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Volumn 64, Issue 1, 2015, Pages 21-29

Antioxidants inhibit the inflammatory and apoptotic processes in an intermittent hypoxia model of sleep apnea

Author keywords

Intermittent hypoxia; Liver; Sleep apnea

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 6; HYPOXIA INDUCIBLE FACTOR 1ALPHA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MELATONIN; PROTEIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANTIOXIDANT; CASPASE; HIF1A PROTEIN, MOUSE; VASCULOTROPIN A;

EID: 84922074199     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-014-0778-5     Document Type: Article
Times cited : (24)

References (71)
  • 2
    • 84862997325 scopus 로고    scopus 로고
    • Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues
    • PID: 22372715
    • Zhou W, Li S, Wan N, Zhang Z, Guo R, Chen B. Effects of various degrees of oxidative stress induced by intermittent hypoxia in rat myocardial tissues. Respirology. 2012;17(5):821–9.
    • (2012) Respirology. , vol.17 , Issue.5 , pp. 821-829
    • Zhou, W.1    Li, S.2    Wan, N.3    Zhang, Z.4    Guo, R.5    Chen, B.6
  • 3
    • 0037316130 scopus 로고    scopus 로고
    • Obstructive sleep apnoea syndrome—an oxidative stress disorder
    • PID: 12586529
    • Lavie L. Obstructive sleep apnoea syndrome—an oxidative stress disorder. Sleep Med Rev. 2003;7:35–51.
    • (2003) Sleep Med Rev , vol.7 , pp. 35-51
    • Lavie, L.1
  • 4
    • 27144536591 scopus 로고    scopus 로고
    • Sleep-disordered breathing and cerebrovascular disease: a mechanistic approach
    • PID: 16243616
    • Lavie L. Sleep-disordered breathing and cerebrovascular disease: a mechanistic approach. Neurol Clin. 2005;23:1059–75.
    • (2005) Neurol Clin , vol.23 , pp. 1059-1075
    • Lavie, L.1
  • 5
    • 33746701376 scopus 로고    scopus 로고
    • Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases
    • COI: 1:CAS:528:DC%2BD28XktFSktL8%3D, PID: 16678006
    • Suzuki YJ, Jain V, Park AM, Day RM. Oxidative stress and oxidant signaling in obstructive sleep apnea and associated cardiovascular diseases. Free Radic Biol Med. 2006;40:1683–92.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1683-1692
    • Suzuki, Y.J.1    Jain, V.2    Park, A.M.3    Day, R.M.4
  • 6
    • 57749100366 scopus 로고    scopus 로고
    • Oxidative stress—a unifying paradigm in obstructive sleep apnea and comorbidities
    • COI: 1:CAS:528:DC%2BD1MXitVykt7w%3D, PID: 19110132
    • Lavie L. Oxidative stress—a unifying paradigm in obstructive sleep apnea and comorbidities. Prog Cardiovasc Dis. 2009;51:303–12.
    • (2009) Prog Cardiovasc Dis , vol.51 , pp. 303-312
    • Lavie, L.1
  • 7
    • 0027458059 scopus 로고
    • Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants and 3-aminobenzamide
    • COI: 1:CAS:528:DyaK2cXmvFantQ%3D%3D, PID: 8284091
    • Aalto TK, Raivio KO. Nucleotide depletion due to reactive oxygen metabolites in endothelial cells: effects of antioxidants and 3-aminobenzamide. Pediatr Res. 1993;34:572–6.
    • (1993) Pediatr Res , vol.34 , pp. 572-576
    • Aalto, T.K.1    Raivio, K.O.2
  • 8
    • 0029934194 scopus 로고    scopus 로고
    • Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite
    • COI: 1:CAS:528:DyaK28Xjt1Gkt7c%3D, PID: 8635236
    • Szabo C, Zingarelli B, Salzman AL. Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitrite. Circ Res. 1996;78:1051–63.
    • (1996) Circ Res , vol.78 , pp. 1051-1063
    • Szabo, C.1    Zingarelli, B.2    Salzman, A.L.3
  • 9
    • 0028294246 scopus 로고
    • Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity
    • COI: 1:CAS:528:DyaK2cXhvVelt70%3D, PID: 8080500
    • Zhang J, Dawson VL, Dawson TM, Snyder SH. Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science. 1994;263:687–9.
