메뉴 건너뛰기




Volumn 21, Issue 4, 2015, Pages 1081-1090

Hyperhomocysteinemia as a potential contributor of colorectal cancer development in inflammatory bowel diseases: A review

Author keywords

Colorectal cancer; Hyperhomocysteinemia; Inflammatory bowel disease

Indexed keywords

DNA; HOMOCYSTEINE; OXYGEN RADICAL; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

EID: 84921789418     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i4.1081     Document Type: Review
Times cited : (42)

References (70)
  • 1
    • 67649875285 scopus 로고    scopus 로고
    • Review article: Diet and inflammatory bowel disease-epidemiology and treatment
    • [PMID: 19438426]
    • Yamamoto T, Nakahigashi M, Saniabadi AR. Review article: diet and inflammatory bowel disease-epidemiology and treatment. Aliment Pharmacol Ther 2009; 30: 99-112 [PMID: 19438426 DOI: 10.1111/j.1365-2036.2009.04035.x]
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 99-112
    • Yamamoto, T.1    Nakahigashi, M.2    Saniabadi, A.R.3
  • 2
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities
    • [PMID: 16378007]
    • Hanauer SB. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 2006; 12 Suppl 1: S3-S9 [PMID: 16378007 DOI: 10.1097/01.MIB.0000195385.19268.68]
    • (2006) Inflamm Bowel Dis , vol.12 , pp. S3-S9
    • Hanauer, S.B.1
  • 3
    • 84856390929 scopus 로고    scopus 로고
    • Inflammatory bowel disease and colon cancer
    • [PMID: 21822822]
    • Jawad N, Direkze N, Leedham SJ. Inflammatory bowel disease and colon cancer. Recent Results Cancer Res 2011; 185: 99-115 [PMID: 21822822 DOI: 10.1007/978-3-642-03503-6-6]
    • (2011) Recent Results Cancer Res , vol.185 , pp. 99-115
    • Jawad, N.1    Direkze, N.2    Leedham, S.J.3
  • 4
  • 5
    • 84878098649 scopus 로고    scopus 로고
    • Homocysteine imbalance: A pathological metabolic marker
    • [PMID: 23153729]
    • Schalinske KL, Smazal AL. Homocysteine imbalance: a pathological metabolic marker. Adv Nutr 2012; 3: 755-762 [PMID: 23153729 DOI: 10.3945/an.112.002758]
    • (2012) Adv Nutr , vol.3 , pp. 755-762
    • Schalinske, K.L.1    Smazal, A.L.2
  • 7
    • 77953017808 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and the role of B vitamins in cancer
    • [PMID: 22933895]
    • Plazar N, Jurdana M. Hyperhomocysteinemia and the role of B vitamins in cancer. Radiol Oncol 2010; 44: 79-85 [PMID: 22933895 DOI: 10.2478/v10019-010-0022-z]
    • (2010) Radiol Oncol , vol.44 , pp. 79-85
    • Plazar, N.1    Jurdana, M.2
  • 8
    • 80051546464 scopus 로고    scopus 로고
    • The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients
    • [PMID: 21533764]
    • Kedzierska M, Malinowska J, Glowacki R, Olas B, Bald E, Jeziorski A, Piekarski J. The elevated homocysteine stimulates changes of haemostatic function of plasma isolated from breast cancer patients. Mol Cell Biochem 2011; 355: 193-199 [PMID: 21533764 DOI: 10.1007/s11010-011-0854-x]
    • (2011) Mol Cell Biochem , vol.355 , pp. 193-199
    • Kedzierska, M.1    Malinowska, J.2    Glowacki, R.3    Olas, B.4    Bald, E.5    Jeziorski, A.6    Piekarski, J.7
  • 9
  • 10
    • 77950240233 scopus 로고    scopus 로고
    • Plasma homocysteine and cysteine and risk of breast cancer in women
