Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

EMBO Journal

Volumn 34, Issue 3, 2015, Pages 275-293

  Dai, Siyuan ^a   Tang, Zijian ^a,b   Cao, Junyue ^a   Zhou, Wei ^a   Li, Huawen ^a   Sampson, Stephen ^a   Dai, Chengkai ^a  

^a JACKSON LABORATORY   (United States)

^b UNIVERSITY OF MAINE   (United States)

Author keywords

AMPK; HSF1; metformin; proteostasis; tumorigenesis

Indexed keywords

ADENYLATE KINASE; ANTIDIABETIC AGENT; BORTEZOMIB; DNA; GLUCOSE; HEAT SHOCK TRANSCRIPTION FACTOR 1; MESSENGER RNA; METFORMIN; NUCLEAR PROTEIN; PROTEASOME INHIBITOR; PROTEOME; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; HSF1 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CANCER INHIBITION; CARCINOGENESIS; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEAT SHOCK; HEK293 CELL LINE; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; METABOLIC STRESS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEOTOXIC STRESS RESPONSE; SENSOR; SINGLE DRUG DOSE; TUMOR CELL; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; DRUG EFFECTS; EXPERIMENTAL NEOPLASM; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; SCID MOUSE; TRANSGENIC MOUSE; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; PHOSPHORYLATION; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84922267421     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201489062     Document Type: Article

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