Cytokine-induced loss of glucocorticoid function: Effect of kinase inhibitors, long-acting β2-adrenoceptor agonist and glucocorticoid receptor ligands

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Rider, Christopher F ^a   Shah, Suharsh ^a   Miller Larsson, Anna ^b   Giembycz, Mark A ^a   Newton, Robert ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CICLESONIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1C; DEXAMETHASONE; FLUTICASONE FUROATE; FLUTICASONE PROPIONATE; FORMOTEROL; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR LIGAND; GSK 9027; GW 870086; HORMONE RECEPTOR AFFECTING AGENT; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C INHIBITOR; RGS2 PROTEIN; RU 24858; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FORMOTEROL FUMARATE; GLUCOCORTICOID RECEPTOR; I KAPPA B KINASE; IKK2 PROTEIN, HUMAN; LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ARTICLE; BEAS 2B CELL LINE; CDKN1C GENE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DUSP1 GENE; EPITHELIUM CELL; GENE; GENE EXPRESSION; GLUCOCORTICOID RESPONSE ELEMENT; HORMONE ACTION; HORMONE RESISTANCE; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; RESPIRATORY EPITHELIUM; RGS2 GENE; SMOOTH MUSCLE FIBER; TSC22D3 GENE; ASTHMA; BRONCHUS; CELL LINE; CYTOLOGY; DRUG RESISTANCE; METABOLISM; PHYSIOLOGY; RESPIRATORY MUCOSA; SMOOTH MUSCLE CELL; TRANSCRIPTION INITIATION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ASTHMA; BRONCHI; CELL LINE; DEXAMETHASONE; DRUG RESISTANCE; EPITHELIAL CELLS; FORMOTEROL FUMARATE; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-1BETA; LIGANDS; MYOCYTES, SMOOTH MUSCLE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; RECEPTORS, GLUCOCORTICOID; RESPIRATORY MUCOSA; TRANSCRIPTIONAL ACTIVATION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84921941583     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0116773     Document Type: Article

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