A unique insertion in STARD9's motor domain regulates its stability

Molecular Biology of the Cell

Volumn 26, Issue 3, 2015, Pages 440-452

  Senese, Silvia ^a   Cheung, Keith ^a   Lo, Yu Chen ^a   Gholkar, Ankur A ^a   Xia, Xiaoyu ^a   Wohlschlegel, James A ^a,b   Torres, Jorge Z ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN B; DEUBIQUITINASE; HISTONE H3; KINESIN; POLO LIKE KINASE 1; PROTEASOME; SCF BETA TRCP UBIQUITIN LIGASE; SECURIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN RELATED LIPID TRANSFER DOMAIN CONTAINING 9 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; BTRC PROTEIN, HUMAN; CARRIER PROTEIN; CELL CYCLE PROTEIN; ONCOPROTEIN; POLO-LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; STARD9 PROTEIN, HUMAN;

ARTICLE; CELL CYCLE REGULATION; CELL DIVISION; IMMUNOBLOTTING; MITOSIS; MITOSIS SPINDLE; PERICENTRIOLAR REGION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEOMICS; UBIQUITINATION; AMINO ACID SEQUENCE; CHEMISTRY; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SPINDLE APPARATUS; ULTRASTRUCTURE;

MAMMALIA;

AMINO ACID SEQUENCE; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; CARRIER PROTEINS; CELL CYCLE PROTEINS; HUMANS; MITOSIS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; SPINDLE APPARATUS; UBIQUITINATION;

EID: 84921830188     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-03-0829     Document Type: Article

References (46)

1. Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR (2004). Aurora B regulates MCAK at the mitotic centromere. Dev Cell 6, 253-268.
2. Barford D (2011). Structure, function and mechanism of the anaphase promoting complex (APC/C). Q Rev Biophys 44, 153-190.
3. Barr FA, Sillje HH, Nigg EA (2004). Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol 5, 429-440.
4. Bertran MT, Sdelci S, Regue L, Avruch J, Caelles C, Roig J (2011). Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. EMBO J 30, 2634-2647.
5. Budde PP, Kumagai A, Dunphy WG, Heald R (2001). Regulation of Op18 during spindle assembly in Xenopus egg extracts. J Cell Biol 153, 149-158.
6. Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF (2003). Degradation of Cdc25A by beta- TrCP during S phase and in response to DNA damage. Nature 426, 87-91.
7. Cahu J, Olichon A, Hentrich C, Schek H, Drinjakovic J, Zhang C, Doherty- Kirby A, Lajoie G, Surrey T (2008). Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One 3, e3936.
8. Cardozo T, Pagano M (2004). The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 5, 739-751.
9. Casenghi M, Meraldi P, Weinhart U, Duncan PI, Korner R, Nigg EA (2003). Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell 5, 113-125.
10. Colovos C, Yeates TO (1993). Verification of protein structures: patterns of nonbonded atomic interactions. Protein Sci 2, 1511-1519.
11. Elia AE, Cantley LC, Yaffe MB (2003). Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299, 1228-1231.
12. Frescas D, Pagano M (2008). Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer. Nat Rev Cancer 8, 438-449.
13. Funabiki H, Murray AW (2000). The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102, 411-424.
14. Gordon DM, Roof DM (2001). Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p. Proc Natl Acad Sci USA 98, 12515-12520.
15. Hansen DV, Loktev AV, Ban KH, Jackson PK (2004). Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell 15, 5623-5634.
16. Hildebrandt ER, Hoyt MA (2001). Cell cycle-dependent degradation of the Saccharomyces cerevisiae spindle motor Cin8p requires APC(Cdh1) and a bipartite destruction sequence. Mol Biol Cell 12, 3402-3416.
17. Jang CY, Coppinger JA, Seki A, Yates JR 3rd, Fang G (2009). Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J Cell Sci 122, 1334-1341.
18. Kanarek N, London N, Schueler-Furman O, Ben-Neriah Y (2010). Ubiquitination and degradation of the inhibitors of NF-kappaB. Cold Spring Harb Perspect Biol 2, a000166.
19. Laney JD, Hochstrasser M (2011). Analysis of protein ubiquitination. Curr Protoc Protein Sci Chapter 14, Unit 14.15.
20. Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC (2003). betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol 23, 402-413.
21. Laskowski RA, Moss DS, Thornton JM (1993). Main-chain bond lengths and bond angles in protein structures. J Mol Biol 231, 1049-1067.
22. Lee K, Rhee K (2011). PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis. J Cell Biol 195, 1093-1101.
23. Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB (2007). Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J 26, 2262-2273.
24. Luthy R, Bowie JU, Eisenberg D (1992). Assessment of protein models with three-dimensional profiles. Nature 356, 83-85.
25. Mailand N, Bekker-Jensen S, Bartek J, Lukas J (2006). Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress. Mol Cell 23, 307-318.
26. Malcos JL, Cyr RJ (2011). An ungrouped plant kinesin accumulates at the preprophase band in a cell cycle-dependent manner. Cytoskeleton (Hoboken) 68, 247-258.
27. Margottin F, Bour SP, Durand H, Selig L, Benichou S, Richard V, Thomas D, Strebel K, Benarous R (1998). A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol Cell 1, 565-574.
28. Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK (2003). Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell 4, 813-826.
29. Oshimori N, Ohsugi M, Yamamoto T (2006). The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Nat Cell Biol 8, 1095-1101.
30. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE (2004). UCSF Chimera-a visualization system for exploratory research and analysis. J Comput Chem 25, 1605-1612.
31. Ramachandran GN, Ramakrishnan C, Sasisekharan V (1963). Stereochemistry of polypeptide chain configurations. J Mol Biol 7, 95-99.
32. Rath O, Kozielski F (2012). Kinesins and cancer. Nat Rev Cancer 12, 527-539.
33. Sali A, Blundell TL (1993). Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234, 779-815.
34. Sdelci S, Bertran MT, Roig J (2011). Nek9, Nek6, Nek7 and the separation of centrosomes. Cell Cycle 10, 3816-3817.
35. Seki A, Coppinger JA, Du H, Jang CY, Yates JR 3rd, Fang G (2008a). Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol 181, 65-78.
36. Seki A, Coppinger JA, Jang CY, Yates JR, Fang G (2008b). Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science 320, 1655-1658.
37. Senese S, Lo YC, Huang D, Zangle TA, Gholkar AA, Robert L, Homet B, Ribas A, Summers MK, Teitell MA, et al. (2014). Chemical dissection of the cell cycle: probes for cell biology and anti-cancer drug development. Cell Death Dis 5, e1462.
38. Shen MY, Sali A (2006). Statistical potential for assessment and prediction of protein structures. Protein Sci 15, 2507-2524.
39. Torres JZ (2012). STARD9/Kif16a is a novel mitotic kinesin and antimitotic target. Bioarchitecture 2, 19-22.
40. Torres JZ, Ban KH, Jackson PK (2010). A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles. Mol Biol Cell 21, 897-904.
41. Torres JZ, Miller JJ, Jackson PK (2009). High-throughput generation of tagged stable cell lines for proteomic analysis. Proteomics 9, 2888-2891.
42. Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, et al. (2011). The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell 147, 1309-1323.
43. Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, et al. (2009). TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Blood 114, 5290-5298.
44. Verhey KJ, Hammond JW (2009). Traffic control: regulation of kinesin motors. Nat Rev Mol Cell Biol 10, 765-777.
45. Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW (1999). The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro. Genes Dev 13, 270-283.
46. Zhang L, Shao H, Huang Y, Yan F, Chu Y, Hou H, Zhu M, Fu C, Aikhionbare F, Fang G, et al. (2011). PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity. J Biol Chem 286, 3033-3046.