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Volumn 41, Issue 2, 2015, Pages 105-113

Drug radiotherapy combinations: Review of previous failures and reasons for future optimism

Author keywords

Chemo radiotherapy; Drug radiotherapy combinations; Radiosensitisation; Tumour hypoxia

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; 2 NITROIMIDAZOLE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALKALINE PHOSPHATASE; AMIFOSTINE; ANGIOGENESIS INHIBITOR; ARABINOSIDE; ATR PROTEIN; BEVACIZUMAB; BIOLOGICAL MARKER; BUPARLISIB; CARBONATE DEHYDRATASE; CEDIRANIB; CETUXIMAB; EVEROLIMUS; EVOFOSFAMIDE; FLUORODEOXYGLUCOSE F 18; GEFITINIB; METFORMIN; MISONIDAZOLE; NELFINAVIR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NIMORAZOLE; NITROIMIDAZOLE; NITROIMIDAZOLE DERIVATIVE; PANITUMUMAB; SELUMETINIB; TEMSIROLIMUS; TIRAPAZAMINE; UNINDEXED DRUG; ANTINEOPLASTIC AGENT; RADIOSENSITIZING AGENT;

EID: 84921763721     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2014.12.012     Document Type: Review
Times cited : (72)

References (82)
  • 1
    • 22444441668 scopus 로고    scopus 로고
    • Towards evidence-based guidelines for radiotherapy infrastructure and staffing needs in Europe: the ESTRO QUARTS project
    • Epub 2005/08/10
    • Bentzen S.M., Heeren G., Cottier B., Slotman B., Glimelius B., Lievens Y., et al. Towards evidence-based guidelines for radiotherapy infrastructure and staffing needs in Europe: the ESTRO QUARTS project. Radiother Oncol 2005, 75(3):355-365. Epub 2005/08/10.
    • (2005) Radiother Oncol , vol.75 , Issue.3 , pp. 355-365
    • Bentzen, S.M.1    Heeren, G.2    Cottier, B.3    Slotman, B.4    Glimelius, B.5    Lievens, Y.6
  • 2
    • 84870454408 scopus 로고    scopus 로고
    • Image-guided radiotherapy: from current concept to future perspectives
    • Epub 2012/11/21
    • Jaffray D.A. Image-guided radiotherapy: from current concept to future perspectives. Nat Rev Clin Oncol 2012, 9(12):688-699. Epub 2012/11/21.
    • (2012) Nat Rev Clin Oncol , vol.9 , Issue.12 , pp. 688-699
    • Jaffray, D.A.1
  • 3
    • 2342635919 scopus 로고    scopus 로고
    • Cell death by mitotic catastrophe: a molecular definition
    • Epub 2004/04/13
    • Castedo M., Perfettini J.L., Roumier T., Andreau K., Medema R., Kroemer G. Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004, 23(16):2825-2837. Epub 2004/04/13.
    • (2004) Oncogene , vol.23 , Issue.16 , pp. 2825-2837
    • Castedo, M.1    Perfettini, J.L.2    Roumier, T.3    Andreau, K.4    Medema, R.5    Kroemer, G.6
  • 4
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Epub 2004/07/16
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004, 14(3):198-206. Epub 2004/07/16.
    • (2004) Semin Radiat Oncol , vol.14 , Issue.3 , pp. 198-206
    • Vaupel, P.1
  • 5
    • 77952298828 scopus 로고    scopus 로고
    • Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer
    • Epub 2010/03/31
    • Auperin A., Le Pechoux C., Rolland E., Curran W.J., Furuse K., Fournel P., et al. Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol 2010, 28(13):2181-2190. Epub 2010/03/31.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2181-2190
    • Auperin, A.1    Le Pechoux, C.2    Rolland, E.3    Curran, W.J.4    Furuse, K.5    Fournel, P.6
  • 6
    • 0035828388 scopus 로고    scopus 로고
    • Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis
    • Epub 2001/09/21
    • Green J.A., Kirwan J.M., Tierney J.F., Symonds P., Fresco L., Collingwood M., et al. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 2001, 358(9284):781-786. Epub 2001/09/21.
    • (2001) Lancet , vol.358 , Issue.9284 , pp. 781-786
    • Green, J.A.1    Kirwan, J.M.2    Tierney, J.F.3    Symonds, P.4    Fresco, L.5    Collingwood, M.6
  • 7
    • 66949128922 scopus 로고    scopus 로고
    • Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients
    • Epub 2009/05/19
    • Pignon J.P., le Maitre A., Maillard E., Bourhis J. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 2009, 92(1):4-14. Epub 2009/05/19.