    • [PMID: 20197471]
    • Lin J, Lee IM, Song Y, Cook NR, Selhub J, Manson JE, Buring JE, Zhang SM. Plasma homocysteine and cysteine and risk of breast cancer in women. Cancer Res 2010; 70: 2397-2405 [PMID: 20197471 DOI: 10.1158/0008-5472.CAN-09-3648]
    • (2010) Cancer Res , vol.70 , pp. 2397-2405
    • Lin, J.1    Lee, I.M.2    Song, Y.3    Cook, N.R.4    Selhub, J.5    Manson, J.E.6    Buring, J.E.7    Zhang, S.M.8
  • 13
    • 84867103263 scopus 로고    scopus 로고
    • Chronic intestinal inflammation: Inflammatory bowel disease and colitis-associated colon cancer
    • [PMID: 22586430]
    • Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol 2012; 3: 107 [PMID: 22586430 DOI: 10.3389/fimmu.2012.00107]
    • (2012) Front Immunol , vol.3 , pp. 107
    • Rubin, D.C.1    Shaker, A.2    Levin, M.S.3
  • 14
    • 0033858146 scopus 로고    scopus 로고
    • Changes in the incidence of inflammatory bowel disease: What does it mean?
    • [PMID: 10967506]
    • Russel MG. Changes in the incidence of inflammatory bowel disease: what does it mean? Eur J Intern Med 2000; 11: 191-196 [PMID: 10967506 DOI: 10.1016/S0953-6205(00)00090-X]
    • (2000) Eur J Intern Med , vol.11 , pp. 191-196
    • Russel, M.G.1
  • 15
    • 78449250096 scopus 로고    scopus 로고
    • Canadian digestive health foundation public impact series inflammatory bowel disease in canada: Incidence, prevalence, and direct and indirect economic impact
    • [PMID: 21157579]
    • Fedorak RN, Wong K, Bridges R. Canadian Digestive Health Foundation Public Impact Series. Inflammatory bowel disease in Canada: Incidence, prevalence, and direct and indirect economic impact. Can J Gastroenterol 2010; 24: 651-655 [PMID: 21157579]
    • (2010) Can J Gastroenterol , vol.24 , pp. 651-655
    • Fedorak, R.N.1    Wong, K.2    Bridges, R.3
  • 16
    • 60349126284 scopus 로고    scopus 로고
    • Inflammatory bowel disease: A survey of the epidemiology in Asia
    • [PMID: 19236540]
    • Goh K, Xiao SD. Inflammatory bowel disease: a survey of the epidemiology in Asia. J Dig Dis 2009; 10: 1-6 [PMID: 19236540 DOI: 10.1111/j.1751-2980.2008.00355.x]
    • (2009) J Dig Dis , vol.10 , pp. 1-6
    • Goh, K.1    Xiao, S.D.2
  • 17
    • 84866173368 scopus 로고    scopus 로고
    • Etiology of inflammatory bowel disease: A unified hypothesis
    • [PMID: 22553395]
    • Qin X. Etiology of inflammatory bowel disease: a unified hypothesis. World J Gastroenterol 2012; 18: 1708-1722 [PMID: 22553395 DOI: 10.3748/wjg.v18.i15.1708]
    • (2012) World J Gastroenterol , vol.18 , pp. 1708-1722
    • Qin, X.1
  • 18
    • 84864270977 scopus 로고    scopus 로고
    • Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010
    • [PMID: 22609382]
    • Herrinton LJ, Liu L, Levin TR, Allison JE, Lewis JD, Velayos F. Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010. Gastroenterology 2012; 143: 382-389 [PMID: 22609382 DOI: 10.1053/j.gastro.2012.04.054]
    • (2012) Gastroenterology , vol.143 , pp. 382-389
    • Herrinton, L.J.1    Liu, L.2    Levin, T.R.3    Allison, J.E.4    Lewis, J.D.5    Velayos, F.6
  • 19
    • 84864859115 scopus 로고    scopus 로고
    • Colorectal cancer in inflammatory bowel disease: What is the real magnitude of the risk?
