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Volumn 19, Issue 5, 2013, Pages 1094-1105

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SONIC HEDGEHOG PROTEIN; STATHMIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKER; WNT PROTEIN;

EID: 84874852214     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-3039     Document Type: Article
Times cited : (120)

References (52)
  • 3
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15: 10-7.
    • (1983) Gynecol Oncol , vol.15 , pp. 10-17
    • Bokhman, J.V.1
  • 4
    • 84864330983 scopus 로고    scopus 로고
    • Markers for individualised therapy in endometrial carcinoma
    • Salvesen HB, Haldorsen IS, Trovik J. Markers for individualised therapy in endometrial carcinoma. Lancet Oncol 2012;13:e353-61.
    • (2012) Lancet Oncol , vol.13
    • Salvesen, H.B.1    Haldorsen, I.S.2    Trovik, J.3
  • 5
    • 54849432745 scopus 로고    scopus 로고
    • GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival
    • e1-7
    • Engelsen IB, Stefansson IM, Akslen LA, Salvesen HB. GATA3 expression in estrogen receptor alpha-negative endometrial carcinomas identifies aggressive tumors with high proliferation and poor patient survival. Am J Obstet Gynecol 2008;199: 543 e1-7.
    • (2008) Am J Obstet Gynecol , vol.199 , pp. 543
    • Engelsen, I.B.1    Stefansson, I.M.2    Akslen, L.A.3    Salvesen, H.B.4
  • 6
    • 60449115147 scopus 로고    scopus 로고
    • Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer
    • Jongen V, Briet J, de Jong R, ten Hoor K, Boezen M, van der Zee A, et al. Expression of estrogen receptor-alpha and -beta and progesterone receptor-A and -B in a large cohort of patients with endometrioid endometrial cancer. Gynecol Oncol 2009;112: 537-42.
    • (2009) Gynecol Oncol , vol.112 , pp. 537-542
    • Jongen, V.1    Briet, J.2    De Jong, R.3    Ten Hoor, K.4    Boezen, M.5    Van Der Zee, A.6
  • 7
    • 34548700355 scopus 로고    scopus 로고
    • Hormone therapy in advanced and recurrent endometrial cancer: A systematic review
    • Decruze SB, Green JA. Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer 2007; 17: 964-78.
    • (2007) Int J Gynecol Cancer , vol.17 , pp. 964-978
    • Decruze, S.B.1    Green, J.A.2
  • 9
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119: 1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 10
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139: 871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 11
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009;119: 1429-37.
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 12
    • 72949100977 scopus 로고    scopus 로고
    • Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer
    • Hung JJ, Yang MH, Hsu HS, Hsu WH, Liu JS, Wu KJ. Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax 2009;64: 1082-9.
    • (2009) Thorax , vol.64 , pp. 1082-1089
    • Hung, J.J.1    Yang, M.H.2    Hsu, H.S.3    Hsu, W.H.4    Liu, J.S.5    Wu, K.J.6
  • 13
    • 75649086115 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer
    • Micalizzi DS, Ford HL. Epithelial-mesenchymal transition in development and cancer. Future Oncol 2009;5: 1129-43.
    • (2009) Future Oncol , vol.5 , pp. 1129-1143
    • Micalizzi, D.S.1    Ford, H.L.2
  • 14
    • 4143051355 scopus 로고    scopus 로고
    • Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer
    • MellLK,Meyer JJ, TretiakovaM,KhramtsovA,GongC,YamadaSD,etal. Prognostic significance of E-cadherin protein expression in pathological stage I-III endometrial cancer. Clin Cancer Res 2004;10: 5546-53.
    • (2004) Clin Cancer Res , vol.10 , pp. 5546-5553
    • Mell, L.K.1    Meyer, J.J.2    Tretiakova, M.3    Khramtsov, A.4    Gong, C.5    Yamada, S.D.6
  • 15
    • 2142760943 scopus 로고    scopus 로고
    • Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer
    • Stefansson IM, Salvesen HB, Akslen LA. Prognostic impact of alterations in P-cadherin expression and related cell adhesion markers in endometrial cancer. J Clin Oncol 2004;22: 1242-52.
    • (2004) J Clin Oncol , vol.22 , pp. 1242-1252
    • Stefansson, I.M.1    Salvesen, H.B.2    Akslen, L.A.3
  • 16
    • 79951827548 scopus 로고    scopus 로고
    • Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer
    • Mannelqvist M, Stefansson IM, Bredholt G, Hellem Bo T, Oyan AM, Jonassen I, et al. Gene expression patterns related to vascular invasion and aggressive features in endometrial cancer. Am J Pathol 2011; 178: 861-71.