    • (2009) Radiother Oncol , vol.92 , Issue.1 , pp. 4-14
    • Pignon, J.P.1    le Maitre, A.2    Maillard, E.3    Bourhis, J.4
  • 8
    • 33750580102 scopus 로고    scopus 로고
    • Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203
    • Epub 2006/09/30
    • Gerard J.P., Conroy T., Bonnetain F., Bouche O., Chapet O., Closon-Dejardin M.T., et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006, 24(28):4620-4625. Epub 2006/09/30.
    • (2006) J Clin Oncol , vol.24 , Issue.28 , pp. 4620-4625
    • Gerard, J.P.1    Conroy, T.2    Bonnetain, F.3    Bouche, O.4    Chapet, O.5    Closon-Dejardin, M.T.6
  • 9
    • 40749094856 scopus 로고    scopus 로고
    • Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer
    • Epub 2008/03/01
    • Bussink J., van der Kogel A.J., Kaanders J.H. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol 2008, 9(3):288-296. Epub 2008/03/01.
    • (2008) Lancet Oncol , vol.9 , Issue.3 , pp. 288-296
    • Bussink, J.1    van der Kogel, A.J.2    Kaanders, J.H.3
  • 10
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Epub 2006/02/10
    • Bonner J.A., Harari P.M., Giralt J., Azarnia N., Shin D.M., Cohen R.B., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. New Engl J Med 2006, 354(6):567-578. Epub 2006/02/10.
    • (2006) New Engl J Med , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3    Azarnia, N.4    Shin, D.M.5    Cohen, R.B.6
  • 11
    • 80053368876 scopus 로고    scopus 로고
    • A Randomized Phase III Trial (RTOG 0522) of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III-IV Head and Neck Squamous Cell Carcinomas (HNC).
    • editors. American Society of Clinical Oncology Annual Meeting; Chicago:
    • Ang KK, Zhang Q, Rosenthal DI, Nguyen-Tan PF, Sherman E, Weber R, et al., editors. A Randomized Phase III Trial (RTOG 0522) of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III-IV Head and Neck Squamous Cell Carcinomas (HNC). American Society of Clinical Oncology Annual Meeting; 2011; Chicago: J Clin Oncol.
    • (2011) J Clin Oncol.
    • Ang, K.K.1    Zhang, Q.2    Rosenthal, D.I.3    Nguyen-Tan, P.F.4    Sherman, E.5    Weber, R.6
  • 13
    • 84874110209 scopus 로고    scopus 로고
    • Systematic review of amifostine for the management of oral mucositis in cancer patients
    • Epub 2012/10/12
    • Nicolatou-Galitis O., Sarri T., Bowen J., Di Palma M., Kouloulias V.E., Niscola P., et al. Systematic review of amifostine for the management of oral mucositis in cancer patients. Support Care Cancer 2013, 21(1):357-364. Epub 2012/10/12.
    • (2013) Support Care Cancer , vol.21 , Issue.1 , pp. 357-364
    • Nicolatou-Galitis, O.1    Sarri, T.2    Bowen, J.3    Di Palma, M.4    Kouloulias, V.E.5    Niscola, P.6
  • 15
    • 0024384825 scopus 로고
    • Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study
    • Epub 1989/04/01
    • Overgaard J., Hansen H.S., Andersen A.P., Hjelm-Hansen M., Jorgensen K., Sandberg E., et al. Misonidazole combined with split-course radiotherapy in the treatment of invasive carcinoma of larynx and pharynx: report from the DAHANCA 2 study. Int J Radiat Oncol Biol Phys 1989, 16(4):1065-1068. Epub 1989/04/01.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , Issue.4 , pp. 1065-1068
    • Overgaard, J.1    Hansen, H.S.2    Andersen, A.P.3    Hjelm-Hansen, M.4    Jorgensen, K.5    Sandberg, E.6
  • 16
    • 0031909654 scopus 로고    scopus 로고
    • A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85
    • Epub 1998/03/24
    • Overgaard J., Hansen H.S., Overgaard M., Bastholt L., Berthelsen A., Specht L., et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol 1998, 46(2):135-146. Epub 1998/03/24.
    • (1998) Radiother Oncol , vol.46 , Issue.2 , pp. 135-146
    • Overgaard, J.1    Hansen, H.S.2    Overgaard, M.3    Bastholt, L.4    Berthelsen, A.5    Specht, L.6
  • 17
    • 84455209531 scopus 로고    scopus 로고
    • Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck
    • Epub 2011/10/15
    • Toustrup K., Sorensen B.S., Lassen P., Wiuf C., Alsner J., Overgaard J. Gene expression classifier predicts for hypoxic modification of radiotherapy with nimorazole in squamous cell carcinomas of the head and neck. Radiother Oncol 2012, 102(1):122-129. Epub 2011/10/15.