    • [PMID: 22876036]
    • Dyson JK, Rutter MD. Colorectal cancer in inflammatory bowel disease: what is the real magnitude of the risk? World J Gastroenterol 2012; 18: 3839-3848 [PMID: 22876036 DOI: 10.3748/wjg.v18.i29.3839]
    • (2012) World J Gastroenterol , vol.18 , pp. 3839-3848
    • Dyson, J.K.1    Rutter, M.D.2
  • 20
    • 84867695582 scopus 로고    scopus 로고
    • Colorectal cancer in patients with inflammatory bowel disease: Can we predict risk?
    • [PMID: 22919240]
    • Andersen V, Halfvarson J, Vogel U. Colorectal cancer in patients with inflammatory bowel disease: can we predict risk? World J Gastroenterol 2012; 18: 4091-4094 [PMID: 22919240 DOI: 10.3748/wjg.v18.i31.4091]
    • (2012) World J Gastroenterol , vol.18 , pp. 4091-4094
    • Andersen, V.1    Halfvarson, J.2    Vogel, U.3
  • 21
    • 84873414045 scopus 로고    scopus 로고
    • Colorectal cancer surveillance in patients with inflammatory bowel disease: What is new?
    • [PMID: 22523611]
    • Guagnozzi D, Lucendo AJ. Colorectal cancer surveillance in patients with inflammatory bowel disease: What is new? World J Gastrointest Endosc 2012; 4: 108-116 [PMID: 22523611 DOI: 10.4253/wjge.v4.i4.108]
    • (2012) World J Gastrointest Endosc , vol.4 , pp. 108-116
    • Guagnozzi, D.1    Lucendo, A.J.2
  • 22
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: A meta-analysis
    • [PMID: 11247898]
    • Eaden JA, Abrams KR, Mayberry JF. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001; 48: 526-535 [PMID: 11247898 DOI: 10.1136/gut.48.4.526]
    • (2001) Gut , vol.48 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 23
    • 68849111629 scopus 로고    scopus 로고
    • MHC Class II alleles in ulcerative colitis-associated colorectal cancer
    • [PMID: 19251712]
    • Garrity-Park MM, Loftus EV, Sandborn WJ, Bryant SC, Smyrk TC. MHC Class II alleles in ulcerative colitis-associated colorectal cancer. Gut 2009; 58: 1226-1233 [PMID: 19251712 DOI: 10.1136/gut.2008.166686]
    • (2009) Gut , vol.58 , pp. 1226-1233
    • Garrity-Park, M.M.1    Loftus, E.V.2    Sandborn, W.J.3    Bryant, S.C.4    Smyrk, T.C.5
  • 24
    • 0032771346 scopus 로고    scopus 로고
    • Homocysteine metabolism
    • [PMID: 10448523]
    • Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19: 217-246 [PMID: 10448523 DOI: 10.1146/annurev.nutr.19.1.217]
    • (1999) Annu Rev Nutr , vol.19 , pp. 217-246
    • Selhub, J.1
  • 25
    • 48249126469 scopus 로고    scopus 로고
    • Public health significance of elevated homocysteine
    • [PMID: 18709886]
    • Selhub J. Public health significance of elevated homocysteine. Food Nutr Bull 2008; 29: S116-S125 [PMID: 18709886]
    • (2008) Food Nutr Bull , vol.29 , pp. S116-S125
    • Selhub, J.1
  • 26
    • 33750614452 scopus 로고    scopus 로고
    • Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma
    • [PMID: 17036383]
    • Battistelli S, Vittoria A, Stefanoni M, Bing C, Roviello F. Total plasma homocysteine and methylenetetrahydrofolate reductase C677T polymorphism in patients with colorectal carcinoma. World J Gastroenterol 2006; 12: 6128-6132 [PMID: 17036383]
    • (2006) World J Gastroenterol , vol.12 , pp. 6128-6132