    • (1994) Science , vol.263 , pp. 687-689
    • Zhang, J.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4
  • 10
    • 30844460632 scopus 로고    scopus 로고
    • Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease
    • PID: 16416185
    • Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. Dig Dis Sci. 2005;50:2338–43.
    • (2005) Dig Dis Sci , vol.50 , pp. 2338-2343
    • Singh, H.1    Pollock, R.2    Uhanova, J.3    Kryger, M.4    Hawkins, K.5    Minuk, G.Y.6
  • 12
    • 29144450654 scopus 로고    scopus 로고
    • Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis
    • PID: 16214391
    • Tatsumi K, Saibara T. Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis. Hepatol Res. 2005;33:100–4.
    • (2005) Hepatol Res , vol.33 , pp. 100-104
    • Tatsumi, K.1    Saibara, T.2
  • 13
    • 34249800116 scopus 로고    scopus 로고
    • Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study
    • PID: 17608260
    • Jouet P, Sabate JM, Maillard D, Msika S, Mechler C, Ledoux S, Harnois F, Coffin B. Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study. Obes Surg. 2007;17:478–85.
    • (2007) Obes Surg , vol.17 , pp. 478-485
    • Jouet, P.1    Sabate, J.M.2    Maillard, D.3    Msika, S.4    Mechler, C.5    Ledoux, S.6    Harnois, F.7    Coffin, B.8
  • 14
    • 37349033894 scopus 로고    scopus 로고
    • Liver enzymes and histology in obese patients with obstructive sleep apnea
    • COI: 1:CAS:528:DC%2BD2sXhsVamsrvK, PID: 18090161
    • Kallwitz ER, Herdegen J, Madura J, Jakate S, Cotler SJ. Liver enzymes and histology in obese patients with obstructive sleep apnea. J Clin Gastroenterol. 2007;41:918–21.
    • (2007) J Clin Gastroenterol , vol.41 , pp. 918-921
    • Kallwitz, E.R.1    Herdegen, J.2    Madura, J.3    Jakate, S.4    Cotler, S.J.5
  • 15
    • 37549050510 scopus 로고    scopus 로고
    • Experimental evidence of obstructive sleep apnea syndrome as a second hit accomplice in nonalcoholic steatohepatitis pathogenesis
    • PID: 18007563
    • Zamora-Valdes D, Mendez-Sanchez N. Experimental evidence of obstructive sleep apnea syndrome as a second hit accomplice in nonalcoholic steatohepatitis pathogenesis. Ann Hepatol. 2007;6:281–3.
    • (2007) Ann Hepatol , vol.6 , pp. 281-283
    • Zamora-Valdes, D.1    Mendez-Sanchez, N.2
  • 16
    • 38349073396 scopus 로고    scopus 로고
    • Elevated serum aminotransferase levels in children at risk for obstructive sleep apnea
    • COI: 1:CAS:528:DC%2BD1cXhslOrsrg%3D, PID: 18187742
    • Kheirandish-Gozal L, Sans Capdevila O, Kheirandish E, Gozal D. Elevated serum aminotransferase levels in children at risk for obstructive sleep apnea. Chest. 2008;133:92–9.
    • (2008) Chest , vol.133 , pp. 92-99
    • Kheirandish-Gozal, L.1    Sans Capdevila, O.2    Kheirandish, E.3    Gozal, D.4
  • 18
  • 21
    • 67650266752 scopus 로고    scopus 로고
    • Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
    • COI: 1:STN:280:DC%2BD1MvltVSjsw%3D%3D, PID: 19561283
    • Ryan S, Taylor CT, McNicholas WT. Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax. 2009;64:631–6.
    • (2009) Thorax , vol.64 , pp. 631-636
    • Ryan, S.1    Taylor, C.T.2    McNicholas, W.T.3
  • 22
    • 33645114153 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation
    • PID: 16491391
    • Htoo AK, Greenberg H, Tongia S, Chen G, Henderson T, Wilson D, Liu SF. Activation of nuclear factor kappaB in obstructive sleep apnea: a pathway leading to systemic inflammation. Sleep Breath. 2006;10:43–50.
