메뉴 건너뛰기




Volumn 17, Issue 1, 2010, Pages 112-117

STIM1 gates the store-operated calcium channel ORAI1 in vitro

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; MEMBRANE PROTEIN; ORAI1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; STIM1 PROTEIN, HUMAN; TUMOR PROTEIN;

EID: 77449096553     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.1724     Document Type: Article
Times cited : (215)

References (59)
  • 1
    • 34548233165 scopus 로고    scopus 로고
    • Calcium signalling in lymphocyte activation and disease
    • Feske, S. Calcium signalling in lymphocyte activation and disease. Nat. Rev. Immunol. 7, 690-702 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 690-702
    • Feske, S.1
  • 2
    • 45449093954 scopus 로고    scopus 로고
    • Calcium signaling in lymphocytes
    • Oh-hora, M. & Rao, A. Calcium signaling in lymphocytes. Curr. Opin. Immunol. 20, 250-258 (2008).
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 250-258
    • Oh-Hora, M.1    Rao, A.2
  • 3
    • 37349073896 scopus 로고    scopus 로고
    • Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses
    • Baba, Y. et al. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat. Immunol. 9, 81-88 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 81-88
    • Baba, Y.1
  • 4
    • 37349067978 scopus 로고    scopus 로고
    • Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels
    • Vig, M. et al. Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. Nat. Immunol. 9, 89-96 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 89-96
    • Vig, M.1
  • 5
    • 15544368216 scopus 로고    scopus 로고
    • Store-operated calcium channels
    • Parekh, A.B. & Putney, J.W. Jr. Store-operated calcium channels. Physiol. Rev. 85, 757-810 (2005).
    • (2005) Physiol. Rev. , vol.85 , pp. 757-810
    • Parekh, A.B.1    Putney, J.W.2
  • 6
    • 34347345599 scopus 로고    scopus 로고
    • Recent breakthroughs in the molecular mechanism of capacitative calcium entry (With thoughts on how we got here)
    • Putney, J.W. Jr. Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here). Cell Calcium 42, 103-110 (2007).
    • (2007) Cell Calcium , vol.42 , pp. 103-110
    • Putney, J.W.1
  • 7
    • 34247853462 scopus 로고    scopus 로고
    • Dissecting ICRAC, a store-operated calcium current
    • CRAC, a store-operated calcium current. Trends Biochem. Sci. 32, 235-245 (2007).
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 235-245
    • Hogan, P.G.1    Rao, A.2
  • 8
    • 21044439334 scopus 로고    scopus 로고
    • STIM1, an essential and conserved component of store-operated Ca2+ channel function
    • 2+ channel function. J. Cell Biol. 169, 435-445 (2005).
    • (2005) J. Cell Biol. , vol.169 , pp. 435-445
    • Roos, J.1
  • 9
    • 21844432686 scopus 로고    scopus 로고
    • STIM is a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx
    • 2+ influx. Curr. Biol. 15, 1235-1241 (2005).
    • (2005) Curr. Biol. , vol.15 , pp. 1235-1241
    • Liou, J.1
  • 10
    • 27144515996 scopus 로고    scopus 로고
    • STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
    • 2+ store to the plasma membrane. Nature 437, 902-905 (2005).
    • (2005) Nature , vol.437 , pp. 902-905
    • Zhang, S.L.1
  • 11
    • 33646576875 scopus 로고    scopus 로고
    • A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
    • Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179-185 (2006).
    • (2006) Nature , vol.441 , pp. 179-185
    • Feske, S.1
  • 12
    • 33745139810 scopus 로고    scopus 로고
    • Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity
    • 2+ channel activity. Proc. Natl. Acad. Sci. USA 103, 9357-9362 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9357-9362
    • Zhang, S.L.1
  • 13
    • 33744479684 scopus 로고    scopus 로고
    • CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry
    • 2+ entry. Science 312, 1220-1223 (2006).
    • (2006) Science , vol.312 , pp. 1220-1223
    • Vig, M.1
  • 14
    • 33748655172 scopus 로고    scopus 로고
    • Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
    • Yeromin, A.V. et al. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443, 226-229 (2006).
    • (2006) Nature , vol.443 , pp. 226-229
    • Yeromin, A.V.1
  • 15
    • 33748669602 scopus 로고    scopus 로고
    • Orai1 is an essential pore subunit of the CRAC channel
    • Prakriya, M. et al. Orai1 is an essential pore subunit of the CRAC channel. Nature 443, 230-233 (2006).
    • (2006) Nature , vol.443 , pp. 230-233
    • Prakriya, M.1
  • 16
    • 33749987466 scopus 로고    scopus 로고
    • CRACM1 multimers form the ion-selective pore of the CRAC channel
    • Vig, M. et al. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr. Biol. 16, 2073-2079 (2006).
