An evolutionary biochemist's perspective on promiscuity

Trends in Biochemical Sciences

Volumn 40, Issue 2, 2015, Pages 72-78

  Copley, Shelley D ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Enzyme; Molecular evolution; Promiscuity; Substrate ambiguity

Indexed keywords

AMIDASE; ARYLSULFATASE; CYTOCHROME P450; ESTERASE; GLUTATHIONE TRANSFERASE; HOMOSERINE KINASE; ISOCITRATE DEHYDROGENASE; PHOSPHATASE; MULTIFUNCTIONAL ENZYME;

BIOCHEMISTRY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; NATURAL SELECTION; NONHUMAN; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; REVIEW; TECHNOLOGY; CATALYSIS; CLASSIFICATION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; PROTEIN CONFORMATION;

CATALYSIS; CATALYTIC DOMAIN; EVOLUTION, MOLECULAR; MULTIFUNCTIONAL ENZYMES; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84921613786     PISSN: 09680004     EISSN: 13624326     Source Type: Journal    
DOI: 10.1016/j.tibs.2014.12.004     Document Type: Review

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