메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages

A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions

Author keywords

[No Author keywords available]

Indexed keywords

NERVE CELL ADHESION MOLECULE; NIFEDIPINE; CALCIUM CHANNEL; CD56 ANTIGEN; CELL ADHESION MOLECULE; NCAM1 PROTEIN, MOUSE;

EID: 84898726314     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091643     Document Type: Article
Times cited : (27)

References (52)
  • 1
    • 0034175513 scopus 로고    scopus 로고
    • Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases
    • Frey D, Schneider C, Xu L, Borg J, Spooren W, et al. (2000) Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J Neurosci 20: 2534-2542. (Pubitemid 30220340)
    • (2000) Journal of Neuroscience , vol.20 , Issue.7 , pp. 2534-2542
    • Frey, D.1    Schneider, C.2    Xu, L.3    Borg, J.4    Spooren, W.5    Caroni, P.6
  • 3
    • 23744445580 scopus 로고    scopus 로고
    • A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis
    • DOI 10.1002/cne.20620
    • Schaefer AM, Sanes JR, Lichtman JW (2005) A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis. J Comp Neurol 490: 209-219. doi:10.1002/cne.20620. (Pubitemid 41140989)
    • (2005) Journal of Comparative Neurology , vol.490 , Issue.3 , pp. 209-219
    • Schaefer, A.M.1    Sanes, J.R.2    Lichtman, J.W.3
  • 5
    • 48249145306 scopus 로고    scopus 로고
    • Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy
    • Kariya S, Park G-H, Maeno-Hikichi Y, Leykekhman O, Lutz C, et al. (2008) Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17: 2552-2569.
    • (2008) Hum Mol Genet , vol.17 , pp. 2552-2569
    • Kariya, S.1    Park, G.-H.2    Maeno-Hikichi, Y.3    Leykekhman, O.4    Lutz, C.5
  • 6
    • 58849103600 scopus 로고    scopus 로고
    • Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice
    • Kong L, Wang X, Choe DW, Polley M, Burnett BG, et al. (2009) Impaired Synaptic Vesicle Release and Immaturity of Neuromuscular Junctions in Spinal Muscular Atrophy Mice. J Neurosci 29: 842-851.
    • (2009) J Neurosci , vol.29 , pp. 842-851
    • Kong, L.1    Wang, X.2    Choe, D.W.3    Polley, M.4    Burnett, B.G.5
  • 7
    • 75749129049 scopus 로고    scopus 로고
    • Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice
    • Ruiz R, Casañas JJ, Torres-Benito L, Cano R, Tabares L (2010) Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice. J Neurosci 30: 849-857.
    • (2010) J Neurosci , vol.30 , pp. 849-857
    • Ruiz, R.1    Casañas, J.J.2    Torres-Benito, L.3    Cano, R.4    Tabares, L.5
  • 8
    • 84867511739 scopus 로고    scopus 로고
    • SMN Is Required for Sensory-Motor Circuit Function in Drosophila
    • Imlach WL, Beck ES, Ben Jiwon Choi, Lotti F, Pellizzoni L, et al. (2012) SMN Is Required for Sensory-Motor Circuit Function in Drosophila. Cell 151: 427-439.
    • (2012) Cell , vol.151 , pp. 427-439
    • Imlach, W.L.1    Beck, E.S.2    Choi, B.J.3    Lotti, F.4    Pellizzoni, L.5
  • 9
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA, Jessell TM (2002) Directed differentiation of embryonic stem cells into motor neurons. Cell 110: 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 11
    • 33645219877 scopus 로고    scopus 로고
    • Motoneurons Derived from Embryonic Stem Cells Express Transcription Factors and Develop Phenotypes Characteristic of Medial Motor Column Neurons
    • Soundararajan P, Miles GB, Rubin LL, Brownstone RM, Rafuse VF (2006) Motoneurons Derived from Embryonic Stem Cells Express Transcription Factors and Develop Phenotypes Characteristic of Medial Motor Column Neurons. J Neurosci 26: 3256-3268.
    • (2006) J Neurosci , vol.26 , pp. 3256-3268
    • Soundararajan, P.1    Miles, G.B.2    Rubin, L.L.3    Brownstone, R.M.4    Rafuse, V.F.5
  • 12
    • 80054067251 scopus 로고    scopus 로고
    • Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system
    • Guo X, Gonzalez M, Stancescu M, Vandenburgh HH, Hickman JJ (2011) Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system. Biomaterials 32: 9602-9611.
