메뉴 건너뛰기




Volumn 108, Issue 2, 2015, Pages 237-246

Molecular biophysics of Orai store-operated Ca2+ channels

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL;

EID: 84921493433     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2014.11.3473     Document Type: Review
Times cited : (63)

References (77)
  • 1
    • 0022575011 scopus 로고
    • A model for receptor-regulated calcium entry
    • J.W. Putney Jr. A model for receptor-regulated calcium entry Cell Calcium 7 1986 1 12
    • (1986) Cell Calcium , vol.7 , pp. 1-12
    • Putney, Jr.J.W.1
  • 2
    • 0023767034 scopus 로고
    • Regulation of calcium influx by second messengers in rat mast cells
    • R. Penner, G. Matthews, and E. Neher Regulation of calcium influx by second messengers in rat mast cells Nature 334 1988 499 504
    • (1988) Nature , vol.334 , pp. 499-504
    • Penner, R.1    Matthews, G.2    Neher, E.3
  • 6
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • S. Feske, and Y. Gwack A. Rao A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Nature 441 2006 179 185
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1    Gwack, Y.2    Rao, A.3
  • 9
    • 84862861740 scopus 로고    scopus 로고
    • Ion channels and transporters in lymphocyte function and immunity
    • S. Feske, E.Y. Skolnik, and M. Prakriya Ion channels and transporters in lymphocyte function and immunity Nat. Rev. Immunol. 12 2012 532 547
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 532-547
    • Feske, S.1    Skolnik, E.Y.2    Prakriya, M.3
  • 10
    • 70349162817 scopus 로고    scopus 로고
    • The functional network of ion channels in T lymphocytes
    • M.D. Cahalan, and K.G. Chandy The functional network of ion channels in T lymphocytes Immunol. Rev. 231 2009 59 87
    • (2009) Immunol. Rev. , vol.231 , pp. 59-87
    • Cahalan, M.D.1    Chandy, K.G.2
  • 11
    • 33747643506 scopus 로고    scopus 로고
    • Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
    • J.C. Mercer, and W.I. DeHaven J.W. Putney Jr. Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1 J. Biol. Chem. 281 2006 24979 24990
    • (2006) J. Biol. Chem. , vol.281 , pp. 24979-24990
    • Mercer, J.C.1    Dehaven, W.I.2    Putney, Jr.J.W.3
  • 12
    • 33745759762 scopus 로고    scopus 로고
    • Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
    • C. Peinelt, and M. Vig J.P. Kinet Amplification of CRAC current by STIM1 and CRACM1 (Orai1) Nat. Cell Biol. 8 2006 771 773
    • (2006) Nat. Cell Biol. , vol.8 , pp. 771-773
    • Peinelt, C.1    Vig, M.2    Kinet, J.P.3
  • 13
    • 33746369780 scopus 로고    scopus 로고
    • Orai1 and STIM reconstitute store-operated calcium channel function
    • J. Soboloff, and M.A. Spassova D.L. Gill Orai1 and STIM reconstitute store-operated calcium channel function J. Biol. Chem. 281 2006 20661 20665
    • (2006) J. Biol. Chem. , vol.281 , pp. 20661-20665
    • Soboloff, J.1    Spassova, M.A.2    Gill, D.L.3
  • 15
    • 33748569838 scopus 로고    scopus 로고
    • 2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
    • 2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane J. Cell Biol. 174 2006 803 813
    • (2006) J. Cell Biol. , vol.174 , pp. 803-813
    • Wu, M.M.1    Buchanan, J.2    Lewis, R.S.3
  • 17
    • 84859618951 scopus 로고    scopus 로고
    • Store-operated calcium channels: New perspectives on mechanism and function
    • R.S. Lewis Store-operated calcium channels: new perspectives on mechanism and function Cold Spring Harb. Perspect. Biol. 2011 10.1101/cshperspect.a003970
    • (2011) Cold Spring Harb. Perspect. Biol.
