384100 scopus 로고    scopus 로고
    • Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications
    • Briones T.L., Woods J. Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications. BMC Neurosci 2011, 12:124.
    • (2011) BMC Neurosci , vol.12 , pp. 124
    • Briones, T.L.1    Woods, J.2
  • 97
    • 84876799113 scopus 로고    scopus 로고
    • An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype
    • Whitaker J.W., et al. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med 2013, 5(4):40.
    • (2013) Genome Med , vol.5 , Issue.4 , pp. 40
    • Whitaker, J.W.1
  • 98
    • 79957922071 scopus 로고    scopus 로고
    • Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress
    • Mathews H.L., et al. Epigenetic patterns associated with the immune dysregulation that accompanies psychosocial distress. Brain Behav Immun 2011, 25(5):830-839.
    • (2011) Brain Behav Immun , vol.25 , Issue.5 , pp. 830-839
    • Mathews, H.L.1
  • 99
    • 84455169456 scopus 로고    scopus 로고
    • How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology
    • Toyokawa S., et al. How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology. Soc Sci Med 2012, 74(1):67-74.
    • (2012) Soc Sci Med , vol.74 , Issue.1 , pp. 67-74
    • Toyokawa, S.1
  • 100
    • 84858226590 scopus 로고    scopus 로고
    • DNA methylation as a biomarker for neuropsychiatric diseases
    • Ai S., et al. DNA methylation as a biomarker for neuropsychiatric diseases. Int J Neurosci 2012, 122(4):165-176.
    • (2012) Int J Neurosci , vol.122 , Issue.4 , pp. 165-176
    • Ai, S.1
  • 101
    • 33646382887 scopus 로고    scopus 로고
    • Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients
    • Monk J.P., et al. Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol 2006, 24(12):1852-1859.
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1852-1859
    • Monk, J.P.1
  • 102
    • 84871986003 scopus 로고    scopus 로고
    • A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers
    • Raison C.L., et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry 2013, 70(1):31-41.
    • (2013) JAMA Psychiatry , vol.70 , Issue.1 , pp. 31-41
    • Raison, C.L.1
  • 103
    • 84878124765 scopus 로고    scopus 로고
    • The inflammasome: pathways linking psychological stress, depression, and systemic illnesses
    • Iwata M., Ota K.T., Duman R.S. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 2013, 31:105-114.
    • (2013) Brain Behav Immun , vol.31 , pp. 105-114
    • Iwata, M.1    Ota, K.T.2    Duman, R.S.3
  • 104
    • 66249113481 scopus 로고    scopus 로고
    • Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain
    • Perez-Medrano A., et al. Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain. J Med Chem 2009, 52(10):3366-3376.
    • (2009) J Med Chem , vol.52 , Issue.10 , pp. 3366-3376
    • Perez-Medrano, A.1
  • 105
    • 49249112999 scopus 로고    scopus 로고
    • DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis
    • Shiue H.S., et al. DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. J Altern Complement Med 2008, 14(6):689-698.
    • (2008) J Altern Complement Med , vol.14 , Issue.6 , pp. 689-698
    • Shiue, H.S.1
  • 106
    • 84859739039 scopus 로고    scopus 로고
    • Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture
    • Zhang Z.J., Wang X.M., McAlonan G.M. Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture. Evid Based Complement Alternat Med 2012, 2012:429412.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 429412
    • Zhang, Z.J.1    Wang, X.M.2    McAlonan, G.M.3
  • 107
    • 84875709278 scopus 로고    scopus 로고
    • Systematic review of acupuncture in cancer care: a synthesis of the evidence
    • Garcia M.K., et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol 2013, 31(7):952-960.
    • (2013) J Clin Oncol , vol.31 , Issue.7 , pp. 952-960
    • Garcia, M.K.1
  • 108
    • 76249090328 scopus 로고    scopus 로고
    • Effects of electroacupuncture treatment on impaired cognition and quality of life in Taiwanese stroke patients
    • Chou P., Chu H., Lin J.G. Effects of electroacupuncture treatment on impaired cognition and quality of life in Taiwanese stroke patients. J Altern Complement Med 2009, 15(10):1067-1073.
    • (2009) J Altern Complement Med , vol.15 , Issue.10 , pp. 1067-1073
    • Chou, P.1    Chu, H.2    Lin, J.G.3
  • 109
    • 0029189455 scopus 로고
    • Ionic mechanism of acupuncture on improvement of learning and memory in aged mammals
    • Deng Q.S., Fang Z.C., Yin Y. Ionic mechanism of acupuncture on improvement of learning and memory in aged mammals. Am J Chin Med 1995, 23(1):1-9.