    • (2006) Curr. Biol. , vol.16 , pp. 2073-2079
    • Vig, M.1
  • 17
    • 33645217935 scopus 로고    scopus 로고
    • STIM1 has a plasma membrane role in the activation of tore-operated Ca2+ channels
    • 2+ channels. Proc. Natl. Acad. Sci. USA 103, 4040-4045 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 4040-4045
    • Spassova, M.A.1
  • 18
    • 33747643506 scopus 로고    scopus 로고
    • Large store-operated calcium selective currents due to co- expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1
    • Mercer, J.C. et al. Large store-operated calcium selective currents due to co- expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J. Biol. Chem. 281, 24979-24990 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 24979-24990
    • Mercer, J.C.1
  • 19
    • 33748569838 scopus 로고    scopus 로고
    • Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane
    • 2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J. Cell Biol. 174, 803-813 (2006).
    • (2006) J. Cell Biol. , vol.174 , pp. 803-813
    • Wu, M.M.1    Buchanan, J.2    Luik, R.M.3    Lewis, R.S.4
  • 20
    • 33750940411 scopus 로고    scopus 로고
    • Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
    • 2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 103, 16704-16709 (2006).
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 16704-16709
    • Baba, Y.1
  • 21
    • 34547175313 scopus 로고    scopus 로고
    • Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion
    • 2+ store depletion. Proc. Natl. Acad. Sci. USA 104, 9301-9306 (2007).
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 9301-9306
    • Liou, J.1    Fivaz, M.2    Inoue, T.3    Meyer, T.4
  • 22
    • 34249716803 scopus 로고    scopus 로고
    • Relocalization of STIM1 for activation of store-operated Ca2+ entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca2+ store
    • 2+ store. J. Biol. Chem. 282, 12176-12185 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 12176-12185
    • Ong, H.L.1
  • 23
    • 33750056991 scopus 로고    scopus 로고
    • Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
    • Xu, P. et al. Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1. Biochem. Biophys. Res. Commun. 350, 969-976 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 969-976
    • Xu, P.1
  • 24
    • 33748548406 scopus 로고    scopus 로고
    • The elementary unit of store- operated Ca2+ entry: Local activation of CRAC channels by STIM1 at ER-plasma membrane junctions
    • 2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J. Cell Biol. 174, 815-825 (2006).
    • (2006) J. Cell Biol. , vol.174 , pp. 815-825
    • Luik, R.M.1    Wu, M.M.2    Buchanan, J.3    Lewis, R.S.4
  • 25
    • 47949132511 scopus 로고    scopus 로고
    • Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation
    • Luik, R.M., Wang, B., Prakriya, M., Wu, M.M. & Lewis, R.S. Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Nature 454, 538-542 (2008).
    • (2008) Nature , vol.454 , pp. 538-542
    • Luik, R.M.1    Wang, B.2    Prakriya, M.3    Wu, M.M.4    Lewis, R.S.5
  • 26
    • 43149090543 scopus 로고    scopus 로고
    • Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation
    • Muik, M. et al. Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J. Biol. Chem. 283, 8014-8022 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 8014-8022
    • Muik, M.1
  • 27
    • 56649094581 scopus 로고    scopus 로고
    • STIM 1-Orai 1 interactions and Orai 1 conformational changes revealed by live-cell FRET microscopy
    • Navarro-Borelly, L. et al. STIM 1-Orai 1 interactions and Orai 1 conformational changes revealed by live-cell FRET microscopy. J. Physiol. (Lond.) 586, 5383-5401 (2008).
    • (2008) J. Physiol. (Lond.) , vol.586 , pp. 5383-5401
    • Navarro-Borelly, L.1
  • 29
    • 53149128421 scopus 로고    scopus 로고
    • Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
    • Stathopulos, P.B., Zheng, L., Li, G.Y., Plevin, M.J. & Ikura, M. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell 135, 110-122 (2008).
