NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers

Neuropsychopharmacology

Volumn 14, Issue 5, 1996, Pages 301-307

  Malhotra, Anil K ^a   Pinals, Debra A ^a   Weingartner, Herbert ^b   Sirocco, Karen ^b   Missar, C David ^a   Pickar, David ^a   Breier, Alan ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Cognition; Ketamine; Memory; Psychotic disorders; Receptors, glutamate; Receptors, N methyl d aspartate

Indexed keywords

KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PLACEBO;

ADULT; ARTICLE; ATTENTION; BEHAVIOR; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; NORMAL HUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0029927565     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0893-133X(95)00137-3     Document Type: Article

References (35)

1. Abraham WC, Mason SE (1988): Effects of the NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anesthetized rats. Brain Res 462:40-46
2. Byrd LD, Standish LJ, Howell LL (1987): Behavioral effects of phencyclidine and ketamine alone and in combination with other drugs. Eur J Pharmacol 144:331-341
3. Cohen ML, Chan SL, Bhargava HN, Trevor AJ (1974): Inhibition of mammalian brain acetylcholinesterase by ketamine. Biochem Pharmacol 23:1647-1652
4. Endicott J, Spitzer RL (1978): A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia. Arch Gen Psychiatr 35:837-844
5. Flood JF, Morley JE, Lanthorn TH (1992): Effect on memory processing by D-cycloserine, an agonist of the NMDA/ glycine receptor. Eur J Pharmacol 221:249-254
6. Ghoneim MM, Hinrichs JV, Mewaldt SP, Petersen RC (1985): Ketamine: Behavioral effects of subanesthetic doses. J Clin Psychopharmacol 5:70-77
7. Hampton RY, Medzihradsky F, Woods JH, Dahlstrom PJ (1982): Stereospecific binding of 3H-phencyclidine in brain membranes. Life Sci 30:2147-2154
8. Harris EW, Ganong AH, Cotman CW (1984): Long-term potentiation in the hippocampus involves activation of N-methyl-d-aspartate receptors. Brain Res 323:132-137
9. Harris JA, Biersner RJ, Edwards D, Bailey LW (1975): Attention, learning, and personality during ketamine emergence: A plot study. Anesth Analg 54:169-172
10. Hedlund JL, Vieweg BW (1980): The Brief Psychiatric Rating Scale (BPRS): A comprehensive review. J Oper Psychiatr 11:48-64
11. Javitt DC, Zukin SR (1991): Recent advances in the phencyclidine model of schizophrenia. Am J Psychiat 148:1301-1308
12. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB Jr, Charney DS (1994): Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatr 51:199-214
13. Lee EYH, Lee CP, Wang HI, Lin WR (1993): Hippocampal CRF, NE, and NMDA system interactions in memory processing in the rat. Synapse 14:144-153
14. Luby ED, Cohen BD, Rosenbaum G, Gottlieb JS, Kelley R (1959): Study of a new schizophrenomimetic drug - sernyl. Arch Neurol Psychiatr 81:363-369
15. Moretti RJ, Hassan SZ, Goodman LI, Meltzer HY (1984): Comparison of ketamine and thiopental in healthy volunteers: Effects on mental status, mood, and personality. Anesth Analg 63:1087-1096
16. Morris RGM, Anderson E, Lynch GS, Baudry M (1986): Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319:774-776
17. Murata S, Kawasaki K (1993): Common and uncommon behavioral effects of antagonists for different modulatory sites in the NMDA receptor/channel complex. Eur J Pharmacol 239:9-15
18. Ohno M, Yamamoto T, Watanabe S (1994): Intrahippocampal administration of a glycine site antagonist impairs working memory performance of rats. Eur J Pharmacol 253: 183-187
19. Olney JW, Labruyere J, Price MT (1989): Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362
20. Overall JE, Gorham DR (1962): The brief psychiatric rating scale. Psychol Rep 10:799-812
21. Oye I, Hustveit O, Moberg ER, Pausen O, Skoglund LA (1991): The chiral forms of ketamine as probes for NMDA receptor function in humans. In Kameyama T, Nabeshima T, Domino EF (eds), NMDA Receptor Related Agents: Biochemistry, Pharmacology, and Behavior, Ann Arbor, MI, NPP Books, pp 381-389
22. Oye I, Paulsen O, Maurset A (1992): Effects of ketamine on sensory perception: Evidence for a role of N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 260:1209-1213
23. Pandit SK, Kothary SP, Kumar SM (1980): Low dose intravenous infusion technique with ketamine. Anaesthesia 35:669-675
24. Rothman S (1988): Noncompetitive N-methyl-D-aspartate antagonists effect multiple ionic currents. J Pharmacol Exp Ther 246:137-142
25. Saykin AJ, Gur RC, Gur RE, Mozley PD, Mozley LH, Resnick SM, Kester DB, Stafiniak P (1991): Neuropsychological function in schizophrenia. Arch Gen Psychiatry 48:618-624
26. Shapiro ML, Caramanos Z (1990): NMDA antagonist MK-801 impairs acquisition but not performance of spatial working and reference memory. Psychobiology 18: 231-243
27. Smith DJ, Pekoe GM, Martin LL, Coalgate B (1980): The interaction of ketamine with the opiate receptor. Life Sci 26:789-795
28. Smith DJ, Azzaro AJ, Zaldivar SB, Palmer S, Lee HS (1981): Properties of the optical isomers and metabolites of ketamine on the high affinity transport and catabolism of monoamines. Neuropharmacology 20:391-396
29. Tamlyn D, McKenna PJ, Mortimer AM, Lund CE, Hammond S, Baddeley AD (1992): Memory impairment in schizophrenia: Its extent, affiliations and neuropsychological character. Psychol Med 22:101-115
30. Weingartner HJ, Langer D, Grice J, Rapoport J (1982): Acquisition and retrieval of information in amphetamine-treated hyperactive children. Psychiatr Res 6:21-29
31. Weingartner HJ, Rudorfer MV, Buchsbaum MS, Linnoila M (1983a): Effects of serotonin on memory impairments produced by ethanol. Science 221:472-473
32. Weingartner HJ, Grafman J, Boutelle W, Kayne W, Martin PR (1983b): Forms of memory failure. Science 221:380-382
33. Weingartner HJ, Hommer D, Lister RG, Thompsom K, Wolkowitz O (1992): Selective effects of triazolam on memory. Psychopharmacology 106:341-345
34. Zhang DX, Levy WB (1992): Ketamine blocks the induction of LTP at the lateral entorhinal cortex-dentate gyrus synapses. Brain Res 593:124-127
35. Zukin SR, Zukin RS (1979): Specific [3H]phencyclidine binding in rat central nervous system. Proc Natl Acad Sci 76:5372-5376