    • Lewis, R.S.1
  • 18
    • 84908582415 scopus 로고    scopus 로고
    • Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions
    • M.M. Wu, E.D. Covington, and R.S. Lewis Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions Mol. Biol. Cell 25 2014 3672 3685
    • (2014) Mol. Biol. Cell , vol.25 , pp. 3672-3685
    • Wu, M.M.1    Covington, E.D.2    Lewis, R.S.3
  • 19
    • 84880743513 scopus 로고    scopus 로고
    • The neglected CRAC proteins: Orai2, Orai3, and STIM2
    • M. Hoth, and B.A. Niemeyer The neglected CRAC proteins: Orai2, Orai3, and STIM2 Curr. Top. Membr 71 2013 237 271
    • (2013) Curr. Top. Membr , vol.71 , pp. 237-271
    • Hoth, M.1    Niemeyer, B.A.2
  • 20
    • 33748669602 scopus 로고    scopus 로고
    • Orai1 is an essential pore subunit of the CRAC channel
    • M. Prakriya, and S. Feske P.G. Hogan Orai1 is an essential pore subunit of the CRAC channel Nature 443 2006 230 233
    • (2006) Nature , vol.443 , pp. 230-233
    • Prakriya, M.1    Feske, S.2    Hogan, P.G.3
  • 21
    • 33749987466 scopus 로고    scopus 로고
    • CRACM1 multimers form the ion-selective pore of the CRAC channel
    • M. Vig, and A. Beck R. Penner CRACM1 multimers form the ion-selective pore of the CRAC channel Curr. Biol. 16 2006 2073 2079
    • (2006) Curr. Biol. , vol.16 , pp. 2073-2079
    • Vig, M.1    Beck, A.2    Penner, R.3
  • 22
    • 33748655172 scopus 로고    scopus 로고
    • Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
    • A.V. Yeromin, and S.L. Zhang M.D. Cahalan Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai Nature 443 2006 226 229
    • (2006) Nature , vol.443 , pp. 226-229
    • Yeromin, A.V.1    Zhang, S.L.2    Cahalan, M.D.3
  • 23
    • 48049094820 scopus 로고    scopus 로고
    • 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size
    • R. Schindl, and J. Bergsmann C. Romanin 2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size J. Biol. Chem. 283 2008 20261 20267
    • (2008) J. Biol. Chem. , vol.283 , pp. 20261-20267
    • Schindl, R.1    Bergsmann, J.2    Romanin, C.3
  • 25
  • 26
    • 77950416379 scopus 로고    scopus 로고
    • Pore architecture of the ORAI1 store-operated calcium channel
    • Y. Zhou, and S. Ramachandran P.G. Hogan Pore architecture of the ORAI1 store-operated calcium channel Proc. Natl. Acad. Sci. USA 107 2010 4896 4901
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 4896-4901
    • Zhou, Y.1    Ramachandran, S.2    Hogan, P.G.3
  • 27
    • 61349137530 scopus 로고    scopus 로고
    • STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    • C.Y. Park, and P.J. Hoover R.S. Lewis STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1 Cell 136 2009 876 890
    • (2009) Cell , vol.136 , pp. 876-890
    • Park, C.Y.1    Hoover, P.J.2    Lewis, R.S.3
  • 28
    • 61849107063 scopus 로고    scopus 로고
    • SOAR and the polybasic STIM1 domains gate and regulate Orai channels
    • J.P. Yuan, and W. Zeng S. Muallem SOAR and the polybasic STIM1 domains gate and regulate Orai channels Nat. Cell Biol. 11 2009 337 343
    • (2009) Nat. Cell Biol. , vol.11 , pp. 337-343
    • Yuan, J.P.1    Zeng, W.2    Muallem, S.3
  • 29
    • 76749153012 scopus 로고    scopus 로고
    • 2+ influx by interacting with the C-terminal acidic coiled coil of Orai1
    • 2+ influx by interacting with the C-terminal acidic coiled coil of Orai1 Biochemistry 49 2010 1067 1071
    • (2010) Biochemistry , vol.49 , pp. 1067-1071
    • Calloway, N.1    Holowka, D.2    Baird, B.3
  • 30
    • 69249152563 scopus 로고    scopus 로고
