Systemic delivery of stable siRNA-encapsulating lipid vesicles: Optimization, biodistribution, and tumor suppression

Molecular Pharmaceutics

Volumn 12, Issue 2, 2015, Pages 610-620

  Dar, Ghulam Hassan ^a   Gopal, Vijaya ^a   Rao, N Madhusudhana ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

cationic lipid; cholesterol; DSPE PEG (2000); gene silencing; pharmacokinetics; RNAi therapeutics; siRNA delivery; xenograft tumor

Indexed keywords

ALCOHOL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLETHANOLAMINE; SMALL INTERFERING RNA; CHOLESTEROL; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; ENCAPSULATION; FEMALE; FLUORESCENCE MICROSCOPY; GENE SILENCING; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID VESICLE; LIVER CELL DAMAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG SCREENING; HELA CELL LINE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CHOLESTEROL; GENE SILENCING; HELA CELLS; HUMANS; LIPIDS; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922171458     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500677x     Document Type: Article

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