    • (2006) Sleep Breath , vol.10 , pp. 43-50
    • Htoo, A.K.1    Greenberg, H.2    Tongia, S.3    Chen, G.4    Henderson, T.5    Wilson, D.6    Liu, S.F.7
  • 23
    • 33645122617 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo
    • COI: 1:CAS:528:DC%2BD28XivV2ku7g%3D, PID: 16554025
    • Greenberg H, Ye X, Wilson D, Htoo AK, Hendersen T, Liu SF. Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo. Biochem Biophys Res Commun. 2006;343:591–6.
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 591-596
    • Greenberg, H.1    Ye, X.2    Wilson, D.3    Htoo, A.K.4    Hendersen, T.5    Liu, S.F.6
  • 24
    • 36849063168 scopus 로고    scopus 로고
    • Inflammation and oxidative stress in obstructive sleep apnea syndrome
    • COI: 1:CAS:528:DC%2BD2sXhsVahsbjI
    • Selmi C, Montano N, Furlan R, Keen CL, Gershwin ME. Inflammation and oxidative stress in obstructive sleep apnea syndrome. Exp Biol Med (Maywood). 2007;232:1409–13.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 1409-1413
    • Selmi, C.1    Montano, N.2    Furlan, R.3    Keen, C.L.4    Gershwin, M.E.5
  • 27
    • 0024205742 scopus 로고
    • Acetylcysteine: a drug that is much more than a mucokinetic
    • COI: 1:CAS:528:DyaL1MXmvVygsg%3D%3D, PID: 3066412
    • Ziment I. Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother. 1988;42:513–9.
    • (1988) Biomed Pharmacother , vol.42 , pp. 513-519
    • Ziment, I.1
  • 28
    • 79959818879 scopus 로고    scopus 로고
    • Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure
    • COI: 1:CAS:528:DC%2BC3MXhtFWitLnF, PID: 21729291
    • Rosa DP, Martinez D, Picada JN, Semedo JG, Marroni NP. Hepatic oxidative stress in an animal model of sleep apnoea: effects of different duration of exposure. Comp Hepatol. 2011;10:1.
    • (2011) Comp Hepatol , vol.10 , pp. 1
    • Rosa, D.P.1    Martinez, D.2    Picada, J.N.3    Semedo, J.G.4    Marroni, N.P.5
  • 30
    • 0024780087 scopus 로고
    • Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis
    • COI: 1:STN:280:DyaK3c7gsFaitg%3D%3D, PID: 2557883
    • Halliwell B. Free radicals, reactive oxygen species and human disease: a critical evaluation with special reference to atherosclerosis. Br J Exp Pathol. 1989;70:737–57.
    • (1989) Br J Exp Pathol , vol.70 , pp. 737-757
    • Halliwell, B.1
  • 32
    • 33745009246 scopus 로고    scopus 로고
    • Effects of melatonin on streptozotocin-induced diabetic liver injury in rats
    • COI: 1:CAS:528:DC%2BD28XnvV2jsbw%3D, PID: 16714049
    • Guven A, Yavuz O, Cam M, Ercan F, Bukan N, Comunoglu C, Gokce F. Effects of melatonin on streptozotocin-induced diabetic liver injury in rats. Acta Histochem. 2006;108:85–93.
    • (2006) Acta Histochem , vol.108 , pp. 85-93
    • Guven, A.1    Yavuz, O.2    Cam, M.3    Ercan, F.4    Bukan, N.5    Comunoglu, C.6    Gokce, F.7
  • 33
  • 36
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • COI: 1:CAS:528:DyaE28XksVehtrY%3D, PID: 942051
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 37
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • COI: 1:CAS:528:DyaE1MXltVajsw%3D%3D, PID: 672633
    • Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302–10.
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 38
    • 0015523099 scopus 로고
    • The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
    • COI: 1:CAS:528:DyaE38XhsFSntLk%3D, PID: 4623845
    • Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem. 1972;247:3170–5.
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 39
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • COI: 1:CAS:528:DC%2BD3MXlsFags7s%3D, PID: 5432063
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680–5.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 40
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
    • COI: 1:CAS:528:DyaE1MXmtVKltLw%3D, PID: 388439
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA. 1979;76:4350–4.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 41
    • 34247866246 scopus 로고    scopus 로고
    • Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice
    • COI: 1:CAS:528:DC%2BD2sXmt1aqs7o%3D, PID: 17272404
    • Park AM, Suzuki YJ. Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. J Appl Physiol. 2007;102:1806–14.