    • Molecular determinants of the coupling between STIM1 and Orai channels: Differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant
    • I. Frischauf, and M. Muik C. Romanin Molecular determinants of the coupling between STIM1 and Orai channels: differential activation of Orai1-3 channels by a STIM1 coiled-coil mutant J. Biol. Chem. 284 2009 21696 21706
    • (2009) J. Biol. Chem. , vol.284 , pp. 21696-21706
    • Frischauf, I.1    Muik, M.2    Romanin, C.3
  • 31
    • 43149090543 scopus 로고    scopus 로고
    • Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation
    • M. Muik, and I. Frischauf C. Romanin Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation J. Biol. Chem. 283 2008 8014 8022
    • (2008) J. Biol. Chem. , vol.283 , pp. 8014-8022
    • Muik, M.1    Frischauf, I.2    Romanin, C.3
  • 34
    • 84885160599 scopus 로고    scopus 로고
    • The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1
    • I. Derler, and P. Plenk C. Romanin The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1 J. Biol. Chem. 288 2013 29025 29034
    • (2013) J. Biol. Chem. , vol.288 , pp. 29025-29034
    • Derler, I.1    Plenk, P.2    Romanin, C.3
  • 35
    • 78650070349 scopus 로고    scopus 로고
    • A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
    • A. Lis, and S. Zierler R. Penner A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating J. Gen. Physiol. 136 2010 673 686
    • (2010) J. Gen. Physiol. , vol.136 , pp. 673-686
    • Lis, A.1    Zierler, S.2    Penner, R.3
  • 36
    • 84878452016 scopus 로고    scopus 로고
    • The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels
    • B.A. McNally, and A. Somasundaram M. Prakriya The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels J. Physiol. 591 2013 2833 2850
    • (2013) J. Physiol. , vol.591 , pp. 2833-2850
    • McNally, B.A.1    Somasundaram, A.2    Prakriya, M.3
  • 37
    • 77449096553 scopus 로고    scopus 로고
    • STIM1 gates the store-operated calcium channel ORAI1 in vitro
    • Y. Zhou, and P. Meraner P.G. Hogan STIM1 gates the store-operated calcium channel ORAI1 in vitro Nat. Struct. Mol. Biol. 17 2010 112 116
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 112-116
    • Zhou, Y.1    Meraner, P.2    Hogan, P.G.3
  • 38
    • 67650100398 scopus 로고    scopus 로고
    • Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant
    • I. Derler, and M. Fahrner C. Romanin Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant J. Biol. Chem. 284 2009 15903 15915
    • (2009) J. Biol. Chem. , vol.284 , pp. 15903-15915
    • Derler, I.1    Fahrner, M.2    Romanin, C.3
  • 39
    • 80055088386 scopus 로고    scopus 로고
    • Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91
    • S.L. Zhang, and A.V. Yeromin M.D. Cahalan Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91 Proc. Natl. Acad. Sci. USA 108 2011 17838 17843
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 17838-17843
    • Zhang, S.L.1    Yeromin, A.V.2    Cahalan, M.D.3
  • 40
    • 84856961815 scopus 로고    scopus 로고
    • Gated regulation of CRAC channel ion selectivity by STIM1
    • B.A. McNally, and A. Somasundaram M. Prakriya Gated regulation of CRAC channel ion selectivity by STIM1 Nature 482 2012 241 245
    • (2012) Nature , vol.482 , pp. 241-245
    • McNally, B.A.1    Somasundaram, A.2    Prakriya, M.3
  • 41
    • 34247193635 scopus 로고    scopus 로고
    • 2+ channel subunit, Orai
    • 2+ channel subunit, Orai J. Mol. Biol. 368 2007 1284 1291
    • (2007) J. Mol. Biol. , vol.368 , pp. 1284-1291
    • Cai, X.1
  • 42
    • 35648980119 scopus 로고    scopus 로고
    • 2+-dependent fast inactivation of CRAC channels: Evidence for coupling of permeation and gating