    • (2012) Radiother Oncol , vol.102 , Issue.1 , pp. 122-129
    • Toustrup, K.1    Sorensen, B.S.2    Lassen, P.3    Wiuf, C.4    Alsner, J.5    Overgaard, J.6
  • 18
    • 84887954229 scopus 로고    scopus 로고
    • Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates
    • Epub 2013/10/17
    • Rami M., Dubois L., Parvathaneni N.K., Alterio V., van Kuijk S.J., Monti S.M., et al. Hypoxia-targeting carbonic anhydrase IX inhibitors by a new series of nitroimidazole-sulfonamides/sulfamides/sulfamates. J Med Chem 2013, 56(21):8512-8520. Epub 2013/10/17.
    • (2013) J Med Chem , vol.56 , Issue.21 , pp. 8512-8520
    • Rami, M.1    Dubois, L.2    Parvathaneni, N.K.3    Alterio, V.4    van Kuijk, S.J.5    Monti, S.M.6
  • 19
    • 84887019683 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs
    • Epub 2013/07/16
    • Dubois L., Peeters S.G., van Kuijk S.J., Yaromina A., Lieuwes N.G., Saraya R., et al. Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs. Radiother Oncol 2013, 108(3):523-528. Epub 2013/07/16.
    • (2013) Radiother Oncol , vol.108 , Issue.3 , pp. 523-528
    • Dubois, L.1    Peeters, S.G.2    van Kuijk, S.J.3    Yaromina, A.4    Lieuwes, N.G.5    Saraya, R.6
  • 20
    • 67649380881 scopus 로고    scopus 로고
    • Tirapazamine: a novel agent targeting hypoxic tumor cells
    • Reddy S.B., Williamson S.K. Tirapazamine: a novel agent targeting hypoxic tumor cells. Expert Opin Investig Drugs 2009, 18(1):77-87.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.1 , pp. 77-87
    • Reddy, S.B.1    Williamson, S.K.2
  • 21
    • 84896341950 scopus 로고    scopus 로고
    • Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy
    • Epub 2013/12/18
    • Saggar J.K., Tannock I.F. Activity of the hypoxia-activated pro-drug TH-302 in hypoxic and perivascular regions of solid tumors and its potential to enhance therapeutic effects of chemotherapy. Int J Cancer 2014, 134(11):2726-2734. Epub 2013/12/18.
    • (2014) Int J Cancer , vol.134 , Issue.11 , pp. 2726-2734
    • Saggar, J.K.1    Tannock, I.F.2
  • 22
    • 84863786833 scopus 로고    scopus 로고
    • TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules
    • Epub 2012/03/03
    • Liu Q., Sun J.D., Wang J., Ahluwalia D., Baker A.F., Cranmer L.D., et al. TH-302, a hypoxia-activated prodrug with broad in vivo preclinical combination therapy efficacy: optimization of dosing regimens and schedules. Cancer Chemother Pharmacol 2012, 69(6):1487-1498. Epub 2012/03/03.
    • (2012) Cancer Chemother Pharmacol , vol.69 , Issue.6 , pp. 1487-1498
    • Liu, Q.1    Sun, J.D.2    Wang, J.3    Ahluwalia, D.4    Baker, A.F.5    Cranmer, L.D.6
  • 23
    • 84907515188 scopus 로고    scopus 로고
    • Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma
    • Chawla S.P., Cranmer L.D., Van Tine B.A., Reed D.R., Okuno S.H., Butrynski J.E., et al. Phase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma. J Clin Oncol 2014, 32(29):3299-3306.
    • (2014) J Clin Oncol , vol.32 , Issue.29 , pp. 3299-3306
    • Chawla, S.P.1    Cranmer, L.D.2    Van Tine, B.A.3    Reed, D.R.4    Okuno, S.H.5    Butrynski, J.E.6
  • 24
    • 84863994324 scopus 로고    scopus 로고
    • Elusive goal of targeting tumor hypoxia for therapeutic gain
    • Peters L., Rischin D. Elusive goal of targeting tumor hypoxia for therapeutic gain. J Clin Oncol 2012, 30(15):1741-1743.
    • (2012) J Clin Oncol , vol.30 , Issue.15 , pp. 1741-1743
    • Peters, L.1    Rischin, D.2
  • 25
    • 84907981841 scopus 로고    scopus 로고
    • PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence
    • Epub 2014/07/02
    • Lopci E., Grassi I., Chiti A., Nanni C., Cicoria G., Toschi L., et al. PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence. Am J Nucl Med Mol Imaging 2014, 4(4):365-384. Epub 2014/07/02.
