Apoptolidins A and C activate AMPK in metabolically sensitive cell types and are mechanistically distinct from oligomycin A

Biochemical Pharmacology

Volumn 93, Issue 3, 2015, Pages 251-265

  Serrill, Jeffrey D ^a   Tan, Michelle ^a   Fotso, Serge ^a,g   Sikorska, Justyna ^a   Kasanah, Noer ^a,h   Hau, Andrew M ^a   McPhail, Kerry L ^a   Santosa, Dwi Andreas ^b,c   Zabriskie, T Mark ^a   Mahmud, Taifo ^a   Viollet, Benoit ^d,e,f   Proteau, Philip J ^a   Ishmael, Jane E ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b BOGOR AGRICULTURAL UNIVERSITY   (Indonesia)

^c Indonesian Center for Biodiversity and Biotechnology   (Indonesia)

^d INSTITUT COCHIN   (France)

^e CNRS   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g DOW AGROSCIENCES LLC   (United States)

^h GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

Apoptolidin A; Coibamide A; Mitochondrial inhibitor; Oligomycin A; Warburg effect

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOLIDIN A; APOPTOLIDIN C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; OLIGOMYCIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; MACROLIDE; PYRONE DERIVATIVE;

ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CELL ENERGY; CELL METABOLISM; CELL RESPIRATION; CELL STRESS; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; EC50; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; GLYCOLYSIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LUNG CANCER; MITOCHONDRIAL MEMBRANE; MOUSE; MTT ASSAY; NON SMALL CELL LUNG CANCER; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY CHAIN; ANIMAL; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; MACROLIDES; MICE; MICE, KNOCKOUT; OLIGOMYCINS; PYRONES; SOIL MICROBIOLOGY;

EID: 84921712618     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.11.015     Document Type: Article

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