Rate-limiting steps of oral absorption for poorly water-soluble drugs in dogs; prediction from a miniscale dissolution test and a physiologically-based computer simulation

Pharmaceutical Research

Volumn 25, Issue 10, 2008, Pages 2334-2344

  Takano, Ryusuke ^a   Furumoto, Kentaro ^a   Shiraki, Koji ^a   Takata, Noriyuki ^a   Hayashi, Yoshiki ^a   Aso, Yoshinori ^a   Yamashita, Shinji ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b SETSUNAN UNIVERSITY   (Japan)

Author keywords

Dissolution; In vitro in vivo correlation; Oral absorption; Poorly water soluble; Rate limiting step

Indexed keywords

APREPITANT; DANAZOL; GRISEOFULVIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPUTER SIMULATION; CRYSTAL; DISSOLUTION; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM; DRUG METABOLISM; DRUG PENETRATION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; MALE; MASS SPECTROMETER; MODEL; NONHUMAN; PARTICLE SIZE; PREDICTION; PRIORITY JOURNAL; SOLID STATE;

ADMINISTRATION, ORAL; ANIMALS; COMPUTER SIMULATION; DANAZOL; DOGS; GRISEOFULVIN; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; MORPHOLINES; NONLINEAR DYNAMICS; PARTICLE SIZE; PERMEABILITY; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 51649116580     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9637-9     Document Type: Article

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