N-acetylcysteine effects on genotoxic and oxidative stress parameters in cirrhotic rats with hepatopulmonary syndrome

Basic and Clinical Pharmacology and Toxicology

Volumn 102, Issue 4, 2008, Pages 370-376

  Vercelino, Rafael ^a   Tieppo, Juliana ^a   Dias, Alexandre Simões ^a,b   Marroni, Cláudio Augusto ^c   Garcia, Eduardo ^c   Meurer, Luise ^a   Picada, Jaqueline Nascimento ^d   Marroni, Norma Possa ^a,d  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b Methodist University Center   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^d UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; NITRIC ACID DERIVATIVE; NITRITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERIAL GAS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE DUCT LIGATION; COMET ASSAY; COMMON BILE DUCT; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; GENOTOXICITY; HEPATOPULMONARY SYNDROME; LIPID PEROXIDATION; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER PROTECTION; LIVER WEIGHT; LUNG FUNCTION; LUNG HOMOGENATE; LUNG WEIGHT; MALE; MICRONUCLEUS TEST; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREATMENT DURATION; VASODILATATION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 40849147201     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2007.00181.x     Document Type: Article

References (48)

1. Krowka MJ, Dickson ER, Cortese DA. Hepatopulmonary syndrome. Clinical observations and lack of therapeutic response to somatostatin analogue. Chest 1993 104 : 515 21.
2. Fallon MB, Abrams GA, McGrath JW, Hou Z, Luo B. Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome. Am J Physiol 1997 272 : G779 84.
3. Aboussouan LS, Stoller JK. The hepatopulmonary syndrome. Baillieres Best Pract Res Clin Gastroenterol 2000 14 : 1033 48.
4. Rodriguez-Roisin R, Roca J, Agusti AG, Mastai R, Wagner PD, Bosch J. Gas exchange and pulmonary vascular reactivity in patients with liver cirrhosis. Am Rev Respir Dis 1987 135 : 1085 92.
5. Fallon MB. Mechanisms of pulmonary vascular complications of liver disease: hepatopulmonary syndrome. J Clin Gastroenterol 2005 39 (4 Suppl 2 S138 42.
6. Chang SW, Ohara N. Pulmonary circulatory dysfunction in rats with biliary cirrhosis. An animal model of the hepatopulmonary syndrome. Am Rev Respir Dis 1992 145 : 798 805.
7. Rabiller A, Nunes H, Lebrec D et al. Prevention of gram-negative translocation reduces the severity of hepatopulmonary syndrome. Am J Respir Crit Care Med 2002 166 : 514 7.
8. Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996 271 : C1424 37.
9. Nunes H, Lebrec D, Mazmanian M et al. Role of nitric oxide in hepatopulmonary syndrome in cirrhotic rats. Am J Respir Crit Care Med 2001 164 : 879 85.
10. Lauterburg BH, Corcoran GB, Mitchell JR. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 1983 71 : 980 91.
11. Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003 60 : 6 20.
12. Farombi EO. Genotoxicity of chloroquine in rat liver cells: protective role of free radical scavengers. Cell Biol Toxicol 2006 22 : 159 67.
13. Zhao J, Liu XJ. Antioxidative and immunomodulatory role of melatonin, sodium selenite, N-acetyl-L-cysteine and quercetin on human umbilical blood. Pharmazie 2005 60 : 683 8.
14. Morley N, Curnow A, Salter L, Campbell S, Gould D. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. J Photochem Photobiol B 2003 72 : 55 60.
15. Balansky RB, D'Agostini F, Zanacchi P, De Flora S. Protection by N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke. Cancer Lett 1992 64 : 123 31.
16. Balansky RM, De Flora S. Interactions between N-acetylcysteine and sodium selenite in modulating the clastogenicity of urethane and 2-acetylaminofluorene in mice. Int J Cancer 2004 108 : 158 61.
17. Pastor A, Collado PS, Almar M, Gonzalez-Gallego J. Antioxidant enzyme status in biliary obstructed rats: effects of N-acetylcysteine. J Hepatol 1997 27 : 363 70.
18. Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct obstruction: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 1984 65 : 305 11.
19. Blesa S, Cortijo J, Mata M et al. Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen. Eur Respir J 2003 21 : 394 400.
20. Mavournin KH, Blakey DH, Cimino MC, Salamone MF, Heddle JA. The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the US Environmental Protection Agency Gene-Tox Program. Mutat Res 1990 239 : 29 80.