    • Battistelli, S.1    Vittoria, A.2    Stefanoni, M.3    Bing, C.4    Roviello, F.5
  • 27
    • 77951121781 scopus 로고    scopus 로고
    • Homocysteine metabolism and its relation to health and disease
    • [PMID: 20091801]
    • Williams KT, Schalinske KL. Homocysteine metabolism and its relation to health and disease. Biofactors 2010; 36: 19-24 [PMID: 20091801]
    • (2010) Biofactors , vol.36 , pp. 19-24
    • Williams, K.T.1    Schalinske, K.L.2
  • 28
    • 0036294472 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker
    • [PMID: 12104077]
    • Wu LL, Wu JT. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 2002; 322: 21-28 [PMID: 12104077 DOI: 10.1016/S0009-8981(02)00174-2]
    • (2002) Clin Chim Acta , vol.322 , pp. 21-28
    • Wu, L.L.1    Wu, J.T.2
  • 29
    • 39649102151 scopus 로고    scopus 로고
    • Association of hyperhomocysteinemia and folate deficiency with colon tumors in patients with inflammatory bowel disease
    • [PMID: 17941074]
    • Phelip JM, Ducros V, Faucheron JL, Flourie B, Roblin X. Association of hyperhomocysteinemia and folate deficiency with colon tumors in patients with inflammatory bowel disease. Inflamm Bowel Dis 2008; 14: 242-248 [PMID: 17941074 DOI: 10.1002/ibd.20309]
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 242-248
    • Phelip, J.M.1    Ducros, V.2    Faucheron, J.L.3    Flourie, B.4    Roblin, X.5
  • 30
    • 80755140110 scopus 로고    scopus 로고
    • Hypothesis: Hyperhomocysteinemia is an indicator of oxidant stress
    • [PMID: 21963358]
    • Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med Hypotheses 2011; 77: 1088-1093 [PMID: 21963358 DOI: 10.1016/j.mehy.2011.09.009]
    • (2011) Med Hypotheses , vol.77 , pp. 1088-1093
    • Hoffman, M.1
  • 31
    • 0030272793 scopus 로고    scopus 로고
    • Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis
    • [PMID: 8921985]
    • Shen HM, Ong CN. Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis. Mutat Res 1996; 366: 23-44 [PMID: 8921985 DOI: 10.1016/S0165-1110(96)90005-6]
    • (1996) Mutat Res , vol.366 , pp. 23-44
    • Shen, H.M.1    Ong, C.N.2
  • 32
    • 84920167946 scopus 로고    scopus 로고
    • High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities
    • [PMID: 24280101]
    • Chiang FF, Wang HM, Lan YC, Yang MH, Huang SC, Huang YC. High homocysteine is associated with increased risk of colorectal cancer independently of oxidative stress and antioxidant capacities. Clin Nutr 2014; 33: 1054-1060 [PMID: 24280101 DOI: 10.1016/j.clnu.2013.11.007]
    • (2014) Clin Nutr , vol.33 , pp. 1054-1060
    • Chiang, F.F.1    Wang, H.M.2    Lan, Y.C.3    Yang, M.H.4    Huang, S.C.5    Huang, Y.C.6
  • 35
    • 80055017405 scopus 로고    scopus 로고
    • Meta-analysis: Hyperhomocysteinaemia in inflammatory bowel diseases
    • [PMID: 21967576]
    • Oussalah A, Guéant JL, Peyrin-Biroulet L. Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases. Aliment Pharmacol Ther 2011; 34: 1173-1184 [PMID: 21967576 DOI: 10.1111/j.1365-2036.2011.04864.x]
    • (2011) Aliment Pharmacol Ther , vol.34 , pp. 1173-1184
    • Oussalah, A.1    Guéant, J.L.2    Peyrin-Biroulet, L.3
  • 36
    • 79953107378 scopus 로고    scopus 로고