    • (2011) Biomaterials , vol.32 , pp. 9602-9611
    • Guo, X.1    Gonzalez, M.2    Stancescu, M.3    Vandenburgh, H.H.4    Hickman, J.J.5
  • 13
    • 84860543316 scopus 로고    scopus 로고
    • Functional Neuromuscular Junctions Formed by Embryonic Stem Cell-Derived Motor Neurons
    • Umbach JA, Adams KL, Gundersen CB, Novitch BG (2012) Functional Neuromuscular Junctions Formed by Embryonic Stem Cell-Derived Motor Neurons. PLoS ONE 7: e36049.
    • (2012) PLoS ONE , vol.7
    • Umbach, J.A.1    Adams, K.L.2    Gundersen, C.B.3    Novitch, B.G.4
  • 14
    • 0030273379 scopus 로고    scopus 로고
    • Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth
    • DOI 10.1016/S0896-6273(00)80197-X
    • Schuster CM, Davis GW, Fetter RD, Goodman CS (1996) Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17: 641-654. (Pubitemid 26365344)
    • (1996) Neuron , vol.17 , Issue.4 , pp. 641-654
    • Schuster, C.M.1    Davis, G.W.2    Fetter, R.D.3    Goodman, C.S.4
  • 15
    • 0030273550 scopus 로고    scopus 로고
    • Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity
    • DOI 10.1016/S0896-6273(00)80198-1
    • Schuster CM, Davis GW, Fetter RD, Goodman CS (1996) Genetic dissection of structural and functional components of synaptic plasticity. II. Fasciclin II controls presynaptic structural plasticity. Neuron 17: 655-667. (Pubitemid 26365345)
    • (1996) Neuron , vol.17 , Issue.4 , pp. 655-667
    • Schuster, C.M.1    Davis, G.W.2    Fetter, R.D.3    Goodman, C.S.4
  • 16
    • 0034279193 scopus 로고    scopus 로고
    • Structural and functional alterations of neuromuscular junctions in NCAM-deficient mice
    • Rafuse VF, Polo-Parada L, Landmesser LT (2000) Structural and functional alterations of neuromuscular junctions in NCAM-deficient mice. J Neurosci 20: 6529-6539.
    • (2000) J Neurosci , vol.20 , pp. 6529-6539
    • Rafuse, V.F.1    Polo-Parada, L.2    Landmesser, L.T.3
  • 17
    • 0032519649 scopus 로고    scopus 로고
    • Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5
    • Moscoso LM, Cremer H, Sanes JR (1998) Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5. J Neurosci 18: 1465-1477. (Pubitemid 28082431)
    • (1998) Journal of Neuroscience , vol.18 , Issue.4 , pp. 1465-1477
    • Moscoso, L.M.1    Cremer, H.2    Sanes, J.R.3
  • 19
    • 1442275737 scopus 로고    scopus 로고
    • Distinct Roles of Different Neural Cell Adhesion Molecule (NCAM) Isoforms in Synaptic Maturation Revealed by Analysis of NCAM 180 kDa Isoform-Deficient Mice
    • DOI 10.1523/JNEUROSCI.4406-03.2004
    • Polo-Parada L, Bose CM, Plattner F, Landmesser LT (2004) Distinct Roles of Different Neural Cell Adhesion Molecule (NCAM) Isoforms in Synaptic Maturation Revealed by Analysis of NCAM 180 kDa Isoform-Deficient Mice. J Neurosci 24: 1852-1864. (Pubitemid 38292796)
    • (2004) Journal of Neuroscience , vol.24 , Issue.8 , pp. 1852-1864
    • Polo-Parada, L.1    Bose, C.M.2    Plattner, F.3    Landmesser, L.T.4
  • 20
    • 0035819071 scopus 로고    scopus 로고
    • Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctions
    • DOI 10.1016/S0896-6273(01)00521-9
    • Polo-Parada L, Bose CM, Landmesser LT (2001) Alterations in transmission, vesicle dynamics, and transmitter release machinery at NCAM-deficient neuromuscular junctions. Neuron 32: 815-828. (Pubitemid 34024843)
    • (2001) Neuron , vol.32 , Issue.5 , pp. 815-828
    • Polo-Parada, L.1    Bose, C.M.2    Landmesser, L.T.3
  • 21
    • 20444388629 scopus 로고    scopus 로고
    • NCAM 180 acting via a conserved C-terminal domain and MLCK is essential for effective transmission with repetitive stimulation
    • DOI 10.1016/j.neuron.2005.05.018, PII S0896627305004393
    • Polo-Parada L, Plattner F, Bose CM, Landmesser LT (2005) NCAM 180 Acting via a Conserved C-Terminal Domain and MLCK Is Essential for Effective Transmission with Repetitive Stimulation. Neuron 46: 917-931. (Pubitemid 40805352)
    • (2005) Neuron , vol.46 , Issue.6 , pp. 917-931
    • Polo-Parada, L.1    Plattner, F.2    Bose, C.3    Landmesser, L.T.4
  • 22
    • 74549159145 scopus 로고    scopus 로고
    • Neural cell adhesion molecule is required for stability of reinnervated neuromuscular junctions
    • Chipman PH, Franz CK, Nelson A, Schachner M, Rafuse VF (2010) Neural cell adhesion molecule is required for stability of reinnervated neuromuscular junctions. Eur J Neurosci 31: 238-249.