21. Miller B, Potter-Locher F, Seelbach A, Stopper H, Utesch D, Madle S. Evaluation of the in vitro micronucleus test as an alternative to the in vitro chromosomal aberration assay: position of the GUM Working Group on the in vitro micronucleus test. Gesellschaft fur Umwelt-Mutations-forschung. Mutat Res 1998 410 : 81 116.
22. MacGregor JT, Heddle JA, Hite M et al. Guidelines for the conduct of micronucleus assays in mammalian bone marrow erythrocytes. Mutat Res 1987 189 : 103 12.
23. Picada JN, da Silva KV, Erdtmann B, Henriques AT, Henriques JA. Genotoxic effects of structurally related beta-carboline alkaloids. Mutat Res 1997 379 : 135 49.
24. Tice RR, Agurell E, Anderson D et al. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000 35 : 206 21.
25. Picada JN, Flores DG, Zettler CG, Marroni NP, Roesler R, Henriques JA. DNA damage in brain cells of mice treated with an oxidized form of apomorphine. Brain Res Mol Brain Res 2003 114 : 80 5.
26. Nadin SB, Vargas-Roig LM, Ciocca DR. A silver staining method for single-cell gel assay. J Histochem Cytochem 2001 49 : 1183 6.
27. Viana CC, de Oliveira PA, Brum LF, Picada JN, Pereira P. Gamma-decanolactone effect on behavioral and genotoxic parameters. Life Sci 2007 80 : 1014 9.
28. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 1973 134 : 707 16.
29. Misra HP, Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972 247 : 3170 5.
30. Granger DL, Anstey NM, Miller WC, Weinberg JB. Measuring nitric oxide production in human clinical studies. Methods Enzymol 1999 301 : 49 61.
31. Tieppo J, Vercelino R, Dias AS, Marroni CA, Marroni N. [Common bile duct ligation as a model of hepatopulmonary syndrome and oxidative stress]. Arq Gastroenterol 2005 42 : 244 8.
32. Tieppo J, Marroni N. Efeito da Quercetina no Pulmão de Ratsos com Ligadura de Ducto Biliar Comum-Um modelo de Síndrome Hepatopulmonar. Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil 2006.
33. Dekhuijzen PN. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 2004 23 : 629 36.
34. Harrison PM, Wendon JA, Gimson AE, Alexander GJ, Williams R. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med 1991 324 : 1852 7.
35. San-Miguel J, Blade J. Perspective on the current use of bortezomib in multiple myeloma. Haematologica 2006 91 : 871 2.
36. Nakano H, Boudjema K, Alexandre E et al. Protective effects of N-acetylcysteine on hypothermic ischemia-reperfusion injury of rat liver. Hepatology 1995 22 : 539 45.
37. Koeppel TA, Lehmann TG, Thies JC et al. Impact of N-acetylcysteine on the hepatic microcirculation after orthotopic liver transplantation. Transplantation 1996 61 : 1397 402.
38. Montero EF, Quireze C Jr., d'Oliveira DM. Bile duct exclusion from selective vascular inflow occlusion in rat liver: role of ischemic preconditioning and N-acetylcysteine on hepatic reperfusion injury. Transplant Proc 2005 37 : 425 7.
39. Peres W, Tunon MJ, Collado PS, Herrmann S, Marroni N, Gonzalez-Gallego J. The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J Hepatol 2000 33 : 742 50.
40. Pavanato A, Tunon MJ, Sanchez-Campos S et al. Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci 2003 48 : 824 9.
41. Tieppo J, Vercelino R, Dias AS et al. Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food Chem Toxicol 2007 45 : 1140 6.
42. Tsuji F, Miyake Y, Aono H, Kawashima Y, Mita S. Effects of bucillamine and N-acetyl-L-cysteine on cytokine production and collagen-induced arthritis (CIA). Clin Exp Immunol 1999 115 : 26 31.
43. Okay E, Karadenizli A, Muezzinoglu B, Zeybek U, Arzu Ergen H, Isbir T. N-acetylcysteine attenuates bacterial translocation after partial hepatectomy in rats. J Surg Res 2005 127 : 164 70.
44. Titheradge MA. Nitric oxide in septic shock. Biochim Biophys Acta 1999 1411 : 437 55.
45. Zhang XJ, Katsuta Y, Akimoto T, Ohsuga M, Aramaki T, Takano T. Intrapulmonary vascular dilatation and nitric oxide in hypoxemic rats with chronic bile duct ligation. J Hepatol 2003 39 : 724 30.
46. Warner AE, Brain JD. The cell biology and pathogenic role of pulmonary intravascular macrophages. Am J Physiol 1990 258 : L1 12.
47. Santiard D, Ribiere C, Nordmann R, Houee-Levin C. Inactivation of Cu,Zn-superoxide dismutase by free radicals derived from ethanol metabolism: a gamma radiolysis study. Free Radic Biol Med 1995 19 : 121 7.
48. Failli P, Palmieri L, D'Alfonso C et al. Effect of N-acetyl-L-cysteine on peroxynitrite and superoxide anion production of lung alveolar macrophages in systemic sclerosis. Nitric Oxide 2002 7 : 277 82.