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Volumn 130, Issue 1, 2013, Pages 58-63

Predictive ability of estrogen receptor (ER), progesterone receptor (PR), COX-2, Mlh1, and Bcl-2 expressions for regression and relapse of endometrial hyperplasia treated with LNG-IUS: A prospective cohort study

Author keywords

Cohort study; Endometrial hyperplasia; Immunohistochemistry; Intrauterine device medicated; LNG IUS; Steroid receptors

Indexed keywords

BIOLOGICAL MARKER; CYCLOOXYGENASE 2 INHIBITOR; ESTROGEN RECEPTOR; LEVONORGESTREL; PROGESTERONE RECEPTOR; PROTEIN BCL 2; PROTEIN MLH1;

EID: 84879102196     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2013.04.016     Document Type: Article
Times cited : (20)

References (34)
  • 1
    • 0021828824 scopus 로고
    • The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients
    • R.J. Kurman, P.F. Kaminski, and H.J. Norris The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients Cancer 56 1985 403 412
    • (1985) Cancer , vol.56 , pp. 403-412
    • Kurman, R.J.1    Kaminski, P.F.2    Norris, H.J.3
  • 4
    • 79952118889 scopus 로고    scopus 로고
    • Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: A systematic review and metaanalysis
    • I.D. Gallos, M. Shehmar, S. Thangaratinam, T.K. Papapostolou, A. Coomarasamy, and J.K. Gupta Oral progestogens vs levonorgestrel-releasing intrauterine system for endometrial hyperplasia: a systematic review and metaanalysis Am J Obstet Gynecol 203 2010 547.e1-10
    • (2010) Am J Obstet Gynecol , vol.203
    • Gallos, I.D.1    Shehmar, M.2    Thangaratinam, S.3    Papapostolou, T.K.4    Coomarasamy, A.5    Gupta, J.K.6
  • 5
    • 84879083978 scopus 로고    scopus 로고
    • Oral progestogens versus LNG-IUS (Mirena®) treatment for endometrial hyperplasia: A long-term comparative cohort study
    • (submitted for publication)
    • I.D. Gallos, P. Krishan, M. Shehmar, R. Ganesan, and J.K. Gupta Oral progestogens versus LNG-IUS (Mirena®) treatment for endometrial hyperplasia: a long-term comparative cohort study Fertil Steril 2013 (submitted for publication)
    • (2013) Fertil Steril
    • Gallos, I.D.1    Krishan, P.2    Shehmar, M.3    Ganesan, R.4    Gupta, J.K.5
  • 6
    • 84876518382 scopus 로고    scopus 로고
    • Relapse of endometrial hyperplasia after conservative treatment: A cohort study with long term follow up
    • 10.1093/humrep/det049
    • I.D. Gallos, P. Krishan, M. Shehmar, R. Ganesan, and J.K. Gupta Relapse of endometrial hyperplasia after conservative treatment: a cohort study with long term follow up Hum Reprod 28 2013 1231 1236 10.1093/humrep/det049
    • (2013) Hum Reprod , vol.28 , pp. 1231-1236
    • Gallos, I.D.1    Krishan, P.2    Shehmar, M.3    Ganesan, R.4    Gupta, J.K.5
  • 7
    • 32544432714 scopus 로고    scopus 로고
    • Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: A Gynecologic Oncology Group study
    • C.L. Trimble, J. Kauderer, R. Zaino, S. Silverberg, P.C. Lim, and J.J. Burke Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study Cancer 106 2006 812 819
    • (2006) Cancer , vol.106 , pp. 812-819
    • Trimble, C.L.1    Kauderer, J.2    Zaino, R.3    Silverberg, S.4    Lim, P.C.5    Burke, J.J.6
  • 8
    • 84965087391 scopus 로고
    • Endometrial hyperplasia, endometrial carcinoma, and endometriosis produced experimentally by estrogen
