Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population

Clinical Cancer Research

Volumn 13, Issue 8, 2007, Pages 2526-2532

  Wang, Lina ^a   Ke, Qiao ^a   Chen, Wensen ^a   Wang, Jianming ^b   Tan, Yongfei ^c   Zhou, Yan ^c   Hua, Zhaolai ^b   Ding, Weiliang ^c   Niu, Juying ^a   Shen, Jing ^a   Zhang, Zuofeng ^d   Wang, Xinru ^a   Xu, Yaochu ^a   Shen, Hongbing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Yangzhong Cancer Research Institute   (China)

^c Yixing People's Hospital   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE;

ADULT; AGED; ARTICLE; CANCER RISK; CHINA; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; STOMACH CANCER;

ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; DNA, NEOPLASM; HOMOCYSTEINE; HUMANS; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REFERENCE VALUES; RISK FACTORS; STOMACH NEOPLASMS;

EID: 34247855047     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-2293     Document Type: Article

References (48)

1. Plummer M, Franceschi S, Munoz N. Epidemiology of gastric cancer. IARC Sci Publ 2004;157:311-26.
2. Echem R. Gastric cancer is a major cause of cancer death. Niger J Med 2003;12:175-6.
3. Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J 2005;81:419-24.
4. Sun X, Mu R, Zhou Y, et al. 1990-1992 mortality of stomach cancer in China. Zhonghua Zhong Liu Za Zhi 2002;24:4-8.
5. Kobayashi M, Tsubono Y, Sasazuki S, Sasaki S, Tsugane S; JPHC Study Group. Vegetables, fruit and risk of gastric cancer in Japan: a 10-year follow-up of the JPHC study cohort I. Int J Cancer 2002;102: 39-44.
6. Kelley JR, Duggan JM. Gastric cancer epidemiology and risk factors. J Clin Epidemiol 2003;56:1-9.
7. Bailey LB, Gregory JF, Caudill M, Cruz A. The relationship between increased folate stetabolism and the increased requirement for folate in pregnancy. Br J Obstet Gynaecol 2001;108:772-3.
8. Mayne ST, Risch HA, Dubrow R, et al. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 2001;10: 1055-62.
9. Xiao SD, Meng XJ, Shi Y, Hu YB, Zhu SS, Wang CW. Interventional study of high dose folic acid in gastric carcinogenesis in beagles. Gut 2002;50:61-4.
10. Zhu S, Mason J, Shi Y, et al. The effect of folic acid on the development of stomach and other gastrointestinal cancers. Chin Med J Engl 2003;116:15-9.
11. Scott J, Weir D. Folate/vitamin B12 inter-relationships. Essays Biochem 1994;28:63-72.
12. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
13. Molloy AM, Daly S, Mills JL, et al. Thermolabile variant of 5, 10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 1997;349: 1591-3.
14. Vizcaino G, Diez-Ewald M, Herrmann FH, et al. Homocysteinemia and its relationship with the methylenetetrahydrofolate reductase polymorphism in various ethnic groups from western Venezuela. Invest Clin 2005;46:347-55.
15. Shen H, Newmann AS, Hu Z, et al. Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: a case-control analysis in China. Oncol Rep 2005;13:355-60.
16. Lacasana-Navarro M, Galvan-Portillo M, Chen J, Lopez-Cervantes M, Lopez-Carrillo L. Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico. Eur J Cancer 2006;42:528-33.
17. Tan W, Miao X, Wang L, et al. Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status. Carcinogenesis 2005;26:1430-5.
18. Zhang Z, Xu Y, Zhou J, et al. Polymorphisms of thymidylate synthase in the 5′- and 3′-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. Carcinogenesis 2005; 26:1764-9.
19. Stolzenberg-Solomon RZ, Qiao YL, Abnet CC, et al. Esophageal and gastric cardia cancer risk and folate-and vitamin B (12)-related polymorphisms in Linxian, China. Cancer Epidemiol Biomarkers Prev 2003;12: 1222-6.
20. Graziano F, Kawakami K, Watanabe G, et al. Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. Int J Cancer 2004;112: 1010-4.
21. Hol FA, van der Put NM, Geurds MP, et al. Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate- dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects. Clin Genet 1998;53:119-25.
22. Christensen KE, Patel H, Kuzmanov U, Mejia NR, MacKenzie RE. Disruption of the mthfd1 gene reveals a monofunctional 10-formyltetrahydrofolate synthetase in mammalian mitochondria. J Biol Chem 2005; 280:7597-602.
