Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 43, 2011, Pages 17838-17843

  Zhang, Shenyuan L ^a,b   Yeromin, Andriy V ^a   Hu, Junjie ^c   Amcheslavsky, Anna ^a   Zheng, Hongying ^b   Cahalan, Michael D ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c NANKAI UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ca 2+; Gating mechanism; Store operated Ca 2+ entry

Indexed keywords

ALANINE; ARGININE; ASPARTIC ACID; CALCIUM ION; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; CESIUM ION; CYSTEINE; GLYCINE; MUTANT PROTEIN; PROLINE; PROTEIN SUBUNIT; STROMAL INTERACTION MOLECULE 1; TRYPTOPHAN;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; CYTOSOL; DISULFIDE BOND; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SODIUM CURRENT; STORE OPERATED CALCIUM ENTRY; WILD TYPE;

BLOTTING, WESTERN; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL LINE; CLONING, MOLECULAR; DIAMIDE; DISULFIDES; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MUTAGENESIS; MUTATION, MISSENSE; NEOPLASM PROTEINS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS;

EID: 80055088386     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114821108     Document Type: Article

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