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Volumn 12, Issue 6, 2013, Pages 483-

Quantifying biased agonism: Understanding the links between affinity and efficacy

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR;

EID: 84880663464     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd3954-c1     Document Type: Letter
Times cited : (25)

References (10)
  • 1
    • 84875227396 scopus 로고    scopus 로고
    • Signalling bias in new drug discovery: Detection, quantification and therapeutic impact
    • Kenakin, T. & Christopoulos, A. Signalling bias in new drug discovery: detection, quantification and therapeutic impact. Nature Rev. Drug Discov. 12, 205-216 (2013).
    • (2013) Nature Rev. Drug Discov , vol.12 , pp. 205-216
    • Kenakin, T.1    Christopoulos, A.2
  • 2
    • 77049220618 scopus 로고
    • Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory
    • Ariens, E. J. Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. Arch. Int. Pharmacodyn. Ther. 99, 32-49 (1954).
    • (1954) Arch. Int. Pharmacodyn. Ther , vol.99 , pp. 32-49
    • Ariens, E.J.1
  • 3
  • 4
    • 33947595582 scopus 로고
    • (eds Harper, N. J. & Simmonds, A. B.) Academic Press
    • Furchgott, R. F. in Advances in Drug Research (eds Harper, N. J. & Simmonds, A. B.) 21-55 (Academic Press, 1966).
    • (1966) Advances in Drug Research , pp. 21-55
    • Furchgott, R.F.1
  • 5
    • 0021058380 scopus 로고
    • Operational models of pharmacological agonism
    • Black, J. W. & Leff, P. Operational models of pharmacological agonism. Proc. R. Soc. Lond. B Biol. Sci. 220, 141-162 (1983).
    • (1983) Proc. R. Soc. Lond. B Biol. Sci , vol.220 , pp. 141-162
    • Black, J.W.1    Leff, P.2
  • 6
    • 0019137579 scopus 로고
    • A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
    • De Lean, A., Stadel, J. M. & Lefkowitz, R. J. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor. J. Biol. Chem. 255, 7108-7117 (1980).
    • (1980) J. Biol. Chem , vol.255 , pp. 7108-7117
    • De Lean, A.1    Stadel, J.M.2    Lefkowitz, R.J.3
  • 7
    • 0027513982 scopus 로고
    • A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model
    • Samama, P., Cotecchia, S., Costa, T. & Lefkowitz, R. J. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. J. Biol. Chem. 268, 4625-4636 (1993).
    • (1993) J. Biol. Chem , vol.268 , pp. 4625-4636
    • Samama, P.1    Cotecchia, S.2    Costa, T.3    Lefkowitz, R.J.4
  • 8
    • 0030596736 scopus 로고    scopus 로고
    • The cubic ternary complex receptor-occupancy model. III. Resurrecting efficacy
    • Weiss, J. M., Morgan, P. H., Lutz, M. W. & Kenakin, T. P. The cubic ternary complex receptor-occupancy model. III. Resurrecting efficacy. J. Theor. Biol. 181, 381-397 (1996).
    • (1996) J. Theor. Biol , vol.181 , pp. 381-397
    • Weiss, J.M.1    Morgan, P.H.2    Lutz, M.W.3    Kenakin, T.P.4
  • 9
    • 80051979129 scopus 로고    scopus 로고
    • Quantifying ligand bias at seven-transmembrane receptors
    • Rajagopal, S. et al. Quantifying ligand bias at seven-transmembrane receptors. Mol. Pharmacol. 80, 367-377 (2011).
    • (2011) Mol. Pharmacol , vol.80 , pp. 367-377
    • Rajagopal, S.1
  • 10
    • 84858775788 scopus 로고    scopus 로고
    • A simple method for quantifying functional selectivity and agonist bias
    • Kenakin, T. et al. A simple method for quantifying functional selectivity and agonist bias. ACS Chem. Neurosci. 3, 193-203 (2012).
    • (2012) ACS Chem. Neurosci , vol.3 , pp. 193-203
    • Kenakin, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.