    • (2014) Am J Nucl Med Mol Imaging , vol.4 , Issue.4 , pp. 365-384
    • Lopci, E.1    Grassi, I.2    Chiti, A.3    Nanni, C.4    Cicoria, G.5    Toschi, L.6
  • 26
    • 33646454133 scopus 로고    scopus 로고
    • Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02
    • Epub 2006/05/02.
    • Rischin D, Hicks RJ, Fisher R, Binns D, Corry J, Porceddu S, et al. Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2006;24(13):2098-2104. Epub 2006/05/02.
    • (2006) Journal of clinical oncology: official journal of the American Society of Clinical Oncology , vol.24 , Issue.13 , pp. 2098-2104
    • Rischin, D.1    Hicks, R.J.2    Fisher, R.3    Binns, D.4    Corry, J.5    Porceddu, S.6
  • 28
    • 84868360868 scopus 로고    scopus 로고
    • Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer
    • Zips D., Zophel K., Abolmaali N., Perrin R., Abramyuk A., Haase R., et al. Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer. Radiother Oncol 2012, 105(1):21-28.
    • (2012) Radiother Oncol , vol.105 , Issue.1 , pp. 21-28
    • Zips, D.1    Zophel, K.2    Abolmaali, N.3    Perrin, R.4    Abramyuk, A.5    Haase, R.6
  • 30
    • 77958466808 scopus 로고    scopus 로고
    • Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma
    • Epub 2010/06/30
    • Koch C.J., Scheuermann J.S., Divgi C., Judy K.D., Kachur A.V., Freifelder R., et al. Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma. Eur J Nucl Med Mol Imaging 2010, 37(11):2048-2059. Epub 2010/06/30.
    • (2010) Eur J Nucl Med Mol Imaging , vol.37 , Issue.11 , pp. 2048-2059
    • Koch, C.J.1    Scheuermann, J.S.2    Divgi, C.3    Judy, K.D.4    Kachur, A.V.5    Freifelder, R.6
  • 31
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Epub 2009/02/26
    • Nagy J.A., Chang S.H., Dvorak A.M., Dvorak H.F. Why are tumour blood vessels abnormal and why is it important to know?. Br J Cancer 2009, 100(6):865-869. Epub 2009/02/26.
    • (2009) Br J Cancer , vol.100 , Issue.6 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 32
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Epub 1953/12/01
    • Gray L.H., Conger A.D., Ebert M., Hornsey S., Scott O.C. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953, 26(312):638-648. Epub 1953/12/01.
    • (1953) Br J Radiol , vol.26 , Issue.312 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3    Hornsey, S.4    Scott, O.C.5
  • 33
  • 34
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
    • Epub 2007/04/20
    • Giantonio B.J., Catalano P.J., Meropol N.J., O'Dwyer P.J., Mitchell E.P., Alberts S.R., et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007, 25(12):1539-1544. Epub 2007/04/20.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6
  • 35
    • 79960096827 scopus 로고    scopus 로고
    • Normalization of the vasculature for treatment of cancer and other diseases
    • Epub 2011/07/12
    • Goel S., Duda D.G., Xu L., Munn L.L., Boucher Y., Fukumura D., et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011, 91(3):1071-1121. Epub 2011/07/12.
    • (2011) Physiol Rev , vol.91 , Issue.3 , pp. 1071-1121
    • Goel, S.1    Duda, D.G.2    Xu, L.3    Munn, L.L.4    Boucher, Y.5    Fukumura, D.6
  • 36
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Epub 2006/12/15
    • Sandler A., Gray R., Perry M.C., Brahmer J., Schiller J.H., Dowlati A., et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. New Engl J Med 2006, 355(24):2542-2550. Epub 2006/12/15.
    • (2006) New Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3    Brahmer, J.4    Schiller, J.H.5    Dowlati, A.6
  • 37
    • 34250660932 scopus 로고    scopus 로고
    • Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization
    • Epub 2007/06/05
    • Dings R.P., Loren M., Heun H., McNiel E., Griffioen A.W., Mayo K.H., et al. Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization. Clin Cancer Res 2007, 13(11):3395-3402. Epub 2007/06/05.
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3395-3402
    • Dings, R.P.1    Loren, M.2    Heun, H.3    McNiel, E.4    Griffioen, A.W.5    Mayo, K.H.6
  • 38
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • Epub 2014/02/21
    • Chinot O.L., Wick W., Mason W., Henriksson R., Saran F., Nishikawa R., et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. New Engl J Med 2014, 370(8):709-722. Epub 2014/02/21.