    • 2+-dependent fast inactivation of CRAC channels: evidence for coupling of permeation and gating J. Gen. Physiol. 130 2007 525 540
    • (2007) J. Gen. Physiol. , vol.130 , pp. 525-540
    • Yamashita, M.1    Navarro-Borelly, L.2    Prakriya, M.3
  • 43
    • 84885442352 scopus 로고    scopus 로고
    • Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101
    • A. Amcheslavsky, O. Safrina, and M.D. Cahalan Orai3 TM3 point mutation G158C alters kinetics of 2-APB-induced gating by disulfide bridge formation with TM2 C101 J. Gen. Physiol. 142 2013 405 412
    • (2013) J. Gen. Physiol. , vol.142 , pp. 405-412
    • Amcheslavsky, A.1    Safrina, O.2    Cahalan, M.D.3
  • 44
    • 80053431699 scopus 로고    scopus 로고
    • 2+ (CRAC) channel gating and permeation properties
    • 2+ (CRAC) channel gating and permeation properties J. Biol. Chem. 286 2011 35318 35328
    • (2011) J. Biol. Chem. , vol.286 , pp. 35318-35328
    • Srikanth, S.1    Yee, M.K.2    Ribalet, B.3
  • 45
    • 0027175061 scopus 로고
    • Calcium release-activated calcium current in rat mast cells
    • M. Hoth, and R. Penner Calcium release-activated calcium current in rat mast cells J. Physiol. 465 1993 359 386
    • (1993) J. Physiol. , vol.465 , pp. 359-386
    • Hoth, M.1    Penner, R.2
  • 46
    • 0028940921 scopus 로고
    • Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback
    • A. Zweifach, and R.S. Lewis Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback J. Gen. Physiol. 105 1995 209 226
    • (1995) J. Gen. Physiol. , vol.105 , pp. 209-226
    • Zweifach, A.1    Lewis, R.S.2
  • 47
    • 34247386336 scopus 로고    scopus 로고
    • 2+ channels with distinct functional properties
    • 2+ channels with distinct functional properties Curr. Biol. 17 2007 794 800
    • (2007) Curr. Biol. , vol.17 , pp. 794-800
    • Lis, A.1    Peinelt, C.2    Penner, R.3
  • 51
    • 80052408057 scopus 로고    scopus 로고
    • Molecular determinants within N terminus of Orai3 protein that control channel activation and gating
    • J. Bergsmann, and I. Derler C. Romanin Molecular determinants within N terminus of Orai3 protein that control channel activation and gating J. Biol. Chem. 286 2011 31565 31575
    • (2011) J. Biol. Chem. , vol.286 , pp. 31565-31575
    • Bergsmann, J.1    Derler, I.2    Romanin, C.3
  • 53
    • 80051959475 scopus 로고    scopus 로고
    • 2+ (CRAC) channels by stromal interaction molecule 1 (STIM1)
    • 2+ (CRAC) channels by stromal interaction molecule 1 (STIM1) Proc. Natl. Acad. Sci. USA 108 2011 13299 13304
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13299-13304
    • Hoover, P.J.1    Lewis, R.S.2
  • 54
    • 67649653747 scopus 로고    scopus 로고
    • Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins
    • N. Scrimgeour, and T. Litjens G.Y. Rychkov Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins J. Physiol. 587 2009 2903 2918
    • (2009) J. Physiol. , vol.587 , pp. 2903-2918
    • Scrimgeour, N.1    Litjens, T.2    Rychkov, G.Y.3
  • 56
    • 50349103128 scopus 로고    scopus 로고
    • Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry
    • W.I. DeHaven, and J.T. Smyth J.W. Putney Jr. Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry J. Biol. Chem. 283 2008 19265 19273
    • (2008) J. Biol. Chem. , vol.283 , pp. 19265-19273
    • Dehaven, W.I.1    Smyth, J.T.2    Putney, Jr.J.W.3
  • 57
    • 47249095816 scopus 로고    scopus 로고
    • 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
    • C. Peinelt, and A. Lis R. Penner 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels J. Physiol. 586 2008 3061 3073
