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Volumn 15, Issue 1, 2010, Pages 69-79

Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: A synopsis and meta-analysis of genetic association studies

Author keywords

CBS; Crohn's disease; Folate; Gene; Homocysteine; Inflammatory bowel disease; Meta analysis; MTHFR; MTR; MTRR; Polymorphism; TCN2; Ulcerative colitis

Indexed keywords

FOLIC ACID; HOMOCYSTEINE;

EID: 75749094714     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.3109/13547500903297184     Document Type: Article
Times cited : (19)

References (59)
  • 1
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. (2007). Inflammatory bowel disease: cause and immunobiology. Lancet 369:1627-1640
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 4
    • 38049026746 scopus 로고    scopus 로고
    • Detecting association using epistatic information
    • Chapman J, Clayton D. (2007). Detecting association using epistatic information. Genet Epidemiol 31:894-909.
    • (2007) Genet Epidemiol , vol.31 , pp. 894-909
    • Chapman, J.1    Clayton, D.2
  • 5
    • 51949094637 scopus 로고    scopus 로고
    • Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis in central China
    • Chen M, Peyrin-Biroulet L, Xia B, Gueant-Rodriguez RM, Bronowicki JP, Bigard MA, Guèant JL. (2008). Methionine synthase A2756G polymorphism may predict ulcerative colitis and methylenetetrahydrofolate reductase C677T pancolitis in central China. BMC Med Genet 9:78.
    • (2008) BMC Med Genet , vol.9 , pp. 78
    • Chen, M.1    Peyrin-Biroulet, L.2    Xia, B.3    Gueant-Rodriguez, R.M.4    Bronowicki, J.P.5    Bigard, M.A.6    Guèant, J.L.7
  • 6
    • 0035922669 scopus 로고    scopus 로고
    • Epidemiological methods for studying genes and environmental factors in complex diseases
    • Clayton D, McKeigue PM. (2001). Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 358:1356-1360
    • (2001) Lancet , vol.358 , pp. 1356-1360
    • Clayton, D.1    McKeigue, P.M.2
  • 7
    • 41049093347 scopus 로고
    • The combination of estimates from different experiments
    • Cochran WG. (1954). The combination of estimates from different experiments. Biometrics 10:101-129
    • (1954) Biometrics , vol.10 , pp. 101-129
    • Cochran, W.G.1
  • 8
    • 1642556843 scopus 로고    scopus 로고
    • Gene-environment interactions and the etiology of common complex disease
    • Cooper RS. (2003). Gene-environment interactions and the etiology of common complex disease. Ann Intern Med 139:437-440
    • (2003) Ann Intern Med , vol.139 , pp. 437-440
    • Cooper, R.S.1
  • 9
    • 25144501575 scopus 로고    scopus 로고
    • Genetic association studies
    • Cordell HJ, Clayton DG. (2005). Genetic association studies. Lancet 366:1121-1131
    • (2005) Lancet , vol.366 , pp. 1121-1131
    • Cordell, H.J.1    Clayton, D.G.2
  • 12
    • 0037267068 scopus 로고    scopus 로고
    • How important are comprehensive literature searches and the assessment of trial quality in systematic reviews?
    • Egger M, Juni P, Bartlett C, Holenstein F, Sterne J. (2003). How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Health Technol Assess 7:1-76.
    • (2003) Health Technol Assess , vol.7 , pp. 1-76
    • Egger, M.1    Juni, P.2    Bartlett, C.3    Holenstein, F.4    Sterne, J.5
  • 17
    • 33748090675 scopus 로고    scopus 로고
    • A modified test for smallstudy effects in meta-analyses of controlled trials with binary endpoints
    • Harbord RM, Egger M, Sterne JA. (2006). A modified test for smallstudy effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25:3443-3457
    • (2006) Stat Med , vol.25 , pp. 3443-3457
