A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain

Biochimica et Biophysica Acta - Biomembranes

Volumn 1848, Issue 4, 2015, Pages 976-983

  Sensoy, Ozge ^a   Weinstein, Harel ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Biased molecular dynamics; GPCR signaling; GPCRPDZ interaction; interaction; Membrane insertion GPCR membrane; Palmitoylation and depalmitoylation; Steered molecular dynamics simulation

Indexed keywords

DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GIPC1 PROTEIN; GIPC2 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; GIPC1 PROTEIN, HUMAN; LIGAND; PALMITIC ACID; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; HELIX 8; LIGAND BINDING; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PALMITOYLATION; PDZ DOMAIN; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; X RAY; BINDING SITE; BIOLOGY; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROCEDURES; PROTEIN SECONDARY STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CELL MEMBRANE; COMPUTATIONAL BIOLOGY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PALMITIC ACID; PDZ DOMAINS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, DOPAMINE D2;

EID: 84921715323     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2014.12.002     Document Type: Article

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