    • Prevalence and risk factors of hyperhomocysteinemia in Tunisian patients with Crohn's disease
    • [PMID: 21453879]
    • Kallel L, Feki M, Sekri W, Segheir L, Fekih M, Boubaker J, Kaabachi N, Filali A. Prevalence and risk factors of hyperhomocysteinemia in Tunisian patients with Crohn's disease. J Crohns Colitis 2011; 5: 110-114 [PMID: 21453879 DOI: 10.1016/j.crohns.2010.10.010]
    • (2011) J Crohns Colitis , vol.5 , pp. 110-114
    • Kallel, L.1    Feki, M.2    Sekri, W.3    Segheir, L.4    Fekih, M.5    Boubaker, J.6    Kaabachi, N.7    Filali, A.8
  • 37
    • 42449117676 scopus 로고    scopus 로고
    • Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: Correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications
    • [PMID: 18344891]
    • Erzin Y, Uzun H, Celik AF, Aydin S, Dirican A, Uzunismail H. Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections: correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications. J Clin Gastroenterol 2008; 42: 481-486 [PMID: 18344891 DOI: 10.1097/MCG.0b013e318046eab0]
    • (2008) J Clin Gastroenterol , vol.42 , pp. 481-486
    • Erzin, Y.1    Uzun, H.2    Celik, A.F.3    Aydin, S.4    Dirican, A.5    Uzunismail, H.6
  • 38
    • 21244498561 scopus 로고    scopus 로고
    • Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease
    • [PMID: 15947551]
    • Mahmood A, Needham J, Prosser J, Mainwaring J, Trebble T, Mahy G, Ramage J. Prevalence of hyperhomocysteinaemia, activated protein C resistance and prothrombin gene mutation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2005; 17: 739-744 [PMID: 15947551 DOI: 10.1097/00042737-200507000-00008]
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 739-744
    • Mahmood, A.1    Needham, J.2    Prosser, J.3    Mainwaring, J.4    Trebble, T.5    Mahy, G.6    Ramage, J.7
  • 39
    • 0037256412 scopus 로고    scopus 로고
    • Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: Role of inflammation and correlation with acute phase reactants
    • [PMID: 12526945]
    • Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, Meucci G, Spina L, de Franchis R. Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am J Gastroenterol 2003; 98: 112-117 [PMID: 12526945 DOI: 10.1111/j.1572-0241.2003.07160.x]
    • (2003) Am J Gastroenterol , vol.98 , pp. 112-117
    • Saibeni, S.1    Cattaneo, M.2    Vecchi, M.3    Zighetti, M.L.4    Lecchi, A.5    Lombardi, R.6    Meucci, G.7    Spina, L.8    De Franchis, R.9
  • 40
    • 75749094714 scopus 로고    scopus 로고
    • Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: A synopsis and meta-analysis of genetic association studies
    • [PMID: 20085490]
    • Zintzaras E. Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies. Biomarkers 2010; 15: 69-79 [PMID: 20085490 DOI: 10.3109/13547500903297184]
    • (2010) Biomarkers , vol.15 , pp. 69-79
    • Zintzaras, E.1
  • 41
    • 0034933207 scopus 로고    scopus 로고
    • Hyperhomocysteinemia and inflammatory bowel disease: Prevalence and predictors in a cross-sectional study
    • [PMID: 11467646]
    • Romagnuolo J, Fedorak RN, Dias VC, Bamforth F, Teltscher M. Hyperhomocysteinemia and inflammatory bowel disease: prevalence and predictors in a cross-sectional study. Am J Gastroenterol 2001; 96: 2143-2149 [PMID: 11467646 DOI: 10.1111/j.1572-0241.2001.03950.x]