    • (2008) Cell , vol.135 , pp. 110-122
    • Stathopulos, P.B.1    Zheng, L.2    Li, G.Y.3    Plevin, M.J.4    Ikura, M.5
  • 30
    • 35748956408 scopus 로고    scopus 로고
    • Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 complex
    • Varnai, P., Toth, B., Toth, D.J., Hunyady, L. & Balla, T. Visualization and manipulation of plasma membrane-endoplasmic reticulum contact sites indicates the presence of additional molecular components within the STIM1-Orai1 complex. J. Biol. Chem. 282, 29678-29690 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 29678-29690
    • Varnai, P.1    Toth, B.2    Toth, D.J.3    Hunyady, L.4    Balla, T.5
  • 31
    • 33745759762 scopus 로고    scopus 로고
    • Amplification of CRAC current by STIM1 and CRACM1 (Orai1)
    • Peinelt, C. et al. Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat. Cell Biol. 8, 771-773 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 771-773
    • Peinelt, C.1
  • 32
    • 33746369780 scopus 로고    scopus 로고
    • Orai1 and STIM reconstitute store-operated calcium channel function
    • Soboloff, J. et al. Orai1 and STIM reconstitute store-operated calcium channel function. J. Biol. Chem. 281, 20661-20665 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 20661-20665
    • Soboloff, J.1
  • 33
    • 0033199505 scopus 로고    scopus 로고
    • Steady-state free Ca2+ in the yeast endoplasmic reticulum reaches only 10 μM and is mainly controlled by the secretory pathway pump Pmr1
    • 2+ in the yeast endoplasmic reticulum reaches only 10 μM and is mainly controlled by the secretory pathway pump Pmr1. EMBO J. 18, 4733-4743 (1999).
    • (1999) EMBO J , vol.18 , pp. 4733-4743
    • Strayle, J.1    Pozzan, T.2    Rudolph, H.K.3
  • 35
  • 36
    • 0018930046 scopus 로고
    • Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
    • Novick, P., Field, C. & Schekman, R. Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21, 205-215 (1980).
    • (1980) Cell , vol.21 , pp. 205-215
    • Novick, P.1    Field, C.2    Schekman, R.3
  • 37
    • 0029843493 scopus 로고    scopus 로고
    • The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae
    • TerBush, D.R., Maurice, T., Roth, D. & Novick, P. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15, 6483-6494 (1996).
    • (1996) EMBO J , vol.15 , pp. 6483-6494
    • Terbush, D.R.1    Maurice, T.2    Roth, D.3    Novick, P.4
  • 38
    • 0025823999 scopus 로고
    • Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis
    • Nakamoto, R.K., Rao, R. & Slayman, C.W. Expression of the yeast plasma membrane [H+]ATPase in secretory vesicles. A new strategy for directed mutagenesis. J. Biol. Chem. 266, 7940-7949 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 7940-7949
    • Nakamoto, R.K.1    Rao, R.2    Slayman, C.W.3
  • 39
    • 0028307550 scopus 로고
    • Phosphatidylcholine translocase: A physiological role for the mdr2 gene
    • Ruetz, S. & Gros, P. Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell 77, 1071-1081 (1994).
    • (1994) Cell , vol.77 , pp. 1071-1081
    • Ruetz, S.1    Gros, P.2
  • 40
    • 0028806965 scopus 로고
    • Functional expression of the human CHIP28 water channel in a yeast secretory mutant
    • Laize, V. et al. Functional expression of the human CHIP28 water channel in a yeast secretory mutant. FEBS Lett. 373, 269-274 (1995).
    • (1995) FEBS Lett , vol.373 , pp. 269-274
    • Laize, V.1
  • 41
    • 0031890395 scopus 로고    scopus 로고
    • Reconstitution of water channel function of aquaporins 1 and 2 by expression in yeast secretory vesicles
    • Coury, L.A. et al. Reconstitution of water channel function of aquaporins 1 and 2 by expression in yeast secretory vesicles. Am. J. Physiol. 274, F34-F42 (1998).
    • (1998) Am. J. Physiol. , vol.274 , pp. F34-F42
    • Coury, L.A.1
  • 42
    • 33748136477 scopus 로고    scopus 로고
    • STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
    • crac and TRPC1 channels. Nat. Cell Biol. 8, 1003-1010 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1003-1010
    • Huang, G.N.1
  • 43
    • 47749147270 scopus 로고    scopus 로고
    • Store-dependent and -independent modes regulating Ca2+ release- activated Ca2+ channel activity of human Orai1 and Orai3
    • 2+ channel activity of human Orai1 and Orai3. J. Biol. Chem. 283, 17662-17671 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 17662-17671
    • Zhang, S.L.1
  • 44
    • 55549083129 scopus 로고    scopus 로고
    • The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
    • Penna, A. et al. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature 456, 116-120 (2008).
    • (2008) Nature , vol.456 , pp. 116-120
    • Penna, A.1
  • 45
    • 51649121732 scopus 로고    scopus 로고
    • Functional stoichiometry of the unitary calcium-release-activated calcium channel
    • Ji, W. et al. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc. Natl. Acad. Sci. USA 105, 13668-13673 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13668-13673
    • Ji, W.1
  • 46
    • 35748966974 scopus 로고    scopus 로고
    • Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation
    • 2+ channel activation. J. Biol. Chem. 282, 29448-29456 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 29448-29456
    • Li, Z.1
  • 47
    • 61349137530 scopus 로고    scopus 로고
    • STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1
    • Park, C.Y. et al. STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Cell 136, 876-890 (2009).
