Effect of polyethylene glycol conjugation on conformational and colloidal stability of a monoclonal antibody antigen-binding fragment (Fab)

Molecular Pharmaceutics

Volumn 12, Issue 2, 2015, Pages 562-575

  Roque, Cristopher ^a   Sheung, Anthony ^a   Rahman, Nausheen ^a   Ausar, S Fernando ^a  

^a Bioprocess Research and Development   (Canada)

Author keywords

diffusion interaction parameter; monoclonal antibody; phase diagram; physical stability; stability

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; MACROGOL; MACROGOL DERIVATIVE; MONOCLONAL ANTIBODY;

ARTICLE; CIRCULAR DICHROISM; COLLOID; DRUG CONFORMATION; DRUG CONJUGATION; DRUG STABILITY; FLUORESCENCE SPECTROSCOPY; FORCE; IMAGING; MEASUREMENT; MECHANICAL STRESS; MICROFLOW IMAGING; OPTICAL DENSITY; PH; PRIORITY JOURNAL; STEREOSPECIFICITY; TEMPERATURE DEPENDENCE; THERMOSTABILITY; TRANSITION TEMPERATURE; ULTRAVIOLET IRRADIATION; CHEMISTRY; PHOTON CORRELATION SPECTROSCOPY; PROTEIN CONFORMATION; PROTEIN STABILITY; SPECTROFLUOROMETRY;

ANTIBODIES, MONOCLONAL; CIRCULAR DICHROISM; DYNAMIC LIGHT SCATTERING; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN FAB FRAGMENTS; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; PROTEIN STABILITY; SPECTROMETRY, FLUORESCENCE;

EID: 84922110524     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500658w     Document Type: Article

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