-
1
-
-
37249004920
-
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
-
Wells, J.A. & McClendon, C.L. Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450, 1001-1009 (2007).
-
(2007)
Nature
, vol.450
, pp. 1001-1009
-
-
Wells, J.A.1
McClendon, C.L.2
-
2
-
-
79953777824
-
Macrocycles are great cycles: Applications, opportunities, and challenges of synthetic macrocycles in drug discovery
-
Marsault, E. & Peterson, M.L. Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J. Med. Chem. 54, 1961-2004 (2011).
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1961-2004
-
-
Marsault, E.1
Peterson, M.L.2
-
3
-
-
84875138812
-
Getting in shape: Controlling peptide bioactivity and bioavailability using conformational constraints
-
Bock, J.E., Gavenonis, J. & Kritzer, J.A. Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints. ACS Chem. Biol. 8, 488-499 (2013).
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 488-499
-
-
Bock, J.E.1
Gavenonis, J.2
Kritzer, J.A.3
-
4
-
-
44949231073
-
Peptidomimetics a synthetic tool of drug discovery
-
Vagner, J., Qu, H. & Hruby, V.J. Peptidomimetics, a synthetic tool of drug discovery. Curr. Opin. Chem. Biol. 12, 292-296 (2008).
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 292-296
-
-
Vagner, J.1
Qu, H.2
Hruby, V.J.3
-
5
-
-
57449084703
-
Exploring β-sheet structure and interactions with chemical model systems
-
Nowick, J.S. Exploring β-sheet structure and interactions with chemical model systems. Acc. Chem. Res. 41, 1319-1330 (2008).
-
(2008)
Acc. Chem. Res.
, vol.41
, pp. 1319-1330
-
-
Nowick, J.S.1
-
6
-
-
84875436143
-
Inhibition of α-helix-mediated protein-protein interactions using designed molecules
-
Azzarito, V., Long, K., Murphy, N.S. & Wilson, A.J. Inhibition of α-helix-mediated protein-protein interactions using designed molecules. Nat. Chem. 5, 161-173 (2013).
-
(2013)
Nat. Chem.
, vol.5
, pp. 161-173
-
-
Azzarito, V.1
Long, K.2
Murphy, N.S.3
Wilson, A.J.4
-
7
-
-
34548141882
-
Secondary structure based analysis and classification of biological interfaces: Identification of binding motifs in protein-protein interactions
-
Guharoy, M. & Chakrabarti, P. Secondary structure based analysis and classification of biological interfaces: identification of binding motifs in protein-protein interactions. Bioinformatics 23, 1909-1918 (2007).
-
(2007)
Bioinformatics
, vol.23
, pp. 1909-1918
-
-
Guharoy, M.1
Chakrabarti, P.2
-
8
-
-
38549092067
-
HotSprint: Database of computational hot spots in protein interfaces
-
Guney, E., Tuncbag, N., Keskin, O. & Gursoy, A. HotSprint: database of computational hot spots in protein interfaces. Nucleic Acids Res. 36, D662-D666 (2008).
-
(2008)
Nucleic Acids Res.
, vol.36
-
-
Guney, E.1
Tuncbag, N.2
Keskin, O.3
Gursoy, A.4
-
9
-
-
84863270608
-
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists
-
Koes, D. et al. Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS ONE 7, e32839 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Koes, D.1
-
10
-
-
77958105231
-
Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors
-
Jochim, A.L. & Arora, P.S. Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors. ACS Chem. Biol. 5, 919-923 (2010).
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 919-923
-
-
Jochim, A.L.1
Arora, P.S.2
-
11
-
-
84885995896
-
HippDB: A database of readily targeted helical protein-protein interactions
-
Bergey, C.M., Watkins, A.M. & Arora, P.S. HippDB: a database of readily targeted helical protein-protein interactions. Bioinformatics 29, 2806-2807 (2013).