    • (1995) Am J Chin Med , vol.23 , Issue.1 , pp. 1-9
    • Deng, Q.S.1    Fang, Z.C.2    Yin, Y.3
  • 110
    • 84862782540 scopus 로고    scopus 로고
    • FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
    • Feng Y., et al. FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients. Magn Reson Imaging 2012, 30(5):672-682.
    • (2012) Magn Reson Imaging , vol.30 , Issue.5 , pp. 672-682
    • Feng, Y.1
  • 111
    • 65549116015 scopus 로고    scopus 로고
    • Electroacupuncture on the head points for improving gnosia in patients with vascular dementia
    • Zhao L., et al. Electroacupuncture on the head points for improving gnosia in patients with vascular dementia. J Tradit Chin Med 2009, 29(1):29-34.
    • (2009) J Tradit Chin Med , vol.29 , Issue.1 , pp. 29-34
    • Zhao, L.1
  • 112
    • 84865166600 scopus 로고    scopus 로고
    • Effect of acupuncture in mild cognitive impairment and Alzheimer disease: a functional MRI study
    • Wang Z., et al. Effect of acupuncture in mild cognitive impairment and Alzheimer disease: a functional MRI study. PLoS One 2012, 7(8):e42730.
    • (2012) PLoS One , vol.7 , Issue.8 , pp. e42730
    • Wang, Z.1
  • 113
    • 79952182383 scopus 로고    scopus 로고
    • Potential therapeutic uses of BDNF in neurological and psychiatric disorders
    • Nagahara A.H., Tuszynski M.H. Potential therapeutic uses of BDNF in neurological and psychiatric disorders. Nat Rev Drug Discov 2011, 10(3):209-219.
    • (2011) Nat Rev Drug Discov , vol.10 , Issue.3 , pp. 209-219
    • Nagahara, A.H.1    Tuszynski, M.H.2
  • 114
    • 83055185674 scopus 로고    scopus 로고
    • Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging
    • Zeng Y., et al. Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci 2011, 31(49):17800-17810.
    • (2011) J Neurosci , vol.31 , Issue.49 , pp. 17800-17810
    • Zeng, Y.1
  • 115
    • 0037462449 scopus 로고    scopus 로고
    • The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    • Egan M.F., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112(2):257-269.
    • (2003) Cell , vol.112 , Issue.2 , pp. 257-269
    • Egan, M.F.1
  • 116
    • 15744378045 scopus 로고    scopus 로고
    • Association between BDNF val66 met genotype and episodic memory
    • Dempster E., et al. Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet 2005, 134B(1):73-75.
    • (2005) Am J Med Genet B Neuropsychiatr Genet , vol.134 B , Issue.1 , pp. 73-75
    • Dempster, E.1
  • 117
    • 0043135252 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
    • Hariri A.R., et al. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 2003, 23(17):6690-6694.
    • (2003) J Neurosci , vol.23 , Issue.17 , pp. 6690-6694
    • Hariri, A.R.1
  • 118
    • 77951004217 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume
    • Erickson K.I., et al. Brain-derived neurotrophic factor is associated with age-related decline in hippocampal volume. J Neurosci 2010, 30(15):5368-5375.
    • (2010) J Neurosci , vol.30 , Issue.15 , pp. 5368-5375
    • Erickson, K.I.1
  • 119
    • 84862766568 scopus 로고    scopus 로고
    • Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls
    • Zhang X.Y., et al. Cognitive and serum BDNF correlates of BDNF Val66Met gene polymorphism in patients with schizophrenia and normal controls. Hum Genet 2012, 131(7):1187-1195.
    • (2012) Hum Genet , vol.131 , Issue.7 , pp. 1187-1195
    • Zhang, X.Y.1
  • 120
    • 0030658839 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is reduced in Alzheimer's disease
    • Connor B., et al. Brain-derived neurotrophic factor is reduced in Alzheimer's disease. Brain Res Mol Brain Res 1997, 49(1-2):71-81.
    • (1997) Brain Res Mol Brain Res , vol.49 , Issue.1-2 , pp. 71-81
    • Connor, B.1
  • 121
    • 0030451939 scopus 로고    scopus 로고
    • Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
    • Narisawa-Saito M., et al. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 1996, 7(18):2925-2928.
    • (1996) Neuroreport , vol.7 , Issue.18 , pp. 2925-2928
    • Narisawa-Saito, M.1
  • 122
    • 0033624420 scopus 로고    scopus 로고
    • Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease
    • Hock C.H., et al. Alterations in neurotrophins and neurotrophin receptors in Alzheimer's disease. J Neural Transm Suppl 2000, 59:171-174.
