Elevated serum aminotransferase levels in children at risk for obstructive sleep apnea

Chest

Volumn 133, Issue 1, 2008, Pages 92-99

  Kheirandish Gozal, Leila ^a   Sans Capdevila, Oscar ^a   Kheirandish, Ebrahim ^b   Gozal, David ^a,c  

^a University of Louisville School of Medicine   (United States)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

Fatty liver; Obesity; Sleep apnea

Indexed keywords

AMINOTRANSFERASE; GLUCOSE; INSULIN; LIPID; LIVER ENZYME;

ADOLESCENT; AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; FATTY LIVER; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SLEEP APNEA SYNDROME; SNORING;

EID: 38349073396     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.07-0773     Document Type: Article

References (49)

1. Patton HM, Sirlin C, Behlin C, et al. Pediatric nonalcoholic fatty liver disease; a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr 2006; 43:413-427
2. Moran JR, Ghishan FK, Halter SA, et al. Steatohepatitis in obese children: a cause of chronic liver dysfunction. Am J Gastroenterol 1983; 78:374-377
3. Rashid M, Roberts EA. Nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr 2000; 30:48-53
4. Molleston JP, White F, Teckman J, et al. Obese children with steatohepatitis can develop cirrhosis in childhood. Am J Gastroenterol 2002; 97:2460-2462
5. Schwimmer JB, Deutsch R, Rauch JB, et al. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003; 143:500-505
6. Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 2000; 136:727-733
7. Tominaga K, Kurata JH, Chen YK, et al. Prevalence of fatty liver in Japanese children and relationship to obesity: an epidemiological ultrasonographic survey. Dig Dis Sci 1995; 40:2002-2009
8. Park HS, Han JH, Choi KM, et al. Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents. Am J Clin Nutr 2005; 82:1046-1051
9. Schwimmer JB, McGreal N, Deutsch R, et al. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005; 115:e.561-e565
10. Tauman R, Gozal D. Obesity and obstructive sleep apnea in children. Paediatr Respir Rev 2006; 7:247-259
11. Gozal D, Kheirandish L. Oxidant stress and inflammation in the snoring child: confluent pathways to upper airway pathogenesis and end-organ morbidity. Sleep Med Rev 2006; 10:83-96
12. Tauman R, Ivanenko A, O'Brien LM, et al. Plasma C-reactive protein in children with sleep-disordered breathing. Pediatrics 2004; 113:e.564-e569
13. Kheirandish-Gozal L, Sans Capdevila O, Tauman R, et al. Plasma C-reactive protein in non-obese children with obstructive sleep apnea before and after adenotonsillectomy. J Clin Sleep Med 2006; 2:301-304
14. Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 2005; 112:2660-2667
15. Singh H, Pollock R, Uhanova J, et al. Symptoms of obstructive sleep apnea in patients with nonalcoholic fatty liver disease. Dig Dis Sci 2005; 50:2338-2343
16. Tsang SW, Ng WF, Wu BP, et al. Predictors of fibrosis in Asian patients with non-alcoholic steatohepatitis. J Gastroenterol Hepatol 2006; 21:116-121
17. Tanne F, Gagnadoux F, Chazouilleres O, et al. Chronic liver injury during obstructive sleep apnea. Hepatology 2005; 41:1290-1296
18. Chin K, Nakamura T, Takahashi K, et al. Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am J Med 2003; 114:370-376
19. Montgomery-Downs HE, O'Brien LM, Gulliver TE, et al. Polysomnographic characteristics in normal preschool and early school-age children. Pediatrics 2006; 117:741-753
20. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring systems for sleep stages of human subject. Washington DC: National Institutes of Health, 1968; Publication No. 204
21. American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. Am J Respir Crit Care Med 1996; 153:866-878
22. American Sleep Disorders Association. EEG arousals: scoring and rules and examples; Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992; 15:173-184
23. Mograss MA, Ducharme FM, Brouillette RT. Movement/arousals: description, classification, and relationship to sleep apnea in children. Am J Respir Crit Care Med 1994; 150:1690-1696
24. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC growth charts: United States. Adv Data 2000; 8:1-27
25. Tauman R, O'Brien LM, Ivanenko A, et al. Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children. Pediatrics 2005; 116:e66-e73
26. Yu AS, Keeffe EB. Elevated AST or ALT to nonalcoholic fatty liver disease: accurate predictor of disease prevalence? Am J Gastroenterol 2003; 98:955-956
27. Seist G, Schiele F, Galteau M, et al. Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values. Clin Chem 1975; 151:260-265
28. Schwimmer JB, Deutsch R, Rauch JB, et al. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003; 143:500-505
29. Louthan MV, Barve S, McClain CJ, et al. Decreased serum adiponectin: au early event in pediatric nonalcoholic fatty liver disease. J Pediatr 2005; 147:835-838
30. Utzschneider KM, Kahn SE. Review: the role of insulin resistance in non-alcoholic fatty liver disease. J Clin Endocrinol Metab 2006; 91; 4753-4761
31. McClain CJ, Mokshagundam SP, Barve SS, et al. Mechanisms of non-alcoholic steatohepatitis. Alcohol 2004; 34:67-79
32. Bugianesi E, Gastaldelli A, Vanni E, et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms. Diabetologia 2005; 48:634-642
33. Albano E, Mottaran E, Occhino G, et al. Review article: role of oxidative stress in the progression of non-alcoholic steatosis. Aliment Pharmacol Ther 2005; 22(suppl):71-73
34. Malaguarnera L, Madeddu R, Palio E, et al. Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. J Hepatol 2005; 42:585-591
35. Panasiuk A, Dzieciol J, Panasiuk B, et al. Expression of p53, Bax and Bcl-2 proteins in hepatocytes in non-alcoholic fatty liver disease. World J Gastroenterol 2006; 12:6198-6202
36. Malaguarnera L, Di Rosa M, Zambito AM, et al. Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease. Gut 2006; 55:1313-1320
37. Yamazaki Y, Kakizaki S, Horiguchi N, et al. The role of nuclear receptor CAR in the pathogenesis of non-alcoholic steatohepatitis. Gut 2006; 56:565-574
38. Louthan MV, Theriot JA, Zimmerman E, et al. Decreased prevalence of nonalcoholic fatty liver disease in black obese children. J Pediatr Gastroenterol Nutr 2005; 41:426-429
39. Barcelo A, Miralles C, Barbe F, et al. Abnormal lipid peroxidation in patients with sleep apnoea. Eur Respir J 2000; 16:644-647
40. Barcelo A, Barbe F, de la Pena M, et al. Antioxidant status in patients with sleep apnoea and impact of continuous positive airway pressure treatment. Eur Respir J 2006; 27:756-760
41. Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004; 27:123-128
42. Tan KC, Chow WS, Lam JC, et al. HDL dysfunction in obstructive sleep apnea. Atherosclerosis 2006; 184:377-382
43. Tan KC, Chow WS, Lam JC, et al. Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea. Sleep 2006; 29:329-333
44. Schulz R, Mahmoudi S, Hattar K, et al. Enhanced release of superoxide from polymorphonuclear neutrophils in obstructive sleep apnea: impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med 2000; 162:566-570
45. Serpero LD, Kheirandish L, Sans Capdevila O, et al. Sleep fragmentation and circulating TNFα levels in children with sleep-disordered breathing [abstract]. Proc Am Thorac Soc 2006; 3:A555
46. Shamsuzzaman AS, Winnicki M, Lanfranchi P, et al. Elevated C-reactive protein in patients with obstructive sleep apnea. Circulation 2002; 105:2462-2464
47. Kageyama N, Nomura M, Nakaya Y, et al. Relationship between adhesion molecules with hs-CRP and changes therein after ARB (Valsartan) administration in patients with obstructive sleep apnea syndrome. J Med Invest 2006; 53:134-139
48. Larkin EK, Rosen CL, Kirchner HL, et al. Variation of C-reactive protein levels in adolescents association with sleep-disordered breathing and sleep duration. Circulation 2005; 111:1978-1984
49. Baldwin CM, Bootzin RR, Schwenke DC, et al. Antioxidant nutrient intake and supplements as potential moderators of cognitive decline and cardiovascular disease in obstructive sleep apnea. Sleep Med Rev 2005; 9:459-476