    • Harbord, R.M.1    Egger, M.2    Sterne, J.A.3
  • 18
    • 0035459399 scopus 로고    scopus 로고
    • The power of statistical tests in metaanalysis
    • Hedges LV. Pigott DP. (2001). The power of statistical tests in metaanalysis. Psychol Meth 6:203-217
    • (2001) Psychol Meth , vol.6 , pp. 203-217
    • Hedges, L.V.1    Pigott, D.P.2
  • 21
    • 0036211765 scopus 로고    scopus 로고
    • Direction and impact of language bias in meta-analyses of controlled trials: Empirical study
    • Juni P, Holenstein F, Sterne J, Bartlett C, Egger M. (2002). Direction and impact of language bias in meta-analyses of controlled trials: empirical study. Int J Epidemiol 31:115-123
    • (2002) Int J Epidemiol , vol.31 , pp. 115-123
    • Juni, P.1    Holenstein, F.2    Sterne, J.3    Bartlett, C.4    Egger, M.5
  • 22
    • 68549092835 scopus 로고    scopus 로고
    • Genomic convergence of genomewide investigations for complex traits
    • Kitsios GD, Zintzaras E. (2009a). Genomic convergence of genomewide investigations for complex traits. Ann Hum Genet 73:514-519
    • (2009) Ann Hum Genet , vol.73 , pp. 514-519
    • Kitsios, G.D.1    Zintzaras, E.2
  • 23
    • 70249115596 scopus 로고    scopus 로고
    • Genome-wide association studies: Hypothesis. "free or engaged"?
    • Kitsios GD, Zintzaras E. (2009b). Genome-wide association studies: hypothesis. "Free or engaged"? Transl Res 154:161-164
    • (2009) Transl Res , vol.154 , pp. 161-164
    • Kitsios, G.D.1    Zintzaras, E.2
  • 27
    • 0032810850 scopus 로고    scopus 로고
    • Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications
    • Mahmud N, Molloy A, McPartlin J, Corbally R, Whitehead AS, Scott JM, Weir DG. (1999). Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications. Gut 45:389-394
    • (1999) Gut , vol.45 , pp. 389-394
    • Mahmud, N.1    Molloy, A.2    McPartlin, J.3    Corbally, R.4    Whitehead, A.S.5    Scott, J.M.6    Weir, D.G.7
  • 28
    • 0028220787 scopus 로고
    • Vitamin B-6 deficiency vs folate deficiency: Comparison of responses to methionine loading in rats
    • Miller JW, Nadeau MR, Smith D, Selhub J. (1994). Vitamin B-6 deficiency vs folate deficiency: comparison of responses to methionine loading in rats. Am J Clin Nutr 59:1033-1039
    • (1994) Am J Clin Nutr , vol.59 , pp. 1033-1039
    • Miller, J.W.1    Nadeau, M.R.2    Smith, D.3    Selhub, J.4
  • 30
    • 0035865701 scopus 로고    scopus 로고
    • Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: Relation to transcobalamin and homocysteine concentration in blood
    • Namour F, Olivier J, Abdelmouttaleb I, Adjalla C, Debard R, Salvat C, Guéant J. (2001). Transcobalamin codon 259 polymorphism in HT-29 and Caco-2 cells and in Caucasians: relation to transcobalamin and homocysteine concentration in blood. Blood 97:1092-1098
    • (2001) Blood , vol.97 , pp. 1092-1098
    • Namour, F.1    Olivier, J.2    Abdelmouttaleb, I.3    Adjalla, C.4    Debard, R.5    Salvat, C.6    Guéant, J.7
  • 34
    • 3142729014 scopus 로고    scopus 로고
    • Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine
    • Stipanuk MH. (2004). Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24:539-577
    • (2004) Annu Rev Nutr , vol.24 , pp. 539-577
    • Stipanuk, M.H.1
  • 38
    • 0033869354 scopus 로고    scopus 로고
    • Inflammatory bowel diseases are not associated with major hereditary conditions predisposing to thrombosis
    • Vecchi M, Sacchi E, Saibeni S, Meucci G, Tagliabue L, Duca F, De Franchis R. (2000). Inflammatory bowel diseases are not associated with major hereditary conditions predisposing to thrombosis. Dig Dis Sci 45:1465-1469