    • (2000) J Neural Transm Suppl , vol.59 , pp. 171-174
    • Hock, C.H.1
  • 123
    • 84869029796 scopus 로고    scopus 로고
    • Relationship between brain-derived neurotrophic factor and cognitive function of obstructive sleep apnea/hypopnea syndrome patients
    • Wang W.H., et al. Relationship between brain-derived neurotrophic factor and cognitive function of obstructive sleep apnea/hypopnea syndrome patients. Asian Pac J Trop Med 2012, 5(11):906-910.
    • (2012) Asian Pac J Trop Med , vol.5 , Issue.11 , pp. 906-910
    • Wang, W.H.1
  • 124
    • 84866730153 scopus 로고    scopus 로고
    • Electroacupuncture enhances motor recovery performance with brain-derived neurotrophic factor expression in rats with cerebral infarction
    • Kim M.W., et al. Electroacupuncture enhances motor recovery performance with brain-derived neurotrophic factor expression in rats with cerebral infarction. Acupunct Med 2012, 30(3):222-226.
    • (2012) Acupunct Med , vol.30 , Issue.3 , pp. 222-226
    • Kim, M.W.1
  • 125
    • 69849113668 scopus 로고    scopus 로고
    • Effect of electroacupuncture on the permeability of blood-brain barrier for nerve growth factor and its relevance to PKC pathway in cerebral ischemia rats
    • Lin X.M., et al. Effect of electroacupuncture on the permeability of blood-brain barrier for nerve growth factor and its relevance to PKC pathway in cerebral ischemia rats. Zhen Ci Yan Jiu 2009, 34(2):110-113.
    • (2009) Zhen Ci Yan Jiu , vol.34 , Issue.2 , pp. 110-113
    • Lin, X.M.1
  • 126
    • 40949093544 scopus 로고    scopus 로고
    • Epigenetics at the epicenter of modern medicine
    • Feinberg A.P. Epigenetics at the epicenter of modern medicine. JAMA 2008, 299(11):1345-1350.
    • (2008) JAMA , vol.299 , Issue.11 , pp. 1345-1350
    • Feinberg, A.P.1
  • 127
    • 84864461542 scopus 로고    scopus 로고
    • Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities
    • Oliveira A.M., Hemstedt T.J., Bading H. Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities. Nat Neurosci 2012, 15(8):1111-1113.
    • (2012) Nat Neurosci , vol.15 , Issue.8 , pp. 1111-1113
    • Oliveira, A.M.1    Hemstedt, T.J.2    Bading, H.3
  • 128
    • 84857368903 scopus 로고    scopus 로고
    • Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder
    • Levkovitz Y., et al. Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. J Affect Disord 2012, 136(3):1174-1178.
    • (2012) J Affect Disord , vol.136 , Issue.3 , pp. 1174-1178
    • Levkovitz, Y.1
  • 129
    • 80355125163 scopus 로고    scopus 로고
    • Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2
    • Miwa M., et al. Effects of betaine on lipopolysaccharide-induced memory impairment in mice and the involvement of GABA transporter 2. J Neuroinflammation 2011, 8:153.
    • (2011) J Neuroinflammation , vol.8 , pp. 153
    • Miwa, M.1
  • 130
    • 84862777943 scopus 로고    scopus 로고
    • An epigenetic blockade of cognitive functions in the neurodegenerating brain
    • Graff J., et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012, 483(7388):222-226.
    • (2012) Nature , vol.483 , Issue.7388 , pp. 222-226
    • Graff, J.1
  • 131
    • 84866387948 scopus 로고    scopus 로고
    • Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity
    • Fass D.M., et al. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology 2013, 64:81-96.
    • (2013) Neuropharmacology , vol.64 , pp. 81-96
    • Fass, D.M.1
  • 132
    • 76749091005 scopus 로고    scopus 로고
    • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    • Kilgore M., et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010, 35(4):870-880.
    • (2010) Neuropsychopharmacology , vol.35 , Issue.4 , pp. 870-880
    • Kilgore, M.1
  • 133
    • 79958265915 scopus 로고    scopus 로고
    • After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders
    • Huber K., Superti-Furga G. After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders. Bioorg Med Chem 2011, 19(12):3616-3624.
    • (2011) Bioorg Med Chem , vol.19 , Issue.12 , pp. 3616-3624
    • Huber, K.1    Superti-Furga, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.