    • (2011) Am J Pathol , vol.178 , pp. 861-871
    • Mannelqvist, M.1    Stefansson, I.M.2    Bredholt, G.3    Hellem Bo, T.4    Oyan, A.M.5    Jonassen, I.6
  • 17
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki M, Mimori K, Yokobori T, Ishi H, Beppu T, Nakamori S, et al. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci 2010;101: 293-9.
    • (2010) Cancer Sci , vol.101 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6
  • 18
    • 83455210823 scopus 로고    scopus 로고
    • Is the epithelial-tomesenchymal transition clinically relevant for the cancer patient?
    • Krasnapolski MA, Todaro LB, de Kier Joffe EB. Is the epithelial- tomesenchymal transition clinically relevant for the cancer patient? Curr Pharm Biotechnol 2011;12: 1891-9.
    • (2011) Curr Pharm Biotechnol , vol.12 , pp. 1891-1899
    • Krasnapolski, M.A.1    Todaro, L.B.2    De Kier Joffe, E.B.3
  • 19
    • 63849308483 scopus 로고    scopus 로고
    • Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation
    • Salvesen HB, Carter SL, Mannelqvist M, Dutt A, Getz G, Stefansson IM, et al. Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. Proc Natl Acad Sci U S A 2009;106: 4834-9.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4834-4839
    • Salvesen, H.B.1    Carter, S.L.2    Mannelqvist, M.3    Dutt, A.4    Getz, G.5    Stefansson, I.M.6
  • 20
    • 2642557954 scopus 로고    scopus 로고
    • Prognostic impact of histological grade and vascular invasion compared with tumour cell proliferation in endometrial carcinoma of endometrioid type
    • Stefansson IM, Salvesen HB, Immervoll H, Akslen LA. Prognostic impact of histological grade and vascular invasion compared with tumour cell proliferation in endometrial carcinoma of endometrioid type. Histopathology 2004;44: 472-9.
    • (2004) Histopathology , vol.44 , pp. 472-479
    • Stefansson, I.M.1    Salvesen, H.B.2    Immervoll, H.3    Akslen, L.A.4
  • 21
    • 77953916879 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 1995;57: 11.
    • (1995) J R Stat Soc , vol.57 , pp. 11
    • Benjamini, Y.1    Hochberg, Y.2
  • 23
    • 35348890683 scopus 로고    scopus 로고
    • Ontesting the significance of gene sets
    • Efron B, Tibshirani R.Ontesting the significance of gene sets. Ann Appl Stat 2007;1: 22.
    • (2007) Ann Appl Stat , vol.1 , pp. 22
    • Efron, B.1    Tibshirani, R.2
  • 24
    • 33749335282 scopus 로고    scopus 로고
    • The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
    • Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, et al. The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science 2006;313: 1929-35.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3    Modell, J.W.4    Blat, I.C.5    Wrobel, M.J.6
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(delta delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(delta delta C(T)) method. Methods 2001;25: 402-8.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 26
    • 28244483194 scopus 로고    scopus 로고
    • Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease
    • Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res 2005;65: 10938-45.
    • (2005) Cancer Res , vol.65 , pp. 10938-10945
    • Bellovin, D.I.1    Bates, R.C.2    Muzikansky, A.3    Rimm, D.L.4    Mercurio, A.M.5
  • 27
    • 37249054451 scopus 로고    scopus 로고
    • Bench to bedside and back again: Molecular mechanisms of alpha-catenin function and roles in tumorigenesis
    • Benjamin JM, Nelson WJ. Bench to bedside and back again: molecular mechanisms of alpha-catenin function and roles in tumorigenesis. Semin Cancer Biol 2008;18: 53-64.
    • (2008) Semin Cancer Biol , vol.18 , pp. 53-64
    • Benjamin, J.M.1    Nelson, W.J.2
  • 28
    • 79956000555 scopus 로고    scopus 로고
    • Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer
    • Trovik J, Wik E, Stefansson IM, Marcickiewicz J, Tingulstad S, StaffAC, et al. Stathmin overexpression identifies high-risk patients and lymph node metastasis in endometrial cancer. Clin Cancer Res 2011;17: 3368-77.