    • W.A. Meissner, S.C. Sommers, and G. Sherman Endometrial hyperplasia, endometrial carcinoma, and endometriosis produced experimentally by estrogen Cancer 10 1957 500 509
    • (1957) Cancer , vol.10 , pp. 500-509
    • Meissner, W.A.1    Sommers, S.C.2    Sherman, G.3
  • 9
    • 77749258716 scopus 로고    scopus 로고
    • Prognostic significance of oestrogen and progesterone receptor expression and others in LNG-IUS (Mirena®) treatment of endometrial hyperplasia: An immunohistochemical study
    • E. Akesson, I.D. Gallos, R. Ganesan, R. Varma, and J.K. Gupta Prognostic significance of oestrogen and progesterone receptor expression and others in LNG-IUS (Mirena®) treatment of endometrial hyperplasia: an immunohistochemical study Acta Obstet Gynecol Scand 89 2010 393 398
    • (2010) Acta Obstet Gynecol Scand , vol.89 , pp. 393-398
    • Akesson, E.1    Gallos, I.D.2    Ganesan, R.3    Varma, R.4    Gupta, J.K.5
  • 10
    • 0028873380 scopus 로고
    • Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies
    • K. Watanabe, H. Sasano, N. Harada, M. Ozaki, H. Niikura, and S. Sato Aromatase in human endometrial carcinoma and hyperplasia. Immunohistochemical, in situ hybridization, and biochemical studies Am J Pathol 146 1995 491 500
    • (1995) Am J Pathol , vol.146 , pp. 491-500
    • Watanabe, K.1    Sasano, H.2    Harada, N.3    Ozaki, M.4    Niikura, H.5    Sato, S.6
  • 11
    • 16844364010 scopus 로고    scopus 로고
    • Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: Tissue microarray analysis
    • J.M. Fowler, N. Ramirez, D.E. Cohn, N. Kelbick, J. Pavelka, and I. Ben Shachar Correlation of cyclooxygenase-2 (COX-2) and aromatase expression in human endometrial cancer: tissue microarray analysis Am J Obstet Gynecol 192 2005 1262 1271
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 1262-1271
    • Fowler, J.M.1    Ramirez, N.2    Cohn, D.E.3    Kelbick, N.4    Pavelka, J.5    Ben Shachar, I.6
  • 12
    • 0037174891 scopus 로고    scopus 로고
    • The postmenopausal ovary as an androgen-producing gland; Hypothesis on the etiology of endometrial cancer
    • V.H. Jongen, A.V. Sluijmer, and M.J. Heineman The postmenopausal ovary as an androgen-producing gland; hypothesis on the etiology of endometrial cancer Maturitas 43 2002 77 85
    • (2002) Maturitas , vol.43 , pp. 77-85
    • Jongen, V.H.1    Sluijmer, A.V.2    Heineman, M.J.3
  • 13
    • 0037103036 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in endometrial carcinoma: Correlation with clinicopathologic parameters and clinical outcome
    • G. Ferrandina, F. Legge, F.O. Ranelletti, G.F. Zannoni, N. Maggiano, and A. Evangelisti Cyclooxygenase-2 expression in endometrial carcinoma: correlation with clinicopathologic parameters and clinical outcome Cancer 95 2002 801 807
    • (2002) Cancer , vol.95 , pp. 801-807
    • Ferrandina, G.1    Legge, F.2    Ranelletti, F.O.3    Zannoni, G.F.4    Maggiano, N.5    Evangelisti, A.6
  • 16
    • 0036219594 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression in endometrial cancer: Correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase
    • R. Fujiwaki, K. Iida, H. Kanasaki, T. Ozaki, K. Hata, and K. Miyazaki Cyclooxygenase-2 expression in endometrial cancer: correlation with microvessel count and expression of vascular endothelial growth factor and thymidine phosphorylase Hum Pathol 33 2002 213 219