-
(2013)
Bioinformatics
, vol.29
, pp. 2806-2807
-
-
Bergey, C.M.1
Watkins, A.M.2
Arora, P.S.3
-
12
-
-
77957947345
-
Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions?
-
London, N., Raveh, B., Movshovitz-Attias, D. & Schueler-Furman, O. Can self-inhibitory peptides be derived from the interfaces of globular protein-protein interactions? Proteins 78, 3140-3149 (2010).
-
(2010)
Proteins
, vol.78
, pp. 3140-3149
-
-
London, N.1
Raveh, B.2
Movshovitz-Attias, D.3
Schueler-Furman, O.4
-
13
-
-
32044470909
-
Structure and thermodynamic characterization of the EphB4/ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity
-
Chrencik, J.E. et al. Structure and thermodynamic characterization of the EphB4/ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure 14, 321-330 (2006).
-
(2006)
Structure
, vol.14
, pp. 321-330
-
-
Chrencik, J.E.1
-
14
-
-
0037195144
-
A simple physical model for binding energy hot spots in protein-protein complexes
-
Kortemme, T. & Baker, D. A simple physical model for binding energy hot spots in protein-protein complexes. Proc. Natl. Acad. Sci. USA 99, 14116-14121 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14116-14121
-
-
Kortemme, T.1
Baker, D.2
-
15
-
-
3242879771
-
Computational alanine scanning of protein-protein interfaces
-
Kortemme, T., Kim, D. & Baker, D. Computational alanine scanning of protein-protein interfaces. Sci. STKE 2004, pl2 (2004).
-
(2004)
Sci. STKE
, vol.2004
-
-
Kortemme, T.1
Kim, D.2
Baker, D.3
-
16
-
-
77949617607
-
PyRosetta: A script-based interface for implementing molecular modeling algorithms using Rosetta
-
Chaudhury, S., Lyskov, S. & Gray, J.J. PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta. Bioinformatics 26, 689-691 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 689-691
-
-
Chaudhury, S.1
Lyskov, S.2
Gray, J.J.3
-
17
-
-
38649087636
-
Spatial chemical conservation of hot spot interactions in protein-protein complexes
-
Shulman-Peleg, A., Shatsky, M., Nussinov, R. & Wolfson, H.J. Spatial chemical conservation of hot spot interactions in protein-protein complexes. BMC Biol. 5, 43 (2007).
-
(2007)
BMC Biol.
, vol.5
, pp. 43
-
-
Shulman-Peleg, A.1
Shatsky, M.2
Nussinov, R.3
Wolfson, H.J.4
-
18
-
-
48549093368
-
MSDmotif: Exploring protein sites and motifs
-
Golovin, A. & Henrick, K. MSDmotif: exploring protein sites and motifs. BMC Bioinformatics 9, 312 (2008).
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 312
-
-
Golovin, A.1
Henrick, K.2
-
19
-
-
0032479179
-
Anatomy of hot spots in protein interfaces
-
Bogan, A.A. & Thorn, K.S. Anatomy of hot spots in protein interfaces. J. Mol. Biol. 280, 1-9 (1998).
-
(1998)
J. Mol. Biol.
, vol.280
, pp. 1-9
-
-
Bogan, A.A.1
Thorn, K.S.2
-
20
-
-
0024246956
-
Surface subunit interfaces and interior of oligomeric proteins
-
Janin, J., Miller, S. & Chothia, C. Surface, subunit interfaces and interior of oligomeric proteins. J. Mol. Biol. 204, 155-164 (1988).
-
(1988)
J. Mol. Biol.
, vol.204
, pp. 155-164
-
-
Janin, J.1
Miller, S.2
Chothia, C.3
-
21
-
-
1842405464
-
Studies of protein-protein interfaces: A statistical analysis of the hydrophobic effect
-
Tsai, C.-J., Lin, S.L., Wolfson, H.J. & Nussinov, R. Studies of protein-protein interfaces: a statistical analysis of the hydrophobic effect. Protein Sci. 6, 53-64 (1997).