    • (2014) New Engl J Med , vol.370 , Issue.8 , pp. 709-722
    • Chinot, O.L.1    Wick, W.2    Mason, W.3    Henriksson, R.4    Saran, F.5    Nishikawa, R.6
  • 41
    • 84858857598 scopus 로고    scopus 로고
    • NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
    • Epub 2012/03/29
    • Fokas E., Yoshimura M., Prevo R., Higgins G., Hackl W., Maira S.M., et al. NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity. Radiat Oncol 2012, 7:48. Epub 2012/03/29.
    • (2012) Radiat Oncol , vol.7 , pp. 48
    • Fokas, E.1    Yoshimura, M.2    Prevo, R.3    Higgins, G.4    Hackl, W.5    Maira, S.M.6
  • 42
    • 33745095268 scopus 로고    scopus 로고
    • Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer
    • Epub 2006/05/30
    • Albert J.M., Kim K.W., Cao C., Lu B. Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer. Mol Cancer Ther 2006, 5(5):1183-1189. Epub 2006/05/30.
    • (2006) Mol Cancer Ther , vol.5 , Issue.5 , pp. 1183-1189
    • Albert, J.M.1    Kim, K.W.2    Cao, C.3    Lu, B.4
  • 43
    • 24944520308 scopus 로고    scopus 로고
    • HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo
    • Epub 2005/09/17
    • Gupta A.K., Cerniglia G.J., Mick R., McKenna W.G., Muschel R.J. HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo. Cancer Res 2005, 65(18):8256-8265. Epub 2005/09/17.
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8256-8265
    • Gupta, A.K.1    Cerniglia, G.J.2    Mick, R.3    McKenna, W.G.4    Muschel, R.J.5
  • 44
    • 65649120430 scopus 로고    scopus 로고
    • In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase
    • Epub 2009/04/16
    • Chung E.J., Brown A.P., Asano H., Mandler M., Burgan W.E., Carter D., et al. In vitro and in vivo radiosensitization with AZD6244 (ARRY-142886), an inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 kinase. Clin Cancer Res 2009, 15(9):3050-3057. Epub 2009/04/16.
    • (2009) Clin Cancer Res , vol.15 , Issue.9 , pp. 3050-3057
    • Chung, E.J.1    Brown, A.P.2    Asano, H.3    Mandler, M.4    Burgan, W.E.5    Carter, D.6
  • 45
    • 68049144956 scopus 로고    scopus 로고
    • Tumor vascular changes mediated by inhibition of oncogenic signaling
    • Epub 2009/07/23
    • Qayum N., Muschel R.J., Im J.H., Balathasan L., Koch C.J., Patel S., et al. Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res 2009, 69(15):6347-6354. Epub 2009/07/23.
    • (2009) Cancer Res , vol.69 , Issue.15 , pp. 6347-6354
    • Qayum, N.1    Muschel, R.J.2    Im, J.H.3    Balathasan, L.4    Koch, C.J.5    Patel, S.6
  • 46
    • 84855371890 scopus 로고    scopus 로고
    • Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature
    • Epub 2011/11/24
    • Fokas E., Im J.H., Hill S., Yameen S., Stratford M., Beech J., et al. Dual inhibition of the PI3K/mTOR pathway increases tumor radiosensitivity by normalizing tumor vasculature. Cancer Res 2012, 72(1):239-248. Epub 2011/11/24.
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 239-248
    • Fokas, E.1    Im, J.H.2    Hill, S.3    Yameen, S.4    Stratford, M.5    Beech, J.6
  • 47
    • 84858756851 scopus 로고    scopus 로고
    • A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response
    • Epub 2012/03/20
    • Rengan R., Mick R., Pryma D., Rosen M.A., Lin L.L., Maity A.M., et al. A phase I trial of the HIV protease inhibitor nelfinavir with concurrent chemoradiotherapy for unresectable stage IIIA/IIIB non-small cell lung cancer: a report of toxicities and clinical response. J Thorac Oncol 2012, 7(4):709-715. Epub 2012/03/20.
    • (2012) J Thorac Oncol , vol.7 , Issue.4 , pp. 709-715
    • Rengan, R.1    Mick, R.2    Pryma, D.3    Rosen, M.A.4    Lin, L.L.5    Maity, A.M.6
  • 48
    • 84879032265 scopus 로고    scopus 로고
    • Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer
    • Epub 2013/05/08
    • Buijsen J., Lammering G., Jansen R.L., Beets G.L., Wals J., Sosef M., et al. Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer. Radiother Oncol 2013, 107(2):184-188. Epub 2013/05/08.
    • (2013) Radiother Oncol , vol.107 , Issue.2 , pp. 184-188
    • Buijsen, J.1    Lammering, G.2    Jansen, R.L.3    Beets, G.L.4    Wals, J.5    Sosef, M.6
  • 49
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Epub 2005/04/15
    • Farmer H., McCabe N., Lord C.J., Tutt A.N., Johnson D.A., Richardson T.B., et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005, 434(7035):917-921. Epub 2005/04/15.
