HIV-1 Tat activates a RhoA signaling pathway to reduce NMDA-evoked calcium responses in hippocampal neurons via an actin-dependent mechanism

Journal of Neurochemistry

Volumn 132, Issue 3, 2015, Pages 354-366

  Krogh, Kelly A ^a   Lyddon, Elizabeth ^a   Thayer, Stanley A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Actin; HIV Tat; intracellular calcium; neurotoxicity; NMDA receptor; ROCK

Indexed keywords

ACTIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TRANSACTIVATOR PROTEIN; AMINO ACID RECEPTOR STIMULATING AGENT; CALCIUM; DNA; N METHYLASPARTIC ACID;

ACTIN FILAMENT; ADAPTATION; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FEMALE; FETUS; HIPPOCAMPUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERM EXPOSURE; NONHUMAN; POLYMERIZATION; PRIMARY CELL CULTURE; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ACTINS; ANIMALS; CALCIUM; DNA; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; N-METHYLASPARTATE; NEURONS; PRIMARY CELL CULTURE; RATS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS;

EID: 84921478314     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12936     Document Type: Article

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