    • (2000) Dig Dis Sci , vol.45 , pp. 1465-1469
    • Vecchi, M.1    Sacchi, E.2    Saibeni, S.3    Meucci, G.4    Tagliabue, L.5    Duca, F.6    De Franchis, R.7
  • 40
    • 0031687887 scopus 로고    scopus 로고
    • A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity
    • Weisberg I, Tran P, Christensen B, Sibani S, Rozen R. (1998). A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172
    • (1998) Mol Genet Metab , vol.64 , pp. 169-172
    • Weisberg, I.1    Tran, P.2    Christensen, B.3    Sibani, S.4    Rozen, R.5
  • 41
    • 35748981184 scopus 로고    scopus 로고
    • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet 39:1329-1337
    • (2007) Nat Genet , vol.39 , pp. 1329-1337
  • 42
    • 34547633637 scopus 로고    scopus 로고
    • Factor v Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients
    • Yasa MH, Bolaman Z, Yukselen V, Kadikoylu G, Karaoglul AO, Batun S. (2007). Factor V Leiden G1691A, prothrombin G20210A, and MTHFR C677T mutations in Turkish inflammatory bowel disease patients. Hepatogastroenterology 54:1438-1442
    • (2007) Hepatogastroenterology , vol.54 , pp. 1438-1442
    • Yasa, M.H.1    Bolaman, Z.2    Yukselen, V.3    Kadikoylu, G.4    Karaoglul, A.O.5    Batun, S.6
  • 43
    • 33845252483 scopus 로고    scopus 로고
    • A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: Data from Turkey
    • Yilmaz S, Bayan K, Tüzün Y, Batun S, Altintaş A. (2006). A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease: data from Turkey. J Thromb Thrombolysis 22:205-212
    • (2006) J Thromb Thrombolysis , vol.22 , pp. 205-212
    • Yilmaz, S.1    Bayan, K.2    Tüzün, Y.3    Batun, S.4    Altintaş, A.5
  • 44
    • 39149085324 scopus 로고    scopus 로고
    • Genetic risk factors for placental abruption: A HuGE review and meta-analysis
    • Zdoukopoulos N, Zintzaras E. (2008). Genetic risk factors for placental abruption: a HuGE review and meta-analysis. Epidemiology 19:309-323
    • (2008) Epidemiology , vol.19 , pp. 309-323
    • Zdoukopoulos, N.1    Zintzaras, E.2
  • 45
    • 23844441200 scopus 로고    scopus 로고
    • The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: A meta-analysis
    • Zintzaras E, Chatzoulis DZ, Karabatsas CH, Stefanidis I. (2005). The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis. J Hum Genet 50:267-275
    • (2005) J Hum Genet , vol.50 , pp. 267-275
    • Zintzaras, E.1    Chatzoulis, D.Z.2    Karabatsas, C.H.3    Stefanidis, I.4
  • 47
    • 12744274510 scopus 로고    scopus 로고
    • Heterogeneity testing in meta-analysis of genome searches
    • Zintzaras E, Ioannidis JP. (2005). Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol 28:123-137
    • (2005) Genet Epidemiol , vol.28 , pp. 123-137
    • Zintzaras, E.1    Ioannidis, J.P.2
  • 48
    • 37648998741 scopus 로고    scopus 로고
    • Meta-analysis for ranked discovery datasets: Theoretical framework and empirical demonstration for microarrays
    • Zintzaras E, Ioannidis JP. (2008). Meta-analysis for ranked discovery datasets: theoretical framework and empirical demonstration for microarrays. Comput Biol Chem 32:38-46.
    • (2008) Comput Biol Chem , vol.32 , pp. 38-46
    • Zintzaras, E.1    Ioannidis, J.P.2
  • 49
    • 33750586809 scopus 로고    scopus 로고
    • Endothelial NO synthase gene polymorphisms and hypertension: A meta-analysis
    • Zintzaras E, Kitsios G, Stefanidis I. (2006b). Endothelial NO synthase gene polymorphisms and hypertension: a meta-analysis. Hypertension 48:700-710
    • (2006) Hypertension , vol.48 , pp. 700-710
    • Zintzaras, E.1    Kitsios, G.2    Stefanidis, I.3
  • 50
    • 33750090420 scopus 로고    scopus 로고