    • (2011) Clin Cancer Res , vol.17 , pp. 3368-3377
    • Trovik, J.1    Wik, E.2    Stefansson, I.M.3    Marcickiewicz, J.4    Tingulstad, S.5    Staff, A.C.6
  • 29
    • 84870777479 scopus 로고    scopus 로고
    • KRAS gene amplification but not mutation associates with aggressive and metastatic endometrial cancer
    • Birkeland E, Wik E, Trovik J, Werner HM, Mjos S, Kusanmano K, et al. KRAS gene amplification but not mutation associates with aggressive and metastatic endometrial cancer. Br J Cancer 2012;107: 1997-2004.
    • (2012) Br J Cancer , vol.107 , pp. 1997-2004
    • Birkeland, E.1    Wik, E.2    Trovik, J.3    Werner, H.M.4    Mjos, S.5    Kusanmano, K.6
  • 30
    • 33645242374 scopus 로고    scopus 로고
    • TGF-beta 1-induced PAI-1 expression is e box/USF-dependent and requires EGFR signaling
    • Kutz SM, Higgins CE, Samarakoon R, Higgins SP, Allen RR, Qi L, et al. TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling. Exp Cell Res 2006;312: 1093-105.
    • (2006) Exp Cell Res , vol.312 , pp. 1093-1105
    • Kutz, S.M.1    Higgins, C.E.2    Samarakoon, R.3    Higgins, S.P.4    Allen, R.R.5    Qi, L.6
  • 31
    • 0037165140 scopus 로고    scopus 로고
    • Prediction of central nervous system embryonal tumour outcome based on gene expression
    • Pomeroy SL, Tamayo P, Gaasenbeek M, Sturla LM, Angelo M, McLaughlin ME, et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002;415: 436-42.
    • (2002) Nature , vol.415 , pp. 436-442
    • Pomeroy, S.L.1    Tamayo, P.2    Gaasenbeek, M.3    Sturla, L.M.4    Angelo, M.5    McLaughlin, M.E.6
  • 32
    • 13144286421 scopus 로고    scopus 로고
    • Receptor and secreted targets of Wnt- 1/beta-catenin signalling in mouse mammary epithelial cells
    • Kenny PA, Enver T, Ashworth A. Receptor and secreted targets of Wnt- 1/beta-catenin signalling in mouse mammary epithelial cells. BMC Cancer 2005;5: 3.
    • (2005) BMC Cancer , vol.5 , pp. 3
    • Kenny, P.A.1    Enver, T.2    Ashworth, A.3
  • 33
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia F, Chu ML, Mauviel A. Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem2001;276: 17058-62.
    • (2001) J Biol Chem , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 34
    • 0037453706 scopus 로고    scopus 로고
    • MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    • Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 2003;113: 207-19.
    • (2003) Cell , vol.113 , pp. 207-219
    • Fujita, N.1    Jaye, D.L.2    Kajita, M.3    Geigerman, C.4    Moreno, C.S.5    Wade, P.A.6
  • 35
    • 45549105619 scopus 로고    scopus 로고
    • Gene expression profiles in breast cancer to identify estrogen receptor target genes
    • Nagai MA, Brentani MM. Gene expression profiles in breast cancer to identify estrogen receptor target genes. Mini Rev Med Chem 2008; 8: 448-54.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 448-454
    • Nagai, M.A.1    Brentani, M.M.2
  • 37
    • 34250687198 scopus 로고    scopus 로고
    • Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
    • Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity. Proc Natl Acad Sci U S A 2007;104: 7564-9.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7564-7569
    • Saal, L.H.1    Johansson, P.2    Holm, K.3    Gruvberger-Saal, S.K.4    She, Q.B.5    Maurer, M.6
  • 39
    • 0018906234 scopus 로고
    • Clinical correlates of estrogen- and progesterone-binding proteins in human endometrial adenocarcinoma
    • Creasman WT, McCarty KS Sr, Barton TK, McCarty KS Jr. Clinical correlates of estrogen- and progesterone-binding proteins in human endometrial adenocarcinoma. Obstet Gynecol 1980;55: 363-70.
    • (1980) Obstet Gynecol , vol.55 , pp. 363-370
    • Creasman, W.T.1    McCarty Sr., K.S.2    Barton, T.K.3    McCarty Jr., K.S.4
  • 40
    • 0024216968 scopus 로고
    • DNA ploidy and steroid receptors as predictors of disease course in patients with endometrial carcinoma
    • Iversen OE, Utaaker E, Skaarland E. DNA ploidy and steroid receptors as predictors of disease course in patients with endometrial carcinoma. Acta Obstet Gynecol Scand 1988;67: 531-7.