    • (2009) Cell , vol.136 , pp. 876-890
    • Park, C.Y.1
  • 48
    • 67650100398 scopus 로고    scopus 로고
    • Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant
    • Derler, I. et al. Increased hydrophobicity at the N terminus/membrane interface impairs gating of the severe combined immunodeficiency-related ORAI1 mutant. J. Biol. Chem. 284, 15903-15915 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 15903-15915
    • Derler, I.1
  • 49
    • 0025162252 scopus 로고
    • Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate
    • Meyer, T., Wensel, T. & Stryer, L. Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate. Biochemistry 29, 32-37 (1990).
    • (1990) Biochemistry , vol.29 , pp. 32-37
    • Meyer, T.1    Wensel, T.2    Stryer, L.3
  • 50
    • 33646570865 scopus 로고    scopus 로고
    • Ca2+ indicators based on computationally redesigned calmodulin- peptide pairs
    • 2+ indicators based on computationally redesigned calmodulin- peptide pairs. Chem. Biol. 13, 521-530 (2006).
    • (2006) Chem. Biol. , vol.13 , pp. 521-530
    • Palmer, A.E.1
  • 51
    • 61849107063 scopus 로고    scopus 로고
    • SOAR and the polybasic STIM1 domains gate and regulate Orai channels
    • Yuan, J.P. et al. SOAR and the polybasic STIM1 domains gate and regulate Orai channels. Nat. Cell Biol. 11, 337-343 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 337-343
    • Yuan, J.P.1
  • 52
    • 66749085475 scopus 로고    scopus 로고
    • A cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels
    • Muik, M. et al. A cytosolic homomerization and a modulatory domain within STIM1 C terminus determine coupling to ORAI1 channels. J. Biol. Chem. 284, 8421-8426 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 8421-8426
    • Muik, M.1
  • 53
    • 67349237167 scopus 로고    scopus 로고
    • A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels
    • Kawasaki, T., Lange, I. & Feske, S. A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels. Biochem. Biophys. Res. Commun. 385, 49-54 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.385 , pp. 49-54
    • Kawasaki, T.1    Lange, I.2    Feske, S.3
  • 54
    • 0032145257 scopus 로고    scopus 로고
    • Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: Expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae
    • Miller, C.A. III, Martinat, M.A. & Hyman, L.E. Assessment of aryl hydrocarbon receptor complex interactions using pBEVY plasmids: expression vectors with bi-directional promoters for use in Saccharomyces cerevisiae. Nucleic Acids Res. 26, 3577-3583 (1998).
    • (1998) Nucleic Acids Res , vol.26 , pp. 3577-3583
    • Miller, C.1    Martinat, M.A.2    Hyman, L.E.3
  • 55
    • 0001203596 scopus 로고
    • Secretion of foreign proteins from Saccharomyces cerevisiae directed by a-factor gene fusions
    • Bitter, G.A., Chen, K.K., Banks, A.R. & Lai, P.H. Secretion of foreign proteins from Saccharomyces cerevisiae directed by a-factor gene fusions. Proc. Natl. Acad. Sci. USA 81, 5330-5334 (1984).
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5330-5334
    • Bitter, G.A.1    Chen, K.K.2    Banks, A.R.3    Lai, P.H.4
  • 56
    • 3242877618 scopus 로고    scopus 로고
    • DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data
    • Whitmore, L. & Wallace, B.A. DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data. Nucleic Acids Res. 32, W668-W673 (2004).
    • (2004) Nucleic Acids Res , vol.32 , pp. W668-W673
    • Whitmore, L.1    Wallace, B.A.2
  • 57
    • 0032764780 scopus 로고    scopus 로고
    • Use of yeast sec6 mutant for purification of vesicles containing recombinant membrane proteins
    • Coury, L.A., Zeidel, M.L. & Brodsky, J.L. Use of yeast sec6 mutant for purification of vesicles containing recombinant membrane proteins. Methods Enzymol. 306, 169-186 (1999).
    • (1999) Methods Enzymol , vol.306 , pp. 169-186
    • Coury, L.A.1    Zeidel, M.L.2    Brodsky, J.L.3
  • 58
    • 40949123088 scopus 로고    scopus 로고
    • Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance
    • Oh-hora, M. et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat. Immunol. 9, 432-443 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 432-443
    • Oh-Hora, M.1
  • 59
    • 12344308991 scopus 로고    scopus 로고
    • Deletion of a conserved II4 silencer impairs T helper type 1- mediated immunity
    • Ansel, K.M. et al. Deletion of a conserved II4 silencer impairs T helper type 1- mediated immunity. Nat. Immunol. 5, 1251-1259 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 1251-1259
    • Ansel, K.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.