    • (2001) Am J Gastroenterol , vol.96 , pp. 2143-2149
    • Romagnuolo, J.1    Fedorak, R.N.2    Dias, V.C.3    Bamforth, F.4    Teltscher, M.5
  • 42
    • 2442671468 scopus 로고    scopus 로고
    • Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate
    • [PMID: 15083316]
    • Akoglu B, Milovic V, Caspary WF, Faust D. Hyperproliferation of homocysteine-treated colon cancer cells is reversed by folate and 5-methyltetrahydrofolate. Eur J Nutr 2004; 43: 93-99 [PMID: 15083316 DOI: 10.1007/s00394-004-0446-6]
    • (2004) Eur J Nutr , vol.43 , pp. 93-99
    • Akoglu, B.1    Milovic, V.2    Caspary, W.F.3    Faust, D.4
  • 44
    • 84870936027 scopus 로고    scopus 로고
    • Biomarkers of platelet activation in acute coronary syndromes
    • [PMID: 23014768]
    • Ferroni P, Riondino S, Vazzana N, Santoro N, Guadagni F, Davì G. Biomarkers of platelet activation in acute coronary syndromes. Thromb Haemost 2012; 108: 1109-1123 [PMID: 23014768 DOI: 10.1160/TH12-08-0550]
    • (2012) Thromb Haemost , vol.108 , pp. 1109-1123
    • Ferroni, P.1    Riondino, S.2    Vazzana, N.3    Santoro, N.4    Guadagni, F.5    Davì, G.6
  • 45
    • 0036278536 scopus 로고    scopus 로고
    • A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability
    • [PMID: 11889073]
    • Shannon B, Gnanasampanthan S, Beilby J, Iacopetta B. A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 2002; 50: 520-524 [PMID: 11889073 DOI: 10.1136/gut.50.4.520]
    • (2002) Gut , vol.50 , pp. 520-524
    • Shannon, B.1    Gnanasampanthan, S.2    Beilby, J.3    Iacopetta, B.4
  • 47
    • 84917743913 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis
    • [PMID: 24649029]
    • Zhao M, Li X, Xing C, Zhou B. Association of methylenetetrahydrofolate reductase C677T and A1298C polymorphisms with colorectal cancer risk: A meta-analysis. Biomed Rep 2013; 1: 781-791 [PMID: 24649029 DOI: 10.3892/br.2013.134]
    • (2013) Biomed Rep , vol.1 , pp. 781-791
    • Zhao, M.1    Li, X.2    Xing, C.3    Zhou, B.4
  • 49
    • 79951929509 scopus 로고    scopus 로고
    • Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients
    • [PMID: 21264789]
    • Kaji E, Kato J, Saito S, Harada K, Kuwaki K, Tatsukawa M, Morikawa T, Hiraoka S, Matsushima H, Yamamoto K. Serum folate and homocysteine levels are associated with colon tumorigenesis in end-stage renal disease patients. Nutr Cancer 2011; 63: 202-211 [PMID: 21264789 DOI: 10.1080/01635581.2011.523501]
    • (2011) Nutr Cancer , vol.63 , pp. 202-211
    • Kaji, E.1    Kato, J.2    Saito, S.3    Harada, K.4    Kuwaki, K.5    Tatsukawa, M.6    Morikawa, T.7    Hiraoka, S.8    Matsushima, H.9    Yamamoto, K.10
  • 50
    • 35148846824 scopus 로고    scopus 로고
    • Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: Association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia
    • [PMID: 17921385]
    • Al-Ghnaniem R, Peters J, Foresti R, Heaton N, Pufulete M. Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia. Am J Clin Nutr 2007; 86: 1064-1072 [PMID: 17921385]
    • (2007) Am J Clin Nutr , vol.86 , pp. 1064-1072
    • Al-Ghnaniem, R.1    Peters, J.2    Foresti, R.3    Heaton, N.4    Pufulete, M.5
