-
1
-
-
84875227396
-
Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
-
Kenakin, T. & Christopoulos, A. Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nature Rev. Drug Discov. 12, 205-216 (2013).
-
(2013)
Nature Rev. Drug Discov
, vol.12
, pp. 205-216
-
-
Kenakin, T.1
Christopoulos, A.2
-
2
-
-
77049220618
-
Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory
-
Ariens, E. J. Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Arch. Int. Pharmacodyn. Ther. 99, 32-49 (1954).
-
(1954)
Arch. Int. Pharmacodyn. Ther
, vol.99
, pp. 32-49
-
-
Ariens, E.J.1
-
3
-
-
0010673662
-
A modification of receptor theory
-
Stephenson, R. P. A modification of receptor theory. Br. J. Pharmacol. Chemother. 11, 379-393 (1956).
-
(1956)
Br. J. Pharmacol. Chemother
, vol.11
, pp. 379-393
-
-
Stephenson, R.P.1
-
4
-
-
33947595582
-
-
(eds Harper, N. J. & Simmonds, A. B.) Academic Press
-
Furchgott, R. F. in Advances in Drug Research (eds Harper, N. J. & Simmonds, A. B.) 21-55 (Academic Press, 1966).
-
(1966)
Advances in Drug Research
, pp. 21-55
-
-
Furchgott, R.F.1
-
5
-
-
0021058380
-
Operational models of pharmacological agonism
-
Black, J. W. & Leff, P. Operational models of pharmacological agonism. Proc. R. Soc. Lond. B Biol. Sci. 220, 141-162 (1983).
-
(1983)
Proc. R. Soc. Lond. B Biol. Sci
, vol.220
, pp. 141-162
-
-
Black, J.W.1
Leff, P.2
-
6
-
-
0019137579
-
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
-
De Lean, A., Stadel, J. M. & Lefkowitz, R. J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J. Biol. Chem. 255, 7108-7117 (1980).
-
(1980)
J. Biol. Chem
, vol.255
, pp. 7108-7117
-
-
De Lean, A.1
Stadel, J.M.2
Lefkowitz, R.J.3
-
7
-
-
0027513982
-
A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
-
Samama, P., Cotecchia, S., Costa, T. & Lefkowitz, R. J. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268, 4625-4636 (1993).
-
(1993)
J. Biol. Chem
, vol.268
, pp. 4625-4636
-
-
Samama, P.1
Cotecchia, S.2
Costa, T.3
Lefkowitz, R.J.4
-
8
-
-
0030596736
-
The cubic ternary complex receptor-occupancy model. III. Resurrecting efficacy
-
Weiss, J. M., Morgan, P. H., Lutz, M. W. & Kenakin, T. P. The cubic ternary complex receptor-occupancy model. III. Resurrecting efficacy. J. Theor. Biol. 181, 381-397 (1996).
-
(1996)
J. Theor. Biol
, vol.181
, pp. 381-397
-
-
Weiss, J.M.1
Morgan, P.H.2
Lutz, M.W.3
Kenakin, T.P.4
-
9
-
-
80051979129
-
Quantifying ligand bias at seven-transmembrane receptors
-
Rajagopal, S. et al. Quantifying ligand bias at seven-transmembrane receptors. Mol. Pharmacol. 80, 367-377 (2011).
-
(2011)
Mol. Pharmacol
, vol.80
, pp. 367-377
-
-
Rajagopal, S.1
-
10
-
-
84858775788
-
A simple method for quantifying functional selectivity and agonist bias
-
Kenakin, T. et al. A simple method for quantifying functional selectivity and agonist bias. ACS Chem. Neurosci. 3, 193-203 (2012).
-
(2012)
ACS Chem. Neurosci
, vol.3
, pp. 193-203
-
-
Kenakin, T.1
|