    • (2007) J Appl Physiol , vol.102 , pp. 1806-1814
    • Park, A.M.1    Suzuki, Y.J.2
  • 42
    • 51749092435 scopus 로고    scopus 로고
    • l-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats
    • COI: 1:CAS:528:DC%2BD1cXht1GktbrI, PID: 18567603
    • Dutta A, Ray K, Singh VK, Vats P, Singh SN, Singh SB. l-carnitine supplementation attenuates intermittent hypoxia-induced oxidative stress and delays muscle fatigue in rats. Exp Physiol. 2008;93:1139–46.
    • (2008) Exp Physiol , vol.93 , pp. 1139-1146
    • Dutta, A.1    Ray, K.2    Singh, V.K.3    Vats, P.4    Singh, S.N.5    Singh, S.B.6
  • 43
    • 62449342906 scopus 로고    scopus 로고
    • Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia
    • COI: 1:CAS:528:DC%2BD1MXktVWiurc%3D, PID: 19317794
    • Bertuglia S, Reiter RJ. Melatonin reduces microvascular damage and insulin resistance in hamsters due to chronic intermittent hypoxia. J Pineal Res. 2009;46:307–13.
    • (2009) J Pineal Res , vol.46 , pp. 307-313
    • Bertuglia, S.1    Reiter, R.J.2
  • 44
    • 0141450467 scopus 로고    scopus 로고
    • Plasma levels of nitric oxide and l-arginine in sleep apnea patients: effects of nCPAP treatment
    • COI: 1:CAS:528:DC%2BD2cXjtFWqu70%3D, PID: 14500996
    • Lavie L, Hefetz A, Luboshitzky R, Lavie P. Plasma levels of nitric oxide and l-arginine in sleep apnea patients: effects of nCPAP treatment. J Mol Neurosci. 2003;21:57–63.
    • (2003) J Mol Neurosci , vol.21 , pp. 57-63
    • Lavie, L.1    Hefetz, A.2    Luboshitzky, R.3    Lavie, P.4
  • 45
    • 0037531465 scopus 로고    scopus 로고
    • Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine
    • COI: 1:CAS:528:DC%2BD3sXksVOrtrk%3D, PID: 12798437
    • Sohn HY, Krotz F, Gloe T, Keller M, Theisen K, Klauss V, Pohl U. Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine. Cardiovasc Res. 2003;58:638–46.
    • (2003) Cardiovasc Res , vol.58 , pp. 638-646
    • Sohn, H.Y.1    Krotz, F.2    Gloe, T.3    Keller, M.4    Theisen, K.5    Klauss, V.6    Pohl, U.7
  • 47
    • 33646356722 scopus 로고    scopus 로고
    • Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
    • COI: 1:CAS:528:DC%2BD28XksFyhsrk%3D, PID: 16357071
    • Phillips SA, Olson EB, Lombard JH, Morgan BJ. Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries. J Appl Physiol. 2006;100:1117–23.
    • (2006) J Appl Physiol , vol.100 , pp. 1117-1123
    • Phillips, S.A.1    Olson, E.B.2    Lombard, J.H.3    Morgan, B.J.4
  • 48
    • 77955560224 scopus 로고    scopus 로고
    • Continuous positive airway pressure improves sleep apnea associated fatty liver
    • PID: 20066542
    • Shpirer I, Copel L, Broide E, Elizur A. Continuous positive airway pressure improves sleep apnea associated fatty liver. Lung. 2010;188(4):301–7.
    • (2010) Lung , vol.188 , Issue.4 , pp. 301-307
    • Shpirer, I.1    Copel, L.2    Broide, E.3    Elizur, A.4
  • 49
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • COI: 1:CAS:528:DC%2BD2MXitVGhug%3D%3D, PID: 15522905
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J. 2005;19:136–8.
    • (2005) FASEB J , vol.19 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3
  • 50
    • 0030944781 scopus 로고    scopus 로고
    • Review: nonalcoholic steatohepatitis
    • COI: 1:STN:280:DyaK2szjvVyhug%3D%3D, PID: 9195388
    • Ludwig J, McGill DB, Lindor KD. Review: nonalcoholic steatohepatitis. J Gastroenterol Hepatol. 1997;12:398–403.