    • (2005) Nature , vol.434 , Issue.7035 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3    Tutt, A.N.4    Johnson, D.A.5    Richardson, T.B.6
  • 50
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Epub 2005/04/15
    • Bryant H.E., Schultz N., Thomas H.D., Parker K.M., Flower D., Lopez E., et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005, 434(7035):913-917. Epub 2005/04/15.
    • (2005) Nature , vol.434 , Issue.7035 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3    Parker, K.M.4    Flower, D.5    Lopez, E.6
  • 51
    • 0027976408 scopus 로고
    • Initial events in the cellular effects of ionizing radiations: clustered damage in DNA
    • Epub 1994/01/01
    • Goodhead D.T. Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol 1994, 65(1):7-17. Epub 1994/01/01.
    • (1994) Int J Radiat Biol , vol.65 , Issue.1 , pp. 7-17
    • Goodhead, D.T.1
  • 52
    • 23344444636 scopus 로고    scopus 로고
    • Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
    • Epub 2005/08/02
    • Saleh-Gohari N., Bryant H.E., Schultz N., Parker K.M., Cassel T.N., Helleday T. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol Cell Biol 2005, 25(16):7158-7169. Epub 2005/08/02.
    • (2005) Mol Cell Biol , vol.25 , Issue.16 , pp. 7158-7169
    • Saleh-Gohari, N.1    Bryant, H.E.2    Schultz, N.3    Parker, K.M.4    Cassel, T.N.5    Helleday, T.6
  • 53
    • 77957944911 scopus 로고    scopus 로고
    • Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers
    • Epub 2010/04/23
    • Powell C., Mikropoulos C., Kaye S.B., Nutting C.M., Bhide S.A., Newbold K., et al. Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers. Cancer Treat Rev 2010, 36(7):566-575. Epub 2010/04/23.
    • (2010) Cancer Treat Rev , vol.36 , Issue.7 , pp. 566-575
    • Powell, C.1    Mikropoulos, C.2    Kaye, S.B.3    Nutting, C.M.4    Bhide, S.A.5    Newbold, K.6
  • 55
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: making it safe to play with knives
    • Epub 2010/10/23
    • Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Mol Cell 2010, 40(2):179-204. Epub 2010/10/23.
    • (2010) Mol Cell , vol.40 , Issue.2 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 56
    • 77958498222 scopus 로고    scopus 로고
    • The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer
    • Epub 2010/11/03
    • Smith J., Tho L.M., Xu N., Gillespie D.A. The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. Adv Cancer Res 2010, 108:73-112. Epub 2010/11/03.
    • (2010) Adv Cancer Res , vol.108 , pp. 73-112
    • Smith, J.1    Tho, L.M.2    Xu, N.3    Gillespie, D.A.4
  • 57
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Epub 2008/10/25
    • Ding L., Getz G., Wheeler D.A., Mardis E.R., McLellan M.D., Cibulskis K., et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455(7216):1069-1075. Epub 2008/10/25.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3    Mardis, E.R.4    McLellan, M.D.5    Cibulskis, K.6
  • 58
    • 79953773734 scopus 로고    scopus 로고
    • Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents
    • Epub 2011/03/19
    • Charrier J.D., Durrant S.J., Golec J.M., Kay D.P., Knegtel R.M., MacCormick S., et al. Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem 2011, 54(7):2320-2330. Epub 2011/03/19.
    • (2011) J Med Chem , vol.54 , Issue.7 , pp. 2320-2330
    • Charrier, J.D.1    Durrant, S.J.2    Golec, J.M.3    Kay, D.P.4    Knegtel, R.M.5    MacCormick, S.6
  • 59
    • 84875143334 scopus 로고    scopus 로고
    • Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity
    • Epub 2013/02/12
    • Foote K.M., Blades K., Cronin A., Fillery S., Guichard S.S., Hassall L., et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem 2013, 56(5):2125-2138. Epub 2013/02/12.
    • (2013) J Med Chem , vol.56 , Issue.5 , pp. 2125-2138
    • Foote, K.M.1    Blades, K.2    Cronin, A.3    Fillery, S.4    Guichard, S.S.5    Hassall, L.6
  • 60
    • 84871237979 scopus 로고    scopus 로고
    • Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
    • Epub 2012/12/12
    • Fokas E., Prevo R., Pollard J.R., Reaper P.M., Charlton P.A., Cornelissen B., et al. Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation. Cell Death Dis 2012, 3:e441. Epub 2012/12/12.