-
(1997)
Protein Sci.
, vol.6
, pp. 53-64
-
-
Tsai, C.-J.1
Lin, S.L.2
Wolfson, H.J.3
Nussinov, R.4
-
22
-
-
0026335990
-
Rational design of receptor-specific variants of human growth hormone
-
Cunningham, B.C. & Wells, J.A. Rational design of receptor-specific variants of human growth hormone. Proc. Natl. Acad. Sci. USA 88, 3407-3411 (1991).
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 3407-3411
-
-
Cunningham, B.C.1
Wells, J.A.2
-
23
-
-
0027132013
-
Comparison of a structural and a functional epitope
-
Cunningham, B.C. & Wells, J.A. Comparison of a structural and a functional epitope. J. Mol. Biol. 234, 554-563 (1993).
-
(1993)
J. Mol. Biol.
, vol.234
, pp. 554-563
-
-
Cunningham, B.C.1
Wells, J.A.2
-
24
-
-
0029770041
-
Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution
-
Sundström, M. et al. Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J. Biol. Chem. 271, 32197-32203 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32197-32203
-
-
Sundström, M.1
-
25
-
-
84862557429
-
A phase i first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas
-
Hong, D.S. et al. A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. Clin. Cancer Res. 18, 3396-3406 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 3396-3406
-
-
Hong, D.S.1
-
26
-
-
33747606306
-
Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling
-
Lo, S.-C., Li, X., Henzl, M.T., Beamer, L.J. & Hannink, M. Structure of the Keap1: Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J. 25, 3605-3617 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 3605-3617
-
-
Lo, S.-C.1
Li, X.2
Henzl, M.T.3
Beamer, L.J.4
Hannink, M.5
-
27
-
-
81355124042
-
Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance
-
Chen, Y., Inoyama, D., Kong, A.-N.T., Beamer, L.J. & Hu, L. Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance. Chem. Biol. Drug Des. 78, 1014-1021 (2011).
-
(2011)
Chem. Biol. Drug Des.
, vol.78
, pp. 1014-1021
-
-
Chen, Y.1
Inoyama, D.2
Kong, A.-N.T.3
Beamer, L.J.4
Hu, L.5
-
28
-
-
84877659801
-
Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity
-
Hancock, R., Schaap, M., Pfister, H. & Wells, G. Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity. Org. Biomol. Chem. 11, 3553-3557 (2013).
-
(2013)
Org. Biomol. Chem.
, vol.11
, pp. 3553-3557
-
-
Hancock, R.1
Schaap, M.2
Pfister, H.3
Wells, G.4
-
29
-
-
84878531946
-
Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments
-
Hörer, S., Reinert, D., Ostmann, K., Hoevels, Y. & Nar, H. Crystal-contact engineering to obtain a crystal form of the Kelch domain of human Keap1 suitable for ligand-soaking experiments. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69, 592-596 (2013).
-
(2013)
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
, vol.69
, pp. 592-596
-
-
Hörer, S.1
Reinert, D.2
Ostmann, K.3
Hoevels, Y.4
Nar, H.5
-
30
-
-
47149092405
-
Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy
-
Chen, Q. et al. Targeting the p27 E3 ligase SCFSkp2 results in p27-and Skp2-mediated cell-cycle arrest and activation of autophagy. Blood 111, 4690-4699 (2008).
-
(2008)
Blood
, vol.111
, pp. 4690-4699
-
-
Chen, Q.1
-
31
-
-
25844441096
-
Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubipuitin ligase
-
Hao, B. et al. Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubipuitin ligase. Mol. Cell 20, 9-19 (2005).