  • 51
    • 84861984223 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study
    • [PMID: 22844384]
    • Yin G, Ming H, Zheng X, Xuan Y, Liang J, Jin X. Methylenetetrahydrofolate reductase C677T gene polymorphism and colorectal cancer risk: A case-control study. Oncol Lett 2012; 4: 365-369 [PMID: 22844384]
    • (2012) Oncol Lett , vol.4 , pp. 365-369
    • Yin, G.1    Ming, H.2    Zheng, X.3    Xuan, Y.4    Liang, J.5    Jin, X.6
  • 53
    • 0031716221 scopus 로고    scopus 로고
    • Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
    • [PMID: 9771864]
    • Kim YI, Fawaz K, Knox T, Lee YM, Norton R, Arora S, Paiva L, Mason JB. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps. Am J Clin Nutr 1998; 68: 866-872 [PMID: 9771864]
    • (1998) Am J Clin Nutr , vol.68 , pp. 866-872
    • Kim, Y.I.1    Fawaz, K.2    Knox, T.3    Lee, Y.M.4    Norton, R.5    Arora, S.6    Paiva, L.7    Mason, J.B.8
  • 54
    • 84865989620 scopus 로고    scopus 로고
    • Hyperhomocysteinemia is a risk factor for colorectal adenoma in women
    • [PMID: 22962532]
    • Lim YJ, Kim JH, Park SK, Son HJ, Kim JJ, Kim YH. Hyperhomocysteinemia is a risk factor for colorectal adenoma in women. J Clin Biochem Nutr 2012; 51: 132-135 [PMID: 22962532 DOI: 10.3164/jcbn.D-11-00025]
    • (2012) J Clin Biochem Nutr , vol.51 , pp. 132-135
    • Lim, Y.J.1    Kim, J.H.2    Park, S.K.3    Son, H.J.4    Kim, J.J.5    Kim, Y.H.6
  • 55
    • 11144236628 scopus 로고    scopus 로고
    • Colorectal cancer and the methylenetetrahydrofolate reductase 677C-& gt; T and methionine synthase 2756A-& gt; G polymorphisms: A study of 2,168 case-control pairs from the JANUS cohort
    • [PMID: 15598777]
    • Ulvik A, Vollset SE, Hansen S, Gislefoss R, Jellum E, Ueland PM. Colorectal cancer and the methylenetetrahydrofolate reductase 677C-& gt; T and methionine synthase 2756A-& gt; G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev 2004; 13: 2175-2180 [PMID: 15598777]
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , pp. 2175-2180
    • Ulvik, A.1    Vollset, S.E.2    Hansen, S.3    Gislefoss, R.4    Jellum, E.5    Ueland, P.M.6
  • 59
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • [PMID: 15659508]
    • Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 2005; 23: 609-618 [PMID: 15659508 DOI: 10.1200/JCO.2005.01.086]
    • (2005) J Clin Oncol , vol.23 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 60
    • 46349096806 scopus 로고    scopus 로고
    • Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer
    • [PMID: 18584349]
    • Jensen LH, Lindebjerg J, Crüger DG, Brandslund I, Jakobsen A, Kolvraa S, Nielsen JN. Microsatellite instability and the association with plasma homocysteine and thymidylate synthase in colorectal cancer. Cancer Invest 2008; 26: 583-589 [PMID: 18584349 DOI: 10.1080/07357900801970992]
    • (2008) Cancer Invest , vol.26 , pp. 583-589
    • Jensen, L.H.1    Lindebjerg, J.2    Crüger, D.G.3    Brandslund, I.4    Jakobsen, A.5    Kolvraa, S.6    Nielsen, J.N.7
  • 61
    • 33846516821 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and colorectal cancer risk: Is homocysteine the missing link?