    • (2002) Hum Pathol , vol.33 , pp. 213-219
    • Fujiwaki, R.1    Iida, K.2    Kanasaki, H.3    Ozaki, T.4    Hata, K.5    Miyazaki, K.6
  • 17
    • 0032893186 scopus 로고    scopus 로고
    • Down-regulation of bcl-2 is a potential marker of the efficacy of progestin therapy in the treatment of endometrial hyperplasia
    • C.A. Amezcua, W. Zheng, L.I. Muderspach, and J.C. Felix Down-regulation of bcl-2 is a potential marker of the efficacy of progestin therapy in the treatment of endometrial hyperplasia Gynecol Oncol 73 1999 126 136
    • (1999) Gynecol Oncol , vol.73 , pp. 126-136
    • Amezcua, C.A.1    Zheng, W.2    Muderspach, L.I.3    Felix, J.C.4
  • 18
    • 0036311084 scopus 로고    scopus 로고
    • Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia
    • N. Horowitz, K. Pinto, D.G. Mutch, T.J. Herzog, J.S. Rader, and R. Gibb Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia Gynecol Oncol 86 2002 62 68
    • (2002) Gynecol Oncol , vol.86 , pp. 62-68
    • Horowitz, N.1    Pinto, K.2    Mutch, D.G.3    Herzog, T.J.4    Rader, J.S.5    Gibb, R.6
  • 19
    • 48349142778 scopus 로고    scopus 로고
    • Endometrial hyperplasia, endometrial cancer and prevention: Gaps in existing research of modifiable risk factors
    • F. Linkov, R. Edwards, J. Balk, Z. Yurkovetsky, B. Stadterman, and A. Lokshin Endometrial hyperplasia, endometrial cancer and prevention: gaps in existing research of modifiable risk factors Eur J Cancer 44 2008 1632 1644
    • (2008) Eur J Cancer , vol.44 , pp. 1632-1644
    • Linkov, F.1    Edwards, R.2    Balk, J.3    Yurkovetsky, Z.4    Stadterman, B.5    Lokshin, A.6
  • 20
    • 84892372742 scopus 로고
    • The robust inference for the Cox proportional hazards model
    • D.Y. Lin, and J.L. Wei The robust inference for the Cox proportional hazards model J Am Stat Assoc 84 1989 1074 1078
    • (1989) J Am Stat Assoc , vol.84 , pp. 1074-1078
    • Lin, D.Y.1    Wei, J.L.2
  • 21
    • 0029804330 scopus 로고    scopus 로고
    • Immunohistochemical determination of oestrogen receptor: Comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients
    • D.M. Barnes, W.H. Harris, P. Smith, R.R. Millis, and R.D. Rubens Immunohistochemical determination of oestrogen receptor: comparison of different methods of assessment of staining and correlation with clinical outcome of breast cancer patients Br J Cancer 74 1996 1445 1451
    • (1996) Br J Cancer , vol.74 , pp. 1445-1451
    • Barnes, D.M.1    Harris, W.H.2    Smith, P.3    Millis, R.R.4    Rubens, R.D.5
  • 22
    • 84869509852 scopus 로고    scopus 로고
    • The study design and compliance may affect strength of inferences
    • I.D. Gallos, and J.K. Gupta The study design and compliance may affect strength of inferences Am J Obstet Gynecol 207 2012 e9 e10
    • (2012) Am J Obstet Gynecol , vol.207
    • Gallos, I.D.1    Gupta, J.K.2
  • 24
    • 33847382959 scopus 로고    scopus 로고
    • Relaxing the rule of ten events per variable in logistic and Cox regression
    • E. Vittinghoff, and C.E. McCulloch Relaxing the rule of ten events per variable in logistic and Cox regression Am J Epidemiol 165 2007 710 718
    • (2007) Am J Epidemiol , vol.165 , pp. 710-718
    • Vittinghoff, E.1    McCulloch, C.E.2
  • 25
    • 0037009948 scopus 로고    scopus 로고
    • Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: A systematic quantitative review
    • T.J. Clark, D. Voit, J.K. Gupta, C. Hyde, F. Song, and K.S. Khan Accuracy of hysteroscopy in the diagnosis of endometrial cancer and hyperplasia: a systematic quantitative review JAMA 288 2002 1610 1621
    • (2002) JAMA , vol.288 , pp. 1610-1621
    • Clark, T.J.1    Voit, D.2    Gupta, J.K.3    Hyde, C.4    Song, F.5    Khan, K.S.6
  • 27
    • 0036514977 scopus 로고    scopus 로고
    • Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: A systematic quantitative review
    • T.J. Clark, C.H. Mann, N. Shah, K.S. Khan, F. Song, and J.K. Gupta Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review BJOG 109 2002 313 321
    • (2002) BJOG , vol.109 , pp. 313-321
    • Clark, T.J.1    Mann, C.H.2    Shah, N.3    Khan, K.S.4    Song, F.5    Gupta, J.K.6
  • 28
    • 34047257689 scopus 로고    scopus 로고
    • Morphologic changes in the endometrium associated with the use of the mirena coil: A retrospective study of 106 cases
    • R.K. Hejmadi, S. Chaudhri, R. Ganesan, and T.P. Rollason Morphologic changes in the endometrium associated with the use of the mirena coil: a retrospective study of 106 cases Int J Surg Pathol 15 2 2007 Apr 148 154
    • (2007) Int J Surg Pathol , vol.15 , Issue.2 , pp. 148-154
    • Hejmadi, R.K.1    Chaudhri, S.2    Ganesan, R.3    Rollason, T.P.4
  • 30
    • 0019867399 scopus 로고
    • Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: Therapeutic implications
    • C.E. Ehrlich, P.C. Young, and R.E. Cleary Cytoplasmic progesterone and estradiol receptors in normal, hyperplastic, and carcinomatous endometria: therapeutic implications Am J Obstet Gynecol 141 1981 539 546
    • (1981) Am J Obstet Gynecol , vol.141 , pp. 539-546
    • Ehrlich, C.E.1    Young, P.C.2    Cleary, R.E.3
  • 31
    • 0031672319 scopus 로고    scopus 로고
    • Steroid receptor concentrations as a prognostic factor in atypical endometrial hyperplasia
    • B. Lindahl, and R. Willen Steroid receptor concentrations as a prognostic factor in atypical endometrial hyperplasia Anticancer Res 18 1998 3793 3795
    • (1998) Anticancer Res , vol.18 , pp. 3793-3795
    • Lindahl, B.1    Willen, R.2
  • 32
    • 0027984203 scopus 로고
    • Failure of down-regulation of estrogen receptors and progesterone receptors after medroxyprogesterone acetate administration for endometrial hyperplasias
    • H. Masuzawa, N.H. Badokhon, K. Nakayama, I. Konishi, T. Nikaido, and S. Fujii Failure of down-regulation of estrogen receptors and progesterone receptors after medroxyprogesterone acetate administration for endometrial hyperplasias Cancer 74 1994 2321 2328
    • (1994) Cancer , vol.74 , pp. 2321-2328
    • Masuzawa, H.1    Badokhon, N.H.2    Nakayama, K.3    Konishi, I.4    Nikaido, T.5    Fujii, S.6
  • 33
    • 84879100230 scopus 로고    scopus 로고
    • Prediction of regression and relapse of endometrial hyperplasia treated with LNG-IUS (Mirena®) or oral progestogens: A cohort study
    • (in press)
    • I.D. Gallos, R. Ganesan, and J.K. Gupta Prediction of regression and relapse of endometrial hyperplasia treated with LNG-IUS (Mirena®) or oral progestogens: a cohort study Obstet Gynecol 2013 (in press)
    • (2013) Obstet Gynecol
    • Gallos, I.D.1    Ganesan, R.2    Gupta, J.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.