    • (1988) Acta Obstet Gynecol Scand , vol.67 , pp. 531-537
    • Iversen, O.E.1    Utaaker, E.2    Skaarland, E.3
  • 41
    • 0033003177 scopus 로고    scopus 로고
    • Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group
    • Thigpen JT, Brady MF, Alvarez RD, Adelson MD, Homesley HD, Manetta A, et al. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol 1999;17: 1736-44.
    • (1999) J Clin Oncol , vol.17 , pp. 1736-1744
    • Thigpen, J.T.1    Brady, M.F.2    Alvarez, R.D.3    Adelson, M.D.4    Homesley, H.D.5    Manetta, A.6
  • 42
    • 36649011436 scopus 로고    scopus 로고
    • The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas
    • Blechschmidt K, Kremmer E, Hollweck R, Mylonas I, Hofler H, Kremer M, et al. The E-cadherin repressor snail plays a role in tumor progression of endometrioid adenocarcinomas. Diagn Mol Pathol 2007;16: 222-8.
    • (2007) Diagn Mol Pathol , vol.16 , pp. 222-228
    • Blechschmidt, K.1    Kremmer, E.2    Hollweck, R.3    Mylonas, I.4    Hofler, H.5    Kremer, M.6
  • 43
    • 36849002930 scopus 로고    scopus 로고
    • The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha
    • Dhasarathy A, Kajita M, Wade PA. The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol 2007;21: 2907-18.
    • (2007) Mol Endocrinol , vol.21 , pp. 2907-2918
    • Dhasarathy, A.1    Kajita, M.2    Wade, P.A.3
  • 44
    • 75649088874 scopus 로고    scopus 로고
    • Mechanisms of the epithelial-mesenchymal transition by TGF-beta
    • Wendt MK, Allington TM, Schiemann WP. Mechanisms of the epithelial-mesenchymal transition by TGF-beta. Future Oncol 2009;5: 1145-68.
    • (2009) Future Oncol , vol.5 , pp. 1145-1168
    • Wendt, M.K.1    Allington, T.M.2    Schiemann, W.P.3
  • 45
    • 80051589341 scopus 로고    scopus 로고
    • High-risk endometrial carcinoma profiling identifies TGF-beta1 as a key factor in the initiation of tumor invasion
    • Muinelo-Romay L, Colas E, Barbazan J, Alonso-Alconada L, Alonso- Nocelo M, Bouso M, et al. High-risk endometrial carcinoma profiling identifies TGF-beta1 as a key factor in the initiation of tumor invasion. Mol Cancer Ther 2011;10: 1357-66.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1357-1366
    • Muinelo-Romay, L.1    Colas, E.2    Barbazan, J.3    Alonso-Alconada, L.4    Alonso- Nocelo, M.5    Bouso, M.6
  • 46
    • 84864472736 scopus 로고    scopus 로고
    • The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer
    • Tang D, Xu S, Zhang Q, Zhao W. The expression and clinical significance of the androgen receptor and E-cadherin in triple-negative breast cancer. Med Oncol 2012;29: 526-33.
    • (2012) Med Oncol , vol.29 , pp. 526-533
    • Tang, D.1    Xu, S.2    Zhang, Q.3    Zhao, W.4
  • 47
    • 37249030356 scopus 로고    scopus 로고
    • A switch from Ecadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer
    • Gravdal K, Halvorsen OJ, Haukaas SA, Akslen LA. A switch from Ecadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res 2007;13: 7003-11.
    • (2007) Clin Cancer Res , vol.13 , pp. 7003-7011
    • Gravdal, K.1    Halvorsen, O.J.2    Haukaas, S.A.3    Akslen, L.A.4
  • 48
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol 2011;29: 3278-85.
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3    Kamel-Reid, S.4    Biagi, J.5    Provencher, D.M.6
  • 52
    • 80054690349 scopus 로고    scopus 로고
    • PIK3CA mutations and amplification in endometrioid endometrial carcinomas: Relation to other genetic defects and clinicopathologic status of the tumors
    • Konopka B, Janiec-Jankowska A, Kwiatkowska E, Najmola U, Bidzinski M, Olszewski W, et al. PIK3CA mutations and amplification in endometrioid endometrial carcinomas: relation to other genetic defects and clinicopathologic status of the tumors. Hum Pathol 2011;42: 1710-9.
    • (2011) Hum Pathol , vol.42 , pp. 1710-1719
    • Konopka, B.1    Janiec-Jankowska, A.2    Kwiatkowska, E.3    Najmola, U.4    Bidzinski, M.5    Olszewski, W.6


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