    • (2012) Cell Death Dis , vol.3 , pp. e441
    • Fokas, E.1    Prevo, R.2    Pollard, J.R.3    Reaper, P.M.4    Charlton, P.A.5    Cornelissen, B.6
  • 61
    • 79959376888 scopus 로고    scopus 로고
    • Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR
    • Epub 2011/04/15
    • Reaper P.M., Griffiths M.R., Long J.M., Charrier J.D., Maccormick S., Charlton P.A., et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol 2011, 7(7):428-430. Epub 2011/04/15.
    • (2011) Nat Chem Biol , vol.7 , Issue.7 , pp. 428-430
    • Reaper, P.M.1    Griffiths, M.R.2    Long, J.M.3    Charrier, J.D.4    Maccormick, S.5    Charlton, P.A.6
  • 62
    • 84865843265 scopus 로고    scopus 로고
    • The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
    • Epub 2012/07/25
    • Prevo R., Fokas E., Reaper P.M., Charlton P.A., Pollard J.R., McKenna W.G., et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther 2012, 13(11):1072-1081. Epub 2012/07/25.
    • (2012) Cancer Biol Ther , vol.13 , Issue.11 , pp. 1072-1081
    • Prevo, R.1    Fokas, E.2    Reaper, P.M.3    Charlton, P.A.4    Pollard, J.R.5    McKenna, W.G.6
  • 63
    • 84863720342 scopus 로고    scopus 로고
    • Targeting radiation-resistant hypoxic tumour cells through ATR inhibition
    • Epub 2012/06/21
    • Pires I.M., Olcina M.M., Anbalagan S., Pollard J.R., Reaper P.M., Charlton P.A., et al. Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. Br J Cancer 2012, 107(2):291-299. Epub 2012/06/21.
    • (2012) Br J Cancer , vol.107 , Issue.2 , pp. 291-299
    • Pires, I.M.1    Olcina, M.M.2    Anbalagan, S.3    Pollard, J.R.4    Reaper, P.M.5    Charlton, P.A.6
  • 64
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • Epub 1995/01/01
    • Secomb T.W., Hsu R., Ong E.T., Gross J.F., Dewhirst M.W. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol 1995, 34(3):313-316. Epub 1995/01/01.
    • (1995) Acta Oncol , vol.34 , Issue.3 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5
  • 65
    • 79953661884 scopus 로고    scopus 로고
    • Understanding the benefit of metformin use in cancer treatment
    • Epub 2011/04/08
    • Dowling R.J., Goodwin P.J., Stambolic V. Understanding the benefit of metformin use in cancer treatment. BMC Med 2011, 9:33. Epub 2011/04/08.
    • (2011) BMC Med , vol.9 , pp. 33
    • Dowling, R.J.1    Goodwin, P.J.2    Stambolic, V.3
  • 66
    • 84877353837 scopus 로고    scopus 로고
    • Metformin use and improved response to therapy in esophageal adenocarcinoma
    • Epub 2012/09/07
    • Skinner H.D., McCurdy M.R., Echeverria A.E., Lin S.H., Welsh J.W., O'Reilly M.S., et al. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol 2013, 52(5):1002-1009. Epub 2012/09/07.
    • (2013) Acta Oncol , vol.52 , Issue.5 , pp. 1002-1009
    • Skinner, H.D.1    McCurdy, M.R.2    Echeverria, A.E.3    Lin, S.H.4    Welsh, J.W.5    O'Reilly, M.S.6
  • 67
    • 84855443905 scopus 로고    scopus 로고
    • TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence
    • Epub 2011/11/18
    • Skinner H.D., Sandulache V.C., Ow T.J., Meyn R.E., Yordy J.S., Beadle B.M., et al. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 2012, 18(1):290-300. Epub 2011/11/18.
    • (2012) Clin Cancer Res , vol.18 , Issue.1 , pp. 290-300
    • Skinner, H.D.1    Sandulache, V.C.2    Ow, T.J.3    Meyn, R.E.4    Yordy, J.S.5    Beadle, B.M.6
  • 69
    • 47349101284 scopus 로고    scopus 로고
    • The role of insulin receptors and IGF-I receptors in cancer and other diseases
    • Epub 2008/05/10
    • Frasca F., Pandini G., Sciacca L., Pezzino V., Squatrito S., Belfiore A., et al. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem 2008, 114(1):23-37. Epub 2008/05/10.
    • (2008) Arch Physiol Biochem , vol.114 , Issue.1 , pp. 23-37
    • Frasca, F.1    Pandini, G.2    Sciacca, L.3    Pezzino, V.4    Squatrito, S.5    Belfiore, A.6
  • 70
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • Epub 2007/11/17
    • Dowling R.J., Zakikhani M., Fantus I.G., Pollak M., Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007, 67(22):10804-10812. Epub 2007/11/17.
