Evolution of Enzymatic Activity in the Enolase Superfamily: Structural Studies of the Promiscuous o-Succinylbenzoate Synthase from Amycolatopsis

Biochemistry

Volumn 43, Issue 19, 2004, Pages 5716-5727

  Thoden, James B ^a   Taylor Ringia, Erika A ^b   Garrett, James B ^b   Gerlt, John A ^b,d   Holden, Hazel M ^a   Rayment, Ivan ^a,c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Department of Biochemistry ^*  (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBON; DEHYDRATION; ENZYME KINETICS; GENES; HYDROPHOBICITY; PHYSIOLOGY; PROTEINS; PROTONS;

ENZYMATIC ACTIVITY; LIGANDED COMPLEXES; MUTATIONAL CHANGES; PROGENITOR ENZYMES;

BIOCHEMISTRY;

2 SUCCINYL 6 HYDROXY 2,4 CYCLOHEXADIENE 1 CARBOXYLATE; 2 SUCCINYLBENZOATE SYNTHASE; AMINO ACID; BENZOIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ENOLASE; LYSINE; N ACETYLMETHIONINE; N ACYLAMINO ACID; N ACYLAMINO ACID RACEMASE; N SUCCINYLMETHIONINE; N SUCCINYLPHENYLGLYCINE; RACEMASE; UNCLASSIFIED DRUG;

AMYCOLATOPSIS; ARTICLE; BACTERIUM; CRYSTAL STRUCTURE; DEHYDRATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; EVOLUTION; GENE DUPLICATION; GENETIC VARIABILITY; HYDROPHOBICITY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RACEMIC MIXTURE; X RAY DIFFRACTION;

ACTINOMYCETALES; ACYL COENZYME A; ACYLATION; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; METHIONINE; MULTIENZYME COMPLEXES; PHOSPHOPYRUVATE HYDRATASE; PROTEIN BINDING; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; SUCCINATE-COA LIGASES;

AMYCOLATOPSIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 2442612271     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0497897     Document Type: Article

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