    • (2008) J. Physiol. , vol.586 , pp. 3061-3073
    • Peinelt, C.1    Lis, A.2    Penner, R.3
  • 59
    • 84899534640 scopus 로고    scopus 로고
    • State-dependent block of Orai3 TM1 and TM3 cysteine mutants: Insights into 2-APB activation
    • A. Amcheslavsky, O. Safrina, and M.D. Cahalan State-dependent block of Orai3 TM1 and TM3 cysteine mutants: insights into 2-APB activation J. Gen. Physiol. 143 2014 621 631
    • (2014) J. Gen. Physiol. , vol.143 , pp. 621-631
    • Amcheslavsky, A.1    Safrina, O.2    Cahalan, M.D.3
  • 60
    • 38149040968 scopus 로고    scopus 로고
    • Orai1 subunit stoichiometry of the mammalian CRAC channel pore
    • O. Mignen, J.L. Thompson, and T.J. Shuttleworth Orai1 subunit stoichiometry of the mammalian CRAC channel pore J. Physiol. 586 2008 419 425
    • (2008) J. Physiol. , vol.586 , pp. 419-425
    • Mignen, O.1    Thompson, J.L.2    Shuttleworth, T.J.3
  • 61
    • 80055076956 scopus 로고    scopus 로고
    • Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states
    • A. Demuro, and A. Penna I. Parker Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states Proc. Natl. Acad. Sci. USA 108 2011 17832 17837
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 17832-17837
    • Demuro, A.1    Penna, A.2    Parker, I.3
  • 62
    • 51649121732 scopus 로고    scopus 로고
    • Functional stoichiometry of the unitary calcium-release-activated calcium channel
    • W. Ji, and P. Xu L. Chen Functional stoichiometry of the unitary calcium-release-activated calcium channel Proc. Natl. Acad. Sci. USA 105 2008 13668 13673
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13668-13673
    • Ji, W.1    Xu, P.2    Chen, L.3
  • 63
    • 55549083129 scopus 로고    scopus 로고
    • The CRAC channel consists of a tetramer formed by STIM-induced dimerization of Orai dimers
    • A. Penna, and A. Demuro M.D. Cahalan The CRAC channel consists of a tetramer formed by STIM-induced dimerization of Orai dimers Nature 456 2008 116 120
    • (2008) Nature , vol.456 , pp. 116-120
    • Penna, A.1    Demuro, A.2    Cahalan, M.D.3
  • 64
    • 78650324846 scopus 로고    scopus 로고
    • Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells
    • J. Madl, and J. Weghuber G.J. Schütz Resting state Orai1 diffuses as homotetramer in the plasma membrane of live mammalian cells J. Biol. Chem. 285 2010 41135 41142
    • (2010) J. Biol. Chem. , vol.285 , pp. 41135-41142
    • Madl, J.1    Weghuber, J.2    Schütz, G.J.3
  • 65
    • 69949095093 scopus 로고    scopus 로고
    • 2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits
    • 2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits J. Physiol. 587 2009 4181 4197
    • (2009) J. Physiol. , vol.587 , pp. 4181-4197
    • Mignen, O.1    Thompson, J.L.2    Shuttleworth, T.J.3
  • 66
    • 80052617830 scopus 로고    scopus 로고
    • The dynamic complexity of the TRPC1 channelosome
    • H.L. Ong, and I.S. Ambudkar The dynamic complexity of the TRPC1 channelosome Channels (Austin) 5 2011 424 431
    • (2011) Channels (Austin) , vol.5 , pp. 424-431
    • Ong, H.L.1    Ambudkar, I.S.2
  • 67
    • 84870655957 scopus 로고    scopus 로고
    • Crystal structure of the calcium release-activated calcium channel Orai
    • X. Hou, and L. Pedi S.B. Long Crystal structure of the calcium release-activated calcium channel Orai Science 338 2012 1308 1313
    • (2012) Science , vol.338 , pp. 1308-1313
    • Hou, X.1    Pedi, L.2    Long, S.B.3
  • 68
    • 84880709162 scopus 로고    scopus 로고
    • How many Orai's does it take to make a CRAC channel?