    • (2010) Eur J Neurosci , vol.31 , pp. 238-249
    • Chipman, P.H.1    Franz, C.K.2    Nelson, A.3    Schachner, M.4    Rafuse, V.F.5
  • 23
    • 0034143427 scopus 로고    scopus 로고
    • The pattern of avian intramuscular nerve branching is determined by the innervating motoneuron and its level of polysialic acid
    • Rafuse VF, Landmesser LT (2000) The pattern of avian intramuscular nerve branching is determined by the innervating motoneuron and its level of polysialic acid. J Neurosci 20: 1056-1065. (Pubitemid 30220463)
    • (2000) Journal of Neuroscience , vol.20 , Issue.3 , pp. 1056-1065
    • Rafuse, V.F.1    Landmesser, L.T.2
  • 24
    • 0022512041 scopus 로고
    • Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle
    • Covault J, Sanes JR (1986) Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscle. J Cell Biol 102: 716-730. (Pubitemid 16013130)
    • (1986) Journal of Cell Biology , vol.102 , Issue.3 , pp. 716-730
    • Covault, J.1    Sanes, J.R.2
  • 26
    • 37549012218 scopus 로고    scopus 로고
    • Selective Targeting of Different Neural Cell Adhesion Molecule Isoforms during Motoneuron Myotube Synapse Formation in Culture and the Switch from an Immature to Mature Form of Synaptic Vesicle Cycling
    • Hata K, Polo-Parada L, Landmesser LT (2007) Selective Targeting of Different Neural Cell Adhesion Molecule Isoforms during Motoneuron Myotube Synapse Formation in Culture and the Switch from an Immature to Mature Form of Synaptic Vesicle Cycling. J Neurosci 27: 14481-14493.
    • (2007) J Neurosci , vol.27 , pp. 14481-14493
    • Hata, K.1    Polo-Parada, L.2    Landmesser, L.T.3
  • 27
    • 0033180516 scopus 로고    scopus 로고
    • Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    • DOI 10.1016/S0896-6273(01)80026-X
    • Arber S, Han B, Mendelsohn M, Smith MA, Jessell TM, et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron 23: 659-674. (Pubitemid 29411557)
    • (1999) Neuron , vol.23 , Issue.4 , pp. 659-674
    • Arber, S.1    Han, B.2    Mendelsohn, M.3    Smith, M.4    Jessell, T.M.5    Sockanathan, S.6
  • 28
    • 34548833278 scopus 로고    scopus 로고
    • Imaging synaptic vesicle exocytosis and endocytosis with FM dyes
    • Gaffield MA, Betz WJ (2007) Imaging synaptic vesicle exocytosis and endocytosis with FM dyes. Nat Protoc 1: 2916-2921.
    • (2007) Nat Protoc , vol.1 , pp. 2916-2921
    • Gaffield, M.A.1    Betz, W.J.2
  • 29
    • 0029965395 scopus 로고    scopus 로고
    • Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: Involvement of Ca2+ and protein kinase C
    • Rafuse VF, Landmesser LT (1996) Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: involvement of Ca2+ and protein kinase C. J Cell Biol 132: 969-983.