    • (1997) J Gastroenterol Hepatol , vol.12 , pp. 398-403
    • Ludwig, J.1    McGill, D.B.2    Lindor, K.D.3
  • 51
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two “hits”?
    • COI: 1:STN:280:DyaK1c3htFartQ%3D%3D, PID: 9547102
    • Day CP, James OF. Steatohepatitis: a tale of two “hits”? Gastroenterology. 1998;114:842–5.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 52
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts
    • COI: 1:CAS:528:DC%2BD1MXntFCjsL0%3D, PID: 19386601
    • Mole DR, Blancher C, Copley RR, Pollard PJ, Gleadle JM, Ragoussis J, Ratcliffe PJ. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts. J Biol Chem. 2009;284:16767–75.
    • (2009) J Biol Chem , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3    Pollard, P.J.4    Gleadle, J.M.5    Ragoussis, J.6    Ratcliffe, P.J.7
  • 53
    • 85047682984 scopus 로고    scopus 로고
    • Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    • COI: 1:CAS:528:DC%2BD1MXltFenurk%3D
    • Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97–106.
    • (2009) Physiology (Bethesda) , vol.24 , pp. 97-106
    • Semenza, G.L.1
  • 54
    • 79960697192 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia
    • COI: 1:CAS:528:DC%2BC3MXhtVKksrvO, PID: 21302291
    • Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 2011;226:2925–33.
    • (2011) J Cell Physiol , vol.226 , pp. 2925-2933
    • Yuan, G.1    Khan, S.A.2    Luo, W.3    Nanduri, J.4    Semenza, G.L.5    Prabhakar, N.R.6
  • 55
    • 79955096123 scopus 로고    scopus 로고
    • Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice
    • COI: 1:CAS:528:DC%2BC3MXltVygu7s%3D, PID: 21520168
    • Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D, Mandrekar P, Szabo G. Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology. 2011;53:1526–37.
    • (2011) Hepatology , vol.53 , pp. 1526-1537
    • Nath, B.1    Levin, I.2    Csak, T.3    Petrasek, J.4    Mueller, C.5    Kodys, K.6    Catalano, D.7    Mandrekar, P.8    Szabo, G.9
  • 56
    • 1642581653 scopus 로고    scopus 로고
    • Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha
    • COI: 1:CAS:528:DC%2BD2cXhtVaksLg%3D, PID: 14525767
    • Blouin CC, Page EL, Soucy GM, Richard DE. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha. Blood. 2004;103:1124–30.
    • (2004) Blood , vol.103 , pp. 1124-1130
    • Blouin, C.C.1    Page, E.L.2    Soucy, G.M.3    Richard, D.E.4
  • 57
    • 34250158361 scopus 로고    scopus 로고
    • Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis
    • COI: 1:CAS:528:DC%2BD2sXmtVKgtLY%3D, PID: 17548584
    • Peyssonnaux C, Cejudo-Martin P, Doedens A, Zinkernagel AS, Johnson RS, Nizet V. Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol. 2007;178:7516–9.
    • (2007) J Immunol , vol.178 , pp. 7516-7519
    • Peyssonnaux, C.1    Cejudo-Martin, P.2    Doedens, A.3    Zinkernagel, A.S.4    Johnson, R.S.5    Nizet, V.6
  • 58
    • 45349097483 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
    • PID: 18393939
    • van Uden P, Kenneth NS, Rocha S. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J. 2008;412:477–84.
    • (2008) Biochem J , vol.412 , pp. 477-484
    • van Uden, P.1    Kenneth, N.S.2    Rocha, S.3
  • 59
    • 44849100198 scopus 로고    scopus 로고
    • NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
    • COI: 1:CAS:528:DC%2BD1cXmvVGmsL8%3D, PID: 18432192
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008;453:807–11.
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6    Johnson, R.S.7    Haddad, G.G.8    Karin, M.9
  • 60
    • 42549144094 scopus 로고    scopus 로고
    • Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis
    • COI: 1:CAS:528:DC%2BD1cXmt1antbg%3D, PID: 18408102
    • Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth HE, Dreano M, de Vos R, Roskams T, Trautwein C. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut. 2008;57:655–63.
