Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

Journal of Biological Chemistry

Volumn 281, Issue 2, 2006, Pages 782-791

  Wang, XiaoZhe ^a   Khaleque, Md Abdul ^a   Mei, Juan Zhao ^a   Zhong, Rong ^a   Gaestel, Matthias ^b   Calderwood, Stuart K ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DRUG PRODUCTS; GENES; MOLECULAR DYNAMICS; PHYSIOLOGY;

CYTOKINE GENES; EUKARYOTIC ORGANISMS; HEAT SHOCKS; PHOSPHORYLATION;

PROTEINS;

CHAPERONE; CYTOKINE; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; NONSTEROID ANTIINFLAMMATORY AGENT; SERINE; DNA BINDING PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR; PHOSPHOSERINE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; DISSOCIATION; DNA BINDING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL NUCLEUS; CHEMISTRY; DIMERIZATION; GEL CHROMATOGRAPHY; GENETIC TRANSFECTION; HELA CELL; IMMUNOPRECIPITATION; INFLAMMATION; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PLASMID; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EUKARYOTA;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL NUCLEUS; CHROMATOGRAPHY, GEL; DIMERIZATION; DNA-BINDING PROTEINS; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MAP KINASE KINASE 2; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PHOSPHOSERINE; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33644872354     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M505822200     Document Type: Article

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