The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Journal of Neuroscience

Volumn 35, Issue 3, 2015, Pages 1199-1210

  May, Patrick C ^a   Willis, Brian A ^a   Lowe, Stephen L ^b   Dean, Robert A ^a   Monk, Scott A ^a   Cocke, Patrick J ^a   Audia, James E ^a,e   Boggs, Leonard N ^a   Borders, Anthony R ^a   Brier, Richard A ^a   Calligaro, David O ^a   Day, Theresa A ^a   Ereshefsky, Larry ^c   Erickson, Jon A ^a   Gevorkyan, Hykop ^d   Gonzales, Celedon R ^a   James, Douglas E ^a   Jhee, Stanford S ^c   Komjathy, Steven F ^a   Li, Linglin ^a   Lindstrom, Terry D ^a   Mathes, Brian M ^a   Martényi, Ferenc ^a,f   Sheehan, Scott M ^a   Stout, Stephanie L ^a   Timm, David E ^a   Vaught, Grant M ^a   Watson, Brian M ^a   Winneroski, Leonard L ^a   Yang, Zhixiang ^a   Mergott, Dustin J ^a   more..

^a ELI LILLY AND COMPANY   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c PAREXEL INTERNATIONAL   (United States)

^d CALIFORNIA CLINICAL TRIALS   (United States)

^e Department of Lead Discovery   (United States)

^f TAKEDA PHARMACEUTICALS   (United States)

Author keywords

Alzheimer s disease; Amyloid beta; BACE1; Clinical trial; Nonclinical animal model

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SECRETASE 2; BETA SECRETASE INHIBITOR; N [3 [(4A,7A) 2 AMINO 4A,5,7,7A TETRAHYDRO 4H FURO[3,4 D][1,3]THIAZIN7A YL] 4 FLUOROPHENYL] 5 FLUOROPICOLINAMIDE; PLACEBO; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; BACE1 PROTEIN, HUMAN; FUSED HETEROCYCLIC RINGS; N-(3-(2-AMINO-4A,5,7,7A-TETRAHYDRO-4H-FURO(3,4-D)(1,3)THIAZIN-7A-YL)-4-FLUOROPHENYL)-5-FLUOROPICOLINAMIDE; PICOLINIC ACID DERIVATIVE; PROTEINASE INHIBITOR; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEAGLE; CELL PROLIFERATION; CONTROLLED STUDY; COUGHING; CRYSTALLOGRAPHY; CYTOTOXICITY; DRUG POTENCY; DRUG RESPONSE; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GINGIVITIS; HEADACHE; HERPETIC STOMATITIS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INSOMNIA; LIQUID CHROMATOGRAPHY; MALE; MOUSE; MUSCLE SPASM; NONHUMAN; NORMAL HUMAN; ORTHOSTATIC HYPOTENSION; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SCOTOMA; SINUS CONGESTION; TANDEM MASS SPECTROMETRY; THORAX PAIN; UPPER RESPIRATORY TRACT INFECTION; VIRUS INFECTION; X RAY DIFFRACTION; XEROSTOMIA; ALZHEIMER DISEASE; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CEREBROSPINAL FLUID; DISEASE MODEL; DOG; METABOLISM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; DISEASE MODELS, ANIMAL; DOGS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MICE; PICOLINIC ACIDS; PROTEASE INHIBITORS;

EID: 84921521397     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4129-14.2015     Document Type: Article

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