    • (2008) Gut , vol.57 , pp. 655-663
    • Beraza, N.1    Malato, Y.2    Vander Borght, S.3    Liedtke, C.4    Wasmuth, H.E.5    Dreano, M.6    de Vos, R.7    Roskams, T.8    Trautwein, C.9
  • 61
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • COI: 1:CAS:528:DyaK1MXotVyhtL0%3D, PID: 10602461
    • Pahl HL. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene. 1999;18:6853–66.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 62
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: basic science and clinical progress
    • COI: 1:CAS:528:DC%2BD2cXns1Ght74%3D, PID: 15294883
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev. 2004;25:581–611.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 63
    • 0034145215 scopus 로고    scopus 로고
    • Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review)
    • COI: 1:CAS:528:DC%2BD3cXhs1agt70%3D, PID: 10677565
    • Minet E, Michel G, Remacle J, Michiels C. Role of HIF-1 as a transcription factor involved in embryonic development, cancer progression and apoptosis (review). Int J Mol Med. 2000;5:253–9.
    • (2000) Int J Mol Med , vol.5 , pp. 253-259
    • Minet, E.1    Michel, G.2    Remacle, J.3    Michiels, C.4
  • 64
    • 0035021585 scopus 로고    scopus 로고
    • The role of TGF-beta 1 in mice hepatic fibrosis by Schistosomiasis Japonica
    • Zhu H, Zeng L, Zhu D, Yuan Y. The role of TGF-beta 1 in mice hepatic fibrosis by Schistosomiasis Japonica. J Tongji Med Univ. 2000;20(320–321):329.
    • (2000) J Tongji Med Univ , vol.20 , Issue.320-321 , pp. 329
    • Zhu, H.1    Zeng, L.2    Zhu, D.3    Yuan, Y.4
  • 65
    • 11144332398 scopus 로고    scopus 로고
    • Hypoxia potentiates transforming growth factor-beta expression of hepatocyte during the cirrhotic condition in rat liver
    • COI: 1:CAS:528:DC%2BD2MXmtVahtQ%3D%3D, PID: 15566519
    • Jeong WI, Do SH, Yun HS, Song BJ, Kim SJ, Kwak WJ, Yoo SE, Park HY, Jeong KS. Hypoxia potentiates transforming growth factor-beta expression of hepatocyte during the cirrhotic condition in rat liver. Liver Int. 2004;24:658–68.
    • (2004) Liver Int , vol.24 , pp. 658-668
    • Jeong, W.I.1    Do, S.H.2    Yun, H.S.3    Song, B.J.4    Kim, S.J.5    Kwak, W.J.6    Yoo, S.E.7    Park, H.Y.8    Jeong, K.S.9
  • 66
    • 0029041124 scopus 로고
    • Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells
    • COI: 1:CAS:528:DyaK2MXmslSnsbk%3D, PID: 7664847
    • Hampl V, Cornfield DN, Cowan NJ, Archer SL. Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Eur Respir J. 1995;8:515–22.
    • (1995) Eur Respir J , vol.8 , pp. 515-522
    • Hampl, V.1    Cornfield, D.N.2    Cowan, N.J.3    Archer, S.L.4
  • 68
    • 0033803047 scopus 로고    scopus 로고
    • Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
    • COI: 1:CAS:528:DC%2BD3cXntVyiurc%3D, PID: 11018065
    • Semenza GL. Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest. 2000;106:809–12.
    • (2000) J Clin Invest , vol.106 , pp. 809-812
    • Semenza, G.L.1
  • 70
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • COI: 1:CAS:528:DC%2BD3MXmsF2jtrs%3D, PID: 11522653
    • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura K, Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res. 2001;61:6548–54.
    • (2001) Cancer Res , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3    Suzuki, A.4    Wang, J.5    Chen, J.6    Niizeki, H.7    Kawamura, K.8    Hosokawa, M.9    Asaka, M.10
  • 71
    • 4944246547 scopus 로고    scopus 로고
    • The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis
    • COI: 1:CAS:528:DC%2BD2cXps1Kls78%3D, PID: 15452150
    • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol. 2004;57:1009–14.
    • (2004) J Clin Pathol , vol.57 , pp. 1009-1014
    • Greijer, A.E.1    van der Wall, E.2


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