Computational prediction of CNS drug exposure based on a novel in vivo dataset

Pharmaceutical Research

Volumn 29, Issue 11, 2012, Pages 3131-3142

  Bergström, Christel A S ^a,b   Charman, Susan A ^b   Nicolazzo, Joseph A ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b MONASH UNIVERSITY   (Australia)

Author keywords

blood brain barrier; CNS exposure; computational model; in silico prediction; physicochemical properties

Indexed keywords

AMANTADINE; ARGININE; ARTEMETHER; ARTEMISIN; CAFFEINE; CARNITINE; COLCHICINE; COLISTIN; CYCLOSPORIN A; DIAZEPAM; DIGOXIN; DOPAMINE; DRUG; ESTRADIOL; GLYCINE; HYPOXANTHINE; IBUPROFEN; IMIPRAMINE; LINOLENIC ACID; LOPERAMIDE; MANNITOL; NAPROXEN; PROPRANOLOL; QUINIDINE; RIMANTADINE; SAQUINAVIR; TAMOXIFEN; UNINDEXED DRUG; VALPROIC ACID; VERAPAMIL;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; BRAIN TO PLASMA RATIO; CENTRAL NERVOUS SYSTEM; DATA BASE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; DRUG EXPOSURE; IN VIVO STUDY; MATHEMATICAL COMPUTING; MOLECULAR BIOLOGY; MOLECULAR MODEL; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PREDICTION; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUALITATIVE ANALYSIS;

ADMINISTRATION, INTRAVENOUS; ANIMALS; ANIMALS, OUTBRED STRAINS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM AGENTS; COMPUTER SIMULATION; MICE; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 84867852176     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0806-5     Document Type: Article

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