The effect of protein PEGylation on physical stability in liquid formulation

Journal of Pharmaceutical Sciences

Volumn 103, Issue 10, 2014, Pages 3043-3054

  Holm, Louise Stenstrup ^a   Mcumber, Aaron ^b   Rasmussen, Jakob Ewald ^c,f   Obiols Rabasa, Marc ^d   Thulstrup, Peter W ^c   Kasimova, Marina R ^e   Randolph, Theodore W ^b   Van De Weert, Marco ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b University of Colorado   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d LUND UNIVERSITY   (Sweden)

^e Symphogen AS   (Denmark)

^f NOVO NORDISK A S   (Denmark)

Author keywords

Calorimetry (DSC); Circular dichroism; Light scattering; Microflow imaging; PEGylation; Physical stability; Protein aggregation; Proteins; Silicone oil; Small angle X ray scattering

Indexed keywords

EGG WHITE; LYSOZYME; MACROGOL; POLYETHYLENE GLYCOL LYSOZYME; PROTEIN AGGREGATE; SILICONE OIL; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; PROTEIN;

ADSORPTION; ARTICLE; CIRCULAR DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STABILITY; FLOW CYTOMETRY; FREEZE THAWING; HIGH TEMPERATURE; LIGHT SCATTERING; LIQUID; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MECHANICAL STRESS; PARTICLE SIZE; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PEGYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; TEMPERATURE STRESS; THERMOSTABILITY; X RAY CRYSTALLOGRAPHY; CHEMISTRY; MICROSCOPY; ULTRAVIOLET SPECTROPHOTOMETRY;

CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; MICROSCOPY; POLYETHYLENE GLYCOLS; PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84921331746     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24094     Document Type: Article

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