23. Cheng J, Zhu WL, Dao JJ, Li SQ, Li Y. Relationship between polymorphism of methylenetetrahydrofolate dehydrogenase and congenital heart defect. Biomed Environ Sci 2005;18:58-64.
24. Li Y, Cheng J, Zhu WL, et al. Study of serum Hcy and polymorphisms of Hcy metabolic enzymes in 192 families affected by congenital heart disease. Beijing Da Xue Xue Bao 2005;37:75-80.
25. Brody LC, Conley M, Cox C, et al. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/ methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 2002;71:1207-15.
26. Parle-McDermott A, Kirke PN, Mills JL, et al. Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet 2006;14:768-72.
27. Shi M, Caprau D, Romitti P, Christensen K, Murray JC. Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1 and GCP2. Birth Defects Res A Clin Mol Teratol 2003;67:545-9.
28. Li SY, Rong M, Iacopetta B. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer. Oncol Rep 2006;15:221-5.
29. Chen J, Kyte C, Valcin M, et al. Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 2004;110:617-20.
30. De Jonge R, Hooijberg JH, van Zelst BD, et al. Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia. Blood 2005;106:717-20. Erratum in: Blood 2005;106:1198.
31. Krajinovic M, Lemieux-Blanchard E, Chiasson S, Primeau M, Costea I, Moghrabi A. Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia. Pharmacogenomics J 2004;4:66-72.
32. Chan EC, Chang PY, Wu TL, Wu JT. Enzymatic assay of homocysteine on microtiter plates or a TECAN analyzer using crude lysate containing recombinant methionine gamma-lyase. Ann Clin Lab Sci 2005;35: 155-60.
33. Takezaki T, Gao CM, Wu JZ, et al. Dietary protective and risk factors for esophageal and stomach cancers in a low-epidemic area for stomach cancer in Jiangsu Province, China: comparison with those in a high-epidemic area. Jpn J Cancer Res 2001;92:1157-65.
34. Engel LS, Chow WH, Vaughan TL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 2003;95:1404-13.
35. Kang SS, Wong PW, Zhou JM, et al. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism 1988;37:611-3.
36. Larsson SC, Giovannucci E, Wolk A. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology 2006;131:1271-83.
37. Wang L, Chen W, Wang J, et al. Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur J Cancer 2006;42:3206-11. Epub 2006 Sep 8.
38. Kohlmeier M, da Costa KA, Fischer LM, Zeisel SH. Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. Proc Natl Acad Sci U S A 2005; 102:16025-30.
39. Wu LL, Wu JT. Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker. Clin Chim Acta 2002:322:21-8.
40. Sun CF, Haven TR, Wu TL, Tsao KC, Wu JT. Serum total homocysteine increases with the rapid proliferation rate of tumor cells and decline upon cell death: a potential new tumor marker. Clin Chim Acta 2002; 321:55-62.
41. Alberg AJ, Selhub J, Shah KV, Viscidi RP, Comstock GW, Helzlsouer KJ. The risk of cervical cancer in relation to serum concentrations of folate, vitamin B12, and homocysteine. Cancer Epidemiol Biomarkers Prev 2000;9:761-4.
42. HartmanTJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5′-phosphate (B(6)), B(12), and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.
43. Almadori G, Bussu F, Galli J, et al. Serum levels of folate, homocysteine, and vitamin B12 in head and neck squamous cell carcinoma and in laryngeal leukoplakia. Cancer 2005;103:284-92.
44. Ruud E, Holmstrom H, Brosstad F, Wesenberg F. Children with acute lymphoblastic leukaemia have high plasma levels of total homocysteine at time of diagnosis. Scand J Clin Lab Invest 2006;66: 67-78.
45. Van Guelpen B, Hultdin J, Johansson I, et al. Low folate levels may protect against colorectal cancer. Gut 2006;55:1461-6.
46. Yilmaz M, Biri A, Bukan N, et al. Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. Gynecol Endocrinol 2005;20:258-63.
47. Giovannucci E. Alcohol, one-carbon metabolism, and colorectal cancer: recent insights from molecular studies. Nutr 2004;134:2475-81S.
48. Ma J, Stampfer MJ, Christensen B, et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocysteine, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 1999;8:825-9.