    • (1996) J Cell Biol , vol.132 , pp. 969-983
    • Rafuse, V.F.1    Landmesser, L.T.2
  • 30
    • 84870228429 scopus 로고    scopus 로고
    • Generation of motor neurons from pluripotent stem cells
    • Chipman PH, Toma JS, Rafuse VF (2012) Generation of motor neurons from pluripotent stem cells. Prog Brain Res 201: 313-331
    • (2012) Prog Brain Res , vol.201 , pp. 313-331
    • Chipman, P.H.1    Toma, J.S.2    Rafuse, V.F.3
  • 31
    • 0032936983 scopus 로고    scopus 로고
    • Development of the vertebrate neuromuscular junction
    • DOI 10.1146/annurev.neuro.22.1.389
    • Sanes JR, Lichtman JW (1999) Development of the vertebrate neuromuscular junction. Annu Rev Neurosci 22: 389-442. (Pubitemid 29144893)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 389-442
    • Sanes, J.R.1    Lichtman, J.W.2
  • 32
    • 37249033781 scopus 로고    scopus 로고
    • NCAM is ubiquitylated, endocytosed and recycled in neurons
    • DOI 10.1242/jcs.019729
    • Diestel S, Schaefer D, Cremer H, Schmitz B (2007) NCAM is ubiquitylated, endocytosed and recycled in neurons. J Cell Sci 120: 4035-4049. (Pubitemid 350269409)
    • (2007) Journal of Cell Science , vol.120 , Issue.22 , pp. 4035-4049
    • Diestel, S.1    Schaefer, D.2    Cremer, H.3    Schmitz, B.4
  • 33
    • 0031021031 scopus 로고    scopus 로고
    • Novel modulatory effect of L-type calcium channels at newly formed neuromuscular junctions
    • Sugiura Y, Ko CP (1997) Novel modulatory effect of L-type calcium channels at newly formed neuromuscular junctions. J Neurosci 17: 1101-1111. (Pubitemid 27043968)
    • (1997) Journal of Neuroscience , vol.17 , Issue.3 , pp. 1101-1111
    • Sugiura, Y.1    Ko, C.-P.2
  • 35
    • 84885440959 scopus 로고    scopus 로고
    • The Neural Cell Adhesion Molecule Promotes Maturation of the Presynaptic Endocytotic Machinery by Switching Synaptic Vesicle Recycling from Adaptor Protein 3 (AP-3)- to AP-2-Dependent Mechanisms
    • Shetty A, Sytnyk V, Leshchyns'ka I, Puchkov D, Haucke V, et al. (2013) The Neural Cell Adhesion Molecule Promotes Maturation of the Presynaptic Endocytotic Machinery by Switching Synaptic Vesicle Recycling from Adaptor Protein 3 (AP-3)- to AP-2-Dependent Mechanisms. J Neurosci 33: 16828-16845.
    • (2013) J Neurosci , vol.33 , pp. 16828-16845
    • Shetty, A.1    Sytnyk, V.2    Leshchyns'ka, I.3    Puchkov, D.4    Haucke, V.5
  • 36
    • 0014962734 scopus 로고
    • Synaptic potentials recorded in cell cultures of nerve and muscle
    • Fischbach GD (1970) Synaptic potentials recorded in cell cultures of nerve and muscle. Science 169: 1331-1333.
    • (1970) Science , vol.169 , pp. 1331-1333
    • Fischbach, G.D.1
  • 37
    • 0022002236 scopus 로고
    • Release of acetylcholine from embryonic neurons upon contact with muscle cell
    • Chow I, Poo MM (1985) Release of acetylcholine from embryonic neurons upon contact with muscle cell. J Neurosci 5: 1076-1082. (Pubitemid 15123055)
    • (1985) Journal of Neuroscience , vol.5 , Issue.4 , pp. 1076-1082
    • Chow, I.1    Poo, M.-M.2
  • 38
    • 0028856002 scopus 로고
    • Acetylcholine receptor aggregation at nerve-muscle contacts in mammalian cultures: Induction by ventral spinal cord neurons is specific to axons
    • Dutton EK, Uhm CS, Samuelsson SJ, Schaffner AE, Fitzgerald SC, et al. (1995) Acetylcholine receptor aggregation at nerve-muscle contacts in mammalian cultures: induction by ventral spinal cord neurons is specific to axons. J Neurosci 15: 7401-7416.
    • (1995) J Neurosci , vol.15 , pp. 7401-7416
    • Dutton, E.K.1    Uhm, C.S.2    Samuelsson, S.J.3    Schaffner, A.E.4    Fitzgerald, S.C.5
  • 39
  • 40
    • 0037079094 scopus 로고    scopus 로고
    • Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon
    • Zhang XH, Poo M-M (2002) Localized synaptic potentiation by BDNF requires local protein synthesis in the developing axon. Neuron 36: 675-688.
    • (2002) Neuron , vol.36 , pp. 675-688
    • Zhang, X.H.1    Poo, M.-M.2
  • 41
    • 79954418381 scopus 로고    scopus 로고
    • Mutant Human Embryonic Stem Cells Reveal Neurite and Synapse Formation Defects in Type 1 Myotonic Dystrophy
    • Marteyn A, Maury Y, Gauthier MM, Lecuyer C, Vernet R, et al. (2011) Mutant Human Embryonic Stem Cells Reveal Neurite and Synapse Formation Defects in Type 1 Myotonic Dystrophy. Cell Stem Cell 8: 434-444.