-
(2005)
Mol. Cell
, vol.20
, pp. 9-19
-
-
Hao, B.1
-
32
-
-
0036829681
-
Three different binding sites of Cks1 are required for p27-ubiquitin ligation
-
Sitry, D. et al. Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J. Biol. Chem. 277, 42233-42240 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42233-42240
-
-
Sitry, D.1
-
33
-
-
28844455956
-
High-throughput screening for inhibitors of the Cks1-Skp2 interaction
-
Huang, K.S. & Vassilev, L.T. High-throughput screening for inhibitors of the Cks1-Skp2 interaction. Methods Enzymol. 399, 717-728 (2005).
-
(2005)
Methods Enzymol.
, vol.399
, pp. 717-728
-
-
Huang, K.S.1
Vassilev, L.T.2
-
34
-
-
84882353683
-
High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1
-
Ungermannova, D. et al. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J. Biomol. Screen. 18, 910-920 (2013).
-
(2013)
J. Biomol. Screen.
, vol.18
, pp. 910-920
-
-
Ungermannova, D.1
-
35
-
-
84871569969
-
Specific small molecule inhibitors of Skp2-mediated p27 degradation
-
Wu, L. et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem. Biol. 19, 1515-1524 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 1515-1524
-
-
Wu, L.1
-
36
-
-
84861847390
-
Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex
-
Huang, J. et al. Structural insight into the regulation of MOF in the male-specific lethal complex and the non-specific lethal complex. Cell Res. 22, 1078-1081 (2012).
-
(2012)
Cell Res.
, vol.22
, pp. 1078-1081
-
-
Huang, J.1
-
37
-
-
79551625231
-
Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1
-
Kadlec, J. et al. Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1. Nat. Struct. Mol. Biol. 18, 142-149 (2011).
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 142-149
-
-
Kadlec, J.1
-
38
-
-
0028916599
-
A hot spot of binding energy in a hormone-receptor interface
-
Clackson, T. & Wells, J. A hot spot of binding energy in a hormone-receptor interface. Science 267, 383-386 (1995).
-
(1995)
Science
, vol.267
, pp. 383-386
-
-
Clackson, T.1
Wells, J.2
-
39
-
-
0036469060
-
Unraveling hot spots in binding interfaces: Progress and challenges
-
DeLano, W.L. Unraveling hot spots in binding interfaces: progress and challenges. Curr. Opin. Struct. Biol. 12, 14-20 (2002).
-
(2002)
Curr. Opin. Struct. Biol.
, vol.12
, pp. 14-20
-
-
Delano, W.L.1
-
40
-
-
0043245780
-
Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes
-
Gohlke, H., Kiel, C. & Case, D.A. Insights into protein-protein binding by binding free energy calculation and free energy decomposition for the Ras-Raf and Ras-RalGDS complexes. J. Mol. Biol. 330, 891-913 (2003).
-
(2003)
J. Mol. Biol.
, vol.330
, pp. 891-913
-
-
Gohlke, H.1
Kiel, C.2
Case, D.A.3
-
41
-
-
34548779127
-
Hot spots - A review of the protein-protein interface determinant amino-acid residues
-
Moreira, I.S., Fernandes, P.A. & Ramos, M.J. Hot spots-a review of the protein-protein interface determinant amino-acid residues. Proteins 68, 803-812 (2007).
-
(2007)
Proteins
, vol.68
, pp. 803-812
-
-
Moreira, I.S.1
Fernandes, P.A.2
Ramos, M.J.3
-
43
-
-
48749094943
-
Structural determinants of the ADAM inhibition by TIMP-3: Crystal structure of the TACE-N-TIMP-3 complex
-
Wisniewska, M. et al. Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex. J. Mol. Biol. 381, 1307-1319 (2008).
-
(2008)
J. Mol. Biol.
, vol.381
, pp. 1307-1319
-
-
Wisniewska, M.1
-
44
-
-
0021828928
-
Hydrogen bonding and biological specificity analysed by protein engineering
-
Fersht, A.R. et al. Hydrogen bonding and biological specificity analysed by protein engineering. Nature 314, 235-238 (1985).
-
(1985)
Nature
, vol.314
, pp. 235-238
-
-
Fersht, A.R.1
|