    • A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
    • Zintzaras E, Koufakis T, Ziakas PD, Rodopoulou P, Giannouli S, Voulgarelis M. (2006a). A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia. Eur J Epidemiol 21:501-510
    • (2006) Eur J Epidemiol , vol.21 , pp. 501-510
    • Zintzaras, E.1    Koufakis, T.2    Ziakas, P.D.3    Rodopoulou, P.4    Giannouli, S.5    Voulgarelis, M.6
  • 51
    • 39149139125 scopus 로고    scopus 로고
    • Synthesis of genetic association studies for pertinen gene-disease associations requires appropriate methodological and statistical approaches
    • Zintzaras E, Lau J. (2008a). Synthesis of genetic association studies for pertinent gene-disease associations requires appropriate methodological and statistical approaches. J Clin Epidemiol 61:634-645
    • (2008) J Clin Epidemiol , vol.61 , pp. 634-645
    • Zintzaras, E.1    Lau, J.2
  • 52
    • 37549016052 scopus 로고    scopus 로고
    • Trends in meta-analysis of genetic association studies
    • Zintzaras E, Lau J. (2008b). Trends in meta-analysis of genetic association studies. J Hum Genet 53:1-9.
    • (2008) J Hum Genet , vol.53 , pp. 1-9
    • Zintzaras, E.1    Lau, J.2
  • 53
    • 36148965526 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: A meta-analysis
    • Zintzaras E, Uhlig K, Koukoulis GN, Papathanasiou AA, Stefanidis I. (2007). Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis. J Hum Genet 52:881-890
    • (2007) J Hum Genet , vol.52 , pp. 881-890
    • Zintzaras, E.1    Uhlig, K.2    Koukoulis, G.N.3    Papathanasiou, A.A.4    Stefanidis, I.5
  • 54
    • 67650065294 scopus 로고    scopus 로고
    • A field synopsis and meta-analysis of genetic association studies in peripheral arterial disease: The CUMAGAS-PAD database
    • Zintzaras E, Zdoukopoulos N. (2009). A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database. Am J Epidemiol 170:1-11.
    • (2009) Am J Epidemiol , vol.170 , pp. 1-11
    • Zintzaras, E.1    Zdoukopoulos, N.2
  • 55
    • 33745889354 scopus 로고    scopus 로고
    • Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: A meta-analysis
    • Zintzaras E. (2006a). Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet 51:618-624
    • (2006) J Hum Genet , vol.51 , pp. 618-624
    • Zintzaras, E.1
  • 56
    • 34247101730 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: A meta-analysis
    • Zintzaras E. (2007). Brain-derived neurotrophic factor gene polymorphisms and schizophrenia: a meta-analysis. Psychiatr Genet 17:69-75.
    • (2007) Psychiatr Genet , vol.17 , pp. 69-75
    • Zintzaras, E.1
  • 57
    • 33746792898 scopus 로고    scopus 로고
    • C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: A meta-analysis of genetic association studies
    • Zintzaras E. (2006b). C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies. Psychiatr Genet 16:105-115
    • (2006) Psychiatr Genet , vol.16 , pp. 105-115
    • Zintzaras, E.1
  • 58
    • 33645472458 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: A meta-analysis
    • Zintzaras E. (2006c). Methylenetetrahydrofolate reductase gene and susceptibility to breast cancer: a meta-analysis. Clin Genet 69:327-336
    • (2006) Clin Genet , vol.69 , pp. 327-336
    • Zintzaras, E.1
  • 59
    • 42549168530 scopus 로고    scopus 로고
    • Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium
    • Zintzaras E. (2008). Variance estimation of allele-based odds ratio in the absence of Hardy-Weinberg equilibrium. Eur J Epidemiol 23:323-326
    • (2008) Eur J Epidemiol , vol.23 , pp. 323-326
    • Zintzaras, E.1


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