    • (2011) Cell Stem Cell , vol.8 , pp. 434-444
    • Marteyn, A.1    Maury, Y.2    Gauthier, M.M.3    Lecuyer, C.4    Vernet, R.5
  • 42
    • 80052295767 scopus 로고    scopus 로고
    • Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons
    • Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, et al. (2011) Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons. Cell Stem Cell 9: 205-218.
    • (2011) Cell Stem Cell , vol.9 , pp. 205-218
    • Son, E.Y.1    Ichida, J.K.2    Wainger, B.J.3    Toma, J.S.4    Rafuse, V.F.5
  • 44
    • 0037079059 scopus 로고    scopus 로고
    • Roles of neurotransmitter in synapse formation: Development of neuromuscular junctions lacking choline acetyltransferase
    • DOI 10.1016/S0896-6273(02)01020-6
    • Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, et al. (2002) Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron 36: 635-648. (Pubitemid 35346757)
    • (2002) Neuron , vol.36 , Issue.4 , pp. 635-648
    • Misgeld, T.1    Burgess, R.W.2    Lewis, R.M.3    Cunningham, J.M.4    Lichtman, J.W.5    Sanes, J.R.6
  • 45
    • 0033535056 scopus 로고    scopus 로고
    • Neurotransmitter secretion along growing nerve processes: Comparison with synaptic vesicle exocytosis
    • DOI 10.1083/jcb.144.3.507
    • Zakharenko S, Chang S, O'Donoghue M, Popov SV (1999) Neurotransmitter secretion along growing nerve processes: comparison with synaptic vesicle exocytosis. J Cell Biol 144: 507-518. (Pubitemid 29234530)
    • (1999) Journal of Cell Biology , vol.144 , Issue.3 , pp. 507-518
    • Zakharenko, S.1    Chang, S.2    O'Donoghue, M.3    Popov, S.V.4
  • 46
    • 0032572560 scopus 로고    scopus 로고
    • ADP-ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes
    • DOI 10.1083/jcb.142.2.391
    • Ooi CE, Dell'Angelica EC, Bonifacino JS (1998) ADP-ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes. J Cell Biol 142: 391-402. (Pubitemid 28361547)
    • (1998) Journal of Cell Biology , vol.142 , Issue.2 , pp. 391-402
    • Ooi, C.E.1    Dell'Angelica, E.C.2    Bonifacino, J.S.3
  • 47
    • 82455199147 scopus 로고    scopus 로고
    • Induced pluripotent stem cells - Opportunities for disease modelling and drug discovery
    • Grskovic M, Javaherian A, Strulovici B, Daley GQ (2011) Induced pluripotent stem cells - opportunities for disease modelling and drug discovery. Nat Rev Drug Discov 10: 915-929.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 915-929
    • Grskovic, M.1    Javaherian, A.2    Strulovici, B.3    Daley, G.Q.4
  • 48
    • 56549096129 scopus 로고    scopus 로고
    • Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation
    • Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC (2008) Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation. Stem Cell 3: 637-648.
    • (2008) Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 49
    • 84859569070 scopus 로고    scopus 로고
    • Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
    • Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, et al. (2012) Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Pro Natl Acad Sci USA 109: 5803-5808.
    • (2012) Pro Natl Acad Sci USA , vol.109 , pp. 5803-5808
    • Bilican, B.1    Serio, A.2    Barmada, S.J.3    Nishimura, A.L.4    Sullivan, G.J.5
  • 50
    • 84875275232 scopus 로고    scopus 로고
    • Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
    • Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, et al. (2013) Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci USA 110: 4697-4702.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4697-4702
    • Serio, A.1    Bilican, B.2    Barmada, S.J.3    Ando, D.M.4    Zhao, C.5
  • 51
    • 84878883307 scopus 로고    scopus 로고
    • A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitoras a Candidate Therapeutic for ALS
    • Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, et al. (2013) A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitoras a Candidate Therapeutic for ALS. Stem Cell 12: 713-726.
    • (2013) Stem Cell , vol.12 , pp. 713-726
    • Yang, Y.M.1    Gupta, S.K.2    Kim, K.J.3    Powers, B.E.4    Cerqueira, A.5
  • 52
    • 84855447114 scopus 로고    scopus 로고
    • Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: Promise or reality?
    • Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwater TH (2011) Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? J Anat 220: 122-130.
    • (2011) J Anat , vol.220 , pp. 122-130
    • Thomson, S.R.1    Wishart, T.M.2    Patani, R.3    Chandran, S.4    Gillingwater, T.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.