Target competition: Transcription factors enter the limelight

Genome Biology

Volumn 15, Issue 4, 2014, Pages

  Karreth, Florian A ^a,b   Tay, Yvonne ^a   Pandolfi, Pier P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BACTERIAL GENOME; BINDING SITE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; ESCHERICHIA COLI; GENE AMPLIFICATION; GENE CONTROL; GENE EXPRESSION; HUMAN; MATHEMATICAL MODEL; NEOPLASM; NONHUMAN; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; RNA STABILITY; THERMODYNAMICS; BIOLOGICAL MODEL; METABOLISM; BINDING AFFINITY; BINDING COMPETITION; CARCINOGENESIS; COPY NUMBER VARIATION; GENE OVEREXPRESSION; PROTEIN DNA BINDING; PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA RNA INTERACTION;

ESCHERICHIA COLI; GENE EXPRESSION; MODELS, GENETIC; TRANSCRIPTION FACTORS;

EID: 84899528770     PISSN: None     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/gb4174     Document Type: Article

References (7)

1. Brewster RC, Weinert FM, Garcia HG, Song D, Rydenfelt M, Phillips R. The transcription factor titration effect dictates level of gene expression. Cell 2014, 156:1312-1323. 10.1016/j.cell.2014.02.022, 24612990.
2. Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination. Cancer Res 2013, 73:2199-2210. 10.1158/0008-5472.CAN-12-4400, 3618590, 23382044.
3. Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL, Gorospe M. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J 2004, 23:3092-3102. 10.1038/sj.emboj.7600305, 514922, 15257295.
4. Barker A, Epis MR, Porter CJ, Hopkins BR, Wilce MC, Wilce JA, Giles KM, Leedman PJ. Sequence requirements for RNA binding by HuR and AUF1. J Biochem 2012, 151:423-437. 10.1093/jb/mvs010, 22368252.
5. Yoo S, Kim HH, Kim P, Donnelly CJ, Kalinski AL, Vuppalanchi D, Park M, Lee SJ, Merianda TT, Perrone-Bizzozero NI, Twiss JL. A HuD-ZBP1 ribonucleoprotein complex localizes GAP-43 mRNA into axons through its 3' untranslated region AU-rich regulatory element. J Neurochem 2013, 126:792-804. 10.1111/jnc.12266, 23586486.
6. Karreth FA, Pandolfi PP. ceRNA cross-talk in cancer: when ce-bling rivalries go awry. Cancer Discov 2013, 3:1113-1121. 10.1158/2159-8290.CD-13-0202, 24072616.
7. Ala U, Karreth FA, Bosia C, Pagnani A, Taulli R, Léopold V, Tay Y, Provero P, Zecchina R, Pandolfi PP. Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proc Natl Acad Sci U S A 2013, 110:7154-7159. 10.1073/pnas.1222509110, 3645534, 23536298.