Target promiscuity and physicochemical properties contribute to pharmacologically induced ER-stress

Toxicology in Vitro

Volumn 27, Issue 1, 2013, Pages 204-210

  Koslov Davino, E ^a   Wang, X ^a   Schroeter, T ^a  

^a PFIZER INC   (United States)

Author keywords

Endoplasmic reticulum stress; ER stress; In vivo toxicity; Physicochemical properties; Target promiscuity; XBP1

Indexed keywords

TOXIC SUBSTANCE; X BOX BINDING PROTEIN 1;

ARTICLE; BIOACCUMULATION; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; ENDOPLASMIC RETICULUM STRESS; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; IN VIVO STUDY; LIPOPHILICITY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PROTEIN DETERMINATION; SURFACE PROPERTY; UNFOLDED PROTEIN RESPONSE;

CELL LINE, TUMOR; DNA-BINDING PROTEINS; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; ENDOPLASMIC RETICULUM STRESS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; SURFACE PROPERTIES; TRANSCRIPTION FACTORS;

EID: 84869427026     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.10.004     Document Type: Article

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