    • J.L. Thompson, and T.J. Shuttleworth How many Orai's does it take to make a CRAC channel? Sci. Rep 3 2013 1961
    • (2013) Sci. Rep , vol.3 , pp. 1961
    • Thompson, J.L.1    Shuttleworth, T.J.2
  • 69
    • 84921480948 scopus 로고    scopus 로고
    • STIM1 binds to pairs of Orai1 subunits to open the CRAC channel
    • M. Yen, L.A. Lokteva, and R.S. Lewis STIM1 binds to pairs of Orai1 subunits to open the CRAC channel Biophys. J. 106 2014 314a 315a
    • (2014) Biophys. J. , vol.106 , pp. 314a-315a
    • Yen, M.1    Lokteva, L.A.2    Lewis, R.S.3
  • 70
    • 0842304661 scopus 로고    scopus 로고
    • A store-operated calcium channel in Drosophila S2 cells
    • A.V. Yeromin, and J. Roos M.D. Cahalan A store-operated calcium channel in Drosophila S2 cells J. Gen. Physiol. 123 2004 167 182
    • (2004) J. Gen. Physiol. , vol.123 , pp. 167-182
    • Yeromin, A.V.1    Roos, J.2    Cahalan, M.D.3
  • 71
    • 56649094581 scopus 로고    scopus 로고
    • STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy
    • L. Navarro-Borelly, and A. Somasundaram M. Prakriya STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy J. Physiol. 586 2008 5383 5401
    • (2008) J. Physiol. , vol.586 , pp. 5383-5401
    • Navarro-Borelly, L.1    Somasundaram, A.2    Prakriya, M.3
  • 72
    • 79651469360 scopus 로고    scopus 로고
    • Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits
    • Z. Li, and L. Liu T. Xu Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits Cell Res. 21 2011 305 315
    • (2011) Cell Res. , vol.21 , pp. 305-315
    • Li, Z.1    Liu, L.2    Xu, T.3
  • 73
    • 84890960702 scopus 로고    scopus 로고
    • STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry
    • P.B. Stathopulos, and R. Schindl M. Ikura STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry Nat. Commun. 4 2013 2963
    • (2013) Nat. Commun. , vol.4 , pp. 2963
    • Stathopulos, P.B.1    Schindl, R.2    Ikura, M.3
  • 74
    • 84886379846 scopus 로고    scopus 로고
    • Pore waters regulate ion permeation in a calcium release-activated calcium channel
    • H. Dong, and G. Fiorin M.L. Klein Pore waters regulate ion permeation in a calcium release-activated calcium channel Proc. Natl. Acad. Sci. USA 110 2013 17332 17337
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 17332-17337
    • Dong, H.1    Fiorin, G.2    Klein, M.L.3
  • 75
    • 84921466921 scopus 로고    scopus 로고
    • Atomistic molecular dynamics simulations of Drosophila orai in a hydrated lipid bilayer
    • M.L. Wood Atomistic molecular dynamics simulations of Drosophila orai in a hydrated lipid bilayer Biophys. J. 106 2014 316a
    • (2014) Biophys. J. , vol.106 , pp. 316a
    • Wood, M.L.1
  • 76
    • 63849246525 scopus 로고    scopus 로고
    • Protein structure prediction on the Web: A case study using the PHYRE server
    • L.A. Kelley, and M.J.E. Sternberg Protein structure prediction on the Web: a case study using the PHYRE server Nat. Protoc. 4 2009 363 371
    • (2009) Nat. Protoc. , vol.4 , pp. 363-371
    • Kelley, L.A.1    Sternberg, M.J.E.2
  • 77
    • 79251535315 scopus 로고    scopus 로고
    • Graphical analysis of pH-dependent properties of proteins predicted using PROPKA
    • M. Rostkowski, and M.H. Olsson J.H. Jensen Graphical analysis of pH-dependent properties of proteins predicted using PROPKA BMC Struct. Biol. 11 2011 6
    • (2011) BMC Struct. Biol. , vol.11 , pp. 6
    • Rostkowski, M.1    Olsson, M.H.2    Jensen, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.