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10804-10812
    • Dowling, R.J.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 71
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Epub 2012/03/09
    • Gerlinger M., Rowan A.J., Horswell S., Larkin J., Endesfelder D., Gronroos E., et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. New Engl J Med 2012, 366(10):883-892. Epub 2012/03/09.
    • (2012) New Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 73
    • 84859113048 scopus 로고    scopus 로고
    • Genetic heterogeneity and cancer drug resistance
    • Epub 2012/04/04
    • Turner N.C., Reis-Filho J.S. Genetic heterogeneity and cancer drug resistance. Lancet Oncol 2012, 13(4):e178-e185. Epub 2012/04/04.
    • (2012) Lancet Oncol , vol.13 , Issue.4 , pp. e178-e185
    • Turner, N.C.1    Reis-Filho, J.S.2
  • 74
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Epub 2012/03/09
    • Postow M.A., Callahan M.K., Barker C.A., Yamada Y., Yuan J., Kitano S., et al. Immunologic correlates of the abscopal effect in a patient with melanoma. New Engl J Med 2012, 366(10):925-931. Epub 2012/03/09.
    • (2012) New Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3    Yamada, Y.4    Yuan, J.5    Kitano, S.6
  • 75
    • 70149113060 scopus 로고    scopus 로고
    • Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
    • Epub 2009/04/08
    • Lee Y., Auh S.L., Wang Y., Burnette B., Wang Y., Meng Y., et al. Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood 2009, 114(3):589-595. Epub 2009/04/08.
    • (2009) Blood , vol.114 , Issue.3 , pp. 589-595
    • Lee, Y.1    Auh, S.L.2    Wang, Y.3    Burnette, B.4    Wang, Y.5    Meng, Y.6
  • 76
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: an overview of preclinical and translational research
    • Epub 2013/02/08
    • Grosso J.F., Jure-Kunkel M.N. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun 2013, 13:5. Epub 2013/02/08.
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 77
    • 84919475564 scopus 로고    scopus 로고
    • Combination of radiotherapy and immune checkpoint inhibitors
    • Pilones K.A., Vanpouille-Box C., Demaria S. Combination of radiotherapy and immune checkpoint inhibitors. Semin Radiat Oncol 2015, 25(1):28-33.
    • (2015) Semin Radiat Oncol , vol.25 , Issue.1 , pp. 28-33
    • Pilones, K.A.1    Vanpouille-Box, C.2    Demaria, S.3
  • 78
    • 84886944998 scopus 로고    scopus 로고
    • Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment
    • Epub 2013/06/27
    • Demaria S., Pilones K.A., Formenti S.C., Dustin M.L. Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment. Oncoimmunology 2013, 2(3):e23127. Epub 2013/06/27.
    • (2013) Oncoimmunology , vol.2 , Issue.3 , pp. e23127
    • Demaria, S.1    Pilones, K.A.2    Formenti, S.C.3    Dustin, M.L.4
  • 79
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Epub 2009/08/27
    • Dewan M.Z., Galloway A.E., Kawashima N., Dewyngaert J.K., Babb J.S., Formenti S.C., et al. Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 2009, 15(17):5379-5388. Epub 2009/08/27.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3    Dewyngaert, J.K.4    Babb, J.S.5    Formenti, S.C.6
  • 80
    • 84908432369 scopus 로고    scopus 로고
    • PD-1 Inhibitor Approved for Melanoma
    • Epub 2014/11/05.
    • PD-1 Inhibitor Approved for Melanoma. Cancer discovery. 2014;4(11):1249. Epub 2014/11/05.
    • (2014) Cancer discovery , vol.4 , Issue.11 , pp. 1249
  • 81
    • 84877581852 scopus 로고    scopus 로고
    • Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas
    • Epub 2013/03/07
    • Zeng J., See A.P., Phallen J., Jackson C.M., Belcaid Z., Ruzevick J., et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 2013, 86(2):343-349. Epub 2013/03/07.
    • (2013) Int J Radiat Oncol Biol Phys , vol.86 , Issue.2 , pp. 343-349
    • Zeng, J.1    See, A.P.2    Phallen, J.3    Jackson, C.M.4    Belcaid, Z.5    Ruzevick, J.6
  • 82
    • 80052023514 scopus 로고    scopus 로고
    • Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers
    • Harrington K.J., Billingham L.J., Brunner T.B., Burnet N.G., Chan C.S., Hoskin P., et al. Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers. Br J Cancer 2011, 105(5):628-639.
    • (2011) Br J Cancer , vol.105 , Issue.5 , pp. 628-639
    • Harrington, K.J.1    Billingham, L.J.2    Brunner, T.B.3    Burnet, N.G.4    Chan, C.S.5    Hoskin, P.6


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