    • [PMID: 17311671]
    • Phelip JM, Roblin X. Type 2 diabetes mellitus and colorectal cancer risk: is homocysteine the missing link? Am J Gastroenterol 2007; 102: 466-467 [PMID: 17311671 DOI: 10.1111/j.1572-0241.2006.00904-17.x]
    • (2007) Am J Gastroenterol , vol.102 , pp. 466-467
    • Phelip, J.M.1    Roblin, X.2
  • 63
    • 77958458317 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and chemoprevention of colorectal cancer
    • [PMID: 20609543]
    • Serfaty L, Bissonnette M, Poupon R. Ursodeoxycholic acid and chemoprevention of colorectal cancer. Gastroenterol Clin Biol 2010; 34: 516-522 [PMID: 20609543 DOI: 10.1016/j.gcb.2010.05.005]
    • (2010) Gastroenterol Clin Biol , vol.34 , pp. 516-522
    • Serfaty, L.1    Bissonnette, M.2    Poupon, R.3
  • 64
    • 2142641695 scopus 로고    scopus 로고
    • Folate and colorectal neoplasia: Relation between plasma and dietary markers of folate and adenoma recurrence
    • [PMID: 15051616]
    • Martínez ME, Henning SM, Alberts DS. Folate and colorectal neoplasia: relation between plasma and dietary markers of folate and adenoma recurrence. Am J Clin Nutr 2004; 79: 691-697 [PMID: 15051616]
    • (2004) Am J Clin Nutr , vol.79 , pp. 691-697
    • Martínez, M.E.1    Henning, S.M.2    Alberts, D.S.3
  • 66
    • 77958033448 scopus 로고    scopus 로고
    • Baseline plasma total homocysteine and adenoma recurrence: Results from a double blind randomized clinical trial of aspirin and folate supplementation
    • [PMID: 20841390]
    • Levine AJ, Grau MV, Mott LA, Ueland PM, Baron JA. Baseline plasma total homocysteine and adenoma recurrence: results from a double blind randomized clinical trial of aspirin and folate supplementation. Cancer Epidemiol Biomarkers Prev 2010; 19: 2541-2548 [PMID: 20841390 DOI: 10.1158/1055-9965.EPI-10-0536]
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2541-2548
    • Levine, A.J.1    Grau, M.V.2    Mott, L.A.3    Ueland, P.M.4    Baron, J.A.5
  • 67
    • 0027173712 scopus 로고
    • Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis
    • [PMID: 8392076]
    • Lashner BA. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis. J Cancer Res Clin Oncol 1993; 119: 549-554 [PMID: 8392076 DOI: 10.1007/BF01686465]
    • (1993) J Cancer Res Clin Oncol , vol.119 , pp. 549-554
    • Lashner, B.A.1
  • 68
    • 23344454543 scopus 로고    scopus 로고
    • Folate and prevention of colorectal cancer in ulcerative colitis
    • [PMID: 16030431]
    • Biasco G, Di Marco MC. Folate and prevention of colorectal cancer in ulcerative colitis. Eur J Cancer Prev 2005; 14: 395-398 [PMID: 16030431 DOI: 10.1097/00008469-200508000-00013]
    • (2005) Eur J Cancer Prev , vol.14 , pp. 395-398
    • Biasco, G.1    Di Marco, M.C.2
  • 69
    • 77954426622 scopus 로고    scopus 로고
    • Mesalamine protects against colorectal cancer in inflammatory bowel disease
    • [PMID: 19705280]
    • Tang J, Sharif O, Pai C, Silverman AL. Mesalamine protects against colorectal cancer in inflammatory bowel disease. Dig Dis Sci 2010; 55: 1696-1703 [PMID: 19705280 DOI: 10.1007/s10620-009-0942-x]
    • (2010) Dig Dis Sci , vol.55 , pp. 1696-1703
    • Tang, J.1    Sharif, O.2    Pai, C.3    Silverman, A.L.4
  • 70
    • 84861092341 scopus 로고    scopus 로고
    • Managing risks of neoplasia in inflammatory bowel disease
    • [PMID: 22359106]
    • Velayos F. Managing risks of neoplasia in inflammatory bowel disease. Curr Gastroenterol Rep 2012; 14: 174-180 [PMID: 22359106 DOI: 10.1007/s11894-012-0247-7]
    • (2012) Curr Gastroenterol Rep , vol.14 , pp. 174-180
    • Velayos, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.